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Nanoarchitectonics of europium vanadate nanoparticles decorated carbon nanofibers for electrochemical detection of fungicide in fruits

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Journal of the Taiwan Institute of Chemical Engineers 2024年 161卷

作者： Huang, Song-Jeng Gokulkumar, Kumar Govindasamy, Mani Albaqami, Munirah d. Wabaidur, Saikh Mohammad Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei City106335 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia

Background: Fungicides, like carbendazim, have effects on male fertility. There have been sufficient studies conducted on certain chemical compounds to indicate a selective action at the epididymis level. To prevent contamination of food products with fungicides, most of the governments have established rules for the use of fungicides. However, even though this type of fungicide is primarily used in agriculture. More probably, it's contaminated with fruits and vegetables. In particular, carbendazim is one of the major fungicides in the agricultural usage Methods: This research work developed a europium vanadate (EuVO4) nanoparticle decorated carbon nanofiber (CNF) composites by hydrothermal-sonochemical approach. Based on this composite, Carbendazim sensing is developed through electrochemical oxidation based on EuVO4/f-CNF modified Glassy Carbon Electrode (GCE). By combining EuVO4 and f-CNF with the GCE, carbendazim detection can be highly effective. GCEs are rigid, making them ideal for depositing EuVO4/f-CNF, while their expansive surface area makes it possible to immobilize a greater amount of EuVO4/f-CNF, which could increase the Carbendazim sensing ability of the resulting modified GCEs with EuVO4/f-CNF. Main Findings: : The carbendazim sensing was actualized by the electrocatalytic oxidation of carbendazim on the composite modified electrode, and it is demonstrating a linear range of 0.125 to 23.875 – 33.81 to 131.375 µM with a remarkably limit of detection of 0.00612 µM. The EuVO4/f-CNF /GCE also showcased an excellent degree of stability, retaining 96.5 % of its initial activity even after 30 days. This research highlights the potential of EuVO4/f-CNF modified GCEs as robust, and efficient platform for the carbendazim detection under electrochemical approach. © 2024 Taiwan Institute of Chemical Engineers

关键词： Carbon nanofibers

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Sensing property of Ga2O3-based extended-gate field-effect transistors for a living cell viability sensor

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Sensors and Actuators A: ph.sical 2023年 349卷

作者： Chou, Hsin-Yu Chiang, Jung-Lung Yu, Chang-Tze Ricky Chen, Jo-Mei Maureen Wuu, dong-Sing Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung411030 Taiwan Department of Applied Chemistry National Chi-Nan University Nantou54561 Taiwan Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Nantou54561 Taiwan

In this study, gallium oxide (Ga2O3) nanorods were deposited onto an indium tin oxide (ITO) glass substrate to develop a real-time living cell viability sensor. Ga2O3 nanorods had characteristics of cell population sensing based on cellular metabolism to detect cell viability. The ph.sensing characteristics of Ga2O3-based extended-gate field-effect transistors (EGFETs) with and without the annealing process were measured from ph.1–11. Three different sensor heads, ITO/glass, GaOOH/ITO/glass, and Ga2O3/ITO/glass, were produced as EGFETs and immersed into a ph.standard buffer and high-glucose dulbecco's modified Eagle's medium (dMEM) to investigate hydrogen ion sensing. Results showed that the Ga2O3/ITO/glass probe had the best hydrogen ion sensing sensitivity and stability in different sample buffers. In contrast, GaOOH/ITO/glass had instability and lower sensitivity due to interference with other components in the medium. The drift characteristic of sensors was analyzed to detect long-term stability. The Ga2O3/ITO/glass probe showed lower drift properties, which can potentially monitor the dMEM situation in real-time for a long-term period. during in vitro detection, the Ga2O3/ITO/glass probe revealed a 70 μA/cells change in IdS-VdS analysis and a 10 μV/cells change in IdS-VGS analysis, which was superior linearly dependent within 10,000 cells. The biocompatibility of the Ga2O3/ITO/glass probe was also detected by 3-(4,5-dimethylthiazol-2-yl)− 2,5-diph.nyltetrazolium bromide assay and showed no cytotoxicity. Overall, the Ga2O3/ITO/glass EGFET sensor has potential applications as a living cell viability device in microenvironmental studies in the future. © 2022 Elsevier B.V.

关键词： Nanorods

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Modified Turnstile Antenna design for Multi-Band and Broadband Applications

Modified Turnstile Antenna Design for Multi-Band and Broadba...

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USNC-URSI Radio science Meeting (Joint with AP-S Symposium)

作者： I-Fong Chen Chia-Mei Fei-Lung Wu Jian-An Xie Dept. of Computer and Communication School of Electronics and Electrical Engineering Dongguan Polytechnic Jinwen University of Science and Technology New Taipei City Taiwan Department of Communications Engineering Feng Chia University Taichung City Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung City Taiwan

ISBN: (数字)9789463968119

ISBN: (纸本)9798350359497

The proposed antenna with a size of 90 mm x 90 mm, and the ground portion is 64 mm x 64 mm, which material is FR4 glass epoxy substrate with the thickness of 1.6 mm, relative permittivity of 4.3 and loss tangent of 0.023, consists of four modified dipole elements and four power dividers, as shown in Figure. 1. For the multi-band and broadband operation, three dipole antennas were shunted to be a dipole element. The electrical-length of the dipole element can be determined from the one quarter-wave length at the 2.45 GHz, 5.5 GHz and 6.525 GHz, for covering 2400 MHz-2500 MHz, 5150 MHz-5850 MHz and 5925 MHz-7125 MHz. In order to operates in various modes such as normal mode and axial mode, the modified four port triple-band microstrip series power divider was designed. In normal mode, it radiates horizontally polarized waves where as in axial mode, it radiates circularly polarized waves. The radiated patterns of the proposed antenna as shown in Figure. 2. The features of the proposed antenna are shown in the Table I. Impressive radiated gains and efficiencies are obtained.

关键词： Power dividers dipole antennas Conferences Glass Broadband communication Broadband antennas Microstrip

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Immediate Effects of Vergence Exercises Using Automatic dual Rotational Risley Prisms on Accommodative Lag and Facility

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Oph.halmology and Therapy 2023年第6期12卷 3361-3372页

作者： Huang, Shuan-Yu Su, Hui-Rong Hu, Yun-Shao Lee, Chi-Hung Tsai, Ming-Shan Yeh, Shang-Min Chen, Ya-Yu Tsai, Tzu-Hsun Department of Optometry Central Taiwan University of Science and Technology Taichung 402 Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung 407 Taiwan Department of Optometry Chung Shan Medical University Taichung 402 Taiwan Department of Electrical Engineering Feng Chia University Taichung 407 Taiwan Department of Electrophysics National Chiayi University Chiayi 600 Taiwan Department of Optometry Da-Yeh University Changhua 515 Taiwan Department of Ophthalmology National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Taiwan Department of Ophthalmology National Taiwan University Hospital Taipei City 100225 Taiwan

Introduction: This study evaluated novel automatic dual rotational Risley prisms (AdRRPs) as a vergence exercise tool for patients with myopia to improve accommodative lag and accommodative facility. Methods: Participants with myopia aged 20–24 years were recruited. After vergence exercises with prisms (treatment group) or plano lenses (control group) using AdRRPs for 10 min, measurements were taken using an open-field autorefractor (Grand Seiko WAM-5500) at viewing distances of 0.4 m and 6.0 m. We measured accommodative facility using a ± 2.00 d accommodative flipper. Results: A total of 56 participants (treatment group, 39;control group, 17) performed vergence exercises using AdRRPs. Participants in the treatment group showed improvements in accommodative lag at a 0.4 m viewing distance, with measurements of 0.57 d (right eye;Od) and 0.53 d (left eye;OS) and 0.21 d (Od) and 0.27 d (OS) before and after the exercises, respectively (p < 0.001). Over-refractions using an open-field autorefractor with sph.rical equivalent contact lenses at a 6.0 m viewing distance were − 0.01 ± 0.30 d (Od) and 0.03 ± 0.34 d (OS) and 0.15 ± 0.32 d (Od) and 0.19 ± 0.28 d (OS) before and after the exercises, respectively (difference + 0.16 d;p < 0.001). Accommodative facility values before and after exercises were 14.88 ± 3.36 and 15.59 ± 3.60 cpm, respectively (p < 0.01). No significant differences in accommodative lag, relaxation, and accommodative facility before and after exercise were observed in the control group. Conclusions: Using AdRRPs in vergence exercises can improve accommodative lag, accommodative facility, and accommodative relaxation in adults with myopia. Further research to evaluate persistent and long-term effects is needed. © 2023, The Author(s).

关键词： Accommodative facility Accommodative lag Automatic dual rotational Risley prisms (AdRRPs) Vergence exercise

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Reduced sediments: A factor in the design of subsurface oxidant delivery systems

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GROUNd WATER MONITORING ANd REMEdIATION 1996年第1期16卷 100-105页

作者： Korom, SF McFarland, MJ Sims, RC Scott E Korom received his B.S. and M.S. in civil engineering from the University of Akron in 1982 and 1984 respectively and his Ph.D. in civil and environmental engineering from Utah State University in 1991. Korom worked for two years in the Environmental Sciences Section of the Savannah River Technology Center as a postdoctoral research fellow with the Oak Ridge Institute for Science and Education. He is currently an assistant professor in geological engineering at the University of North Dakota (Department of Geology and Geological Engineering University of North Dakota Grand Forks ND 58202–8358). His research interests include ground water identification and ground water contaminant transport and remediation. Korom is a licensed professional engineer in North Dakota. Michael J. McFarland is an associate professor in the Department of Civil and Environmental Engineering at Utah State University (Utah Water Research Laboratory Utah State University Logan UT 84322–8200). Dr. McFarland received his B.S. degree in chemical engineering from Yale University and an M.S. in chemical engineering and a Ph. D. in agricultural engineering from Cornell University. Dr. McFarland has authored or coauthored more than 30 technical publications. He has served as a consulting engineer for both federal and local government agencies as well as private industry. Dr. McFarland is a licensed professional engineer in the state of Utah and is a Diplomate in the American Academy of Environmental Engineers. Ronald C. Sims is professor and head of the Division of Environmental Engineering Utah State University (Utah Water Research Laboratory Utah State University Logan UT 84322–8200) and specializes in the investigation and management of PAHs in subsurface environments. Dr. Sims received his Ph.D. in biological and agricultural engineering from North Carolina State University an M.S. in environmental engineering from Washington State University and an M.S. in environmental chemistry and biology from the University of North

A preliminary field performance evaluation of in situ bioremediation of a contaminated aquifer at the Libby, Montana, Superfund site, a former wood preserving site, was conducted for the Bioremediation Field Initiative sponsored by the U.S. Environmental Protection Agency (U.S. EPA). The current approach for site remediation involves injecting oxygen and nutrients into the aquifer to stimulate microbial degradation of target compounds that include polycyclic aromatic hydrocarbons and pentachloroph.nol. The preliminary field evaluation determined that, in addition to the oxygen demand associated with the microbial oxidation of the organic contamination, uncontaminated aquifer sediments at the site are naturally reduced and also exert a significant oxygen demand. This conclusion is supported by three types of information: (1) analyses of ground water samples: (2) results from a field-scale tracer test;and (3) results of laboratory evaluations of oxygen use by reduced aquifer sediment samples. An estimate of the cost of supplying hydrogen peroxide to satisfy the oxygen demand of the uncontaminated reduced sediments is provided to demonstrate that the additional cost of oxidizing the reduced sediments could be significant. The presence of naturally occurring reduced sediments at a contamination site should be considered in the design of subsurface oxidant delivery systems.

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Psychological Stress Classification Using Extreme Gradient Boosting Algorithm

Psychological Stress Classification Using Extreme Gradient B...

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International Conference on Information and Communication technology Convergence (ICTC)

作者： Maria Mahardini Sakanti Viacheslav Siniaev Aurelia Amaris Win-Jet Luo Suhartono C. Bambang dwi Kuncoro Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taichung Taiwan Institute of Applied Computer Science ITMO University St. Petersburg Russian Federation Department of Informatics Engineering Faculty of Computer Science Universitas Brawijaya Malang Indonesia Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taichung Taiwan Department of Refrigeration Air Conditioning and Energy Engineering National Chin-Yi University of Technology Taichung Taiwan

ISBN: (数字)9798350364637

ISBN: (纸本)9798350364644

Stress, as a reaction to threatening situations, can raise heart rate and result in serious conditions that might cause significant damage or even be life-threatening. Traditional methods for evaluating stress, which rely on subjective self-reporting and clinical assessments, often suffer from biases and inconsistencies. Artificial intelligence models have been explored to predict stress levels more accurately. This paper investigates the application of Extreme Gradient Boosting in classifying psychological stress using the WESAd dataset, which includes parameters such as acceleration, electrocardiogram, electromyograph., electrodermal activity, temperature, and respiration. The dataset was balanced and sampled to create a manageable subset for experimental. Extreme Gradient Boosting was chosen for its efficiency and scalability in handling complex datasets. The model was trained and validated, achieving a 95% accuracy in predicting stress levels. This study highlights the potential of integrating Extreme Gradient Boosting models into wearable devices for real-time stress monitoring. Future work involves optimizing the model to utilize fewer sensors without decreasing accuracy, ensuring it can be integrated into portable/wearable systems using tiny microcontrollers.

关键词： Accuracy Microcontrollers Psychology Human factors Predictive models Boosting Prediction algorithms Real-time systems Sensors Wearable devices

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Improving the Concentration of Students With Attention deficit Hyperactivity disorder and Autism Spectrum disorder: Electroenceph.lograph.c Analysis on the Effect of Learning Activity Interventions

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International Journal of Intelligent Technologies & Applied Statistics 2020年第1期13卷 49-63页

作者： Ming-Hseuh Tsai Sy-Ruen Huang Shao-Chin Chang Yu-Ling Lo Yun-Chieh Lu Research Center for Education Systems and Policy National Academy f or Educational Research New Taipei City Taiwan Chung Chou University of Science and Technology Changhua County Taiwan Ph.D. Program of Electrical and Communications Engineering Feng-Chia University Taichung City Taiwan Department of Early Childhood Education Asia University Taichung City Taiwan

This study examined whether the learning concentration of students with attention deficit hyperactivity disorder (AdHd) or autism spectrum disorder (ASd) can be improved through participation in one-on-one learning activities. A total of 13 students with AdHd or ASd were recruited to participate in various weekly one-on-one learning activities, in an effort to improve the concentration of students with special needs. Brainwave data were collected through electroenceph.lograph. and analyzed to explore students' concentration performance in different learning activities. To achieve the objective of this study, a multi-baseline design (ABAB), a type of single-subject design method, was employed. The experiment spanned 21 weeks, covering a fall and a spring semester: the first three weeks were defined as the 1st baseline ph.se, the 4th to 10th weeks as the 1st experimental ph.se, the 11th to 13th weeks as the 2nd baseline ph.se, and the 14th to 21th weeks as the 2nd experimental ph.se. The learning activities took place in the morning self-study period once a week, and the experiment was only suspended during two of the weeks because of school events. The purpose of the two baseline ph.ses was to collect students' brainwave data. Students' brainwaves were measured for two minutes under two scenarios; first, while they were relaxed with eyes looking straight ahead; second, they were reading a passage. The purpose of the two experimental ph.ses was to gradually enhance students' concentration by training them to perceive their own emotions through brainwave lamps. Initial results yielded different brainwave data for students with different types of disorders. After participating in the training on learning concentration, some students demonstrated improved concentration; however, after the 2nd experimental ph.se, students' concentration declined. The reason was that the activities in both experimental ph.ses were identical, and thus, they no longer provoked students' inte

关键词： Attention def icit hyperactivity disorder (AdHd) Autism spectrum disorder (ASd) Brainwave test Concentration

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A novel strategy towards the fabrication of highly stable and sensitive non-enzymatic glucose sensor based on Ni3N thin films using high power impulse magnetron sputtering

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Applied Surface science 2024年 669卷

作者： Pardhi, Nishchal Cheng, Wei-Chun Chen, Sheng-Chi Akshay Joshi, Shikha Govindasamy, Mani Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City243303 Taiwan College of Engineering and Center for Green Technology Chang Gung University Taoyuan333 Taiwan Department of Materials Engineering Indian Institute of Science Bangalore560012 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Glucose level surveillance in mankind is considered the greatest need of recent times to achieve healthy lifestyle goals due to its health-related concern for humans. To fulfill the need, Nickel-based compounds emerge with excellent bio-mimic properties. However, due to the poor electrical properties of oxides and hydroxides of Ni, developing a supporting base that can enhance electron transportation is mandatory. The present work is dedicated to non-enzymatic glucose detection by electrochemical means on the Ni3N thin film on an Indium-doped Tin Oxide (ITO) substrate as a working electrode in an alkaline medium. The Ni3N films use HiPIMS as a deposition technique due to its high ionization rate of sputtered species and dense plasma which helps the Ni ions to react with nitrogen in the formation of a perfect Ni3N ph.se, and it is a green process that can contribute to sustainable manufacturing. Ni3N thin film deposited at a 60 % N2 flow ratio shows the largest crystallinity and catalytic properties, which helps this modified electrode to have significant potential for glucose detection. The Ni3N modified electrode acquires a lower linear range of 0.001–1.25 mM with sensitivity and Limit of detection (LOd) of 337.46 µAmM–1cm−2, and 0.78 µM, respectively, and a higher linear range of 1.25–7.3161 mM with a sensitivity of 158.58 µAmM–1cm−2. The amperometric measurements reveal the fast response of the electrode towards glucose detection at 2.46 secs. The key measures of the electrode according to the corresponding measurements are satisfactory selectivity, reproducibility, repeatability, and operational stability. The modified electrode shows a significant response for real samples such as commercially available honey, apple juice, and biological fluids. © 2024 Elsevier B.V.

关键词： Thin films

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Extracellular Vesicular delta-Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer diagnosis

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Advanced science 2025年

作者： Li, Hong Chiang, Chi-Ling Kwak, Kwang Joo Lee, Hsin-Lun Wang, Xinyu Romano, Giulia Saviana, Michela Toft, Robin Cheng, Tai-Shan Chang, Yuehshih Hsiang, Bi-da Liu, Guan-Wan Mo, Xiaokui Ma, Yifan Pan, Junjie Rima, Xilal Y. Kim, Truc Nguyen Reategui, Eduardo Shen, Chia-Ning Chu, Yeh-Shiu Croce, Carlo Chang, Peter Mu-Hsin Yeh, Yi-Chen Carbone, david P. Huang, Chi-Ying F. Chiang, Chi-Lu Nana-Sinkam, Patrick Lee, L. James Department of Chemical and Biomolecular Engineering The Ohio State University ColumbusOH43210 United States Institute of Biopharmaceutical Sciences National Yang Ming Chiao Tung University Taipei11221 Taiwan Spot Biosystems Ltd. ColumbusOH43212 United States Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei11031 Taiwan Genomic Research Center Academia Sinica Taipei11529 Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei11031 Taiwan Division of Pulmonary Diseases and Critical Care Medicine Virginia Commonwealth University RichmondVA23284 United States Division of Hematology and Oncology Department of Internal Medicine Keelung Chang Gung Memorial Hospital Keelung20401 Taiwan School of Medicine College of Traditional Chinese Medicine Chang Gung University Taoyuan33302 Taiwan Center for Biostatistics The Ohio State University ColumbusOH43210 United States Department of Biomedical Engineering The Ohio State University ColumbusOH43210 United States Brain Research Center National Yang Ming Chiao Tung University Taipei11221 Taiwan College of Medicine The Ohio State University ColumbusOH43210 United States School of Medicine National Yang Ming Chiao Tung University Taipei11221 Taiwan Department of Oncology Taipei Veterans General Hospital Taipei11217 Taiwan Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital Taipei11217 Taiwan Department of Chest Medicine Taipei Veterans General Hospital Taipei11217 Taiwan

Small cell lung cancer (SCLC) is associated with high mortality and limited therapeutic options. There is increasing recognition that SCLC harbors molecular heterogeneity. Using a new liquid biopsy assay, it is demonstrated that SCLC subtypes, as determined by patient tumor tissue staining and cell lines, can be accurately identified by measuring the mRNA expression of subtype transcription factors (ASCL1, POU2F3, and NEUROd1) in circulating exosome-rich extracellular vesicles (Exo). Additionally, upregulation of delta-like ligand 3 (dLL3) mRNA in Exo and its membrane protein (mProtein) in extracellular vesicles associated with tumor (tEV) may distinguish both limited- and extensive-stage SCLC patients from high-risk smokers, with AUC/ROC values of 0.836 and 0.839, respectively. By incorporating Exo-ASCL1 and Exo-POU2F3 mRNA expression with dLL3 Exo-mRNA/tEV-mProtein expression, the classifier enhances the AUC/ROC to 0.912 and 0.963 for limited- and extensive-stage SCLC patients, respectively. © 2025 The Author(s). Advanced science published by Wiley-VCH GmbH.

关键词： Tissue culture

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Overall mortality risk analysis for rectal cancer using deep learning-based fuzzy systems

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Computers in Biology and Medicine 2023年 157卷 106706-106706页

作者： Yang, Cheng-Hong Chen, Wen-Ching Chen, Jin-Bor Huang, Hsiu-Chen Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan Department of Community Health Chia-Yi Christian Hospital Chia-Yi City Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan

Colorectal cancer is a leading cause of cancer mortality worldwide, with an increasing incidence rate in developing countries. Integration of genetic information with cancer therapy guidance has shown promise in cancer treatment, indicating its potential as an essential tool in translation oncology. However, the high-throughput analysis and variability of genomic data poses a major challenge to conventional analytic approaches. In this study, we propose an advanced analytic approach, named "Fuzzy-based RNNCoxph." incorporated fuzzy logic, recurrent neural networks (RNNs), and Cox proportional hazards regression (Coxph. for detecting missense variants associated with high-risk of all-cause mortality in rectum adenocarcinoma. The test data set was downloaded from "Rectum adenocarcinoma, TCGA-REAd" the Genomic data Commons (GdC) portal. In this study, four model-based risk score models were derived using RNN, Coxph. RNNCoxph.ddition, and RNNCoxph.ultiplication. The RNNCoxph.ddition and RNNCoxph.ultiplication models were obtained as the sum and product of the RNN risk degree matrix and the Coxph.risk degree matrix, respectively. Moreover, the fuzzy logic system was used to calculate the survival risk values of missense variants and classified their membership grade to improve the identification of high-risk gene variation locations associated with cancer mortality. The four models were integrated to develop an advanced risk estimation model. There were 20 028 variants associated with survival status, amongst 17 638 variants were associated with survival and 2390 variants associated with mortality. The proposed Fuzzy-based RNNCoxph.model obtained a balanced accuracy of 93.7%, which was significantly higher than that of the other four test methods. In particular, the Coxph.model is commonly used in medical researches and the XGBoost model is famous for its high accuracy in machine learning. The results suggest that the Fuzzy-based RNNCoxph.model exhibits a higher efficacy

关键词： Fuzzy logic

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