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Lecture Notes in computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2010年 6305 LNCS卷 V-VI页

作者： Resch, Michael Keller, Rainer Gabriel, Edgar Dongarra, Jack J. 70569 Stuttart Germany University of Houston Parallel Software Technologies Laboratory Houston TX 77204 United States University of Tennessee Department of Electrical Engineering and Computer Science KnoxvilleTN 37996 United States

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Analysis of PCR-RFLP gel electrophoresis images for accurate and automated HPV typing

Analysis of PCR-RFLP gel electrophoresis images for accurate...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Christos F. Maramis Anastasios N. Delopoulos Alexandros F. Lambropoulos Information Processing Laboratory Department of Electrical and Computer Engineering School of Engineering Aristotle University of Thessaloniki Thessaloniki Greece Department of Obstetrics and Gynecology General Regional Hospital Papageorgiou School of Medicine Aristotle University of Thessaloniki Thessaloniki Greece

The identification of the types of the human papilomavirus (HPV) that have infected a woman provides valuable information as regards to her risk for developing cervical cancer. HPV typing is often performed by means of manually analyzing PCR-RFLP gel electrophoresis images. However, the typing procedure that is currently employed suffers from unsatisfactory accuracy and high time consumption. In order to treat these problems we propose a novel approach to HPV typing that automates the analysis of the electrophoretic images and concurrently improves the accuracy of the typing decision. The proposed methodology contributes both to the extraction of information from the images through a novel modeling approach and also to the process of making a typing decision based on the above information by the introduction of an original HPV typing algorithm. The efficiency of our approach is demonstrated with the help of a complex worked example that involves multiple HPV infections.

关键词： Estimation Biology

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Spectral clustering approach with sparsifying technique for functional connectivity detection in the resting brain

Spectral clustering approach with sparsifying technique for ...

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International Conference on Intelligent and Advanced Systems, ICIAS

作者： Mahdi Ramezani Amin Heidari Emad Fatemizadeh Hamid Soltanian-Zadeh Biomedical Signal and Image Processing Laboratory Sharif University of Technology Tehran Iran Radiology Image Analysis Laboratory Henry Ford Health System Detroit MI USA Control and Intelligent Processing Center of Excellence Electrical and Computer Engineering Department University of Tehran Iran

The aim of this study is to assess the functional connectivity from resting state functional magnetic resonance imaging (fMRI) data. Spectral clustering algorithm was applied to the realistic and real fMRI data acquired from a resting healthy subject to find functionally connected brain regions. In order to make computation of the spectral decompositions of the entire brain volume feasible, the similarity matrix has been sparsified with the t-nearest-neighbor approach. Realistic data were created to investigate the performance of the proposed algorithm and comparing it to the recently proposed spectral clustering algorithm with the Nystrom approximation and also with some well-known algorithms such as the Cross Correlation Analysis (CCA) and the spatial Independent Component Analysis (sICA). To enhance the performance of the methods, a variety of data pre and post processing steps, including data normalization, outlier removal, dimensionality reduction by using wavelet coefficients, estimation of number of clusters and optimal number of independent components (ICs). Results demonstrate the applicability of the proposed algorithm for functional connectivity analysis.

关键词： Clustering algorithms Algorithm design and analysis Correlation Approximation methods Independent component analysis Time series analysis Approximation algorithms

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A statistical shape model using 2D-principal component analysis from few medical samples and its evaluation

A statistical shape model using 2D-principal component analy...

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International Conference on Software engineering and Data Mining (SEDM)

作者： Tomoko Tateyama Taishi Tanaka Shinya Kohara Amir Hossein Foruzan Akira Furukawa Yen-Wei Chen Intelligent Image Processing Laboratory College of Information Science and Engineering Ritsumeikan University Shiga Japan Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering College of Engineering University of Tehran Tehran Iran Department of Radiology Shiga University of Medical Science Shiga Japan

ISBN: (纸本)9781424473243;9788988678220;9788988678213

Since the medical training samples are very limited, it is difficult to construct a statistical shape model with good generalization using few samples. In this paper, we propose a novel statistical shape modeling method using 2D PCA. The 3D shape is represented as a matrix by spherical parameterization. The experiments showed that our proposed method can reconstruct statistical shape model with good generalization even using fewer samples.

关键词： Biomedical imaging Shape control Biomedical engineering Principal component analysis Liver Information analysis Educational institutions Azimuth Covariance matrix Image analysis

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Comparison of voxel-based morphometry (VBM) and tractography of diffusion tensor MRI (DT-MRI) in temporal lobe epilepsy

Comparison of voxel-based morphometry (VBM) and tractography...

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Iranian Conference on electrical engineering (ICEE)

作者： Maryam Afzali Hamid Soltanian-Zadeh Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran Image Analysis Laboratory Radiology Department Henry Ford Health System Detroit MI USA

ISBN: (纸本)9781424467600

Temporal lobe epilepsy (TLE) is a neurological disease that affects millions of individuals in the world. Majority of TLE patients suffer from refractory seizures. Determining abnormal/damaged regions of the brain that harbor seizure focus is a critical step towards treatment of TLE patients. Diffusion tensor imaging (DTI) is a non-invasive method that we use in this work to determine damaged regions of white matter in the brain. To this end, we apply two methods, voxel based morphometry (VBM) and fiber tracking. We use these methods along with two anisotropy maps (EAR and FA) extracted from the DTI data. We use DTI data of 31 subjects (12 normal subjects and 19 TLE patients) for testing and evaluation studies. The VBM method shows that TLE is associated with reduction of both of FA and EAR values in several regions within the temporal lobes. The tractography method shows abnormal diffusion characteristics in three fiber bundles (fornix, uncinate fasciculus, and cingulum). The results show that the EAR maps are less sensitive to noise than the FA maps and the EAR values change more than the FA values in TLE.

关键词： Tensile stress Magnetic resonance imaging Diffusion tensor imaging Temporal lobe Epilepsy Ear Optical fiber testing Diseases Focusing Medical treatment

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Wireless tomography, Part I: A novel approach to remote sensing

Wireless tomography, Part I: A novel approach to remote sens...

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International Waveform Diversity and Design Conference

作者： R. C. Qiu M. C. Wicks L. Li Z. Hu S. J. Hou P. Chen J. P. Browning Cognitive Radio Institute Department of Electrical and Computer Engineering Center for Manufacturing Research Tennessee Technological University Cookeville TN USA Air Force Research Laboratory Rome NY USA Department of Mathematics Syracuse University Syracuse NY USA Radar Signal Processing Branch Air Force Research Laboratory Dayton OH USA

Wireless tomography, a novel approach to remote sensing, is proposed in Part I of this series. The methodology, literature review, related work, and system engineering are presented. Concrete algorithms and hardware platforms are implemented to demonstrate this concept. Self-cohering tomography is studied in depth. More research will be reported, following this initiative.

关键词： Tomography Wireless communication Wireless sensor networks Sensors Image reconstruction Radar imaging

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Techniques for Automatic Magnetic Resonance Image Classification

Techniques for Automatic Magnetic Resonance Image Classifica...

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International Conference on Genetic and Evolutionary Computing (ICGEC)

作者： Hsian-Min Chen Shih-Yu Chen Jyh Wen Chai Clayton Chi-Chang Chen Chao-Cheng Wu Yen-Chieh Ouyang Ching Tsorng Tsai Ching-Wen Yang San-Kan Lee Chein-I Chang Department of Biomedical Engineering Hungkuang University Taichung Taiwan Department of Electrical Engineering National Chung Hsing University Taichung Taiwan Department of Radiology Taichung Veterans General Hospital Taichung Taiwan Section of Radiology College of Medicine China Medical University Taichung Taiwan Department of Radiological Technology Central Taiwan University of Science and Technology Taichung Taiwan Department of Electrical Engineering National Taipei University of Technology Taipei Taiwan Computer Science Department Tunghai University Taichung Taiwan Computer Center Taichung Veterans General Hospital Taichung Taiwan Remote Sensing Signal and Image Processing Laboratory Department of Computer Science and Electrical Engineering University of Maryland Baltimore County Baltimore MD USA

Designing and developing automatic techniques for magnetic resonance images (MR) for data analysis is very challenging. One popular and public available method, FAST (FMRIB Automatic Segmentation Tool) has been widely used for automatic brain tissue segmentation for this purpose. This paper investigates limitations of this software algorithm on implementation and further develops a new approach to automatic MR brain tissue classification. The proposed new technique first implements an unsupervised training sample generation process (UTSGP) which includes a Pixel Purity Index (PPI) to generate an initial set of training samples that are further refined by a Support Vector Machine. The resulting training samples are then as a set of training samples for an Iterative Fisher's Linear Discriminant Analysis (IFLDA) which implements FLDA iteratively to improve classification. In order to conduct a fair comparison synthetic images are used for performance evaluation. Experimental results show that our proposed technique is superior in practical implementation to this software algorithm in several aspects of generalization ability, flexibility of choosing number of classes to be classified, avoidance of inconsistent results caused by different initial conditions.

关键词： Classification algorithms Training Image segmentation Brain Skull Software algorithms Support vector machines

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Volume-based Magnetic Resonance Brain Image Classification

Volume-based Magnetic Resonance Brain Image Classification

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International Conference on Genetic and Evolutionary Computing (ICGEC)

作者： Yaw-Jiunn Chiou Jyh-Wen Chai Clayton Chi-Chang Chen Shih-Yu Chen Hsian-Min Chen Yen-Chieh Ouyang Wu-Chung Su Ching Tsorng Tsai Ching-Wen Yang San-Kan Lee Chein-I Chang Department of Electrical Engineering National Chung Hsing University Taichung Taiwan Department of Radiology Taichung Veterans General Hospital Taichung Taiwan Section of Radiology College of Medicine China Medical University Taichung Taiwan Department of Radiological Technology Central Taiwan University of Science and Technology Taichung Taiwan Department of Biomedical Engineering Hungkuang University Taichung Taiwan Computer Science Department Tunghai University Taichung Taiwan Computer Center Taichung Veterans General Hospital Taichung Taiwan Remote Sensing Signal and Image Processing Laboratory Department of Computer Science and Electrical Engineering University of Maryland Baltimore MD USA

This paper develops a volume-based technique, called Volume Sphering Analysis (VSA) which can process all acquired Magnetic Resonance (MR) image slices formed image cube using only one set of training samples obtained from an image slice. So, several significant advantages and benefits can be gained from our proposed VSA. In the past, when MR image classification is performed, each image slice requires its own specific training samples and training samples obtained from one slice are not applied to another slice. The VSA allows users to reduce computational time. In addition, it saves significant effort in selecting training samples for each of image slices. Thirdly, it is robust to all image slices compared to the traditional one-slice MR image classification which is sensitive to each image slice. Experimental results demonstrate that the VSA performs as well as does that using specifically selected training samples for individual image slices.

关键词： Training Support vector machine classification Image classification Vectors Volume measurement Magnetic resonance

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Multiple-atlas-based automatic sementation of hippocampus for lateralization in temporal lobe epilepsy

Multiple-atlas-based automatic sementation of hippocampus fo...

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IEEE International Symposium on Biomedical Imaging

作者： Alireza Akhondi-Asl Kourosh Jafari-Khouzani Hamid Soltanian-Zadeh Image Analysis Laboratory Department of Diagnostic Radiology Henry Ford Health System Detroit MI USA School of Cognitive Sciences Institute of Studies in Theoretical Physics and Mathematics Tehran Iran Control and Intelligent Processing Center of Excellence School of Electrical and Computer Engineering University of Tehran Tehran Iran

ISBN: (纸本)9781424441259

We introduce a 3D segmentation framework which uses principal shapes. The probabilistic energy function of the method is defined based on intensity, tissue type, and location information of the structures using a multiple atlas method. For intensity information, nonparametric probability density function is used which considers intensity relation of different structures. To find a local minimum of the energy function, a two-step optimization strategy is used. In the first step, shape parameters are optimized based on the analytic derivatives of the energy function. In the second step, shapes of the structures are fine-tuned using a level set method. The proposed method is shown to be superior to some popular methods in the literature using a dataset of 64 patients with mesial temporal lobe epilepsy. In addition, the method can be used for lateralization with accuracy close to that of manual segmentation.

关键词： Hippocampus Temporal lobe Epilepsy Image segmentation Principal component analysis Shape control Probability density function Level set Skull Algorithm design and analysis

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A Bayesian Perspective on Sparse Regularization for STAP Post-processing

A Bayesian Perspective on Sparse Regularization for STAP Pos...

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IEEE Radar Conference

作者： Jason T. Parker Lee C. Potter Radar Signal Processing Branch Sensors Directorate US Air Force Research Laboratory Department of Electrical and Computer Engineering The Ohio State University

ISBN: (纸本)9781424458110

Traditional Space Time Adaptive processing (STAP) formulations cast the problem as a detection task which results in an optimal decision statistic for a single target in colored Gaussian noise. In the present work, inspired by recent theoretical and algorithmic advances in the field known as compressed sensing, we impose a Laplacian prior on the targets themselves which encourages sparsity in the resulting reconstruction of the angle/Doppler plane. By casting the problem in a Bayesian framework, it becomes readily apparent that sparse regularization can be applied as a post-processing step after the use of a traditional STAP algorithm for clutter estimation. Simulation results demonstrate that this approach allows closely spaced targets to be more easily distinguished.

关键词： Bayesian inference Space time adaptive processing Targets Gaussian noise Compressed sensing

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