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Applications of artificial intelligence to lipid nanoparticle delivery

Particuology 2024年第7期90卷 88-97页

作者： Ye Yuan Yuqi Wu Jiabei Cheng Kaiyuan Yang Yilin Xia Hongguang Wu Xiaoyong Pan Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong UniversityKey Laboratory of System Control and Information ProcessingMinistry of Education of ChinaChina Songjiang Research Institute Songjiang District Central HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Lipid nanoparticles(LNPs)are nanocarriers composed of four lipid components and can be used for gene therapy,protein replacement,and vaccine ***,LNPs also face several challenges,such as toxicity,immune activation,and low delivery *** overcome these challenges,artificial intelligence can be used to optimize the design and formulation of LNPs,as well as to predict their properties and ***,antibody-targeted conjugation can be used to enhance the specificity and selectivity of LNPs by attaching an antibody that recognizes a specific antigen on the cell surface to LNPs.

关键词： Artificial intelligence Lipid nanoparticles Antibody Targeted conjugation

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Contour extraction model introducing contrast adaptive characteristics based on visual pathway

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Multimedia Tools and Applications 2024年第15期84卷 14693-14717页

作者： Fang, Tao Cai, Zhefei Fan, Yingle College of Electronics and Information Hangzhou Dianzi University Hangzhou310018 China Zhejiang Provincial Key Laboratory of Information Processing Communication and Networking Hangzhou310027 China Laboratory of Pattern Recognition and Image Processing Hangzhou Dianzi University Hangzhou310018 China

Effectively extracting image subject contours holds significant importance for subsequent image processing tasks. Recognizing the pivotal role of contrast features in contour characterization, this paper proposes a novel contour extraction model with contrast adaptive characteristics, inspired by visual perception simulation visual pathways. Firstly, leveraging the color antagonism traits of retinal ganglion cells, we construct a color image contrast calculation model to enhance the representation of visual information contrast. Furthermore, drawing upon the feed-forward impact of the retina on Lateral Geniculate Nucleus (LGN) cells, we introduce a contrast gain control mechanism to extract multi-directional primary contour responses. Secondly, employing the LIF neuron network to simulate the lateral geniculate body's information flow processing mechanism, we encode visual information via pulse firing to eliminate redundant contour details. Then, by considering the primary visual cortex (V1) cell's receptive field size variation with contrast, we devise a contrast-adaptive dynamic receptive field model. Additionally, we develop a texture suppression model based on the orientation/contrast disparity between the receptive field model's center and periphery. Finally, integrating the primary contour response and the image obtained through the inhibition model, we fuse features to derive the final image subject target contour. This study employs the BSDS500 dataset and the RuG40 dataset for experimentation. Comparative analysis against mainstream methods demonstrates our approach's superior ability to retain the main image outline while suppressing non-edge textures, with P-value indicators for contour detection of 0.58 and 0.50, respectively. Furthermore, visual analysis using box and whisker plots confirms the robustness of our proposed method. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.

关键词： Textures

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Object detection algorithm based on residual deformable convolution pyramid 4

Object detection algorithm based on residual deformable conv...

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4th International Conference on Computer Vision and pattern Analysis, ICCPA 2024

作者： Huang, Bin Wang, Sanqian Li, Linjie Fu, Xiang Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition Nanchang Hangkong University Nanchang*** China School of Software Nanchang Hangkong University Nanchang*** China

ISBN: (纸本)9781510682528

Considering the challenges associated with robots in optoelectronic imaging applications, typically require real-time and accurate recognition and localization of targets, especially in complex environments. Due to the potential challenges of noise, blurring, or dense targets in the images obtained by optoelectronic imaging systems, traditional object detection algorithms may face issues such as semantic information loss and difficulty in detecting small targets. By introducing residual deformable convolution structures, feature representation can be enhanced in optoelectronic imaging systems, and the shape of the convolution kernel can be dynamically adjusted to adapt to the non rigid deformation of the target, thereby better capturing the detailed features of small targets. Experimental results exhibit that RAFPN enhances the mAP of object detection algorithms RetinaNet, Faster R-CNN, and GFL by 1.2%, 0.9%, and 1.1% respectively on the MS COCO dataset, effectively enhancing the performance of object detection algorithms in optoelectronic imaging. © 2024 SPIE.

关键词： Optoelectronic devices

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An efficient multiparty quantum secret sharing scheme using a single qudit

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Chinese Physics B 2023年第8期32卷 161-170页

作者：胡文文熊邦书周日贵 School of Information Engineering Nanchang Hangkong UniversityNanchang 330063China Key Laboratory of Image Processing and Pattern Recognition of Jiangxi Province Nanchang Hangkong UniversityNanchang 330063China College of Information Engineering Shanghai Maritime UniversityShanghai 201306China

The aim of quantum secret sharing,as one of most promising components of quantum cryptograph,is one-tomultiparty secret communication based on the principles of quantum *** this paper,an efficient multiparty quantum secret sharing protocol in a high-dimensional quantum system using a single qudit is *** participant's shadow is encoded on a single qudit via a measuring basis encryption method,which avoids the waste of qudits caused by basis *** analysis indicates that the proposed protocol is immune to general attacks,such as the measure-resend attack,entangle-and-measure attack and Trojan horse *** to former protocols,the proposed protocol only needs to perform the single-qudit measurement operation,and can share the predetermined dits instead of random bits or dits.

关键词： quantum secret sharing high-dimensional measurement basis encrypted security analysis

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Research on the Detection of Abnormal Cervical Cells Based on Improved YOLOv7 9

Research on the Detection of Abnormal Cervical Cells Based o...

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9th International Conference on Intelligent Computing and Signal processing, ICSP 2024

作者： Wang, Xuewei Yuan, Shuang Yang, Lidong Niu, Dawei Inner Mongolia University of Science and Technology School of Digtial and Intelligence Industry Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing Inner Mongolia China

ISBN: (纸本)9798350376548

Cervical cytologic screening is clinically important for the prevention and diagnosis of cervical cancer. Aiming at the many challenges in the detection of abnormal cervical cells, including the difficult detection of small targets of abnormal cervical cells, complex backgrounds, and uneven cell morphology, a detection algorithm for abnormal cervical cells based on improved YOLOv7 was proposed. The algorithm utilizes Deformable Convolutional Networks v2 (DCNv2) that adaptively de-tunes the scale and receptive field size to more effectively cope with the complexity and diversity of cervical cell images. The experimental results show that the improved YOLOv7 algorithm mAP achieves 57.26%, up to 73.88% accuracy, and 46.90% recall on the cervical abnormal cell dataset. Compared with the benchmark model, they increased by 4.07%, 3.39%, and 5.69%, respectively. © 2024 IEEE.

关键词： Convolution

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Contour detection network simulating the primary visual pathway

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Digital Signal processing: A Review Journal 2025年 165卷

作者： Chen, Ke Fan, Yingle Fang, Tao Laboratory of Pattern Recognition and Image Processing Hangzhou Dianzi University Zhejiang Hangzhou310018 China

Biological vision exhibits exceptional contour perception capabilities. In view of this, research on contour detection guided by biological vision is gradually gaining attention. Inspired by the transmission and processing of visual signals in the primary visual pathway, this study proposes a lightweight contour detection network called the Primary-Visual-Pathway UNet (PVP-UNet), comprising an encoder and a decoder. Primarily, inspiration from the binocular vision mechanism, we transmit the original image through dual deformable convolution modules that simulate the receptive fields of the left and right retinas in the encoder. Utilizing the characteristic of the optic chiasm, the output features of the retinal layers are split, swapped, and merged for further processing. Subsequently, dilated convolution modules and normal convolution modules are involved to simulate the magnocellular (M) and parvocellular (P) pathways of the lateral geniculate nucleus (LGN), respectively. An inhibition module was designed based on the suppression mechanism of classical/non-classical receptive fields (CRF/NCRF) in the primary visual cortex (V1). Additionally, the interconnection pattern of the inhibition modules is deployed by leveraging the aggregation characteristics of simple cells to complex cells in the V1 layer. Inspired by the feedback mechanism of visual information, the feature fusion module is introduced in the decoder to integrate features from different encoding layers in the reverse direction of signal transmission along the primary visual pathway. Our experiments show that the respective Optimal Dataset Scale (ODS) scores achieve 0.811, 0.756, and 0.896 on BSDS500, NYUD, and BIPED datasets. The experimental results demonstrate that the proposed network effectively suppresses background noise and highlights primary contours, exhibiting excellent detection performance on the tested datasets. The code is available at https://***/k3chencoco/PVP-UNet. © 2025 Elsevie

关键词： Binocular vision

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FASTC: A Fast Attentional Framework for Semantic Traversability Classification Using Point Cloud 26

FASTC: A Fast Attentional Framework for Semantic Traversabil...

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26th European Conference on Artificial Intelligence, ECAI 2023

作者： Chen, Yirui Wei, Pengjin Liu, Zhenhuan Wang, Bingchao Yang, Jie Liu, Wei Institute of Image Processing and Pattern Recognition Department of Automation Shanghai Jiao Tong University China Key Laboratory of System Control and Information Processing Ministry of Education China

ISBN: (纸本)9781643684369

Producing traversability maps and understanding the surroundings are crucial prerequisites for autonomous navigation. In this paper, we address the problem of traversability assessment using point clouds. We propose a novel pillar feature extraction module that utilizes PointNet to capture features from point clouds organized in vertical volume and a 2D encoder-decoder structure to conduct traversability classification instead of the widely used 3D convolutions. This results in less computational cost while even better performance is achieved at the same time. We then propose a new spatio-temporal attention module to fuse multi-frame information, which can properly handle the varying density problem of LIDAR point clouds, and this makes our module able to assess distant areas more accurately. Comprehensive experimental results on augmented Semantic KITTI and RELLIS-3D datasets show that our method is able to achieve superior performance over existing approaches both quantitatively and quantitatively. Our code is publicly available at https://***/chenyirui/FASTC. © 2023 The Authors.

关键词： Semantics

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Prototype-guided Unsupervised Domain Adaptation for Semantic Segmentation

Prototype-guided Unsupervised Domain Adaptation for Semantic...

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2023 IEEE International Conference on Control, Electronics and Computer Technology, ICCECT 2023

作者： Xia, Shaoqi Huang, Hua Li, Qishen He, Yifan Nanchang Hangkong University Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition School of Information Engineering Jiangxi Nanchang China Nanchang Hangkong University School of Information Engineering Nanchang China Nanchang Hangkong University Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition School of Software Nanchang China

ISBN: (纸本)9798350399028

Semantic segmentation is one of the most important research directions in the field of computer vision, and has a wide range of applications for autonomous driving, medical imaging, intelligent security, etc. Unsupervised domain adaptation is the mainstream research topic in recent years, which can use a large number of labeled source samples to complete the segmentation task in target domain without labeled target samples. In this paper, we propose a prototype-guided unsupervised domain adaptation for semantic segmentation based on ProDA model. Due to lacking of labeled target samples and the prior probability, a prototype distance loss based on target domain is proposed to optimize the distribution of features by measuring the distance between features and the updated prototype and designing an adaptive threshold strategy. Meanwhile, a smoothing loss is proposed to alleviate the impact of source samples on our model and improve the prediction performance of the network. By conducting experiments on the GTA5 to Cityscapes scenarios, the results show that compared with the original model, the loss optimization improves mIoU by1.52. © 2023 IEEE.

关键词： Semantic Segmentation

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ChromTR:chromosome detection in raw metaphase cell images via deformable transformers

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Frontiers of Medicine 2024年第6期18卷 1100-1114页

作者： Chao Xia Jiyue Wang Xin You Yaling Fan Bing Chen Saijuan Chen Jie Yang Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong UniversityShanghai200240China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China

Chromosome karyotyping is a critical way to diagnose various hematological malignancies and genetic diseases,of which chromosome detection in raw metaphase cell images is the most critical and challenging *** this work,focusing on the joint optimization of chromosome localization and classification,we propose ChromTR to accurately detect and classify 24 classes of chromosomes in raw metaphase cell *** incorporates semantic feature learning and class distribution learning into a unified DETR-based detection ***,we first propose a Semantic Feature Learning Network(SFLN)for semantic feature extraction and chromosome foreground region segmentation with object-wise ***,we construct a Semantic-Aware Transformer(SAT)with two parallel encoders and a Semantic-Aware decoder to integrate global visual and semantic *** provide a prediction with a precise chromosome number and category distribution,a Category Distribution Reasoning Module(CDRM)is built for foreground-background objects and chromosome class distribution *** evaluate ChromTR on 1404 newly collected R-band metaphase images and the public G-band dataset *** proposed ChromTR outperforms all previous chromosome detection methods with an average precision of 92.56%in R-band chromosome detection,surpassing the baseline method by 3.02%.In a clinical test,ChromTR is also confident in tackling normal and numerically abnormal *** extended to the chromosome enumeration task,ChromTR also demonstrates state-of-the-art performances on R-band and G-band two metaphase image *** these superior performances to other methods,our proposed method has been applied to assist clinical karyotype diagnosis.

关键词： chromosome detection deformable transformer metaphase cell image distribution reasoning

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Dynamic Frame Interpolation in Wavelet Domain

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IEEE Transactions on image processing 2023年 32卷 5296-5309页

作者： Kong, Lingtong Jiang, Boyuan Luo, Donghao Chu, Wenqing Tai, Ying Wang, Chengjie Yang, Jie Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Department of Automation Shanghai200240 China Tencent Youtu Laboratory Shanghai200233 China Nanjing University School of Intelligence Science and Technology Suzhou215163 China

Video frame interpolation is an important low-level vision task, which can increase frame rate for more fluent visual experience. Existing methods have achieved great success by employing advanced motion models and synthesis networks. However, the spatial redundancy when synthesizing the target frame has not been fully explored, that can result in lots of inefficient computation. On the other hand, the computation compression degree in frame interpolation is highly dependent on both texture distribution and scene motion, which demands to understand the spatial-temporal information of each input frame pair for a better compression degree selection. In this work, we propose a novel two-stage frame interpolation framework termed WaveletVFI to address above problems. It first estimates intermediate optical flow with a lightweight motion perception network, and then a wavelet synthesis network uses flow aligned context features to predict multi-scale wavelet coefficients with sparse convolution for efficient target frame reconstruction, where the sparse valid masks that control computation in each scale are determined by a crucial threshold ratio. Instead of setting a fixed value like previous methods, we find that embedding a classifier in the motion perception network to learn a dynamic threshold for each sample can achieve more computation reduction with almost no loss of accuracy. On the common high resolution and animation frame interpolation benchmarks, proposed WaveletVFI can reduce computation up to 40% while maintaining similar accuracy, making it perform more efficiently against other state-of-the-arts. © 1992-2012 IEEE.

关键词： Wavelet transforms

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