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AMYLOID-POSITIVE COGNITIVE IMPAIRMENT IS LESS “ALZHEIMER’S-LIKE” IN THE ABSENCE OF TAU

Alzheimer's & Dementia 2019年第7期15卷 P1299-P1299页

作者： Lauren McCollum Sandhitsu R. Das Long Xie Salena Cui Robin de Flores Laura Wisse Paul A. Yushkevich David A. Wolk University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Department of Neurology University of Pennsylvania Philadelphia PA USA

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P4-068: AMYLOID-POSITIVE COGNITIVE IMPAIRMENT IS LESS “ALZHEIMER'S-LIKE” IN THE ABSENCE OF TAU

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Alzheimer's & Dementia 2019年第7S_PART_25期15卷

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Early stages of tau pathology and its associations with functional connectivity, atrophy and memory

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Alzheimer's & Dementia 2021年第S5期17卷

作者： David Berron Jacob W. Vogel Philip Insel Joana B. Pereira Long Xie Laura Wisse Paul A. Yushkevich Sebastian Palmqvist Niklas Mattsson-Carlgren Erik Stomrud Ruben Smith Olof Strandberg Oskar Hansson Clinical Memory Research Unit Department of Clinical Sciences Lund University Lund Sweden German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany Department of Psychiatry University of Pennsylvania Philadelphia PA USA Clinical Memory Research Unit Department of Clinical Sciences Malmö Lund University Malmö Sweden Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden Stockholm Sweden Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Lund University Lund Sweden Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Memory Clinic Skåne University Hospital Malmö Sweden Clinical Memory Research Unit Lund University Malmö Sweden Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden

Background In Alzheimer’s disease, postmortem studies have shown that the first cortical site where neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial temporal lobe that largely overlaps with area 35, and the entorhinal cortex. Here we used tau-PET imaging to investigate the sequence of tau pathology progression within the human medial temporal lobe and across regions in the posterior-medial system. Our objective was to study how medial temporal tau is related to functional connectivity, regional atrophy, and memory performance. Method We included 215 β-amyloid negative cognitively unimpaired, 81 β-amyloid positive cognitively unimpaired and 87 β-amyloid positive individuals with mild cognitive impairment, who each underwent [18]F-RO948 tau and [18]F-flutemetamol amyloid PET imaging, structural T1-MRI and memory assessments as part of the Swedish BioFINDER-2 study. Result First, event-based modelling revealed that the entorhinal cortex and area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, area 36 and the parahippocampal cortex. In later stages, tau accumulation became abnormal in neocortical temporal and finally parietal brain regions (see Figure 1). Second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. Tau load, but not atrophy, in these regions was associated with lower memory performance. Further, tau-related reductions in functional connectivity in critical networks between the medial temporal lobe and regions in the posterior-medial system were associated with this early memory impairment. Finally, in patients with mild cognitive impairment, the association of tau load in the hippocampus with memory performance was partially mediated by

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Publisher Correction: Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo

Nature Mental Health

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Nature Mental Health 2024年 1120页

作者： Cynthia H. Y. Fu Danilo Arnone Roland Zahn Allan H. Young Mathilde Antoniades Guray Erus Jose A. Garcia Yong Fan Haochang Shou Ashish Singh Christos Davatzikos Stephen R. Arnott Stephen C. Strother Taolin Chen Kun Qin Qiyong Gong Ki Sueng Choi Helen S. Mayberg Cherise Chin Fatt Madhukar H. Trivedi Benicio N. Frey Vibe G. Frokjaer Melanie Ganz Gitte M. Knudsen Beata R. Godlewska Catherine J. Harmer Stefanie Hassel Keith Ho Susan Rotzinger Sidney H. Kennedy Andrew M. McIntosh Aleks Stolicyn Heather C. Whalley Matthew D. Sacchet Jonathan Savitz Teresa A. Victor Martin P. Paulus Irina Strigo Duygu Tosun Dongtao Wei Jiang Qiu Toby Wise Ian M. Anderson J. F. William Deakin Rebecca Elliott W. Edward Craighead Boadie W. Dunlop Ian H. Gotlib Chao-Gan Yan School of Psychology University of East London London UK Centre for Affective Disorders Department of Psychological Medicine Institute of Psychiatry Psychology and Neuroscience King’s College London London UK South London and Maudsley NHS Foundation Trust Bethlem Royal Hospital London UK Center for Biomedical Image Computing and Analytics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Penn Statistics in Imaging and Visualization Endeavor (PennSIVE) Center Department of Biostatistics Epidemiology and Informatics University of Pennsylvania Philadelphia PA USA Rotman Research Institute Baycrest Centre Toronto Ontario Canada Department of Medical Biophysics University of Toronto Toronto Ontario Canada Huaxi MR Research Center Department of Radiology West China Hospital Sichuan University Chengdu China Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu China Department of Radiology Taihe Hospital Hubei University of Medicine Shiyan China Nash Family Center for Advanced Circuit Therapeutics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Center for Depression Research and Clinical Care University of Texas Southwestern Medical Center Dallas TX USA Department of Psychiatry and Behavioural Neurosciences McMaster University Hamilton Ontario Canada Mood Disorders Treatment and Research Centre and Women’s Health Concerns Clinic St Joseph’s Healthcare Hamilton Hamilton Ontario Canada Neurobiology Research Unit University Hospital Rigshospitalet Copenhagen Denmark Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Department of Psychiatry Psychiatric Centre Copenhagen Copenhagen Denmark Department of Computer Science University of Copenhagen Copenhagen Denmark Department of Psychiatry University of Oxford Oxford UK Oxford Health NHS Foundation Trust Warneford Hospital Oxford UK Mathison Centre for Me

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High gamma and beta band oscillations in left ventral posterior parietal cortex are regionally dissociated during verbal episodic encoding and recall

arXiv

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arXiv 2019年

作者： Rubinstein, D. Camarillo-Rodriguez, L. Waldman, Z.J. Orosz, I. Stein, J. Das, S. Gorniak, R. Sharan, A.D. Gross, R. Lega, B.C. Zaghloul, K. Jobst, B.C. Davis, K.A. Wanda, P.A. Worrell, G. Sperling, M.R. Weiss, S.A. Depts. of Neurology and Neuroscience Dept. of Neurology Dept. of Radiology Dept. of Neurosurgery Thomas Jefferson University PhiladelphiaPA19107 United States Dept. of Neurology David Geffen School of Medicine at UCLA Los AngelesCA90095 United States Penn Image Computing and Science Laboratory Department of Radiology Department of Psychology Department of Neurology University of Pennsylvania PhiladelphiaPA19104 United States Department of Neurosurgery Emory University AtlantaGA United States University of Texas Southwestern Medical Center Department of Neurosurgery DallasTX75390 United States Surgical Neurology Branch NINDS NIH BethesdaMD20892 United States Dartmouth-Hitchcock Medical Center Department of Neurology LebanonNH United States Depts. of Neurology Physiology & biomedical Engineering Mayo Clinic RochesterMN55905

(199) The posterior parietal cortex (PPC) has a unique role in memory retrieval: fMRI1–4 and electrocorticography5 studies suggest that within the ventral PPC (VPC) specifically, there is an anterior-posterior functional divergence between externally-oriented and internally-oriented attention to memory (AtoM)6–9. However, the role of VPC during verbal episodic encoding, and the relationship between encoding- and retrieval-related activity, is less understood. Here we show that activation within a subregion of VPC is doubly dissociated between its anterior and posterior parts, during encoding compared to recall in a free recall task. We found that regional activation defined by increased high gamma power and decreased beta power oscillations during encoding and recall correlated with recall success. During word encoding, iEEG sites that showed this correlation were located anterior to those that showed deactivation. Conversely, during word recall, sites that showed stronger correlations between activity and number of words recalled were located more posteriorly. Our results demonstrate the significance of high gamma and beta oscillations suggesting a push-pull relationship between attention to external stimuli and internal memories within left ventral PPC. Knowledge of this divergence of function along the anterior-posterior axis within left ventral PPC may prove useful for guiding brain stimulation strategies. Copyright © 2019, The Authors. All rights reserved.

关键词： Signal encoding

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White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration

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Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 2016年 4卷 18-27页

作者： Kandel, Benjamin M. Avants, Brian B. Gee, James C. McMillan, Corey T. Erus, Guray Doshi, Jimit Davatzikos, Christos Wolk, David A. Penn Image Computing and Science Laboratory and Department of Bioengineering University of Pennsylvania Philadelphia PA United States Penn Image Computing and Science Laboratory and Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Center for Biomedical Image Computing and Analytics University of Pennsylvania Philadelphia PA United States

Introduction: Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD biomarkers and cognitive tests. Methods: Elderly controls enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 158) underwent florbetapir-PET scans, psychometric testing, neuroimaging with MRI and PET, and APOE genetic testing. Elderly controls the Parkinson's progression markers initiative (PPMI, n = 58) had WMH volume, cerebrospinal fluid (CSF) Aβ_1-42, and APOE status measured. Results: In the ADNI cohort, only WMH volume and APOE ε4 status were associated with cerebral Aβ (standardized β = 0.44 and 1.25, P = .03 and .002). The association between WMH volume and APOE ε4 status with cerebral Aβ (standardized β = 1.12 and 0.26, P = .048 and .045) was confirmed in the PPMI cohort. Discussion: WMH volume is more highly associated with preclinical AD than other AD biomarkers. © 2016 The Authors.

关键词： Aging Alzheimer's disease Amyloid Leukoaraiosis MRI PET Preclinical Alzheimer's disease White matter

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CONTRIBUTION OF TAU, TDP-43, β-AMYLOID AND α-SYNUCLEIN TO MEDIAL TEMPORAL LOBE ATROPHY

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Alzheimer's & Dementia 2019年第7期15卷 P435-P435页

作者： Robin de Flores Laura Wisse Sandhitsu R. Das Long Xie Corey T. McMillan John Q. Trojanowski Murray Grossman Eddie B. Lee David Irwin Paul A. Yushkevich David A. Wolk Department of Neurology University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Penn FTD Center Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia PA USA Penn Memory Center University of Pennsylvania Philadelphia PA USA

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P1-441: CONTRIBUTION OF TAU, TDP-43, β-AMYLOID AND α-SYNUCLEIN TO MEDIAL TEMPORAL LOBE ATROPHY

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Alzheimer's & Dementia 2019年第7S_PART_8期15卷

作者： Robin de Flores Laura Wisse Sandhitsu R. Das Long Xie Corey T. McMillan John Q. Trojanowski Murray Grossman Eddie B. Lee David Irwin Paul A. Yushkevich David A. Wolk Department of Neurology University of Pennsylvania Philadelphia PA USA Penn Image Computing and Science Laboratory (PICSL) University of Pennsylvania Philadelphia PA USA Penn FTD Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia PA USA Penn Memory Center University of Pennsylvania Philadelphia PA USA

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Publisher Correction: Brain charts for the human lifespan

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Nature 2022年第7931期610卷 E6页

作者： R A I Bethlehem J Seidlitz S R White J W Vogel K M Anderson C Adamson S Adler G S Alexopoulos E Anagnostou A Areces-Gonzalez D E Astle B Auyeung M Ayub J Bae G Ball S Baron-Cohen R Beare S A Bedford V Benegal F Beyer J Blangero M Blesa Cábez J P Boardman M Borzage J F Bosch-Bayard N Bourke V D Calhoun M M Chakravarty C Chen C Chertavian G Chetelat Y S Chong J H Cole A Corvin M Costantino E Courchesne F Crivello V L Cropley J Crosbie N Crossley M Delarue R Delorme S Desrivieres G A Devenyi M A Di Biase R Dolan K A Donald G Donohoe K Dunlop A D Edwards J T Elison C T Ellis J A Elman L Eyler D A Fair E Feczko P C Fletcher P Fonagy C E Franz L Galan-Garcia A Gholipour J Giedd J H Gilmore D C Glahn I M Goodyer P E Grant N A Groenewold F M Gunning R E Gur R C Gur C F Hammill O Hansson T Hedden A Heinz R N Henson K Heuer J Hoare B Holla A J Holmes R Holt H Huang K Im J Ipser C R Jack A P Jackowski T Jia K A Johnson P B Jones D T Jones R S Kahn H Karlsson L Karlsson R Kawashima E A Kelley S Kern K W Kim M G Kitzbichler W S Kremen F Lalonde B Landeau S Lee J Lerch J D Lewis J Li W Liao C Liston M V Lombardo J Lv C Lynch T T Mallard M Marcelis R D Markello S R Mathias B Mazoyer P McGuire M J Meaney A Mechelli N Medic B Misic S E Morgan D Mothersill J Nigg M Q W Ong C Ortinau R Ossenkoppele M Ouyang L Palaniyappan L Paly P M Pan C Pantelis M M Park T Paus Z Pausova D Paz-Linares A Pichet Binette K Pierce X Qian J Qiu A Qiu A Raznahan T Rittman A Rodrigue C K Rollins R Romero-Garcia L Ronan M D Rosenberg D H Rowitch G A Salum T D Satterthwaite H L Schaare R J Schachar A P Schultz G Schumann M Schöll D Sharp R T Shinohara I Skoog C D Smyser R A Sperling D J Stein A Stolicyn J Suckling G Sullivan Y Taki B Thyreau R Toro N Traut K A Tsvetanov N B Turk-Browne J J Tuulari C Tzourio É Vachon-Presseau M J Valdes-Sosa P A Valdes-Sosa S L Valk T van Amelsvoort S N Vandekar L Vasung L W Victoria S Villeneuve A Villringer P E Vértes K Wagstyl Y S Wang S K Warfield V Warrier E Westman M L Westwater H C Whalley A V Witte N Yang B Yeo H Y Autism Research Centre Department of Psychiatry University of Cambridge Cambridge UK. rb643@medschl.cam.ac.uk. Brain Mapping Unit Department of Psychiatry University of Cambridge Cambridge UK. rb643@medschl.cam.ac.uk. Department of Psychiatry University of Pennsylvania Philadelphia PA USA. jakob.seidlitz@pennmedicine.upenn.edu. Department of Child and Adolescent Psychiatry and Behavioral Science The Children's Hospital of Philadelphia Philadelphia PA USA. jakob.seidlitz@pennmedicine.upenn.edu. Lifespan Brain Institute The Children's Hospital of Philadelphia and Penn Medicine Philadelphia PA USA. jakob.seidlitz@pennmedicine.upenn.edu. Department of Psychiatry University of Cambridge Cambridge UK. MRC Biostatistics Unit University of Cambridge Cambridge UK. Department of Psychiatry University of Pennsylvania Philadelphia PA USA. Lifespan Informatics & Neuroimaging Center University of Pennsylvania Philadelphia PA USA. Department of Psychology Yale University New Haven CT USA. Developmental Imaging Murdoch Children's Research Institute Melbourne Victoria Australia. Department of Medicine Monash University Melbourne Victoria Australia. UCL Great Ormond Street Institute for Child Health London UK. Weill Cornell Institute of Geriatric Psychiatry Department of Psychiatry Weill Cornell Medicine New York USA. Department of Pediatrics University of Toronto Toronto Canada. Holland Bloorview Kids Rehabilitation Hospital Toronto Canada. The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroInformation University of Electronic Science and Technology of China Chengdu China. University of Pinar del Río "Hermanos Saiz Montes de Oca" Pinar del Río Cuba. MRC Cognition and Brain Sciences Unit University of Cambridge Cambridge UK. Autism Research Centre Department of Psychiatry University of Cambridge Cambridge UK. Department of Psychology School of Philosophy Psychology and Language Sciences University of Edinburgh Edinburgh UK. Queen's

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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Scientific data 2021年第1期8卷 242页

作者： Julien Cohen-Adad Eva Alonso-Ortiz Mihael Abramovic Carina Arneitz Nicole Atcheson Laura Barlow Robert L Barry Markus Barth Marco Battiston Christian Büchel Matthew Budde Virginie Callot Anna J E Combes Benjamin De Leener Maxime Descoteaux Paulo Loureiro de Sousa Marek Dostál Julien Doyon Adam Dvorak Falk Eippert Karla R Epperson Kevin S Epperson Patrick Freund Jürgen Finsterbusch Alexandru Foias Michela Fratini Issei Fukunaga Claudia A M Gandini Wheeler-Kingshott Giancarlo Germani Guillaume Gilbert Federico Giove Charley Gros Francesco Grussu Akifumi Hagiwara Pierre-Gilles Henry Tomáš Horák Masaaki Hori James Joers Kouhei Kamiya Haleh Karbasforoushan Miloš Keřkovský Ali Khatibi Joo-Won Kim Nawal Kinany Hagen H Kitzler Shannon Kolind Yazhuo Kong Petr Kudlička Paul Kuntke Nyoman D Kurniawan Slawomir Kusmia René Labounek Maria Marcella Laganà Cornelia Laule Christine S Law Christophe Lenglet Tobias Leutritz Yaou Liu Sara Llufriu Sean Mackey Eloy Martinez-Heras Loan Mattera Igor Nestrasil Kristin P O'Grady Nico Papinutto Daniel Papp Deborah Pareto Todd B Parrish Anna Pichiecchio Ferran Prados Àlex Rovira Marc J Ruitenberg Rebecca S Samson Giovanni Savini Maryam Seif Alan C Seifert Alex K Smith Seth A Smith Zachary A Smith Elisabeth Solana Y Suzuki George Tackley Alexandra Tinnermann Jan Valošek Dimitri Van De Ville Marios C Yiannakas Kenneth A Weber Ii Nikolaus Weiskopf Richard G Wise Patrik O Wyss Junqian Xu NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. jcohen@polymtl.ca. Functional Neuroimaging Unit CRIUGM Université de Montréal Montreal QC Canada. jcohen@polymtl.ca. Mila - Quebec AI Institute Montreal QC Canada. jcohen@polymtl.ca. NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. Department of Radiology Swiss Paraplegic Centre Nottwil Switzerland. Centre for Advanced Imaging The University of Queensland Brisbane Australia. Department of Radiology University of British Columbia Vancouver BC Canada. Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Charlestown MA USA. Department of Radiology Harvard Medical School Boston MA USA. Harvard-Massachusetts Institute of Technology Health Sciences & Technology Cambridge MA USA. School of Information Technology and Electrical Engineering The University of Queensland Brisbane Australia. NMR Research Unit Queen Square MS Centre UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. Department of Systems Neuroscience University Medical Center Hamburg-Eppendorf Hamburg Germany. Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA. Aix-Marseille Univ CNRS CRMBM Marseille France. APHM Hopital Universitaire Timone CEMEREM Marseille France. Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville TN USA. Department of Computer and Software Engineering Polytechnique Montreal Montreal Canada. CHU Sainte-Justine Research Centre Montreal QC Canada. Centre de Recherche CHUS CIMS Sherbrooke Canada. Sherbrooke Connectivity Imaging Lab (SCIL) Computer Science department Université de Sherbrooke Sherbrooke Canada. Université de Strasbourg CNRS ICube Strasbourg France. UHB - University Hospital Brno and Masaryk University Department of Radiology and Nuclear

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