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Highlights from the 11th ISCB Student Council Symposium 2015. Dublin, Ireland. 10 July 2015

BMC bioinformatics 2016年第3期17 Suppl 3卷 95页

作者： Katie Wilkins Mehedi Hassan Margherita Francescatto Jakob Jespersen R. Gonzalo Parra Bart Cuypers Dan DeBlasio Alexander Junge Anupama Jigisha Farzana Rahman Griet Laenen Sander Willems Lieven Thorrez Yves Moreau Nagarajan Raju Sonia Pankaj Chothani C. Ramakrishnan Masakazu Sekijima M. Michael Gromiha Paddy J Slator Nigel J Burroughs Przemysław Szałaj Zhonghui Tang Paul Michalski Oskar Luo Xingwang Li Yijun Ruan Dariusz Plewczynski Giulia Fiscon Emanuel Weitschek Massimo Ciccozzi Paola Bertolazzi Giovanni Felici Pieter Meysman Manu Vanaerschot Maya Berg Hideo Imamura Jean-Claude Dujardin Kris Laukens Westa Domanova James R. Krycer Rima Chaudhuri Pengyi Yang Fatemeh Vafaee Daniel J. Fazakerley Sean J. Humphrey David E. James Zdenka Kuncic Plant Pathology and Plant-Microbe Biology Section School of Integrative Plant Science Cornell University Ithaca USA Graduate Field of Computational Biology Cornell University Ithaca USA School of Computing & Mathematics University of South Wales Cardiff UK Department of Genome Biology for Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association ᅟ Germany Department of Surgery Massachusetts General Hospital The Broad Institute of MIT and Harvard Boston USA Department of Systems Biology Technical University of Denmark Kemitorvet Denmark Protein Physiology Lab Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires Argentina Molecular Parasitology Unit (MPU) Institute of Tropical Medicine Antwerp Belgium Advanced Database Research and Modeling (ADReM) research group University of Antwerp Antwerpen Belgium Department of Computer Science University of Arizona Tucson USA Department of Veterinary Clinical and Animal Sciences Center for non-coding RNA in Technology and Health University of Copenhagen Copenhagen Denmark University College Dublin Dublin Ireland Department of Electrical Engineering (ESAT) STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Minds Medical IT Department Leuven Belgium Scientific Institute of Public Health (WIV-ISP) Platform of Biotechnology and Molecular Biology (PBB) Brussels Belgium Department of Development and Regeneration @ Kulak KU Leuven Kortrijk Belgium Department of Biotechnology Bhupat and Jyoti Metha School of Biosciences Indian Institute of Technology Madras Chennai India Philips Research North America Briarcliff Manor USA Global Scientific Information and Computing Center (GSIC) Tokyo Institute of Technology Tokyo Japan Systems Biology Centre University of Warwick Senate House Coventry UK Systems Biology Doctoral Training Centre University of Warwick Senate House Coventry UK Center for B

A1 Highlights from the eleventh ISCB Student Council Symposium 2015 Katie Wilkins, Mehedi Hassan, Margherita Francescatto, Jakob Jespersen, R. Gonzalo Parra, Bart Cuypers, Dan DeBlasio, Alexander Junge, Anupama Jigisha, Farzana Rahman O1 Prioritizing a drug’s targets using both gene expression and structural similarity Griet Laenen, Sander Willems, Lieven Thorrez, Yves Moreau O2 Organism specific protein-RNA recognition: A computational analysis of protein-RNA complex structures from different organisms Nagarajan Raju, Sonia Pankaj Chothani, C. Ramakrishnan, Masakazu Sekijima; M. Michael Gromiha O3 Detection of Heterogeneity in Single Particle Tracking Trajectories Paddy J Slator, Nigel J Burroughs O4 3D-NOME: 3D NucleOme Multiscale Engine for data-driven modeling of three-dimensional genome architecture Przemysław Szałaj, Zhonghui Tang, Paul Michalski, Oskar Luo, Xingwang Li, Yijun Ruan, Dariusz Plewczynski O5 A novel feature selection method to extract multiple adjacent solutions for viral genomic sequences classification Giulia Fiscon, Emanuel Weitschek, Massimo Ciccozzi, Paola Bertolazzi, Giovanni Felici O6 A Systems Biology Compendium for Leishmania donovani Bart Cuypers, Pieter Meysman, Manu Vanaerschot, Maya Berg, Hideo Imamura, Jean-Claude Dujardin, Kris Laukens O7 Unravelling signal coordination from large scale phosphorylation kinetic data Westa Domanova, James R. Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J. Fazakerley, Sean J. Humphrey, David E. James, Zdenka Kuncic

关键词： Visceral Leishmaniasis Feature Selection Method Frequent Itemset Mining Leishmania Donovani Student Council

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Wire length of midimew-connected mesh network

Wire length of midimew-connected mesh network

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11th IFIP WG 10.3 International Conference on Network and Parallel computing, NPC 2014

作者： Awal, Md. Rabiul Rahman, M. M. Hafizur Nor, Rizal Mohd Sembok, Tengku Mohd Bin Tengku Miura, Yasuyuki Inoguchi, Yasushi Department of Computer Science KICT IIUM Jalan Gombak Kuala Lumpur 50728 Malaysia Cyber Security Center National Defense University Malaysia Kuala Lumpur 57000 Malaysia Graduate School of Technology Shonan Institute of Technology 1-1-25 Tsujido Nishikaigan Fujisawa Kanagawa Japan Research Center for Advanced Computing Infrastructure JAIST Nomi-Shi Ishikawa 923-1292 Japan

ISBN: (纸本)9783662449165

Midimew connected Mesh Network (MMN) is a Minimal DIstance MEsh with Wrap-around links (midimew) network. In this paper, we present the architecture of MMN and evaluate the total wire length of MMN, TESH, mesh, and torus networks. It is shown that the proposed MMN possesses simple structure and moderate wire length. The total wire length of MMN is slightly higher than that of mesh network and lower than that of 2-D torus network. Overall performance suggests that, MMN is an optimal network among these networks. © 2014 IFIP International Federation for Information Processing.

关键词： Interconnection networks (circuit switching)

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Interference Avoidance through Frequency Assignment and Association Control in IEEE 802.11 WLAN

Interference Avoidance through Frequency Assignment and Asso...

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IEEE International Symposium on Network computing and Applications

作者： Babul P. Tewari Sasthi C. Ghosh Department of Computer Science & Engineering Dr. B. C. Roy Engineering College Durgapur West Bengal India Advanced Computing and Microelectronics Unit Indian Statistical Institute Kolkata India

Very often a denser deployment of APs is required to increase the coverage and capacity in IEEE 802.11 WLAN. It increases the number of APs with overlapping coverage areas. Such overlapping eventually makes more and more clients to fall in the common coverage area of several APs. Interfering APs require different frequency channels for operation in order to avoid the co-channel interference between the APs. Two clients receiving down-link data from two non-interfering APs operating on the same frequency, may also suffer from interference, if both the clients present within the intersecting coverage area of their associating APs. This type of client interference is very common, as the number of available frequency channels is very limited. Ignorance of both types of interference may significantly overestimates the network performance while independent consideration of the frequency assignment and the association control to deal with such interferences, may lead to a sub-optimal solution. In this paper we argue that both the frequency assignment and the association control play an important role and they should be considered simultaneously to improve the overall network performance. We propose an efficient greedy algorithm that jointly deals with the frequency assignment and association control to maximize the aggregate down-link throughput while avoiding both type of interferences. Through simulation, we have shown that our proposed approach is superior than both the traditional approach of dealing with these interferences and the approach that ignores these interferences altogether.

关键词： Throughput Aggregates IEEE 802.11 Standards Frequency control Interchannel interference Channel allocation

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Systematic study of human long intergenic non-coding RNAs and their impact on cancer

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science China(Life sciences) 2013年第4期56卷 324-334页

作者： SUN Liang LUO HaiTao LIAO Qi BU DeChao ZHAO GuoGuang LIU ChangNing LIU YuanNing ZHAO Yi College of Computer Science and Technology Jilin University Bioinformatics Research Group Advanced Computing Research Laboratory Institute of Computing TechnologyChinese Academy of Sciences Department of Preventive Medicine School of Medicine Ningbo University

The functional impact of several long intergenic non-coding RNAs (lincRNAs) has been characterized in previous studies. However, it is difficult to identify lincRNAs on a large-scale and to ascertain their functions or predict their structures in laboratory experiments because of the diversity, lack of knowledge and specificity of expression of lincRNAs. Furthermore, although there are a few well-characterized examples of lincRNAs associated with cancers, these are just the tip of the iceberg owing to the complexity of cancer. Here, by combining RNA-Seq data from several kinds of human cell lines with chromatin-state maps and human expressed sequence tags, we successfully identified more than 3000 human lincRNAs, most of which were new ones. Subsequently, we predicted the functions of 105 lincRNAs based on a coding-non-coding gene co-expression network. Finally, we propose a genetic mediator and key regulator model to unveil the subtle relationships between lincRNAs and lung cancer. Twelve lincRNAs may be principal players in lung tumorigenesis. The present study combines large-scale identification and functional prediction of human lincRNAs, and is a pioneering work in characterizing cancer-associated lincRNAs by bioinformatics.

关键词： lincRNA identification functional annotation cancer

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Comprehensive, open-source resource usage measurement and analysis for HPC systems

Comprehensive, open-source resource usage measurement and an...

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作者： Browne, James C. Deleon, Robert L. Patra, Abani K. Barth, William L. Hammond, John Jones, Matthew D. Furlani, Thomas R. Schneider, Barry I. Gallo, Steven M. Ghadersohi, Amin Gentner, Ryan J. Palmer, Jeffrey T. Simakov, Nikolay Innus, Martins Bruno, Andrew E. White, Joseph P. Cornelius, Cynthia D. Yearke, Thomas Marcus, Kyle Von Laszewski, Gregor Wang, Fugang Department of Computer Science University of Texas Austin TX 78758 United States Center for Computational Research University at Buffalo State University of New York 701 Ellicott Street Buffalo NY 14203 United States Mechanical and Aerospace Engineering Department University at Buffalo State University of New York Amherst NY 14260 United States Texas Advanced Computing Center University of Texas Austin TX 78758 United States National Institute of Science and Technology Gaithersburg MD United States Pervasive Technology Institute Indiana University 2719 East 10th Street Bloomington IN 47408 United States

The important role high-performance computing (HPC) resources play in science and engineering research, coupled with its high cost (capital, power and manpower), short life and oversubscription, requires us to optimize its usage - an outcome that is only possible if adequate analytical data are collected and used to drive systems management at different granularities - job, application, user and system. This paper presents a method for comprehensive job, application and system-level resource use measurement, and analysis and its implementation. The steps in the method are system-wide collection of comprehensive resource use and performance statistics at the job and node levels in a uniform format across all resources, mapping and storage of the resultant job-wise data to a relational database, which enables further implementation and transformation of the data to the formats required by specific statistical and analytical algorithms. Analyses can be carried out at different levels of granularity: job, user, application or system-wide. Measurements are based on a new lightweight job-centric measurement tool 'TACC-Stats', which gathers a comprehensive set of resource use metrics on all compute nodes and data logged by the system scheduler. The data mapping and analysis tools are an extension of the XDMoD project. The method is illustrated with analyses of resource use for the Texas advanced computing Center's Lonestar4, Ranger and Stampede supercomputers and the HPC cluster at the Center for Computational Research. The illustrations are focused on resource use at the system, job and application levels and reveal many interesting insights into system usage patterns and also anomalous behavior due to failure/misuse. The method can be applied to any system that runs the TACC-Stats measurement tool and a tool to extract job execution environment data from the system scheduler. Copyright © 2014 John Wiley & Sons, Ltd.

关键词： Digital storage

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Understanding the implications of virtual machine management on processor microarchitecture design

Understanding the implications of virtual machine management...

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2013 IEEE International Symposium on Performance Analysis of Systems and Software, ISPASS 2013

作者： Sui, Xiufeng Sun, Tao Li, Tao Zhang, Lixin Advanced Computer Systems Laboratory Institute of Computing Technology CAS Beijing China Computer Science and Technology Department University of Science and Technology of China Hefei China Dept. of Electrical and Computer Engineering University of Florida United States

ISBN: (纸本)9781467357777

Cloud computing has demonstrated tremendous capability in a wide spectrum of online services. Virtualization provides an efficient solution to the utilization of modern multicore processor systems while affording significant flexibility. The growing popularity of virtualized datacenters motivates deeper understanding of the interactions between virtual machine management and the micro-architecture behaviors of the privileged domain. We argue that these behaviors must be factored into the design of processor microarchitecture in virtualized datacenters. In this work, we use performance counters on modern servers to study the micro-architectural execution characteristics of the privileged domain while performing various VM management operations. Our study shows that today's state-of-the-art processor still has room for further optimizations when executing virtualized cloud workloads, particularly in the organization of last level caches and on-chip cache coherence protocol. Specifically, our analysis shows that: shared caches could be partitioned to eliminate interference between the privileged domain and guest domains;the cache coherence protocol could support a high degree of data sharing of the privileged domain;and cache capacity or CPU utilization occupied by the privileged domain could be effectively managed when performing management workflows to achieve high system throughput. © 2013 IEEE.

关键词： Virtualization

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A large scale audio fingerprinting system

A large scale audio fingerprinting system

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14th Pacific-Rim Conference on Multimedia, PCM 2013

作者： Jiang, Tao Xiang, Kang Lu, Jing Wu, Rihui Li, Xin Dai, Feng Advanced Computing Research Laboratory Institute of Computing Technology Chinese Academy of Sciences Beijing China University of Chinese Academy of Sciences Beijing 100190 China Department of Computer Science and Technology Tsinghua University Beijing 100084 China

ISBN: (纸本)9783319037301

This paper presents a large scale audio fingerprinting system, which can be used to retrieve intended song from more than a million audio tracks. A time offset of several milliseconds could cause a number of audio fingerprints disappear. To decrease this effect, the query clip is converted to several copies with different start times. The audio fingerprints are mapped to hashes. Based on the statistics of the hashes on 25,000 audio tracks, it is found the frequency of occurrence does not follow the uniform distribution. A compact index structure is used to retain the quick access and none memory waste. Our experiments demonstrate the performance of this large scale audio fingerprinting system, and all of the query audio clips are captured from practical environments by various mobile devices. An iOS application is proposed based on this system and its index dataset contains more than 1 million songs. © Springer International Publishing Switzerland 2013.

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Delay-constrained adaptive early drop for real-time video delivery over IEEE 802.11 wireless networks 13

Delay-constrained adaptive early drop for real-time video de...

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7th International Conference on Ubiquitous Information Management and Communication, ICUIMC 2013

作者： Lee, Sooyong Yang, Giwon Yoon, Yohaan Lee, Kyunghee Hyun, Soon Joo Lee, Ben Kim, Myungchul Samsung Electronics Suwon Korea Republic of Department of Computer Science Korea Advanced Institute of Science and Technology Daejeon Korea Republic of Electronics and Telecommunication Research Institute Daejeon Korea Republic of School of Electrical Engineering and Computer Science Oregon State University Corvallis OR 97330 United States

ISBN: (纸本)9781450319584

The recent proliferation of mobile devices increases the demand for high-quality real-time video services in wireless network. However, the characteristics of wireless medium such as interferences and ease of congestion make it difficult for the delivered video to be played out in a timely manner. The latency introduced by those wireless characteristics severely degrades the perceptual quality of real-time video due to intermittent play out at the client side. In this paper, we propose a delay-constrained adaptive early drop scheme for real-time video delivery over IEEE 802.11 wireless networks. In our scheme, an intermediate router forcibly discards the less important video packets which are expected not to be played out in time. The simulation results demonstrate that the proposed scheme can achieve 20% lower end-to- end delay and60% less frame loss ratio with32% better Peak Signal-to-Noise Ratio (PSNR) compared to the existing cross layer mapping schemes. Copyright © 2013 ACM.

关键词： Quality of service

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Erratum to: Measurement of the inclusive jet cross-section in proton-proton collisions at s = 7 TeV using 4.5 fb −1 of data with the ATLAS detector

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Journal of High Energy Physics 2015年第9期2015卷 1-39页

作者： G. Aad B. Abbott J. Abdallah S. Abdel Khalek O. Abdinov R. Aben B. Abi M. Abolins O. S. AbouZeid H. Abramowicz H. Abreu R. Abreu Y. Abulaiti B. S. Acharya L. Adamczyk D. L. Adams J. Adelman S. Adomeit T. Adye T. Agatonovic-Jovin J. A. Aguilar-Saavedra M. Agustoni S. P. Ahlen F. Ahmadov G. Aielli H. Akerstedt T. P. A. Åkesson G. Akimoto A. V. Akimov G. L. Alberghi J. Albert S. Albrand M. J. Alconada Verzini M. Aleksa I. N. Aleksandrov C. Alexa G. Alexander G. Alexandre T. Alexopoulos M. Alhroob G. Alimonti L. Alio J. Alison B. M. M. Allbrooke L. J. Allison P. P. Allport J. Almond A. Aloisio A. Alonso F. Alonso C. Alpigiani A. Altheimer B. Alvarez Gonzalez M. G. Alviggi K. Amako Y. Amaral Coutinho C. Amelung D. Amidei S. P. Amor Dos Santos A. Amorim S. Amoroso N. Amram G. Amundsen C. Anastopoulos L. S. Ancu N. Andari T. Andeen C. F. Anders G. Anders K. J. Anderson A. Andreazza V. Andrei X. S. Anduaga S. Angelidakis I. Angelozzi P. Anger A. Angerami F. Anghinolfi A. V. Anisenkov N. Anjos A. Annovi A. Antonaki M. Antonelli A. Antonov J. Antos F. Anulli M. Aoki L. Aperio Bella R. Apolle G. Arabidze I. Aracena Y. Arai J. P. Araque A. T. H. Arce J-F. Arguin S. Argyropoulos M. Arik A. J. Armbruster O. Arnaez V. Arnal H. Arnold M. Arratia O. Arslan A. Artamonov G. Artoni S. Asai N. Asbah A. Ashkenazi B. Åsman L. Asquith K. Assamagan R. Astalos M. Atkinson N. B. Atlay B. Auerbach K. Augsten M. Aurousseau G. Avolio G. Azuelos Y. Azuma M. A. Baak A. Baas C. Bacci H. Bachacou K. Bachas M. Backes M. Backhaus J. Backus Mayes E. Badescu P. Bagiacchi P. Bagnaia Y. Bai T. Bain J. T. Baines O. K. Baker P. Balek F. Balli E. Banas Sw. Banerjee A. A. E. Bannoura V. Bansal H. S. Bansil L. Barak S. P. Baranov E. L. Barberio D. Barberis M. Barbero T. Barillari M. Barisonzi T. Barklow N. Barlow B. M. Barnett R. M. Barnett Z. Barnovska A. Baroncelli G. Barone A. J. Barr F. Barreiro J. Barreiro Guimarães da Costa R. Bartoldus A. E. Barton P. Bartos V. Bartsch A. Bassalat A. Basye R. L. Bates J. R. Batley M. Battaglia M. Battistin F. Bauer H CPPM Aix-Marseille Université and CNRS/IN2P3 Marseille France Homer L. Dodge Department of Physics and Astronomy University of Oklahoma Norman United States Institute of Physics Academia Sinica Taipei Taiwan LAL Université Paris-Sud and CNRS/IN2P3 Orsay France Institute of Physics Azerbaijan Academy of Sciences Baku Azerbaijan Nikhef National Institute for Subatomic Physics and University of Amsterdam Amsterdam Netherlands Department of Physics Oklahoma State University Stillwater United States Department of Physics and Astronomy Michigan State University East Lansing United States Department of Physics University of Toronto Toronto Canada Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Tel Aviv Israel Department of Physics Technion: Israel Institute of Technology Haifa Israel CERN Geneva Switzerland Department of Physics Stockholm University Stockholm Sweden The Oskar Klein Centre Stockholm Sweden INFN Gruppo Collegato di Udine Sezione di Trieste Udine Italy ICTP Trieste Italy Department of Physics King’s College London London United Kingdom AGH University of Science and Technology Faculty of Physics and Applied Computer Science Krakow Poland Physics Department Brookhaven National Laboratory Upton United States Department of Physics Yale University New Haven United States Fakultät für Physik Ludwig-Maximilians-Universität München München Germany Particle Physics Department Rutherford Appleton Laboratory Didcot United Kingdom Institute of Physics University of Belgrade Belgrade Serbia Laboratorio de Instrumentacao e Fisica Experimental de Particulas - LIP Lisboa Portugal Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada Granada Spain Albert Einstein Center for Fundamental Physics and Laboratory for High Energy Physics University of Bern Bern Switzerland Department of Physics Boston University Boston United States Joint Institute for Nuclear Research JINR Dubna Dubna Russia INFN

It was found that the non-perturbative corrections calculated using Pythia with the Perugia 2011 tune did not include the effect of the underlying event. The affected correction factors were recomputed using the Pythia 6.427 generator. These corrections are applied as baseline to the NLO pQCD calculations and thus the central values of the theoretical predictions have changed by a few percent with the new corrections. This has a minor impact on the agreement between the data and the theoretical predictions. Figures 2 and 6 to 13, and all the tables have been updated with the new values. A few sentences in the discussion in sections 5.2 and 9 were altered or removed.

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Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016

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Human genomics 2016年第1期10 Suppl 1卷 12页

作者： A. K. Srivastava Y. Wang R. Huang C. Skinner T. Thompson L. Pollard T. Wood F. Luo R. Stevenson R. Polimanti J. Gelernter X. Lin I. Y. Lim Y. Wu A. L. Teh L. Chen I. M. Aris S. E. Soh M. T. Tint J. L. MacIsaac F. Yap K. Kwek S. M. Saw M. S. Kobor M. J. Meaney K. M. Godfrey Y. S. Chong J. D. Holbrook Y. S. Lee P. D. Gluckman N. Karnani A. Kapoor D. Lee A. Chakravarti C. Maercker F. Graf M. Boutros G. Stamoulis F. Santoni P. Makrythanasis A. Letourneau M. Guipponi N. Panousis M. Garieri P. Ribaux E. Falconnet C. Borel S. E. Antonarakis S. Kumar J. Curran J. Blangero S. Chatterjee J. Akiyama D. Auer C. Berrios L. Pennacchio T. R. Donti G. Cappuccio M. Miller P. Atwal A. Kennedy A. Cardon C. Bacino L. Emrick J. Hertecant F. Baumer B. Porter M. Bainbridge P. Bonnen B. Graham R. Sutton Q. Sun S. Elsea Z. Hu P. Wang Y. Zhu J. Zhao M. Xiong David A. Bennett A. Hidalgo-Miranda S. Romero-Cordoba S. Rodriguez-Cuevas R. Rebollar-Vega E. Tagliabue M. Iorio E. D’Ippolito S. Baroni B. Kaczkowski Y. Tanaka H. Kawaji A. Sandelin R. Andersson M. Itoh T. Lassmann Y. Hayashizaki P. Carninci A. R. R. Forrest C. A. Semple E. A. Rosenthal B. Shirts L. Amendola C. Gallego M. Horike-Pyne A. Burt P. Robertson P. Beyers C. Nefcy D. Veenstra F. Hisama R. Bennett M. Dorschner D. Nickerson J. Smith K. Patterson D. Crosslin R. Nassir N. Zubair T. Harrison U. Peters G. Jarvik F. Menghi K. Inaki X. Woo P. Kumar K. Grzeda A. Malhotra H. Kim D. Ucar P. Shreckengast K. Karuturi J. Keck J. Chuang E. T. Liu B. Ji A. Tyler G. Ananda G. Carter H. Nikbakht M. Montagne M. Zeinieh A. Harutyunyan M. Mcconechy N. Jabado P. Lavigne J. Majewski J. B. Goldstein M. Overman G. Varadhachary R. Shroff R. Wolff M. Javle A. Futreal D. Fogelman L. Bravo W. Fajardo H. Gomez C. Castaneda C. Rolfo J. A. Pinto K. C. Akdemir L. Chin S. Patterson C. Statz S. Mockus S. N. Nikolaev X. I. Bonilla L. Parmentier B. King F. Bezrukov G. Kaya V. Zoete V. Seplyarskiy H. Sharpe T. McKee K. Popadin N. Basset-Seguin R. Ben Chaabene M. Andrianova C. Verdan K. Grosdemange O. Sumara M. E JCSRI Greenwood Genetic Center Greenwood USA School of Computing Clemson University Clemson USA Biochemical Genetics Laboratory Greenwood Genetic Center Greenwood USA Department Psychiatry Yale Sch Med and VA CT Healthcare Center West Haven USA Department Genetics Yale Sch Med and VA CT Healthcare Center West Haven USA Department Neurobiology Yale Sch Med and VA CT Healthcare Center West Haven USA Singapore Institute for Clinical Sciences Singapore Singapore National University of Singapore Singapore Singapore University of British Columbia Vancouver Canada KK Women’s and Children’s Hospital Singapore Singapore University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK University of Auckland Auckland New Zealand McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore USA Esslingen University of Applied Sciences Esslingen Germany German Cancer Research Center Heidelberg Germany Department of Genetic Medicine and Development University of Geneva Medical School Geneva Switzerland Geneva University Hospitals-HUG Service of Genetic Medicine Geneva Switzerland GE3 Institute of Genetics and Genomics of Geneva University of Geneva Medical School Geneva Switzerland South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Edinburg USA South Texas Diabetes and Obesity Institute School of Medicine University of Texas Rio-Grande Valley Brownsville USA Institute of Genetic Medicine Johns Hopkins University Baltimore USA Genomics Division Lawrence Berkeley National Laboratory Berkeley USA Molecular and Human Genetics Baylor College of Medicine Houston USA Department of Translational Medical Sciences Federico II University Naples Italy Metabolon Inc Durham USA Section of Pediatric Neurology and Neuroscience Baylor College of Medicine Houston USA Tawam Hospital Abu Dhabi United Arab Emirates Stanford Medical School Stanford USA Sch

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide association study for smoking- and drinking-associated genes in 26,394 American women with African, Asian, European, and Hispanic descents R. Polimanti, J. Gelernter O3 Effects of prenatal environment, genotype and DNA methylation on birth weight and subsequent postnatal outcomes: findings from GUSTO, an Asian birth cohort X. Lin, I. Y. Lim, Y. Wu, A. L. Teh, L. Chen, I. M. Aris, S. E. Soh, M. T. Tint, J. L. MacIsaac, F. Yap, K. Kwek, S. M. Saw, M. S. Kobor, M. J. Meaney, K. M. Godfrey, Y. S. Chong, J. D. Holbrook, Y. S. Lee, P. D. Gluckman, N. Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A. Kapoor, D. Lee, A. Chakravarti O5 Identification of extracellular matrix components inducing cancer cell migration in the supernatant of cultivated mesenchymal stem cells C. Maercker, F. Graf, M. Boutros O6 Single cell allele specific expression (ASE) IN T21 and common trisomies: a novel approach to understand DOWN syndrome and other aneuploidies G. Stamoulis, F. Santoni, P. Makrythanasis, A. Letourneau, M. Guipponi, N. Panousis, M. Garieri, P. Ribaux, E. Falconnet, C. Borel, S. E. Antonarakis O7 Role of microRNA in LCL to IPSC reprogramming S. Kumar, J. Curran, J. Blangero O8 Multiple enhancer variants disrupt gene regulatory network in Hirschsprung disease S. Chatterjee, A. Kapoor, J. Akiyama, D. Auer, C. Berrios, L. Pennacchio, A. Chakravarti O9 Metabolomic profiling for the diagnosis of neurometabolic disorders T. R. Donti, G. Cappuccio, M. Miller, P. Atwal, A. Kennedy, A. Cardon, C. Bacino, L. Emrick, J. Hertecant, F. Baumer, B. Porter, M. Bainbridge, P. Bonnen, B. Graham, R. Sutton, Q. Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer’s

关键词： Pulmonary Arterial Hypertension Oral Squamous Cell Carcinoma Deep Neural Network Autosomal Recessive Polycystic Kidney Disease Whole Genome Bisulfite Sequencing

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