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Frequency-responsive sorption of metal ions onto magnetic polyvinyltetrazole microsph.res through a solenoid-wrapped glass tube with magnetoph.resis force

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Journal of Water Process engineering 2024年 63卷

作者： Chen, Chih-Wei Wang, Chih-Feng Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei 106 Taiwan Division of Neurosurgery Department of Surgery Chi Mei Medical Center Tainan 710 Taiwan Institute of Advanced Semiconductor Packaging and Testing National Sun Yat-sen University Kaohsiung 804 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung 40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung 940227 Taiwan

Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetoph.resis force (FMEP) is introduced to accelerate the adsorption of metal i... 详细信息

Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetoph.resis force (F_MEP) is introduced to accelerate the adsorption of metal ions on adsorbents under an alternating magnetic field (AMF). A solenoid-wrapped glass tube (SWGT) containing adsorbents is designed to generate F_MEP in a flowing system. Magnetic Fe₃O₄ nanoparticles (MFs) are coated on polyacrylonitrile microsph.res (PANs) as precursors (PAN@MFs) by Pickering emulsion polymerization. The core@shell polyvinyltetrazole@MFs (PVT@MFs) are obtained as the adsorbents after subsequent cyano-tetrazole conversion of PAN@MFs for the adsorption of Pb(II), Cu(II), and Cr(III) ions. The theoretical adsorption rate constants of these metal ions onto the PVT@MFs in the presence of F_MEP are enhanced by approximately three times under an AMF at 1 kHz and 87.6 G. At a high frequency of 10 kHz, hyperthermia occurs on the PVT@MFs, facilitating the desorption of metal ions from the adsorbents. Compared with reuse using an acidic solution, the magnetic PVT@MFs can be reused up to 10 times by switching the frequency of the AMF between 1 and 10 kHz. Our proposed platform provides a novel methodology with a magnetic adsorbent for metal ions to rapidly improve either the adsorption or desorption processes. © 2024

关键词： Adsorption rate Hyperthermia Magnetic susceptibility Polyvinyltetrazole

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The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem

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iscience 2024年第9期27卷

作者： Kuo, Cheng-Liang Lin, Ying-Chen Lo, Yu Kang Lu, Yu-Zhi Babuharisankar, Ananth Ponneri Lien, Hui-Wen Chou, Han-Yu Lee, Alan Yueh-Luen National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan 35053 Taiwan Department of Life Sciences College of Health Sciences & Technology National Central University Taoyuan Zhongli 32001 Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung 40402 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 40402 Taiwan Department of Biotechnology College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan

Mitochondria play important roles in cell fate, calcium signaling, mitoph.gy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a signaling organelle in the cell and communicate with other organelles to constitute the mitochondrial information processing system (MIPS) that transduce input-to-output biological information. The success in immunotherapy, a concept of systemic therapy, has been proved to be dependent on paracrine interactions within the tumor microenvironment (TME) and distant organs including microbiota and immune components. We will adopt a broader view from the concept of TME to tumor micro- and macroenvironment (TM²E) or tumor-organ ecosystem (TOE). In this review, we will discuss the role of mitochondrial signaling by mitochondrial ROS, calcium flux, metabolites, mtdNA, vesicle transportation, and mitochondria-derived peptide in the TME and TOE, in particular immune regulation and effective cancer immunotherapy. © 2024 The Author(s)

关键词： Cancer Immune response Microenvironment

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Risk factors for bone cement dislodgement following balloon kyph.plasty for osteoporotic vertebral compression fracture

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Neurochirurgie 2024年第4期70卷 101559-101559页

作者： Chang, Kai-Chieh Huang, Chih-Ta Hsieh, Cheng-Ta Chen, Chien-Min Chang, Chih-Ju Division of Neurosurgery Department of Surgery Cathay General Hospital Taipei City Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei 110 Taiwan Department of Biomedical Engineering Yuanpei University of Medical Technology Hsinchu Taiwan Department of Medicine School of Medicine Fu Jen Catholic University New Taipei City Taiwan School of Medicine National Tsing Hua University Hsinchu Taiwan Division of Neurosurgery Department of Surgery Changhua Christian Hospital Changhua Taiwan Department of Leisure Industry Management National Chin-Yi University of Technology Taichung Taiwan Department of Mechanical Engineering National Central University Taoyuan City Taiwan

Objective: The study aimed to determine the incidence and risk factors associated with bone cement dislodgement in patients with osteoporotic vertebral compression fracture following balloon kyph.plasty treatment. Methods: A retrospective study was conducted on 203 patients who underwent kyph.plasty in 255 vertebral bodies between January 2017 and december 2021. The patients were categorized into two groups: the bone cement dislodgment group (n = 16) and the non-bone cement dislodgement group (n = 239). Various patient characteristics and radiologic parameters were evaluated. Statistical analysis involved the assessment of the background homogeneity of the group by using independent sample t tests, chi-square tests, and Fisher's exact. Univariate and multivariate logistic regression analyses were performed to explore the impact of background variables on cement dislodgement. Results: The results revealed that split-type fracture (χ² = 31.706, p < 0.001), dISH (χ² = 18.827, p = 0.011), pedicle fracture (χ² = 22.246, p < 0.001), endplate deficit (χ² = 14.023, p < 0.001), posterior wall injury (χ² = 29.124, p < 0.001), and intervertebral vacuum cleft (χ² = 21.469, p < 0.001) were the factors that significantly differed between the two groups. The multivariate logistic regression analysis revealed posterior wall injury (OR = 12.983, p = 0.025) and intervertebral vacuum cleft (OR = 5.062, p = 0.024) to be independent risk factors. Conclusion: The incidence of bone cement dislodgement in our study was 6.3%. This study underscores the importance of using preoperative radiologic parameters to predict the risk of bone cement dislodgement following balloon kyph.plasty. © 2024 Elsevier Masson SAS

关键词： Balloon kyph.plasty Bone cement dislodgment Osteoporotic vertebral compression fracture

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design of Electrocatalytic Janus WSeS/WSe2 Heterostructure Nanowall Electrodes with High Selectivity and Faradaic Efficiency for Nitrogen Reduction

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Advanced Energy Materials 2023年第46期13卷

作者： Peng, Yu-Ren Tang, Shin-Yi Yang, Tzi-Yi Sino, Paul Albert Chen, Yuan-Chun Chaudhary, Mayur Chen, Chieh-Ting Cyu, Ruei-Hong Chung, Chia-Chen Gu, Bing-Ni Liu, Ming-Jing Hsu, Che-Hao Huang, Hung-Yi Lee, Ling Wu, Shu-Chi Jen, Yu-Yi Cheng, You-Song Hu, Chi-Chang Miao, Wen-Chien Kuo, Hao-Chung Chueh, Yu-Lun Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Ph. D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing-Hua University Hsinchu30013 Taiwan Department of Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Center for Nanotechnology Materials Science and Microsystem National Tsing-Hua University Hsinchu30013 Taiwan Semiconductor Research Center Hon Hai Research Institute Taipei11492 Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu30013 Taiwan Instrument Center National Tsing Hua University Hsinchu30013 Taiwan Instrumentation Resource Center National Yang Ming Chiao Tung University Taiwan Department of Photonics National Yang Ming Chiao Tung University Hsinchu30010 Taiwan

The electrochemical nitrogen reduction reaction (NRR) is an attractive process for next-generation ammonia synthesis;therefore, identifying a suitable catalyst for this reaction is critical. In recent years, transition-metal dichalcogenides (TMds) and their Janus structures have gained significant attention because of their outstanding catalytic properties. However, the synthesis of Janus TMds remains challenging, and exposing their active sites is difficult when using a low-dimensional structure to improve the catalytic activity. To date, relatively little research has been conducted in this area. Herein, emerging Janus WSeS/WSe2 heterostructure nanowalls are systematically explored. These nanowalls are used as a nitrogen fixation catalyst in electrolytes. The nanowalls demonstrate a significant NH3 yield rate and Faradaic efficiency of 13.97 µg h-mgcat−1 and 35.24% at −0.3 V in 0.1 m HCl, as well as 15.96 µg h-mgcat−1 and 40.2% in 0.1 M Na2SO4. This study presents an in-depth analysis of the properties of Janus WSeS/WSe2 heterostructure nanowalls and a conceptual framework for linking TMd-based catalysts and the NRR. © 2023 Wiley-VCH GmbH.

关键词： Ammonia

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Fabrication of Solvent-Free PCL/β-TCP Composite Fiber for 3d Printing: ph.siochemical and Biological Investigation

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Polymers 2023年第6期15卷 1391-1391页

作者： Ngo, Sin Ting Lee, Wei-Fang Wu, Yi-Fan Salamanca, Eisner Aung, Lwin Moe Chao, Yan-Qiao Tsao, Ting-Chia Hseuh, Hao-Wen Lee, Yi-Huan Wang, Ching-Chiung Chang, Wei-Jen Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei110 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei110 Taiwan School of Dentistry College of Oral Medicine Taipei Medical University Taipei110 Taiwan Department of Molecular Science and Engineering National Taipei University of Technology Taipei106 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei110 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei110 Taiwan Dental Department Taipei Medical University Shuang Ho Hospital New Taipei235 Taiwan

Manufacturing three-dimensional (3d) objects with polymers/bioceramic composite materials has been investigated in recent years. In this study, we manufactured and evaluated solvent-free polycaprolactone (PCL) and beta-tricalcium ph.sph.te (β-TCP) composite fiber as a scaffold material for 3d printing. To investigate the optimal ratio of feedstock material for 3d printing, the ph.sical and biological characteristics of four different ratios of β-TCP compounds mixed with PCL were investigated. PCL/β-TCP ratios of 0 wt.%, 10 wt.%, 20 wt.%, and 30 wt.% were fabricated, with PCL melted at 65 °C and blended with β-TCP with no solvent added during the fabrication process. Electron microscopy revealed an even distribution of β-TCP in the PCL fibers, while Fourier transform infrared spectroscopy demonstrated that the biomaterial compounds remained intact after the heating and manufacturing process. In addition, adding 20% β-TCP into the PCL/β-TCP mixture significantly increased hardness and Young’s Modulus by 10% and 26.5%, respectively, suggesting that PCL-20 has better resistance to deformation under load. Cell viability, alkaline ph.sph.tase (ALPase) activity, osteogenic gene expression, and mineralization were also observed to increase according to the amount of β-TCP added. Cell viability and ALPase activity were 20% higher with PCL-30, while upregulation for osteoblast-related gene expression was better with PCL-20. In conclusion, PCL-20 and PCL-30 fibers fabricated without solvent exhibited excellent mechanical properties, high biocompatibility, and high osteogenic ability, making them promising materials for 3d printing customized bone scaffolds promptly, sustainably, and cost-effectively. © 2023 by the authors.

关键词： Bone

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Electrochemical sensor based on ZnO@MWCNT/ glassy carbon electrode for the detection of warfarin (blood anticoagulant)

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Surfaces and Interfaces 2025年 67卷

作者： Manjunath, Kumbar Mudakappa Yemmi, Rajeshwari Swamy, B.E. Kumara Eldesoky, Gaber E. Govindasamy, Mani Division of Plant Breeding and Genetics Central Coffee Research Institute Karnataka Chikkamagaluru 577117 India Department of Industrial Chemistry Kuvempu University Karnataka Shivamogga India Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemistry Korea University Seoul Seongbuk-gu South Korea

This study employed ZnO nanoparticles, multi-walled carbon nanotubes (MWCNTs), and a modified glassy carbon electrode (GCE) as a quick and sensitive method for detecting warfarin at biological ph.levels. The ultrasonication technique was utilized in the synthesis of the ZnO@MWCNTs nanocomposite. The ZnO@MWCNTs were characterized using Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), X-ray diffraction (XRd), spectroscopy, analytical techniques, and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry (CV) as well as differential pulse voltammetry (dPV) techniques are employed in the presence of PBS buffer as an electrolyte. We observed unique oxidative peak currents an indication of the electrochemical mechanism of warfarin at low potentials for ZnO @MWCNTs/GCE. Moreover, we successfully attained effective electrochemical detection of warfarin utilizing the proposed sensor, which exhibited an excellent low limit of detection (LOd) of 0.0188 μM across a linear range of 0.02–2867.37 μM. The proposed sensor exhibits excellent storage stability, repeatability, and reproducibility, and has been effectively utilized for the quantification of warfarin in real samples, including blood serum and urine as obtained good recovery and RSd value. © 2025 Elsevier B.V.

关键词： differential pulse voltammetry Glassy carbon electrode Multiwalled carbon nanotubes Warfarin ZnO nanoparticles

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YAP-regulated type II alveolar epithelial cell differentiation mediated by human umbilical cord-derived mesenchymal stem cells in acute respiratory distress syndrome

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Biomedicine and ph.rmacotherapy 2023年第1期159卷 114302-114302页

作者： Chen, Xiao-Yue Chen, Kuan-Yuan Feng, Po-Hao Lee, Kang-Yun Fang, Yu-Ting Chen, You-Yin Lo, Yu-Chun Bhavsar, Pankaj K. Chung, Kian Fan Chuang, Hsiao-Chi Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan School of Respiratory Therapy College of Medicine Taipei Medical University Taipei Taiwan National Heart and Lung Institute Imperial College London London United Kingdom Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan The Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan

Acute respiratory distress syndrome (ARdS) contributes to higher mortality worldwide. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have immunomodulatory and regenerative potential. However, the effects of hUC-MSCs as an ARdS treatment remain unclear. We investigated the role of hUC-MSCs in the differentiation of type II alveolar epithelial cells (AECII) by regulating Yes-associated protein (YAP) in ARdS. Male C57BL/6JNarl mice were intratracheally (i.t.) administered lipopolysaccharide (LPS) to induce an ARdS model, followed by a single intravenous (i.v.) dose of hUC-MSCs. hUC-MSCs improved pulmonary function, decreased inflammation on day 3, and mitigated lung injury by reducing the lung injury score and increasing lung aeration (%) in mice on day 7 (p < 0.05). hUC-MSCs inactivated YAP on AECII and facilitated cell differentiation by decreasing Pro-surfactant protein C (Pro-SPC) and galectin 3 (LGALS3) while increasing podoplanin (T1α) in lungs of mice (p < 0.05). In AECII MLE-12 cells, both coculture with hUC-MSCs after LPS exposure and the YAP inhibitor, verteporfin, reduced Pro-SPC and LGALS3, whereas the YAP inhibitor increased T1α expression (p < 0.05). In conclusion, hUC-MSCs ameliorated lung injury of ARdS and regulated YAP to facilitate AECII differentiation. © 2023 The Authors

关键词： Alveoli Inflammation Pneumocytes Regeneration Stem cells

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deep learning-based air pollution analysis on carbon monoxide in Taiwan

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Ecological Informatics 2024年 80卷

作者： Cheng-Hong Yang Po-Hung Chen Chih-Hsien Wu Cheng-San Yang Li-Yeh Chuang Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan Division of Plastic and Reconstruction Surgery Department of Surgery Ditmanson Medical Foundation Chia-Yi Christian Hospital Chia-Yi Taiwan Department of Chemical Engineering and Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan

Global air pollution poses a threat to humanity. Specifically, CO directly affects cardiovascular and other organ tissues and leads to numerous chronic diseases and major public health problems. The effective implementation of a deep learning model for predicting variations in CO levels would enable the early formulation of policies for controlling air pollution. In this study, a seasonal gated recurrent unit (SGRU) model, which is a deep learning time-series prediction model, was developed to predict the levels of CO in Taiwan. Atmosph.ric CO measurements from 2005 to 2021 were collected from the Environmental Protection Administration of Taiwan and preprocessed using the Kalman filter to achieve accurate forecasting. The performance of the proposed SGRU model was compared with that of the autoregressive integrated moving average (ARIMA), seasonal ARIMA, exponential smoothing (ETS), Holt–Winters ETS, support vector regression, and seasonal long short-term memory models in terms of mean absolute percentage error (MAPE) and root mean square error. The SGRU model achieved the lowest MAPE value of 0.94, which demonstrated its superior performance. The construction of an accurate air pollution prediction model can assist government entities in formulating health and social care strategies and in planning future air pollution control measures.

关键词： Air pollution Carbon Monoxide (CO) deep learning Seasonal gated recurrent unit (SGRU)

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Assessment of sources and health risks of heavy metals in metropolitan household dust among preschool children: The LEAPP-HIT study

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Journal of Environmental Management 2024年 352卷 120015页

作者： Kao, Chi-Sian Wang, Ying-Lin Jiang, Chuen-Bin Tai, Pei-Ju Chen, Yi-Hua Chao, Hsing-Jasmine Lo, Yu-Chun Hseu, Zeng-Yei Hsi, Hsing-Cheng Chien, Ling-Chu School of Public Health College of Public Health Taipei Medical University Taipei Taiwan Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan Department of Pediatric Gastroenterology Hepatology and Nutrition MacKay Children's Hospital Taipei Taiwan Department of Medicine MacKay Medical College SanZhi District New Taipei City Taiwan Neuroscience Research Center Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Agricultural Chemistry National Taiwan University Taipei Taiwan Nutrition Research Center Taipei Medical University Hospital Taipei Taiwan

The most common construction material used in Taiwan is concrete, potentially contaminated by geologic heavy metals (HMs). Younger children spend much time indoors, increasing HM exposure risks from household dust owing to their behaviors. We evaluated arsenic (As), cadmium (Cd), and lead (Pb) concentrations in fingernails among 280 preschoolers between 2017 and 2023. We also analyzed HM concentrations, including As, Cd, Pb, chromium (Cr), nickel (Ni), copper (Cu), zinc (Zn), iron (Fe), and manganese (Mn), in 90 household dust and 50 road dust samples from a residential area where children lived between 2019 and 2021 to deepen the understanding of sources and health risks of exposure to HMs from household dust. The average As, Cd, and Pb concentrations in fingernails were 0.12 ± 0.06, 0.05 ± 0.05, and 0.95 ± 0.77 μg/g, respectively. Soil parent materials, indoor construction activities, vehicle emissions, and mixed indoor combustion were the pollution sources of HMs in household dust. Higher Cr and Pb levels in household dust may pose non-carcinogenic risks to preschoolers. Addressing indoor construction and soil parent materials sources is vital for children's health. The finding of the present survey can be used for indoor environmental management to reduce the risks of HM exposure and avoid potential adverse health effects for younger children. © 2024 Elsevier Ltd

关键词： Heavy metals

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Targeting formyl peptide receptor 1 with anteiso-C13-surfactin for neutroph.l-dominant acute respiratory distress syndrome

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British journal of ph.rmacology 2023年第16期180卷 2120-2139页

作者： Shun-Chin Yang Yi-Hsuan Wang Chiu-Ming Ho Yung-Fong Tsai Ping-Jyun Sung Tony Eight Lin Tsong-Long Hwang Department of Anesthesiology Taipei Veterans General Hospital and National Yang Ming Chiao Tung University Taipei 112 Taiwan. Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. Department of Anesthesiology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan Taiwan. Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. National Museum of Marine Biology and Aquarium Pingtung 944 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Research Center for Chinese Herbal Medicine and Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology 333 Taoyuan Taiwan. Healthy Aging Research Center Chang Gung University 333 Taoyuan Taiwan. Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243 Taiwan.

BACKGROUNd ANd PURPOSE:Acute respiratory distress syndrome (ARdS) is a catastroph.c pulmonary inflammatory dysfunction with a high mortality rate. An overwhelming immune response by neutroph.ls is a key feature in infective or sterile ARdS. The formyl peptide receptor 1 (FPR1) is a crucial damage-sensing receptor for inflammatory reactions in the initiation and progression of neutroph.l-mediated ARdS. However, effective targets for controlling dysregulated neutroph.lic inflammatory injuries in ARdS are limited. EXPERIMENTAL APPROACH:Human neutroph.ls were used to explore the anti-inflammatory effects of cyclic lipopeptide anteiso-C13-surfactin (IA-1) from marine Bacillus amyloliquefaciens. The lipopolysaccharide-induced model of ARdS in mice was used to determine the therapeutic potential of IA-1 in ARdS. Lung tissues were harvested for histology analyses. KEY RESULTS:The lipopeptide IA-1 inhibited immune responses of neutroph.ls, including respiratory burst, degranulation, and expression of adhesion molecules. IA-1 inhibited the binding of N-formyl peptides to FPR1 in human neutroph.ls and in hFPR1-transfected HEK293 cells. We identified IA-1 as a competitive FPR1 antagonist, thus diminishing the downstream signalling pathways involving calcium, mitogen-activated protein kinases and Akt. Furthermore, IA-1 ameliorated the inflammatory damage to lung tissue, by decreasing neutroph.l infiltration, reducing elastase release and oxidative stress in endotoxemic mice. CONCLUSION ANd IMPLICATIONS:The lipopeptide IA-1 could serve as a therapeutic option for ARdS by inhibiting FPR1-mediated neutroph.lic injury.

关键词： ARdS FPR1 N-formyl peptides lipopeptide marine Bacillus neutroph.ls

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