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检索条件"机构=Penn Image Computing and Science Laboratory"
105 条 记 录,以下是21-30 订阅
排序:
Deep Learning Registration with Scan-temporal Consistency May Improve Detection of Alzheimer’s Disease Progression
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Alzheimer's & Dementia 2022年 第S5期18卷
作者: Mengjin Dong Long Xie Jiancong Wang Sandhitsu R. Das David A. Wolk Paul A. Yushkevich Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Penn Alzheimer’s Disease Research Center University of Pennsylvania Philadelphia PA USA Penn Alzheimer’s Disease Research Center Perelman School of Medicine Philadelphia PA USA
Background Structural changes in Alzheimer’s disease (AD) can be detected as atrophy in the medial temporal lobe (MTL), which is normally studied by applying volumetric or deformation-based morphometry (DBM) to longi...
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Tau accumulation and degeneration differ across functional networks in atypical Alzheimer's disease phenotypes
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Alzheimer's & Dementia 2022年 第S6期18卷
作者: Jeffrey S Phillips Sarah E Burke Katheryn A Q Cousins Sanaz Arezoumandan Daniel T Ohm Min Chen Philip Cook Jacob G. Dubroff Ilya M. Nasrallah Corey T McMillan Murray Grossman David A. Wolk David J. Irwin Penn FTD Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Penn FTD Center Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA Penn FTD Center University of Pennsylvania Philadelphia PA USA Digital Neuropathology Laboratory Perelman School of Medicine University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Biomedical Image Computing and Analytics University of Pennsylvania Philadelphia PA USA Penn Alzheimer’s Disease Research Center University of Pennsylvania Philadelphia PA USA
Background Recent models of Alzheimer's disease (AD) posit that pathogenic tau propagates through interconnected structural networks, suggesting amnestic and non-amnestic AD (aAD & naAD) phenotypes could refle...
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PART is part of SNAP-MCI
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Alzheimer's & Dementia 2022年 第S6期18卷
作者: Laura EM Wisse Long Xie Xueying Lyu Sandhitsu R. Das Robin de Flores Jacqueline Lane Paul A. Yushkevich David A. Wolk Disease Neuroimaging Initiative Lund University Lund Sweden University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Penn Memory Center University of Pennsylvania Philadelphia PA USA Department of Neurology University of Pennsylvania School of Medicine Philadelphia PA USA Penn Alzheimer’s Disease Research Center University of Pennsylvania Philadelphia PA USA
Background Mild Cognitive Impairment with Suspected non-Alzheimer’s Pathophysiology (SNAP-MCI) represents a group of patients with Alzheimer’s disease (AD) like neurodegeneration without beta-amyloid pathology. Whil...
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Detecting biological changes in longitudinal MRI scans of Alzheimer’s disease patients in the hippocampus region with deep learning
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Alzheimer's & Dementia 2020年 第S5期16卷
作者: Mengjin Dong Long Xie Sandhitsu R. Das David A. Wolk Paul A. Yushkevich Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Penn Memory Center University of Pennsylvania Philadelphia PA USA
Background Alzheimer's Disease (AD) is characterized by gradual loss of gray matter, particularly in the medial temporal lobe (MTL) and hippocampus. Longitudinal change in hippocampal volume on MRI is an effective...
来源: 评论
Neurodegeneration in medial temporal lobe subregions propagates within distinct functional networks in the AD continuum
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Alzheimer's & Dementia 2020年 第S5期16卷
作者: Robin de Flores Sandhitsu R. Das Long Xie Laura Wisse Preya Shah Paul A. Yushkevich David A. Wolk University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA
Background The medial temporal lobe (MTL) is extensively connected to the rest of the brain through two specific networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. As neurodegeneration is thou...
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Reduced longitudinal change in18F-flortaucipir PET is associated with clinical phenotype in atypical Alzheimer’s disease
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Alzheimer's & Dementia 2021年 第S1期17卷
作者: Jeffrey S Phillips Frederick J. Nitchie IV Fulvio Da Re Christopher A Olm Philip Cook Corey T McMillan David J. Irwin James C. Gee Jacob G. Dubroff Murray Grossman Ilya M. Nasrallah Penn FTD Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA School of Medicine and Surgery Milan Center for Neuroscience (NeuroMI) University of Milano-Bicocca Milan Italy Penn Image Computing and Science Laboratory University of Pennsylvania Philadelphia PA USA Digital Neuropathology Laboratory Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) Department of Radiology University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Background Longitudinal positron emission tomography (PET) studies of tau accumulation in Alzheimer’s disease (AD) have noted reduced increases or frank decreases in tau signal. It is unclear whether these reductions...
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Baseline structural MRI and plasma biomarkers predict longitudinal structural atrophy and cognitive decline in early AD
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Alzheimer's & Dementia 2021年 第S1期17卷
作者: Long Xie Sandhitsu R. Das Laura Wisse Ranjit Ittyerah Robin de Flores Paul A. Yushkevich David A. Wolk Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Inserm Inserm UMR-S U1237 Université de Caen-Normandie GIP Cyceron Caen France Penn Memory Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Background In clinical trials targeting early Alzheimer’s disease (AD), recruiting participants that are more likely to progress over the course of the trials is crucial to success. Molecular and neurodegenerative ma...
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A multi-site study of Alzheimer’s disease neuroimaging and cognitive biomarkers in 2819 cognitively normal individuals
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Alzheimer's & Dementia 2023年 第S14期19卷
作者: Long Xie Sandhitsu R. Das Laura EM Wisse Xueying Lyu Emily McGrew Robin de Flores Eli Gibson Paul A. Yushkevich David A. Wolk Alzheimer’s Disease Neuroimaging Initiative Siemens Healthineers Princeton NJ USA Correspondece Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Penn Alzheimer’s Disease Research Center University of Pennsylvania Philadelphia PA USA Department of Diagnostic Radiology Clinical Sciences Lund University Lund Sweden University of Pennsylvania Philadelphia PA USA Normandie Univ UNICAEN INSERM U1237 PhIND “Physiopathology and Imaging of Neurological Disorders” NeuroPresage Team GIP Cyceron Caen France Siemens Heathineers Princeton NJ USA Institute on Aging University of Pennsylvania Philadelphia PA USA
Background Developing effective Alzheimer’s disease (AD) biomarkers in cognitively normal (CN) individuals is crucial. Prior studies have identified neuroimaging and cognitive measures that are sensitive to preclinic...
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Development of the mobile cognitive app performance platform for detection of AD-related cognitive change
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Alzheimer's & Dementia 2020年 第S11期16卷
作者: Dawn Mechanic-Hamilton Sean Lydon Kimberly Halberstadter Jacqueline Lane Sandhitsu R. Das David A. Wolk Penn Memory Center University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA
Background This pilot study investigates the psychometric properties of a mobile app-based memory task, the mobile cognitive app performance platform (mCAPP), to detect memory changes associated with preclinical Alzhe...
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Tau pathology mediates age effects on medial temporal lobe atrophy
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Alzheimer's & Dementia 2020年 第S4期16卷
作者: Laura Wisse Long Xie Sandhitsu R. Das Robin De Flores Paul Yushkevich David A. Wolk the Alzheimer’s Disease Neuroimaging Initiative Lund University Lund Sweden University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA
Background Age effects on the hippocampus are well established, but age-effects on adjacent cortical regions less so. Moreover, aging has often been investigated using cross-sectional designs, seldomly separating agin...
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