MicroRNAs can regulate hundreds of target genes and play a pivotal role in a broad range of biological process. However, relatively little is known about how these highly connected miRNAs-target networks are remodelle...
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MicroRNAs can regulate hundreds of target genes and play a pivotal role in a broad range of biological process. However, relatively little is known about how these highly connected miRNAs-target networks are remodelled in the context of various diseases. Here we examine the dynamic alteration of context-specific miRNA regulation to determine whether modified microRNAs regulation on specific biological processes is a useful information source for predicting cancer prognosis. A new concept, Context-specific miRNA activity (CoMi activity) is introduced to describe the statistical difference between the expression level of a miRNA's target genes and non-targets genes within a given gene set (context).
As the number of mobile devices accessing large- scale WLANs such as campus and metropolitan area networks increases, the need for load balancing among the cells becomes crucial. In addition, the network must also sup...
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Scalar product protocol and privacy preserving add to multiply protocol (PPAtMP) are two significant basic secure multiparty computation protocols. In this paper, we claim that the two protocols are equivalent to each...
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In this paper the authors present an attack on 7-round AES-128/256 to improve the known cryptanalysis by changing the order of round transformation , using the alternative representation of the round keys, exploiting ...
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作者:
M HafeezS AsgharU A MalikA RehmanN RiazDepartment of Computer Science
SZABIST Shaheed Zulfikar Ali Bhutto Institute of Science and Technology Plot 67 Street 9 H-8/4 Islamabad Pakistan ASC
Advanced Scientific Computing National Centre for Physics Quaid-i-Azam University Campus Islamabad Pakistan
In prevailing technology trends it is apparent that the network requirements and technologies will advance in future. Therefore the need of High Performance computing (HPC) based implementation for interconnecting clu...
In prevailing technology trends it is apparent that the network requirements and technologies will advance in future. Therefore the need of High Performance computing (HPC) based implementation for interconnecting clusters is comprehensible for scalability of clusters. Grid computing provides global infrastructure of interconnecting clusters consisting of dispersed computing resources over Internet. On the other hand the leading model for HPC programming is Message Passing Interface (MPI). As compared to Grid computing, MPI is better suited for solving most of the complex computational problems. MPI itself is restricted to a single cluster. It does not support message passing over the internet to use the computing resources of different clusters in an optimal way. We propose a model that provides message passing capabilities between parallel applications over the internet. The proposed model is based on Architecture for Java Universal Message Passing (A-JUMP) framework and Enterprise Service Bus (ESB) named as High Performance computing Bus. The HPC Bus is built using ActiveMQ. HPC Bus is responsible for communication and message passing in an asynchronous manner. Asynchronous mode of communication offers an assurance for message delivery as well as a fault tolerance mechanism for message passing. The idea presented in this paper effectively utilizes wide-area intercluster networks. It also provides scheduling, dynamic resource discovery and allocation, and sub-clustering of resources for different jobs. Performance analysis and comparison study of the proposed framework with P2P-MPI are also presented in this paper.
HPC systems are notorious for operating at a small fraction of their peak performance, and the ongoing migration to multi-core and multi-socket compute nodes further complicates performance optimization. The readily a...
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Numerous class cohesion metrics can be found in the literature. However, they end up capturing different aspects of cohesion. Which metric is best suited for a given situation is always a critical question. This work ...
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Numerous class cohesion metrics can be found in the literature. However, they end up capturing different aspects of cohesion. Which metric is best suited for a given situation is always a critical question. This work focuses on exploring the strengths and weaknesses of each of the selected cohesion metrics. The issues of their applicability to capture varying strengths of cohesion and ability to identify disparate classes are addressed. The metrics are classified into five categories based on their computational approaches. Diversity and similarity among these metrics are brought out. The discussion demonstrates uses of cohesion metrics with the help of typical representative situations.
In this paper we lay out the computational challenges involved in effectively simulating complex phenomena such as sequestering CO2 in oil and gas reservoirs. The challenges arise at multiple levels: (i) the computati...
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ISBN:
(纸本)9781605588186
In this paper we lay out the computational challenges involved in effectively simulating complex phenomena such as sequestering CO2 in oil and gas reservoirs. The challenges arise at multiple levels: (i) the computational complexity of simulating the fundamental processes;(ii) the resource requirements of the computationally demanding simulations;(iii) the need for integrating real-time data (intensive) and computationally intensive simulations;(iv) and the need to implement all of these in a robust, scalable and extensible approach. We will outline the architecture and implementation of the solution we develop in response to these requirements, and discuss results to validate claims that our solution scales to effectively solve desired problem sizes and thus provides the capability to generate novel scientific insight. Copyright 2010 ACM.
As the number of mobile devices accessing large-scale WLANs such as campus and metropolitan area networks increases, the need for load balancing among the cells becomes crucial. In addition, the network must also supp...
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As the number of mobile devices accessing large-scale WLANs such as campus and metropolitan area networks increases, the need for load balancing among the cells becomes crucial. In addition, the network must also support some minimum handoff tolerance defined by an application. This paper proposes a new metric that provides load balance as well as timely handoffs for WLANs by taking into account both direct and hidden node collisions.
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