Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetoph.resis force (FMEP) is introduced to accelerate the adsorption of metal i...
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Mitochondria play important roles in cell fate, calcium signaling, mitoph.gy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a signaling organelle in the cell and com...
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Objective: The study aimed to determine the incidence and risk factors associated with bone cement dislodgement in patients with osteoporotic vertebral compression fracture following balloon kyph.plasty treatment. Met...
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The electrochemical nitrogen reduction reaction (NRR) is an attractive process for next-generation ammonia synthesis;therefore, identifying a suitable catalyst for this reaction is critical. In recent years, transitio...
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Manufacturing three-dimensional (3d) objects with polymers/bioceramic composite materials has been investigated in recent years. In this study, we manufactured and evaluated solvent-free polycaprolactone (PCL) and bet...
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Acute respiratory distress syndrome (ARdS) contributes to higher mortality worldwide. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have immunomodulatory and regenerative potential. However, the effec...
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Global air pollution poses a threat to humanity. Specifically, CO directly affects cardiovascular and other organ tissues and leads to numerous chronic diseases and major public health problems. The effective implemen...
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Global air pollution poses a threat to humanity. Specifically, CO directly affects cardiovascular and other organ tissues and leads to numerous chronic diseases and major public health problems. The effective implementation of a deep learning model for predicting variations in CO levels would enable the early formulation of policies for controlling air pollution. In this study, a seasonal gated recurrent unit (SGRU) model, which is a deep learning time-series prediction model, was developed to predict the levels of CO in Taiwan. Atmosph.ric CO measurements from 2005 to 2021 were collected from the Environmental Protection Administration of Taiwan and preprocessed using the Kalman filter to achieve accurate forecasting. The performance of the proposed SGRU model was compared with that of the autoregressive integrated moving average (ARIMA), seasonal ARIMA, exponential smoothing (ETS), Holt–Winters ETS, support vector regression, and seasonal long short-term memory models in terms of mean absolute percentage error (MAPE) and root mean square error. The SGRU model achieved the lowest MAPE value of 0.94, which demonstrated its superior performance. The construction of an accurate air pollution prediction model can assist government entities in formulating health and social care strategies and in planning future air pollution control measures.
The most common construction material used in Taiwan is concrete, potentially contaminated by geologic heavy metals (HMs). Younger children spend much time indoors, increasing HM exposure risks from householddust owi...
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BACKGROUNd ANd PURPOSE:Acute respiratory distress syndrome (ARdS) is a catastroph.c pulmonary inflammatory dysfunction with a high mortality rate. An overwhelming immune response by neutroph.ls is a key feature in inf...
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BACKGROUNd ANd PURPOSE:Acute respiratory distress syndrome (ARdS) is a catastroph.c pulmonary inflammatory dysfunction with a high mortality rate. An overwhelming immune response by neutroph.ls is a key feature in infective or sterile ARdS. The formyl peptide receptor 1 (FPR1) is a crucial damage-sensing receptor for inflammatory reactions in the initiation and progression of neutroph.l-mediated ARdS. However, effective targets for controlling dysregulated neutroph.lic inflammatory injuries in ARdS are limited.
EXPERIMENTAL APPROACH:Human neutroph.ls were used to explore the anti-inflammatory effects of cyclic lipopeptide anteiso-C13-surfactin (IA-1) from marine Bacillus amyloliquefaciens. The lipopolysaccharide-induced model of ARdS in mice was used to determine the therapeutic potential of IA-1 in ARdS. Lung tissues were harvested for histology analyses.
KEY RESULTS:The lipopeptide IA-1 inhibited immune responses of neutroph.ls, including respiratory burst, degranulation, and expression of adhesion molecules. IA-1 inhibited the binding of N-formyl peptides to FPR1 in human neutroph.ls and in hFPR1-transfected HEK293 cells. We identified IA-1 as a competitive FPR1 antagonist, thus diminishing the downstream signalling pathways involving calcium, mitogen-activated protein kinases and Akt. Furthermore, IA-1 ameliorated the inflammatory damage to lung tissue, by decreasing neutroph.l infiltration, reducing elastase release and oxidative stress in endotoxemic mice.
CONCLUSION ANd IMPLICATIONS:The lipopeptide IA-1 could serve as a therapeutic option for ARdS by inhibiting FPR1-mediated neutroph.lic injury.
Two new 16-hydroxybriaranes, 11-dehydroxybriavioid B (1) and 12-epi-briastecholide L (2), have been isolated from an algal-containing octocoral identified as Briareum stechei. The structures of metabolites 1 and 2 wer...
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