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RELIABILITY-BASEd FATIGUE dESIGN FOR SHIP STRUCTURES

NAVAL ENGINEERS JOURNAL 1987年第3期99卷 135-149页

作者： WHITE, GJ AYYUB, BM Gregory J. White: LCdr. USNR-R is an assistant professor of naval architecture at the U.S. Naval Academy. He received a B. S. degree in engineering mechanics from Vanderbilt University in 1975 an M. E. degree in naval architecture from the University of California Berkeley in 1981 and a Ph.D. from the University of Maryland in 1986. Dr. White served on active duty with the U.S. Navy from 1975 to 1979 first as the damage control assistant aboard the USS Reasoner (FF-1063) and then as the commissioning CIC officer aboard the USS Merrill (DD-976). After leaving active duty and while attending graduate school he worked at Mare Island Naval Shipyard in the scientific section (Code 250.1). Upon completion of graduate school he then worked for Exxon International Company as a research engineer in the R & D division of the tanker department. A lieutenant commander in the Ready Reserve Dr. White drills with the repair department of a submarine tender reserve unit and recently completed the reserve engineering duty officer qualification program. A member of ASNE since 1983 Dr. White is also a member of SNAME and the U.S. Naval Institute Dr. White received the “Jimmie” Hamilton Award for 1985. Bilal M. Ayyub:is currently an assistant professor of civil engineering at the University of Maryland. He received his B. S. degree in civil engineering from the University of Kuwait in 1980. He completed both his M. S. (1981) and Ph.D. (1983) in civil engineering at the Georgia Institute of Technology. While there he was awarded the Kuwait Foundation for the Advancement of Science Fellowship. Dr. Ayyub has extensive background in risk-based analysis and design simulation pre-stressed composite steel girders and construction engineering. He is engaged in research work involving structural reliability bridges marine structures mathematical modelling using the theories of probability statistics and fuzzy sets. His research work is sponsored by the National Transportation Safety Board the University of Maryland the Natio

In the continuing effort to apply reliability methods to marine structures, the next logical step is to include these techniques in the design process. The advantage of doing this would be the ability to design more efficient structures with some measure of certainty of the reliability level involved. The particular application in ship structural design which would benefit the most from using reliability methods is the design against fatigue failure. In this paper, some of the reliability-based methods currently being used (or proposed for use) in the design of structures against fatigue are examined. Each is evaluated as to its suitability for use in the structural design of ships. In addition, the authors propose a new reliability-based fatigue design format which is based on their recently introduced Reliability-Conditioned (RC) design method and the Load and Resistance Factor design (LRFd) code format. This approach is hoped to provide the design engineer with an easy to understand and use tool based on the LRFd format. The RC method will enable him to quickly and accurately design the components of a ship's structure such that a desired level of safety against fatigue is achieved. Each of the methods discussed is used to solve a practical example. The results of that example and several others are used to discuss the relative merits of each method.

关键词： SHIPS

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Review on fate, transport, toxicity and health risk of nanoparticles in natural ecosystems: Emerging challenges in the modern age and solutions toward a sustainable environment

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The science of the total environment 2024年 912卷 169331页

作者： Thien-Khanh Tran Minh-Ky Nguyen Chitsan Lin Tuan-dung Hoang Thanh-Cong Nguyen Aasif Mohmad Lone Akhil Pradiprao Khedulkar Mohamed S Gaballah Jagpreet Singh W Jin Chung d duc Nguyen Advanced Applied Sciences Research Group Dong Nai Technology University Bien Hoa City 76100 Viet Nam Faculty of Technology Dong Nai Technology University Bien Hoa City 76100 Viet Nam. Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City 700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. Electronic address: nmky@hcmuaf.edu.vn. Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. School of Chemistry and Life Science Hanoi University of Science and Technology No. 1 Dai Co Viet Hai Ba Trung Hanoi 100000 Viet Nam Vietnam National University Hanoi VNU Town Hoa Lac Thach That District Hanoi 155500 Viet Nam. Department of Civil Engineering Manipal Institute of Technology Manipal Academy of Higher Education Manipal 576104 Karnataka India. Department of Biomedical Engineering and Environmental Science National Tsing Hua University Hsinchu 30013 Taiwan. CAS Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and Engineering University of Science and Technology of China Hefei 230026 China School of Engineering and Technology Central Michigan University Mt. Pleasant MI 48859 USA. Department of Chemistry University Centre for Research and Development Chandigarh University Gharuan Mohali 140413 India. Department of Civil & Energy System Engineering Kyonggi University Suwon 16227 South Korea. Department of Civil & Energy System Engineering Kyonggi University Suwon 16227 South Korea Institute of Applied Technology and Sustainable Development Nguyen Tat Thanh University Ho Chi Minh City 700000 Viet Nam. Electronic address: nguyensyduc@gmail.com.

In today's era, nanoparticles (NPs) have become an integral part of human life, finding extensive applications in various fields of science, ph.rmacy, medicine, industry, electronics, and communication. The increasing popularity of NP usage worldwide is a testament to their tremendous potential. However, the widespread deployment of NPs unavoidably leads to their release into the environmental matrices, resulting in persistence in ecosystems and bioaccumulation in organisms. Understanding the environmental behavior of NPs poses a significant challenge due to their nanoscale size. Given the current environmental releases of NPs, known negative consequences, and the limited knowledge available for risk management, comprehending the toxicity of NPs in ecosystems is both awaiting and crucial. The present review aims to unravel the potential environmental influences of nano-scaled materials, and provides in-depth inferences of the current knowledge and understanding in this field. The review comprehensively summarizes the sources, fate, transport, toxicity, health risks, and remediation solutions associated with NP pollution in aquatic and soil ecosystems. Furthermore, it addresses the knowledge gaps and outlines further investigation priorities for the sustainable control of NP pollution in these environments. By gaining a holistic understanding of these aspects, we can work toward ensuring the responsible and sustainable use of NPs in today's fast-growing world.

关键词： Bioavailability Fate and transport Nanosized particles Nanotoxicology Silver nanoparticles Toxicity

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Corrigendum to “Seasonal distribution of total and pathogenic Vibrio parahaemolyticus in Chesapeake Bay oysters and waters” [Int. J. of Food Microbiol. 128 (2008) 354–361]

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International Journal of Food Microbiology 2009年第1期130卷 75-75页

作者： Salina Parveen Kumidini A. Hettiarachchi John C. Bowers Jessica L. Jones Mark L. Tamplin Rusty McKay William Beatty Kathy Brohawn Ligia V. daSilva Angelo dePaola Food Science and Technology Ph. D. Program Department of Agriculture Food and Resource Sciences University of Maryland Eastern Shore Princess Anne Maryland 21853 United States Division of Public Health and Biostatistics U. S. Food and Drug Administration College Park Maryland 20740 United States Gulf Coast Seafood Laboratory U. S. Food and Drug Administration Dauphin Island Alabama 36528 United States Food Safety Centre University of Tasmania Hobart Tasmania 7001 Australia Maryland Department of the Environment Baltimore Maryland 21230 United States

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Correction to: Biological synthesis and characterization of iron oxide (FeO) nanoparticles using Pleurotus citrinopileatus extract and its biomedical applications

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Biomass Conversion and Biorefinery 2023年第11期14卷 12587-12587页

作者： Manimaran, Kumar Yanto, dede Heri Yuli Govindasamy, Mani Karunanithi, Bogeshwaran Alasmary, Fatmah Ali Habab, Reem Abdulrahman Research Center for Applied Microbiology National Research and Innovation Agency (BRIN) Cibinong Republic of Indonesia Department of Product Development Institute of Biotechnology Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India Faculty International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Korea University Seongbuk-gu Republic of Korea Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam India Department of Petroleum Engineering Dhaanish Ahmed College of Engineering Chennai India Department of Chemistry College of Science King Saud University Riyadh Saudi Arabia

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Enhanced exopolysaccharide production of Cordyceps militaris via mycelial cell immobilization on plastic composite support in repeated-batch fermentation

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International Journal of Biological Macromolecules 2023年第1期250卷 126267页

作者： Lin, Shin-Ping Sung, Ting-Hsuan Angkawijaya, Artik Elisa Go, Alchris Woo Hsieh, Chang-Wei Hsu, Hsien-Yi Santoso, Shella Permatasari Cheng, Kuan-Chen School of Food Safety Taipei Medical University #250 Wuxing Street Xinyi Dist. Taipei11042 Taiwan Research Center of Biomedical Device Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Nutrition and Health Sciences Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Center for Sustainable Resource Science RIKEN Yokohama230-0045 Japan Department of Chemical Engineering National Taiwan University of Science and Technology #43 Sec. 4 Keelung Rd Taipei10607 Taiwan Department of Food Science and Biotechnology National Chung Hsing University South Dist. Taichung City40227 Taiwan Department of Medical Research China Medical University Hospital North Dist. Taichung City404333 Taiwan Taiwan Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Energy and Environment Department of Materials Science and Engineering City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Jl. Kalijudan 37 East Java Surabaya60114 Indonesia Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung40

Repeated-batch fermentation with fungal mycelia immobilized in plastic composite support (PCS) eliminates the lag ph.se during fermentation and improves metabolite productivity. The strategy is implemented herein, and a novel modified PCS is developed to enhance exopolysaccharide (EPS) production from the medicinal fungus Cordyceps militaris. A modified PCS (SYE + PCS) was made by compositing polypropylene (PP) with a nutrient mixture containing soybean hull, peptone, yeast extract, and minerals (SYE+). The use of SYE + PCS has consistent cell productivity throughout the multiple fermentation cycles, which resulted in a more higher cell productivity after second batch compared to unmodified PCS. The cell grown on SYE + PCS also generates a higher yield of EPS (3.36, 6.93, and 5.72 g/L in the first, second, and third fermentation cycles, respectively) up to three-fold higher than the cell immobilized on unmodified PCS. It is also worth noting that the EPS from mycelium grown on SYE + PCS contains up to 2.3-fold higher cordycepin than those on unmodified PCS. The presence of nutrients in SYE + PCS also affects the hydroph.bicity and surface roughness of the PC, improving mycelial cell adhesion. This study also provides a preliminary antioxidant activity assessment of EPS from immobilized C. militaris grown with SYE + PCS. © 2023

关键词： Mycelium

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Plasma-derived Nanoclusters for Site-Specific Multimodality ph.to/Magnetic Thrombus Theranostics

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Advanced Healthcare Materials 2023年第28期12卷 e2301504页

作者： Liu, Chia-Hung Liu, Ming-Che Jheng, Pei-Ru Yu, Jiashing Fan, Yu-Jui Liang, Jia-Wei Hsiao, Yu-Cheng Chiang, Chih-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Mansel, Bradley W Chen, Yan-Ting Nguyen, Hieu Trung Chuang, Er-Yuan Department of Urology School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center of Urology and Kidney Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road Zhonghe District New Taipei City23561 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei11031 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics School of Biomedical Engineering Research Center of Biomedical Device Innovation Entrepreneurship Education Center College of Interdisciplinary Studies Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering College of Engineering National Taiwan University Taipei106 Taiwan Department of Orthopedics Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Department of Physical Electronics Faculty of Science Masaryk University Brno60177 Czech Republic Department of Materials Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City24301 Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) ph.totherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment. © 2023 Wiley-VCH GmbH.

关键词： diseases

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Affordability, logistics R&d and fleet systems

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NAVAL ENGINEERS JOURNAL 1996年第3期108卷 199-213页

作者： Schulte, dP Skolnick, A He has supported the development and operation of several naval systems including advanced component selection for Trident II fire control and navigation systems. He served as branch manager of the Surface Ship ASW Combat System Branch which acted as the acquisition engineering agent for the AN/SQQ-89 Surface Ship Anti-Submarine Warfare Weapon System. He was then selected to manage the Module Engineering Department which provided engineering support to numerous naval systems including the AN/BSY-1 Submarine Combat System and the Trident II fire control and navigation system. He then served as the deputy program manager for NAVSEA Progressive Maintenance (2M/ATE). He holds a B.S. degree in Electrical Engineering from Purdue University and currently is pursuing a Maste's degree in Public Environmental Affairs at Indiana University—Purdue University Indianapolis. He served at Applied Physics Laboratory/The Johns Hopkins University in missile development then aboard USS Boston (CAG-1) and played leading roles in several weapon system developments (Regulus Terrier Tartar Talos) inertial navigation (Polaris) deep submergence (DSRV) and advanced ship designs (SES). He later was director Combat System Integration Naval Sea Systems Command and head Combat Projects Naval Ship Engineering Center. He led the Navy's High Energy Lasers and Directed Energy Weapons development efforts. He was vice president advanced technology at Operations Research Inc. and vice president maritime engineering at Defense Group Inc. before starting SSC in 1991. Dr. Skolnick holds a B.S. degree in Mathematics and Economics Queens College an M.A. degree in Mathematics and Philosophy Columbia University an M.S. degree in Electrical/Aeronautical Engineering U.S. Naval Postgraduate School and a Ph.D. in Electrical Engineering and Applied Mathematics from Polytechnic University in New York. He is the author of many published papers on engineering design issues source selection procedures and large-scale complex technology problems

The Fleet continues to require high performance systems that can operate with dependability in the seas' unforgiving environments and under hostile action. Those demands are not new. What has changed is the urgent priority formerly assigned to national defense issues. The arguments for continued superpower military strength are now roiled in politics along with unsettled budgets and uncertain force level projections. Current expectations revolve about indefinite fiscal and operational issues (difficult funding constraints and broadband threats). In the actual event of ''doing more with less,'' a practical response is to apply the creative power available from sound engineering judgement and the crucible of experience to the immediate needs of the Fleet. The attempt to shorten the path between advanced development effort and Fleet use has been tried occasionally in the past, often, without exemplary results. The Sustainable Hardware and Affordable Readiness Practices (SHARP) program, is a generic R&d effort under OpNav sponsorship that has been working steadily on sensible solutions to product engineering problems. Armed today with fast-time, large-scale computation abilities and modern tools for technical problem solving coupled with specialized engineering knowledge, it has been refreshed and is underway satisfying existing Fleet needs. The relationship between fully responsive engineering services and current operational needs is always demanding. The connection between advanced engineering development (6.3 category funds) and immediate Fleet usage brings added complexity and challenge, both technical and organizational. Illustrative examples of affordable engineering solutions to ''retain, revise, replace or retire'' questions are presented within the context of both Fleet realities and budgetary limitations. The discussion covers legacy system support, civil/military considerations and Fleet maintenance issues. It describes the substantial and critical payoffs i

关键词： Warships

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Immobilization of poly(hexamethylene biguanide) to cellulose acetate- and cellulose-based nanofiber membranes for antibacterial and cytotoxic studies

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Biochemical engineering Journal 2024年 205卷

作者： dinh Thi My Huong Chi-Yun Wang Pin-Yi Chen Chien Wei Ooi Xue Er Crystal Thew Bing-Lan Liu Chen-Yaw Chiu Shen-Long Tsai Kuei-Hsiang Chen Yu-Kaung Chang Department Chemical Technology and Environment University of Technology and Education the University of Da Nang Da Nang City Viet Nam Department Chemical Engineering/ Graduate School of Biochemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan Department Chemical Engineering National Taiwan University of Science and Technology Taipei City 10607 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Bone and Joint Research Centre Chang Gung Memorial Hospital Taoyuan City 333423 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Chemical Engineering Department School of Engineering Monash University Malaysia Jalan Lagoon Selatan Bandar Sunway Selangor 47500 Malaysia Advanced Engineering Platform School of Engineering Monash University Malaysia Jalan Lagoon Selatan 47500 Bandar Sunway Selangor Malaysia Department of Applied Chemistry Chaoyang University of Technology Taichung 413310 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist Taoyuan City 320315 Taiwan

To develop the environmental antibacterial membrane, the ph.sical attachments of poly (hexamethylene biguanide) hydrochloride (ph.B) on the cellulose acetate (CA) and regenerated cellulose (RC) electrospun nanofiber membranes were employed. The immobilization of ph.B increased the antibacterial efficacy ( AE , %) of nanofiber membranes from 65.67% to approximately 86.13% for CA-ph.B and from 35.09% to approximately 100% for RC-ph.B. The results of the chemical and ph.sical characteristics indicate that the degree of deacetylation of CA nanofiber, the surface charge of the nanofiber, and the density of ph.B immobilized onto the nanofiber primarily affect the antibacterial efficacy. The use of mathematical models, such as the Temkin equilibrium model for ph.B immobilization and the Monod-type model for the relationship between antibacterial activity and immobilization density of ph.B provides a deeper understanding of the interactions and kinetics involved. The rapid achievement of ∼100% AE after only 10 min of contact with Escherichia coli ( E. coli ) is a notable finding, indicating the quick and efficient antibacterial action of RC-ph.B nanofiber membranes. Furthermore, maintaining approximately 100% AE after 20 days of storage underscores the long-term stability of ph.B immobilized on RC nanofiber membranes. The findings suggest that RC-ph.B holds great promise as an antibacterial material for biomedical applications, food packaging industries, and filtration or treatment of water.

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ROLE OF SIMULATION IN RAPId PROTOTYPING FOR CONCEPT dEVELOPMENT

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NAVAL ENGINEERS JOURNAL 1991年第3期103卷 204-211页

作者： KING, JF BARTON, dE J. Fred King:is the manager of the Advanced Technology Department for Unisys in Reston Virginia. He earned his Ph.D. in mathematics from the University of Houston in 1977. He has been principal investigator of research projects in knowledge engineering pattern recognition and heuristic problem-solving. Efforts include the development of a multi-temporal multispectral classifier for identifying graincrops using LANDSAT satellite imagery data for NASA. Also as a member of the research team for a NCI study with Baylor College of Medicine and NASA he helped develop techniques for detection of carcinoma using multispectral microphotometer scans of lung tissue. He established and became technical director of the AI Laboratory for Ford Aerospace where he developed expert scheduling modeling and knowledge acquisition systems for NASA. Since joining Unisys in 1985 he has led the development of object-oriented programming environments blackboard architectures data fusion techniques using neural networks and intelligent data base systems. Douglas E. Barton:is manager of Logistics Information Systems for Unisys in Reston Virginia. He earned his B.A. degree in computer science from the College of William and Mary in 1978 and did postgraduate work in London as a Drapers Company scholar. Since joining Unisys in 1981 his work has concentrated on program management and software engineering of large scale data base management systems and design and implementation of knowledge-based systems in planning and logistics. As chairman of the Logistics Data Subcommittee of the National Security Industrial Association (NSIA) he led an industry initiative which examined concepts in knowledge-based systems in military logistics. His responsibilities also include evaluation development and tailoring of software engineering standards and procedures for data base and knowledge-based systems. He is currently program manager of the Navigation Information Management System which provides support to the Fleet Ballistic Missile Progr

A valuable technique during concept development is rapid prototyping of software for key design components. This approach is particularly useful when the optimum design approach is not readily apparent or several known alternatives need to be rapidly evaluated. A problem inherent in rapid prototyping is the lack of a "target system" with which to interface. Some alternatives are to develop test driver libraries, integrate the prototype with an existing working simulator, or build one for the specific problem. This paper presents a unique approach to concept development using rapid prototyping for concept development and scenario-based simulation for concept verification. The rapid prototyping environment, derived from artificial intelligence technology, is based on a blackboard architecture. The rapid prototype simulation capability is provided through an object-oriented modeling environment. It is shown how both simulation and blackboard technologies are used collectively to rapidly gain insight into a tenacious problem. A specific example will be discussed where this approach was used to evolve the logic of a mission controller for an autonomous underwater vehicle.

关键词： Military engineering

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Transdermal nanolipoplex simultaneously inhibits subcutaneous melanoma growth and suppresses systemically metastatic melanoma by activating host immunity

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Nanomedicine: Nanotechnology, Biology, and Medicine 2023年 47卷 102628-102628页

作者： Chen, Chia-Hung Weng, Tzu-Han Chuang, Cheng-Hsun Huang, Kai-Yao Huang, Sih-Cheng Chen, Pin-Rong Huang, Hsiao-Hsuan Huang, Ling-Ya Shen, Pei-Chun Chuang, Po-Ya Huang, Hsiao-Yen Wu, Yi-Syuan Chang, Hao-Chiun Weng, Shun-Long Liao, Kuang-Wen Department of Medical Research Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan Dependent of Medical Education MacKay Memorial Hospital Taipei10449 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Industrial Development Graduate Program of College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Medicine MacKay Medical College New Taipei City25245 Taiwan Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital Hsinchu City30071 Taiwan MacKay Junior College of Medicine Nursing and Management Taipei City11260 Taiwan Drug Development and Value Creation Research Center College of Dental Medicine Kaohsiung Medical University School of Dentistry Graduate Institute of Medicine College of Medicine Center for Cancer Research Kaohsiung Medical University Kaohsiung City80708 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan City70101 Taiwan Ph.D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu City30068 Taiwan

Benefit for clinical melanoma treatments, the transdermal neoadjuvant therapy could reduce surgery region and increase immunotherapy efficacy. Using lipoplex (Lipo-PEG-PEI-complex, LPPC) encapsulated doxorubicin (dOX) and carrying CpG oligodeoxynucleotide;the transdermally administered nano-liposomal drug complex (LPPC-dOX-CpG) would have high cytotoxicity and immunostimulatory activity to suppress systemic metastasis of melanoma. LPPC-dOX-CpG dramatically suppressed subcutaneous melanoma growth by inducing tumor cell apoptosis and recruiting immune cells into the tumor area. Animal studies further showed that the colonization and growth of spontaneously metastatic melanoma cells in the liver and lung were suppressed by transdermal LPPC-dOX-CpG. Furthermore, NGS analysis revealed IFN-γ and NF-κB pathways were triggered to recruit and activate the antigen-presenting-cells and effecter cells, which could activate the anti-tumor responses as the major mechanism responsible for the therapeutic effect of LPPC-dOX-CpG. Finally, we have successfully proved transdermal LPPC-dOX-CpG as a promising penetrative carrier to activate systemic anti-tumor immunity against subcutaneous and metastatic tumor. © 2022

关键词： Tumors

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