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检索条件"机构=Penn Image Computing and Science Laboratory"
105 条 记 录,以下是41-50 订阅
排序:
Deep Learning for Ultra High Resolution T2-weighted 7 TeslaEx vivoMagnetic Resonance Imaging Reveals Differential Subcortical Atrophy across Neurodegenerative Diseases
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Alzheimer's & Dementia 2022年 第S5期18卷
作者: Pulkit Khandelwal Michael Tran Duong Eunice Chung Shokufeh Sadaghiani Sydney A Lim Sadhana Ravikumar Sanaz Arezoumandan Claire Peterson Madigan L Bedard Noah Capp Ranjit Ittyerah Elyse Migdal Grace Choi Emily Kopp Bridget Loja Patino Eusha Hasan Jiacheng Li Karthik Prabhakaran Gabor Mizsei Marianna Gabrielyan Theresa Schuck John L. Robinson Daniel T Ohm Ilya M. Nasrallah Eddie B Lee John Q Trojanowski Corey T McMillan Murray Grossman David J. Irwin Dylan M Tisdall Sandhitsu R. Das Laura EM Wisse David A. Wolk Paul A. Yushkevich University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Penn FTD Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Digital Neuropathology Laboratory Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA Translational Neuropathology Research Laboratory Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Philadelphia PA USA Penn Alzheimer’s Disease Research Center Perelman School of Medicine Philadelphia PA USA Perelman School of Medicine University og Pennsylvania Philadelphia PA USA Department of Diagnostic Radiology Clinical Sciences Lund University Lund Sweden Lund University Lund Sweden Department of Neurology University of Pennsylvania School of Medicine Philadelphia PA USA Penn Alzheimer’s Disease Research Center University of Pennsylvania Philadelphia PA USA
Background Ex vivo magnetic resonance imaging (MRI) of the brain provides remarkable advantages over in vivo MRI for linking neuroanatomy and morphometry to underlying pathology (Yushkevich et al. 2021, Ravikumar et a...
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Disentangling Alzheimer’s disease neurodegeneration from typical brain aging using MRI and machine learning
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Alzheimer's & Dementia 2022年 第S4期17卷
作者: Gyujoon Hwang Ahmed Abdulkadir Guray Erus Mohamad Habes Raymond Pomponio Haochang Shou Jimit Doshi Elizabeth Mamourian Tanweer Rashid Murat Bilgel Yong Fan Aristeidis Sotiras Dhivya Srinivasan John C. Morris Daniel S. Marcus Marilyn S. Albert Nick Bryan Susan M. Resnick Ilya M. Nasrallah Christos Davatzikos David A. Wolk Center for Biomedical Image Computing and Analytics University of Pennsylvania Philadelphia PA USA Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases University of Texas Health Science Center at San Antonio San Antonio TX USA Penn Statistics in Imaging and Visualization Center University of Pennsylvania Philadelphia PA USA Laboratory of Behavioral Neuroscience National Institute on Aging Baltimore MD USA Washington University in St. Louis St. Louis MO USA Washington University in St Louis St Louis MO USA Johns Hopkins University School of Medicine Baltimore MD USA University of Texas at Austin Austin TX USA Penn Memory Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Background Neuroimaging biomarkers that discriminate between healthy brain aging (BA) and Alzheimer’s disease (AD) are valuable in assessing the heterogeneity of neurodegeneration. Prior work has demonstrated that ma...
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Application of histopathologically derived 3D tau burden map as in-vivo region of interest for biomarker analysis
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Alzheimer's & Dementia 2022年 第S4期17卷
作者: Sandhitsu R. Das Long Xie Robin de Flores Monica Munoz Maria Mercedes Iniguez de Onzono Martin Ranjit Ittyerah Sydney A Lim Sadhana Ravikumar Madigan Lavery Stephen R Pickup Weixia Liu Jiancong Wang Ling Yu Hung Jade Lasserve Nicolas Vergnet Mengjin Dong Salena Cui Lauren McCollum John Robinson Theresa Schuck Murray Grossman Dylan M Tisdall Karthik Prabhakaran Gabor Mizsei Emilio Artacho-Perula Maria del Mar Arroyo Jimenez Maria del Pilar Marcos Rabal Francisco Javier Molina Romero Sandra Cebada Sanchez José Carlos Delgado González Carlos de la Rosa Prieto Marta Córcoles Parada Eddie B Lee John Q Trojanowski Daniel T Ohm Ilya M. Nasrallah Melissa Kelley Jacqueline Lane Michael Dicalogero Laura Wisse David J. Irwin Ricardo Insausti Paul Yushkevich David A. Wolk University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Inserm UMR-S U1237 Université de Caen-Normandie GIP Cyceron Caen France University of Castilla-La Mancha Albacete Spain Thomas Jefferson University Philadelphia PA USA Penn FTD Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA University of Castilla-La Mancha - Albacete Campus Albacete Spain Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Penn Frontotemporal Degeneration Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Penn Memory Center University of Pennsylvania Philadelphia PA USA Department of Diagnostic Radiology Clinical Sciences Lund University Lund Sweden Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Penn Memory Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Background Quantitative three-dimensional maps of tau neurofibrillary tangles (NFT) burden derived from dense serial histology have potential application for in-vivo biomarker studies. We constructed a group-level NFT...
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NOVEL MEASURES OF LONGITUDINAL CHANGE IN MEDIAL TEMPORAL LOBE SUBREGIONS DISCRIMINATE PRECLINICAL ALZHEIMER’S DISEASE PATIENTS FROM AMYLOID-β NEGATIVE CONTROLS
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Alzheimer's & Dementia 2019年 第7期15卷 P397-P398页
作者: Long Xie Laura Wisse Sandhitsu R. Das Ranjit Ittyerah Robin de Flores Paul A. Yushkevich David A. Wolk Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA
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P1-374: NOVEL MEASURES OF LONGITUDINAL CHANGE IN MEDIAL TEMPORAL LOBE SUBREGIONS DISCRIMINATE PRECLINICAL ALZHEIMER'S DISEASE PATIENTS FROM AMYLOID-β NEGATIVE CONTROLS
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Alzheimer's & Dementia 2019年 第7S_PART_7期15卷
作者: Long Xie Laura Wisse Sandhitsu R. Das Ranjit Ittyerah Robin de Flores Paul A. Yushkevich David A. Wolk Alzheimer's Disease Neuroimaging Initiative Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA
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Novel ex vivo MRI atlas of the medial temporal lobe can be used to characterize structural changes due to Alzheimer’s disease pathology
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Alzheimer's & Dementia 2020年 第S4期16卷
作者: Sadhana Ravikumar Laura Wisse Long Xie Ranjit Ittyerah Sandhitsu R. Das John A. Detre Murray Grossman Madigan Lavery Sydney A. Lim David J. Irwin Theresa Schuck John Q. Trojanowski Emilio Artacho-Perula Maria Mercedes Iniguez de Onzono Martin Eddie B. Lee Gabor Mizsei Dylan M. Tisdall Maria del Mar Arroyo Jimenez Monica Munoz Jose Carlos Delgado Gonzalez Marta Corcoles Parada Carlos de la Rosa Prieto Sandra Cebada Sanchez Karthik Prabhakaran Maria del Pilar Marcos Rabal Francisco Javier Molina Romero John L. Robinson David A. Wolk Ricardo Insausti Paul A. Yushkevich Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Penn FTD Center University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia PA USA University of Castilla-La Mancha Albacete Spain Penn Memory Center University of Pennsylvania Philadelphia PA USA
Background Finding effective biomarkers that can support early-stage clinical trials is a major challenge in Alzheimer’s Disease (AD). MRI measures of structural change in the medial temporal lobe (MTL) have proven t...
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High-resolution postmortem MRI reveals TDP-43 association with medial temporal lobe subregional atrophy
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Alzheimer's & Dementia 2020年 第S4期16卷
作者: Laura Wisse Sadhana Ravikumar Ranjit Ittyerah Sydney A. Lim Jacqueline Lane Madigan Lavery Long Xie John L. Robinson Theresa Schuck Murray Grossman Eddie B. Lee Dylan M. Tisdall Karthik Prabhakaran John A. Detre Sandhitsu R. Das Gabor Mizsei Emilio Artacho-Perula Maria Mercedes Iniguez de Onzono Martin Maria del Mar Arroyo Jimenez Monica Munoz Francisco Javier Molina Romero Maria del Pilar Marcos Rabal Sandra Cebada Sanchez Jose Carlos Delgado Gonzalez Carlos de la Rosa Prieto Marta Corcoles Parada David J. Irwin John Q. Trojanowski David A. Wolk Ricardo Insausti Paul A. Yushkevich Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Lund University Lund Sweden Penn Memory Center University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Penn FTD Center University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia PA USA University of Castilla-La Mancha Albacete Spain
Background The medial temporal lobe (MTL) is a hotspot of different neurodegenerative pathologies, and recent studies have shown associations of severity of pathology with atrophy measured on antemortem MRI. However, ...
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Variability in tau-atrophy relationships reveals underlying phenotypes in individuals on the Alzheimer’s disease continuum
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Alzheimer's & Dementia 2020年 第S5期16卷
作者: Sandhitsu R Das Long Xie Lauren McCollum Robin de Flores David J Irwin Ilya M Nasrallah Brad C Dickerson Paul Yushkevich David A Wolk Alzheimer's Disease Neuroimaging Initiative University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Inserm UMR-S U1237 Université de Caen-Normandie GIP Cyceron Caen France Penn FTD Center University of Pennsylvania Philadelphia PA USA Massachusetts General Hospital Boston MA USA Penn Memory Center University of Pennsylvania Philadelphia PA USA
Background Tau neurofibrillary tangles (T) are thought to be the primary driver of downstream neurodegeneration (N) and subsequent cognitive impairment in AD. However, there is substantial variability in the T-N relat...
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Optimized extraction of the medial temporal lobe for postmortem MRI based on custom 3D printed molds
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Alzheimer's & Dementia 2020年 第S4期16卷
作者: Jade Lasserve Sydney A. Lim Laura Wisse Ranjit Ittyerah Sadhana Ravikumar Madigan Lavery John L. Robinson Theresa Schuck Murray Grossman Eddie B. Lee Paul A. Yushkevich Dylan M. Tisdall Karthik Prabhakaran Gabor Mizsei Emilio Artacho-Perula Maria Mercedes Iniguez de Onzono Martin Maria del Mar Arroyo Jimenez Monica Munoz Francisco Javier Molina Romero Maria del Pilar Marcos Rabal David J. Irwin John Q. Trojanowski David A. Wolk Ricardo Insausti Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Penn FTD Center University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia PA USA University of Castilla-La Mancha Albacete Spain Perelman School of Medicine University of Pennsylvania Philadelphia PA USA
Background Structural magnetic resonance imaging (MRI) biomarkers are important for early detection of Alzheimer’s Disease (AD). However, atrophy measures can be confounded by changes due to aging and comorbid non-AD...
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Hippocampal subregional thinning related to tau pathology in early stages of Alzheimer’s disease
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Alzheimer's & Dementia 2022年 第S5期18卷
作者: David Berron Hannah Baumeister Kersten Diers Martin Reuter Long Xie Emil Olsson Felix Andersson Laura EM Wisse Olof Strandberg Ruben Smith Erik Stomrud Oskar Hansson German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany Clinical Memory Research Unit Department of Clinical Sciences Lund University Lund Sweden German Center for Neurodegenerative Diseases (DZNE) Bonn Germany Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA University of Pennsylvania Philadelphia PA USA Clinical Memory Research unit Lund University Lund Sweden Memory Clinic Skåne University Hospital Malmö Sweden Department of Diagnostic Radiology Clinical Sciences Lund University Lund Sweden Clinical Memory Research Unit Lund University Malmö Sweden Neurology Clinic Skåne University Hospital Lund Sweden
Background Subregions in the medial temporal lobe (MTL) are affected early by Alzheimer’s disease (AD) pathology and subject to grey matter atrophy. Measuring the earliest AD-related atrophy in the hippocampus is cha...
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