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Relationship between pulmonary nodule malignancy and surrounding pleurae, airways and vessels: a quantitative study using the public LIDC-IDRI dataset

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arXiv 2021年

作者： Qin, Yulei Gu, Yun Zhang, Hanxiao Yang, Jie Wang, Lihui Wang, Zhexin Yao, Feng Zhu, Yue-Min Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai200240 China Institute of Medical Robotics Shanghai Jiao Tong University Shanghai200240 China CREATIS INSA Lyon CNRS UMR 5220 INSERM U1206 Université de Lyon Villeurbanne69621 France Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province School of Computer Science and Technology Guizhou University Guiyang550025 China Department of Thoracic Surgery Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai200025 China

Objectives: To investigate whether the pleurae, airways and vessels surrounding a nodule on non-contrast computed tomography (CT) can discriminate benign and malignant pulmonary nodules. Materials and Methods: The LIDC-IDRI dataset, one of the largest publicly available CT database, was exploited for study. A total of 1556 nodules from 694 patients were involved in statistical analysis, where nodules with average scorings 3 were respectively denoted as benign and malignant. Besides, 339 nodules from 113 patients with diagnosis ground-truth were independently evaluated. Computer algorithms were developed to segment pulmonary structures and quantify the distances to pleural surface, airways and vessels, as well as the counting number and normalized volume of airways and vessels near a nodule. Odds ratio (OR) and Chi-square (χ2) testing were performed to assess the correlation between features of surrounding structures and nodule malignancy. A non-parametric receiver operating characteristic (ROC) analysis was conducted in logistic regression to evaluate discrimination ability of each structure. Results: For the benign and malignant groups, the average distances from nodules to pleural surface, airways and vessels are respectively (6.56, 5.19), (37.08, 26.43) and (1.42, 1.07) mm. The correlation between nodules and the counting number of airways and vessels that contact or project towards nodules are respectively (OR=22.96, χ2=105.04) and (OR=7.06, χ2=290.11). The correlation between nodules and the volume of airways and vessels are (OR=9.19, χ2=159.02) and (OR=2.29, χ2=55.89). The areas-under-curves (AUCs) for pleurae, airways and vessels are respectively 0.5202, 0.6943 and 0.6529. Conclusion: Our results show that malignant nodules are often surrounded by more pulmonary structures compared with benign ones, suggesting that features of these structures could be viewed as lung cancer biomarkers. © 2021, CC BY.

关键词： Computerized tomography

Learning tubule-sensitive CNNs for pulmonary airway and artery-vein segmentation in CT

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arXiv 2020年

作者： Qin, Yulei Zheng, Hao Gu, Yun Huang, Xiaolin Yang, Jie Wang, Lihui Yao, Feng Zhu, Yue-Min Yang, Guang-Zhong Institute of Image Processing and Pattern Recognition Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China Key Laboratory of Intelligent Medical Image Analysis and Precise Diagnosis of Guizhou Province School of Computer Science and Technology Guizhou University Guiyang China Department of Thoracic Surgery Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China Université de Lyon INSA Lyon CREATIS CNRS INSERM UMR 5220 VilleurbanneU1206 France Institute of Medical Robotics School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China

Training convolutional neural networks (CNNs) for segmentation of pulmonary airway, artery, and vein is challenging due to sparse supervisory signals caused by the severe class imbalance between tubular targets and background. We present a CNNs-based method for accurate airway and artery-vein segmentation in non-contrast computed tomography. It enjoys superior sensitivity to tenuous peripheral bronchioles, arterioles, and venules. The method first uses a feature recalibration module to make the best use of features learned from the neural networks. Spatial information of features is properly integrated to retain relative priority of activated regions, which benefits the subsequent channel-wise recalibration. Then, attention distillation module is introduced to reinforce representation learning of tubular objects. Fine-grained details in high-resolution attention maps are passing down from one layer to its previous layer recursively to enrich context. Anatomy prior of lung context map and distance transform map is designed and incorporated for better artery-vein differentiation capacity. Extensive experiments demonstrated considerable performance gains brought by these components. Compared with state-of-the-art methods, our method extracted much more branches while maintaining competitive overall segmentation performance. Codes and models are available at http://***/News/56. © 2020, CC BY.

关键词： Computerized tomography

AIM 2020 Challenge on image Extreme Inpainting 16th

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AIM 2020 Challenge on Image Extreme Inpainting

Workshops held at the 16th European Conference on Computer Vision, ECCV 2020

作者： Ntavelis, Evangelos Romero, Andrés Bigdeli, Siavash Timofte, Radu Hui, Zheng Wang, Xiumei Gao, Xinbo Shin, Chajin Kim, Taeoh Son, Hanbin Lee, Sangyoun Li, Chao Li, Fu He, Dongliang Wen, Shilei Ding, Errui Bai, Mengmeng Li, Shuchen Zeng, Yu Lin, Zhe Yang, Jimei Zhang, Jianming Shechtman, Eli Lu, Huchuan Zeng, Weijian Ni, Haopeng Cai, Yiyang Li, Chenghua Xu, Dejia Wu, Haoning Han, Yu Nadim, Uddin S. M. Jang, Hae Woong Ahmed, Soikat Hasan Yoon, Jungmin Jung, Yong Ju Li, Chu-Tak Liu, Zhi-Song Wang, Li-Wen Siu, Wan-Chi Lun, Daniel P. K. Suin, Maitreya Purohit, Kuldeep Rajagopalan, A.N. Narang, Pratik Mandal, Murari Chauhan, Pranjal Singh Computer Vision Lab ETH Zürich Zürich Switzerland CSEM Neuchâtel Switzerland School of Electronic Engineering Xidian University Xi’an China Image and Video Pattern Recognition Laboratory School of Electrical and Electronic Engineering Yonsei University Seoul Korea Republic of Baidu Inc. Beijing China Beijing China Dalian University of Technology Dalian China Adobe San Jose United States Rensselaer Polytechnic Institute Troy United States Peking University Beijing China Lab Gachon University Seongnam Korea Republic of Centre for Multimedia Signal Processing Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Kong China Indian Institute of Technology Madras Chennai India BITS Pilani Pilani India MNIT Jaipur Jaipur India

ISBN: (纸本)9783030670696

This paper reviews the AIM 2020 challenge on extreme image inpainting. This report focuses on proposed solutions and results for two different tracks on extreme image inpainting: classical image inpainting and semantically guided image inpainting. The goal of track 1 is to inpaint large part of the image with no supervision. Similarly, the goal of track 2 is to inpaint the image by having access to the entire semantic segmentation map of the input. The challenge had 88 and 74 participants, respectively. 11 and 6 teams competed in the final phase of the challenge, respectively. This report gauges current solutions and set a benchmark for future extreme image inpainting methods. © 2020, Springer Nature Switzerland AG.

关键词： Semantic Segmentation

An Evolutionary Real-Time 3D Route Planner for Aircraft

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Chinese Journal of Systems Engineering and Electronics 2003年第1期000卷

A novel evolutionary route planner for aircraft is proposed in this paper. In the new planner, individual candidates are evaluated with respect to the workspace, thus the computation of the configuration space is not required. By using problem-specific chromosome structure and genetic operators, the routes are generated in real time,with different mission constraints such as minimum route leg length and flying altitude, maximum turning angle, maximum climbing/diving angle and route distance constraint taken into account.

关键词： Evolutionary computation Route planning Route constraints Real time Aircraft

Video segmentation using multiple features based on EM algorithm

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Chinese Journal of Systems Engineering and Electronics 2004年第4期000卷

Object-based video segmentation is an important issue for many multimedia applications. A video segmentation method based on EM algorithm is proposed. We consider video segmentation as an unsupervised classification problem and apply EM algorithm to obtain the maximum-likelihood estimation of the Gaussian model parameters for model-based segmentation. We simultaneously combine multiple features (motion, color) within a maximum likelihood framework to obtain accurate segment results. We also use the temporal consistency among video frames to improve the speed of EM algorithm. Experimental results on typical MPEG-4 sequences and real scene sequences show that our method has an attractive accuracy and robustness.

关键词： video object segmentation maximum-likelihood estimation EM algorithm

Low dose CT image denoising using a generative adversarial network with wasserstein distance and perceptual loss

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arXiv 2017年

作者： Yang, Qingsong Yan, Pingkun Zhang, Yanbo Yu, Hengyong Shi, Yongyi Mou, Xuanqin Kalra, Mannudeep K. Zhang, Yi Sun, Ling Wang, Ge Department of Biomedical Engineering Rensselaer Polytechnic Institute TroyNY12180 United States Department of Electrical and Computer Engineering University of Massachusetts Lowell LowellMA01854 United States Institute of Image Processing and Pattern Recognition Xian Jiaotong University Xian Shaanxi710049 China Department of Radiology Massachusetts General Hospital Harvard Medical School BostonMA United States College of Computer Science Sichuan Universiyt Chengdu610065 China Department of Radiology West China Hospital Sichuan University Chengdu610041 China

The continuous development and extensive use of CT in medical practice has raised a public concern over the associated radiation dose to the patient. Reducing the radiation dose may lead to increased noise and artifacts, which can adversely affect the radiologists judgement and confidence. Hence, advanced image reconstruction from low-dose CT data is needed to improve the diagnostic performance, which is a challenging problem due to its ill-posed nature. Over the past years, various low-dose CT methods have produced impressive results. However, most of the algorithms developed for this application, including the recently popularized deep learning techniques, aim for minimizing the mean-squared-error (MSE) between a denoised CT image and the ground truth under generic penalties. Although the peak signal-to-noise ratio (PSNR) is improved, MSE-or weighted-MSE-based methods can compromise the visibility of important structural details after aggressive denoising. This paper introduces a new CT image denoising method based on the generative adversarial network (GAN) with Wasserstein distance and perceptual similarity. The Wasserstein distance is a key concept of the optimal transport theory, and promises to improve the performance of GAN. The perceptual loss suppresses noise by comparing the perceptual features of a denoised output against those of the ground truth in an established feature space, while the GAN focuses more on migrating the data noise distribution from strong to weak statistically. Therefore, our proposed method transfers our knowledge of visual perception to the image denoising task and is capable of not only reducing the image noise level but also trying to keep the critical information at the same time. Promising results have been obtained in our experiments with clinical CT images. Copyright © 2017, The Authors. All rights reserved.

关键词： image denoising

Addendum to “Hum-PLoc: A novel ensemble classifier for predicting human protein subcellular localization” [Biochem. Biophys. Res. Commun. 347 (2006) 150–157]

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Biochemical and Biophysical Research Communications 2006年第4期348卷 1479-1479页

作者： Kuo-Chen Chou Hong-Bin Shen Gordon Life Science Institute 13784 Torrey Del Mar Drive San Diego CA 92130 USA Institute of Image Processing and Pattern Recognition Shanghai Jiaotong University 1954 Hua-Shan Road Shanghai 200030 China

The figure source equation and its physical consideration

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SYSTEMS AND COMPUTERS IN JAPAN 1996年第9期27卷 83-93页

作者： Aoki, Y Iijima, T Member Japan Advanced Institute of Science and Technology Hokuriku Ishikawa Japan 923 Yasubim Aoki:graduated from the University of Kanazawa Faculty of Engineering Department of Electrical Engineering and Information Science in 1992 and received his Master's degree in 1994 from the Japan Advanced Institute of Science and Technology Hokuriku Department of Information Science where he is currently in the doctoral program engaged in research on pattern recognition. Honorary Member Taizo lijima:graduatedwith a B.E. degree from the Tokyo Institute of Technology in 1948 and received his Ph.D. degree later. He joined the Electro-Technical Laboratories in 1948 and since then has been involved in research on electromagnetic theory and pattern recognition theory image processing voice recognition and research and development of OCR. After serving as the head of Iijima Special Research Laboratories he became Professor at the Tokyo Institute of Technology in 1986. He because Professor Emeritus of that institute in 1986. He became Professor at Tokyo Engineering University and Professor Emeritus there in 1991. In 1991 he became Professor at the Japan Advanced Institute of Science and Technology and was appointed Vice President of the institute in 1992. He served successively as editor examiner secretary of general affairs inspector counsel committee-head of pattern recognition and specialized studies head of Tokyo chapter and vice president of this institute. In 1991 he became Honorary Member. He received the Paper Award from the Institute four times and the Literary Works Award once. He received the Achievement Award and the Distinguished Service Award in 1976 and 1989 respectively. He received the Purple Ribbon Medal from the Emperor in 1989.

Theoretical studies on Iijima's ''Theory of pattern recognition,'' which is known as a method of multiple similarity, have shown clearly that there are situations when it is difficult to determine the viewpoint and visual field, important parameters to introduce topological aspects into the pattern space, observing a figure itself. To cope with this problem, this paper proposes transforming the observed image from a figure f(r) to a second-order differential image rho(r), called ''figure source.'' The aim is to reconstruct the theory in such a way as to enable the application of similarity evaluation methods as in the conventional case, without compromising the current theory, and all the necessary proofs are given. In this paper, the figure source equation as well as rules representing its properties are developed, and several related physical quantities are redefined.

关键词： figure source determination of viewpoint and visual field second-order differential image theory reconstruction figure source equation

Varifocal-Net: A Chromosome Classification Approach Using Deep Convolutional Networks

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arXiv 2018年

作者： Qin, Yulei Wen, Juan Zheng, Hao Huang, Xiaolin Yang, Jie Song, Ning Zhu, Yue-Min Wu, Lingqian Yang, Guang-Zhong Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai200240 China Center for Medical Genetics School of Life Sciences Central South University Changsha410078 China Shanghai Key Laboratory of Reproductive Medicine School of Medicine Shanghai Jiao Tong University Shanghai200025 China Diagens-Hangzhou Hangzhou311121 China University Lyon INSA Lyon CNRS INSERM CREATIS UMR 5220 U1206F-69621 France Hamlyn Centre for Robotic Surgery Imperial College London SW72AZ United Kingdom

Chromosome classification is critical for karyotyping in abnormality diagnosis. To expedite the diagnosis, we present a novel method named Varifocal-Net for simultaneous classification of chromosomes type and polarity using deep convolutional networks. The approach consists of one global-scale network (G-Net) and one local-scale network (L-Net). It follows three stages. The first stage is to learn both global and local features. We extract global features and detect finer local regions via the G-Net. By proposing a varifocal mechanism, we zoom into local parts and extract local features via the L-Net. Residual learning and multi-task learning strategies are utilized to promote high-level feature extraction. The detection of discriminative local parts is fulfilled by a localization subnet of the G-Net, whose training process involves both supervised and weakly-supervised learning. The second stage is to build two multi-layer perceptron classifiers that exploit features of both two scales to boost classification performance. The third stage is to introduce a dispatch strategy of assigning each chromosome to a type within each patient case, by utilizing the domain knowledge of karyotyping. Evaluation results from 1909 karyotyping cases showed that the proposed Varifocal-Net achieved the highest accuracy per patient case (%) of 99.2 for both type and polarity tasks. It outperformed state-of-the-art methods, demonstrating the effectiveness of our varifocal mechanism, multi-scale feature ensemble, and dispatch strategy. The proposed method has been applied to assist practical karyotype diagnosis. Copyright © 2018, The Authors. All rights reserved.

关键词： Computer aided diagnosis