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Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker

BIOLOGICAL PSYCHIATRY 2021年第8期90卷 529-539页

作者： Qi, Shile Schumann, Gunter Bustillo, Juan Turner, Jessica A. Jiang, Rongtao Zhi, Dongmei Fu, Zening Mayer, Andrew R. Vergara, Victor M. Silva, Rogers F. Iraji, Armin Chen, Jiayu Damaraju, Eswar Ma, Xiaohong Yang, Xiao Stevens, Michael Mathalon, Daniel H. Ford, Judith M. Voyvodic, James Mueller, Bryon A. Belger, Aysenil Potkin, Steven G. Preda, Adrian Zhuo, Chuanjun Xu, Yong Chu, Congying Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Quinlan, Erin Burke Desrivieres, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Martinot, Jean-Luc Martinot, Marie-Laure Paillere Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomas Poustka, Luise Hohmann, Sarah Frohner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Calhoun, Vince D. Sui, Jing [a]Tri-institutional Center for Translational Research in Neuroimaging and Data Science Georgia State University Georgia Institute Technology and Emory University Atlanta Georgia [b]Department of Psychiatry University of New Mexico Albuquerque New Mexico [c]Department of Psychology Georgia State University Atlanta Georgia [d]Olin Neuropsychiatry Research Center Hartford Connecticut [e]Department of Psychiatry University of California San Francisco San Francisco California [f]Department of Radiology Duke University Durham North Carolina [g]Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill North Carolina [h]Department of Psychiatry University of Minnesota Minneapolis Minnesota [i]Department of Psychiatry University of California Irvine Irvine California [j]Departments of Psychiatry and Psychology University of Vermont Burlington Vermont [k]Centre for Population Neuroscience and Stratified Medicine Institute for Science and Technology of Brain-Inspired Intelligence Fudan University Shanghai China [l]University of Chinese Academy of Sciences Beijing China [dd]Department of Computer Science and Engineering Nanjing University of Aeronautics and Astronautics Nanjing China [m]Brainnetome Center and National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing China [ee]State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China [n]Psychiatric Laboratory and Mental Health Center the State Key Laboratory of Biotherapy West China Hospital of Sichuan University Chengdu China [o]Department of Psychiatric-Neuroimaging-Genetics and Morbidity Laboratory Nankai University Affiliated Anding Hospital Tianjin China [p]Department of Humanities and Social Science Shanxi Medical University Taiyuan China [q]Department of Psychiatry and Psychotherapy Charité – Universitätsmedizin Berlin Campus Charité Mitte corporate member of Freie Universität Berlin Humboldt-Univers

BACKGROUND: Dysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues. METHODS: A subset of 14-year-old adolescents (IMAGEN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within IMAGEN, n z 1100) and even for the corresponding symptom scores of five types of patient cohorts (non-IMAGEN), including drinking (n = 313), smoking (n = 104), attention-deficit/hyperactivity disorder (n = 320), major depressive disorder (n = 81), and schizophrenia (n = 147), as well as to classify different patient groups with diagnostic labels. RESULTS: Multimodal biomarkers, including the prefrontal cortex, striatum, amygdala, and hippocampus, associated with high NS in 14-year-old adolescents were identified. The prediction models built on these features are able to longitudinally predict five different risk scales, including alcohol drinking, smoking, hyperactivity, depression, and psychosis for the same and unseen 19-year-old adolescents and even predict the corresponding symptom scores of five types of patient cohorts. Furthermore, the identified reward-related multimodal features can classify among attention-deficit/hyperactivity disorder, major depressive disorder, and schizophrenia with an accuracy of 87.2%. CONCLUSIONS: Adolescents with higher NS scores can be used to reveal brain alterations in the reward-related system, implicating potential higher risk for subsequent development of multiple disorders. The identified high-NS- associated multimodal reward-related signatures may serve as a transdiagnostic neuroimaging bi

关键词： ADHD Attention-deficit/hyperactivity disorder Major depressive disorders MDD Novelty seeking Reward processing Schizophrenia Substance use

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Efficient Mode Transfer on a Compact Silicon Chip by Encircling Moving Exceptional Points

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Physical Review Letters 2020年第15期124卷 153903-153903页

作者： Qingjie Liu Shuyi Li Bing Wang Shaolin Ke Chengzhi Qin Kai Wang Weiwei Liu Dingshan Gao Pierre Berini Peixiang Lu School of Physics and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of Technology Wuhan 430205 China School of Electrical Engineering and Computer Science University of Ottawa Ottawa Ontario K1N 6N5 Canada Department of Physics and Center for Research in Photonics University of Ottawa Ottawa Ontario K1N 6N5 Canada CAS Center for Excellence in Ultra-Intense Laser Science Shanghai 201800 China

Exceptional points (EPs) are branch point singularities of self-intersecting Riemann sheets, and they can be observed in a non-Hermitian system with complex eigenvalues. It has been revealed recently that dynamically encircling EPs by adiabatically changing the parameters of a system composed of lossy optical waveguides could lead to asymmetric (input-output) mode transfer. However, the length of the waveguides had to be considerable to ensure adiabatic evolution. Here we demonstrate that the parameters can change adiabatically along a smaller encircling loop by utilizing moving EPs, leading to significant shortening of the structures compared to fixed EPs. Meanwhile, the mode transmittance is remarkably improved and the transfer efficiency persists at ∼90%. Moving EPs are very promising for applications such as highly integrated broadband optical switches and convertors operating at telecommunication wavelengths.

关键词： Metamaterials Optical materials & elements Photonics Waveguides

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Frangi-net

Frangi-net

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Workshop on Bildverarbeitung fur die Medizin, 2018

作者： Fu, Weilin Breininger, Katharina Schaffert, Roman Ravikumar, Nishant Würfl, Tobias Fujimoto, Jim Moult, Eric Maier, Andreas Pattern Recognition Lab Department of Computer Science Friedrich-Alexander-University Erlangen-Nuremberg Erlangen Germany Erlangen Germany Department Electrical Engineering and Computer Science Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge United States

ISBN: (纸本)9783662580950

In this paper, we reformulate the conventional 2-D Frangi vesselness measure into a pre-weighted neural network ("Frangi-Net"), and illustrate that the Frangi-Net is equivalent to the original Frangi filter. Furthermore, we show that, as a neural network, Frangi-Net is trainable. We evaluate the proposed method on a set of 45 high resolution fundus images. After fine-tuning, we observe both qualitative and quantitative improvements in the segmentation quality compared to the original Frangi measure, with an increase up to 17% in F1 score. © Springer-Verlag GmbH Deutschland 2018.

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Overview of the recent experimental research on the J-TEXT tokamak

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Nuclear Fusion 2024年第11期64卷 112005-112005页

作者： Ding, Yonghua Wang, Nengchao Chen, Zhongyong Xia, Donghui Yang, Zhoujun Chen, Zhipeng Zheng, Wei Yan, Wei Li, Da Zhou, Song Xu, Xin Zhang, Xiaoyi Mao, Feiyue Fang, Jiangang Ren, Zhengkang Chen, Xixuan Zhang, Junli Zhang, Xiaobo He, Ying Zhang, Qi Li, You Bai, Wei Mou, Lingke Li, Feng Long, Ting Ke, Rui Gao, Li Shi, Peng Shen, Chengshuo Liu, Jiaxing Guo, Weixin Wang, Lu Li, Hanhui Jiang, Zhonghe Zhang, Xiaoqing Li, Jianchao Rao, Bo Cheng, Zhifeng Zhu, Ping Liu, Minghai Xu, Tao Ma, Shaoxiang Yang, Yong Li, Chuan Wang, Zhijiang Zhang, Ming Yu, Kexun Hu, Xiwei Liang, Y. Yu, Q. Gentle, K.W. Pan, Yuan Gentle, Kenneth William Yu, Qingquan Liang, Yunfeng Jiang, Wei Yi, Lin Zhang, Ya Hu, Qiming Li, Jianchao Huang, Mingxiang Li, Haolong Huang, Zhuo Huang, Jie Wang, Weijun He, Mei Zhao, Qing Xu, Jiayu Zhou, Gangyi Ba, Weigang Yang, Cheng Yao, Junjie Wang, Chuliang He, Bo Hu, Yongzhen Deng, Mingyang Fu, Jingwei Liang, Meiling Guan, Yehong Wu, Hongyan Zhuang, Ge Ding, Weixing Lan, Tao Zeng, Shiyong Hussain, Malik Sadam Lin, Zhifang Liu, Hai Sun, Youwen Zeng, Long Liu, Shaocheng Liao, Liang Zhong, Wulyu Shi, Zhongbing Jiang, Min Dong, Yunbo Xu, Min Wang, Aike Zhang, Xiaolong Liu, Linzi Tong, Ruihai Cheng, Jun Nie, Lin Li, Hui Xu, Jianqiang Yang, Zengchen Wen, Jie Liang, Anshu Zhang, Yipo Wu, Yifan Chen, Chengyuan Zhao, Kaijun Shi, Yuejiang Huang, He Austin, Max Lee, Sanggon Luhmann, Neville C. Domier, Calvin W. Zhu, Yilun Brower, David L. Chen, Jie Ida, K. Takemura, Y. Suzuki, Y. Nagasaki, K. Drews, P. Knieps, A. Han, Xiang Krämer-Flecken, A. Henkel, M. He, Jiyang Zhou, Yinan Jia, Ruo Peng, Yue Wang, Pengyu Li, Jiawei Yang, Jie Lu, Conghui Lu, Yiwei Wang, Rumeng Zhang, Hongqi Zeng, Yingqin Zhang, Guodong Ma, Fangyuan Bala, Abba Alhaji Li, Dingchen Hua, Jiankun Ai, Xinkun Tao, Qinlin Zhong, Yu Li, Yangbo He, Xiangrui Wan, Sui Huang, Shanni Ma, Yiming Qu, Zitong Yu, Shimin Huang, Zhangsheng Lei, Chi School of Electric and Electronic Engineering Huazhong University of Science and Technology Wuhan430074 China Southwestern Institute of Physics Chengdu China Institute of Plasma Physics Chinese Academy of Sciences Hefei China Guizhou University of Commerce Guiyang China Wuhan Institute of Technology Wuhan China ITER Organization Route de Vinon-sur-Verdon CS 90 046 Saint-Paul-lez-DuranceCedex 13067 France Forschungszentrum Jülich GmbH IEK-Plasmaphysik Jülich Germany Max-Planck-Institut für Plasmaphysik Garching Germany Institute of Fusion Studies University of Texas at Austin AustinTX United States University of Texas at Austin AustinTX78712 United States School of Physics Huazhong University of Science and Technology Wuhan430074 China Department of Physics Wuhan University of Technology Wuhan430070 China Princeton Plasma Physics Laboratory PO Box 451 PrincetonNJ08543 United States Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of Technology Wuhan430205 China College of Computer Science South-Central University for Nationalities Wuhan430074 China Shenzhen University Shenzhen518060 China University of Science and Technology of China Hefei230026 China School of Electrical Engineering & Automation Jiangsu Normal University Xuzhou221116 China Southwest Jiaotong University Chengdu China College of Nuclear Science and Engineer East China University of Technology PO Box Nanchang330013 China ENN Science and Technology Development Co. Ltd Hebei Key Laboratory of Compact Fusion Langfang065001 China National Fusion Research Institute Daejeon305-333 Korea Republic of University of California DavisCA95616 United States University of California Los Angeles Los AngelesCA90095 United States National Institute for Fusion Science Toki509-5292 Japan Graduate School of Advanced Science and Engineering Hiroshima University Hiroshima739-8527 Japan Institute of Advanced Energy Kyoto University Gokasho Ky

The J-TEXT capability is enhanced compared to two years ago with several upgrades of its diagnostics and the increase of electron cyclotron resonance heating (ECRH) power to 1 MW. With the application of electron cyclotron wave (ECW), the ECW assisted plasma startup is achieved;the tearing mode is suppressed;the toroidal injection of 300 kW ECW drives around 24 kA current;fast electrons are generated with toroidal injected ECW and the runaway current conversion efficiency increases with ECRH power. The mode coupling between 2/1 and 3/1 modes are extensively studied. The coupled 2/1 and 3/1 modes usually lead to major disruption. Their coupling can be either suppressed or avoided by external resonant magnetic perturbation fields and hence avoids the major disruption. It is also found that the 2/1 threshold of external field is significantly reduced by a pre-excited 3/1 mode, which can be either a locked island or an external kink mode. The disruption control is studied by developing prediction methods capable of cross tokamak application and by new mitigation methods, such as the biased electrode or electromagnetic pellet injector. The high-density operation and related disruptions are studied from various aspects. Approaching the density limit, the collapse of the edge shear layer is observed and such collapse can be prevented by applying edge biasing, leading to an increased density limit. The density limit is also observed to increase, if the plasma is operated in the poloidal divertor configuration or the plasma purity is increased by increasing the pre-filled gas pressure or ECRH power during the start-up phase. © 2024 The Author(s).

关键词： Tokamak devices

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Artificial intelligent techniques and its applications

Artificial intelligent techniques and its applications

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作者： Sundhararajan, Mahalingam Gao, Xiao-Zhi Vahdat Nejad, Hamed Department of Electronics and Communication Engineering Bharath Institute of Higher Education and Research Bharath University Chennai India Department of Machine Vision and Pattern Recognition Laboratory Lappeenranta University of Technology Finland Department of Computer Science and Engineering University of Birjand Birjand Iran

This special issue of the Journal of Intelligent & Fuzzy Systems is a selected collection of papers submitted to the IEEE International Conference on Algorithms, methodology, models and applications in emerging technologies and International Conference on Telecommunication, Power analysis and Computing Techniques and held from February 16-18, 2017 and April 6-8, 2017, Chennai, India. These papers have been reviewed and accepted for presentation at the conference and for publication in the Journal of Intelligent & Fuzzy Systems (JIFS). In this special issue there are 50 papers covering a wide range of tools, techniques and applications of artificial intelligent techniques and applications.

关键词： Fuzzy systems

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Graph-based parallel large scale structure from motion

arXiv

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arXiv 2019年

作者： Chen, Yu Shen, Shuhan Chen, Yisong Wang, Guoping Graphics and Interactive Lab Department of Computer Science and Technology School of Electronic Engineering and Computer Science Peking University National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing100190 China University of Chinese Academy of Sciences Beijing100049 China

While Structure from Motion (SfM) achieves great success in 3D reconstruction, it still meets challenges on large scale scenes. In this work, large scale SfM is deemed as a graph problem, and we tackle it in a divide-and-conquer manner. Firstly, the images clustering algorithm divides images into clusters with strong connectivity, leading to robust local reconstructions. Then followed with an image expansion step, the connection and completeness of scenes are enhanced by expanding along with a maximum spanning tree. After local reconstructions, we construct a minimum spanning tree (MST) to find accurate similarity transformations. Then the MST is transformed into a Minimum Height Tree (MHT) to find a proper anchor node and is further utilized to prevent error accumulation. When evaluated on different kinds of datasets, our approach shows superiority over the state-of-the-art in accuracy and efficiency. Our algorithm is open-sourced in https://***/AIBluefisher/GraphSfM. Copyright © 2019, The Authors. All rights reserved.

关键词： Clustering algorithms

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QuaSI – Quantile sparse image: A prior for spatio-temporal denoising of retinal OCT data

QuaSI – Quantile sparse image: A prior for spatio-temporal ...

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Workshop on Bildverarbeitung fur die Medizin, 2018

作者： Schirrmacher, Franziska Köhler, Thomas Husvogt, Lennart Fujimoto, James G. Hornegger, Joachim Maier, Andreas K. Pattern Recognition Lab Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany Department of Electrical Engineering & Computer Science Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge United States

Optical Coherence Tomography (OCT) is a standard non-invasive imaging modality widely used in opthalmology. Due to its high spatial resolution OCT has become a standard imaging technique. However, speckle noise caused... 详细信息

ISBN: (纸本)9783662580950

关键词： Optical tomography

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Expert Review of Algorithmic Mitotic Count Predictions Ensures High Reliability

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Journal of Comparative Pathology 2022年 191卷 12-12页

作者： C.A. Bertram R. Klopfleisch A. Bartel T.A. Donovan A. Fuchs-Baumgartinger K. Breininger M. Kiupel M. Aubreville Institute of Pathology University of Veterinary Medicine Vienna Austria Institute of Veterinary Pathology Institute for Veterinary Epidemiology and Biostatistics Freie Universität Berlin Berlin Germany Department of Anatomic Pathology Animal Medical Center New York USA Pattern Recognition Lab Computer Sciences Department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander-Universität Erlangen-Nürnberg Erlangen Germany Veterinary Diagnostic Laboratory Michigan State University Lansing USA Technische Hochschule Ingolstadt Ingolstadt Germany

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Structuring Nonlinear Wavefront Emitted from Monolayer Transition-Metal Dichalcogenides

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研究（英文） 2020年第4期 392-401页

作者： Xuanmiao Hong Guangwei Hu Wenchao Zhao Kai Wang Shang Sun Rui Zhu Jing Wu Weiwei Liu Kian Ping Loh Andrew Thye Shen Wee Bing Wang Andrea Al Cheng-Wei Qiu Peixiang Lu Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074 China Department of Electrical and Computer Engineering National University of Singapore 4 Engineering Drive 3 Singapore 117583 Advanced Science Research Center City University of New York New York 10031 USA Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074 China Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074 China Department of Electrical and Computer Engineering National University of Singapore 4 Engineering Drive 3 Singapore 117583 Department of Electrical and Computer Engineering National University of Singapore 4 Engineering Drive 3 Singapore 117583 Department of Physics National University of Singapore 2 Science Drive 3 Singapore 117542 Institute of Materials Research and Engineering Agency for Science Technology and Research 2 Fusionopolis Way Innovis#08-03Singapore 138634 Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074 China Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 17543 Department of Physics National University of Singapore 2 Science Drive 3 Singapore 117542 Centre for Advanced 2D Materials National University of Singapore Block S14 6 Science Drive 2 Singapore 117546 Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074 China Advanced Science Research Center City University of New York New York 10031 USA Department of Electrical and Computer Engineering National University of Singapore 4 Engineering Drive 3 Singapore 117583 Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074 China Hubei Key Laboratory of Optical

The growing demand for tailored nonlinearity calls for a structure with unusual phase discontinuity that allows the realization of nonlinear optical chirality,holographic imaging,and nonlinear wavefront ***-metal dichalcogenide(TMDC)monolayers offer giant optical nonlinearity within a few-angstrom thickness,but limitations in optical absorption and domain size impose restriction on wavefront control of nonlinear emissions using classical light *** contrast,noble metal-based plasmonic nanosieves support giant field enhancements and precise nonlinear phase control,with hundred-nanometer pixel-level resolution;however,they suffer from intrinsically weak nonlinear ***,we report a multifunctional nonlinear interface by integrating TMDC monolayers with plasmonic nanosieves,yielding drastically different nonlinear functionalities that cannot be accessed by either *** a hybrid nonlinear interface allows second-harmonic(SH)orbital angular momentum(OAM)generation,beam steering,versatile polarization control,and holograms,with an effective SH nonlinearityX(2)of-25nm/*** designer platform synergizes the TMDC monolayer and plasmonic nanosieves to empower tunable geometric phases and large field enhancement,paving the way toward multifunctional and ultracompact nonlinear optical devices.

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Aberrant Functional Network Connectivity Transition Probability in Major Depressive Disorder

Aberrant Functional Network Connectivity Transition Probabil...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Elaheh Zendehrouh Mohammad. S. E. Sendi Jing Sui Zening Fu Dongmei Zhi Luxian Lv Xiaohong Ma Qing Ke Xianbin Li Chuanyue Wang Christopher. C. Abbott Jessica A. Turner Robyn. L Miller Vince D. Calhoun Department of Computer Science Georgia State University Atlanta Georgia Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta Georgia Tri-institutional Center for Translational Research in Neuroimaging and Data Science: Georgia State University Georgia Institute of Technology Emory University Atlanta Georgia Brainnetome Center and National Laboratory of Pattern Recognition Beijing China and University of Chinese Academy of Sciences Beijing China Psychiatric Laboratory and Mental Health Center the State Key Laboratory of Biotherapy West China Hospital of Sichuan University Chengdu China Huaxi Brain Research Center West China Hospital of Sichuan University Chengdu China Beijing Key Lab of Mental Disorders Capital Medical University Beijing China Department of Psychiatry University of New Mexico Albuquerque New Mexico

ISBN: (数字)9781728119908

ISBN: (纸本)9781728119915

Major depressive disorder (MDD) is a common and serious mental disorder characterized by a persistent negative feeling and tremendous sadness. In recent decades, several studies used functional network connectivity (FNC), estimated from resting state functional magnetic resonance imaging (fMRI), to investigate the biological signature of MDD. However, the majority of them have ignored the temporal change of brain interaction by focusing on static FNC (sFNC). Dynamic functional network connectivity (dFNC) that explores temporal patterns of functional connectivity (FC) might provide additional information to its static counterpart. In the current study, by applying k-means clustering on dFNC of MDD and healthy subjects (HCs), we estimated 5 different states. Next, we use the hidden Markov model as a potential biomarker to differentiate the dFNC pattern of MDD patients from HCs. Comparing MDD and HC subjects' hidden Markov model (HMM) features, we have highlighted the role of transition probabilities between states as potential biomarkers and identified that transition probability from a lightly- connected state to highly connected one reduces as symptom severity increases in MDD subjects.

关键词： Hidden Markov models Hospitals Functional magnetic resonance imaging Correlation Probability Microsoft Windows Psychiatry

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