检索结果-内蒙古大学图书馆

SWEET: a single-sample network inference method for deciph.ring individual features in disease

Briefings in bioinformatics 2023年第2期24卷 bbad032页

作者： Hsin-Hua Chen Chun-Wei Hsueh Chia-Hwa Lee Ting-Yi Hao Tzu-Ying Tu Lan-Yun Chang Jih-Chin Lee Chun-Yu Lin Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei 110 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Otolaryngology-Head and Neck Surgery Tri-Service General Hospital National Defense Medical Center Taipei 110 Taiwan. Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. Institute of Data Science and Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. Center for Intelligent Drug Systems and Smart Bio-devices National Yang Ming Chiao Tung University Hsinchu 300 Taiwan. School of Dentistry Kaohsiung Medical University Kaohsiung 807 Taiwan.

Recently, extracting inherent biological system information (e.g. cellular networks) from genome-wide expression profiles for developing personalized diagnostic and therapeutic strategies has become increasingly important. However, accurately constructing single-sample networks (SINs) to capture individual characteristics and heterogeneity in disease remains challenging. Here, we propose a sample-specific-weighted correlation network (SWEET) method to model SINs by integrating the genome-wide sample-to-sample correlation (i.e. sample weights) with the differential network between perturbed and aggregate networks. For a group of samples, the genome-wide sample weights can be assessed without prior knowledge of intrinsic subpopulations to address the network edge number bias caused by sample size differences. Compared with the state-of-the-art SIN inference methods, the SWEET SINs in 16 cancers more likely fit the scale-free property, display higher overlap with the human interactomes and perform better in identifying three types of cancer-related genes. Moreover, integrating SWEET SINs with a network proximity measure facilitates characterizing individual features and therapy in diseases, such as somatic mutation, mut-driver and essential genes. Biological experiments further validated two candidate repurposable drugs, albendazole for head and neck squamous cell carcinoma (HNSCC) and lung adenocarcinoma (LUAd) and encorafenib for HNSCC. By applying SWEET, we also identified two possible LUAd subtypes that exhibit distinct clinical features and molecular mechanisms. Overall, the SWEET method complements current SIN inference and analysis methods and presents a view of biological systems at the network level to offer numerous clues for further investigation and clinical translation in network medicine and precision medicine.

关键词： drug repurposing gene expression network inference network medicine precision medicine single-sample network

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Electronic nose in differentiating and ascertaining clinical status among patients with pulmonary nontuberculous mycobacteria: A prospective multicenter study

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The Journal of infection 2023年第3期87卷 255-258页

作者： Meng-Rui Lee Hung-Ling Huang Wei-Chang Huang Shang-Yu Wu Pang-Chun Liu Jui-Ching Wu Meng-Hsuan Cheng Chau-Chyun Sheu Kea-Tiong Tang Jann-Yuan Wang Chao-Chi Ho Jin-Yuan Shih Inn-Wen Chong Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Division of Chest Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Mycobacteria Center of Excellence Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan School of Medicine Chung Shan Medical University Taichung 402 Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung 402 Taiwan Department of Medical Technology Jen-Teh Junior College of Medicine Nursing and Management Miaoli Taiwan. Department. of Electrical Engineering National Tsing Hua University Hsinchu Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan. Department. of Electrical Engineering National Tsing Hua University Hsinchu Taiwan. Electronic address: kttang@ee.nthu.edu.tw. Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan. Electronic address: jywang@ntu.edu.tw. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Respiratory Therapy Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Biological Science & Technology National Chiao Tung University Hsin-Chu Taiwan.

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data on lung and intestinal microbiome after air pollution exposure in ageing rats

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data in brief 2023年 47卷 109004页

作者： Vincent Laiman Yu-Chun Lo Hsin-Chang Chen Tzu-Hsuen Yuan Ta-Chih Hsiao Jen-Kun Chen Ching-Wen Chang Ting-Chun Lin Ssu-Ju Li You-Yin Chen didik Setyo Heriyanto Kian Fan Chung Kai-Jen Chuang Kin-Fai Ho Jer-Hwa Chang Hsiao-Chi Chuang International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Anatomical Pathology Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada - Dr. Sardjito Hospital Yogyakarta Indonesia. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Chemistry College of Science Tunghai University Taichung Taiwan. Department of Health and Welfare College of City Management University of Taipei Taipei Taiwan. Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan. Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes Miaoli Taiwan. Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan. Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan. National Heart and Lung Institute Imperial College London London UK. School of Public Health College of Public Health Taipei Medical University Taipei Taiwan. Department of Public Health School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. School of Public Health and Primary Care the Chinese University of Hong Kong Hong Kong. School of Respiratory Therapy College of Medicine Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan. Division of Pulmonary Medicine Departments of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan.

Air pollution has been linked to respiratory diseases, and urban air pollution can be attributed to a number of emission sources. The emitted particles and gases are the primary components of air pollution that enter the lungs during respiration. Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM) can deposit deep into the respiratory tract via inhalation and has been proposed as a causative agent for adverse respiratory health. In addition, the lung contains a diverse microbial community (microbiome) that maintains normal homeostasis and is significantly altered in a variety of pulmonary disorders. Air pollution, specifically PM, has previously been shown to significantly alter the composition of the lower airway microbiome, which has been linked to decreased lung function in chronic obstructive pulmonary disease (COPd) patients. Surprisingly, the intestinal microbiome has also been implicated in the modulation of pulmonary inflammatory diseases. Therefore, dysbiosis of the lung and intestinal microbiomes pose significant negative effects on human health. This dataset describes the microbial community profiles of the lungs and intestines of ageing rats exposed to ambient unconcentrated traffic-related air pollution for three months. The whole-body exposure system was equipped with and without high efficiency particulate air (HEPA) filtration (gaseous vs. PM pollution). The data can provide valuable information on lung and intestinal microbiome changes, including that which was only found after traffic-related air pollution exposure.

关键词： Air pollution Intestinal microbiome Lung microbiome PM2.5

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Persistence and dynamic structures of diverse ceph.losporinase genes in nontyph.idal Salmonella in cross-sectional surveillance in Taiwan

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International Journal of Antimicrobial Agents 2023年第4期62卷 106944-106944页

作者： Lee, Yuarn-Jang Chang, Yu-Chu Lee, I-Hui Ho, Kuo-Hao Fang, Shiuh-Bin Lauderdale, Tsai-Ling Chen, Ting-Wen Chen, Ku-Chung Huang, Chih-Hung Huang, Tzu-Wen Division of Infectious Diseases Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Division of Infectious Diseases Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Division of Pediatric Gastroenterology and Hepatology Department of Pediatrics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Medical Research Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Pediatrics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Master Program in Clinical Pharmacogenomics and Pharmacoproteomics College of Pharmacy Taipei Medical University Taipei Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Zhunan Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Chemical Engineering and Biotechnology Institute of Chemical Engineering National Taipei University of Technology Taipei Taiwan

Objectives: Nontyph.idal Salmonella (NTS) is a major foodborne pathogen causing from acute gastroenteritis to bacteraemia, particularly in paediatric and elderly patients. Antimicrobial resistance of NTS, especially resistance to extended-spectrum ceph.losporins, has emerged over the past decades. Methods: Thirteen NTS isolates resistant to ceftriaxone or cefotaxime were collected from a teaching hospital in Taipei, and another three from a tertiary hospital, in New Taipei City, Taiwan, from September 2018 to december 2019. Ten other archived isolates from 2000 to 2017 were also obtained. Complete genomes of the 26 isolates were obtained. Serovars, sequence types, resistomes, genetic relatedness, and sequence comparison of plasmids were analyzed. Results: Serogroups B, C2 and E were significantly associated with ampicillin resistance. Over 90% of these 26 isolates are susceptible to carbapenems and colistin. Genomic epidemiology of these isolates shows that bla_CMY-2-harbouring isolates in different serovars were prevalent over two decades, presumably resulting from highly mobile IncI1 plasmid harbouring bla_CMY-2. One type of the IncI1 plasmids contained a mobile element, IS26, which might be involved in the acquisition of antimicrobial resistance genes. Two emerging serovars, S. Goldcoast ST358 harbouring bla_CTX-M-55 on IncHI2 plasmids and S. Anatum ST64 harbouring bla_dHA-1 on IncA/C₂ plasmids persisted in Taiwan, possibly through the clonal spread. Integration of complete or partial plasmid sequences into host chromosomes or multiplications of the antimicrobial resistance genes also appears to be mediated by IS26, in the two emerging clones. Conclusion: The dynamic movement of ceph.losporinase genes mediated by IS26 in NTS is of great concern. © 2023 The Authors

关键词： Amplification Chromosome integration Epidemiology Foodborne pathogen Insertion sequence Whole-genome sequencing

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The Significance of Certain Parameters in Buoyancy System Performance

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Naval Engineers Journal 1971年第4期83卷 75-81页

作者： HANSEN, O. RICHARd UHLER, dALE G. O. Richard Hansen obtained a BSCE from Colorado State University in 1950 and has participated in continuing educational courses at the University of Washington Wayne State University and the University of Michigan. He was employed at Puget Sound Naval Shipyard for five years as a Mechanical Engineer and Project leader in industrial gases and cryogenic O2. Producers for Shipboard Applications followed by seven years at Chrysler Corporation initially as a project engineer in the FBM program subsequently assigned to Mechanical Laboratory achieving Managing Engineer status of a department therein which contained the facilities group instrumentation group and an experimental machine shop. This was followed by employment at Westinghouse Astronuclear Laboratories as a senior engineer conducting studies in two phase liquid hydrogen flow in simulated NERVA cores. Following this he served two years of employment with the Lockheed Georgia Company conducting material studies in combined nuclear cryogenic environments at the NASA 60 megawatt test reactor located in Sandusky Ohio. Joined NAVSEC in 1966 as a mechanical engineer in the compressed air systems group and has been assigned to the Supervisor of Diving Salvage and Ocean Engineering conducting analysis and evaluation of compressed air and gas systems associated with diving and salvage operations. Dale G. Uhler received BSCE degree from Carnegie Institute of Technology in 1964. He spent two years as a construction engineer before entering graduate school at the University of Miami Florida where he received his MS degree in applied mechanics with a minor in Ocean Engineering in 1968. He is now employed as an Ocean Engineer in the office of the U. S. Navy Director of Diving Salvage and Ocean Engineering where he is the project manager for the Large Object Salvage System and related development programs and concurrently working toward his Ph. D. at Catholic University.

The advent of deep ocean technology has created a need of buoyancy at ever increasing depths. This paper concerns itself with two most widely used techniques for dewatering/deballasting, compressed air supplied by surface maintained compressors and high pressure gases contained in pressure vessels. The objective of the paper is to examine the effects on these two techniques of various parameters which, in the author's opinion, are often overlooked by design engineers. This results in a significant degradation of the system under actual operating conditions. The principal parameters involved are structural integrity, geometric properties, material properties and the variance with pressure of the real gas properties and sea water density. This paper is an attempt to appraise designers and users of the impact of the above considerations on proposed buoyancy systems. © 1971 American Society of Naval Engineers

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Influence of human engineering on manning levels and human performance on ships

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NAVAL ENGINEERS JOURNAL 1997年第5期109卷 67-76页

作者： Anderson, dE Oberman, FR Malone, TB Baker, CC David E. Anderson:has a bachelor of science degree in environmental engineering from Florida Technological University and a master's degree in environmental engineering from the University of Central Florida. He is a graduate of the Naval Sea Systems Command's Engineer-In-Training (EIT) Program. Mr. Anderson was instrumental in introducing the collective protection system (CPS) in the U.S. Navy developing the initial forward-fit package for the USS Gunston Hall and the engineering change proposal (ECP) for the USS Wasp. In 1990 he joined the Human Systems Integration (HSI) Division (SEA 55W5) where he was task leader for auxiliary ships. He is currently the HSI manager for the future technology variant of the SeaLift ship and the future carrier. Association of Scientists and Engineers 33rdAnnual Technical Symposium 26 April 1996. Fred R. Oberman:has B.A. and M.A. degrees from the University of Chicago and Loyola University (experimental psychology) and an M.S. degree in industrial engineering and operations research from Virginia Polytechnic Institute (VPI). He has more than 30 years experience in HSI management planning research analysis design and testing in government and private sector positions. He is currently responsible for NavSea HSI generic research and tool development efforts. He is responsible for Human Engineering Specifications and Standards (Commercial Hypertext) and is the NavSea 03D7 representative on HSI in Performance Specifications and for integration of HSI within Integrated Logistic Support (ILS). He has served as DoD HSI SubTAG chair and member of the Simulation and Modeling Test and Evaluation Display and Control Systems Human Computer Interaction Specifications and Standards and Systems Design Sub Tags as a member of the Society of Naval Architects and Marine Engineers (SNAME) Systems Safety Panel and a member of NATO RSG 14 on man-machine analysis. Thomas B. Malone: CHFEP received a Ph.D. in experimental psychology from Fordham University in 1964. He is president of Carlow

The objectives of Human engineering (HE) are generally viewed as increasing human performance, reducing human error, enhancing personnel and equipment safety, and reducing training and related personnel costs. There are other benefits that are thoroughly consistent with the direction of the Navy of the future, chief among these is reduction of required numbers of personnel to operate and maintain Navy ships. The Naval Research Advisory Committee (NRAC) report on Man-Machine technology in the Navy estimated that one of the benefits from increased application of man-machine technology to Navy ship design is personnel reduction as well as improving system availability, effectiveness, and safety The objective of this paper is to discuss aspects of the human engineering design of ships and systems that affect manning requirements, and impact human-performance and safety The paper will also discuss how the application of human engineering leads to improved performance, and crew safety, and reduced workload, all of which influence manning levels. Finally, the paper presents a discussion of tools and case studies of good human engineering design practices which reduce manning.

关键词： Human engineering

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development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management

The journal of liquid biopsy

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The journal of liquid biopsy 2024年 6卷 100167页

作者： Min-Yi Liao Yun-Jie Hao Ching-Shan Luo Ching-Mei Chen Po-Hao Feng Hsin-Yu Yang da-Jeng Yao Kang-Yun Lee Fan-Gang Tseng Department of Power Mechanical Engineering National Tsing Hua University Hsinchu 30013 Taiwan. Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan. International Ph.D. Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan. TMU Research Center of Thoracic Medicine Taipei Medical University Taipei 11031 Taiwan. Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Nano Science and Technology Program National Tsing Hua University Hsinchu 30013 Taiwan. Institute of Nano Engineering and Micro Systems (NEMS) National Tsing Hua University Hsinchu 30013 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan.

Objectives:Many cancer biomarkers such as the circulating tumor cells/microemboli (CTCs/CTM) have been reported significant associations with clinical outcomes. However, different biomarkers have different sensitivities and specificities for cancer types and cohort patients, and synergistic effects between certain biomarkers have also been observed, leading to the inaccurate, fluctuating, and even controversial results when multiple biomarkers are analyzed together. In this paper, a novel combinational index, P-score, was developed for monitoring and predicting the disease condition of lung cancer patients during follow-up visits. Materials and methods:There were totally 13 return patients with 54 blood samples involved in this study to examine the number of CTC and CTM. Information from one group of 7 patients including 27 blood samples with published clinical data was employed to develop while those from another group of 4 patients containing 14 blood samples with unpublished clinical data were used to validate the P score in prediction. Enumerations were based on immunofluorescent staining images. distributions of CTC/CTM and their frequencies in stratified patients were carefully examined and analyzed the ROC curve and AUC value to develop the P score and P score-based prediction model. Results and conclusion:We found that the predictive power of P-score was not only comparable to the traditional cancer marker, in comparison with individual CTC/CTM, more false positives could be corrected by using P-score, thereby to improve the accuracy of analysis. From our preliminary validation tests, the prognosis and disease progression monitored longitudinally by P-score were further confirmed by clinical outcome data from ph.sicians and its sensitivity was even better than those from individual biomarkers. We believe that this novel combinational indicator could be a promising tool to interpret clinical outcomes more accurately from multiple factors, particularly useful

关键词： Circulating tumor cells/microemboli Combinational index disease monitoring and prognosis drug screening Lung cancer

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PERFORMANCE OF A PRIORITIZEd ON-BOARd BASEBANd SWITCH FOR A MULTISERVICE MULTIBEAM SATELLITE

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INTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS 1994年第3期12卷 283-297页

作者： BOHM, S ELHAKEEM, AK HACHICHA, M Department of Electrical and Computer Engineering Concordia University 1455 De Maisonneuve Blvd. West Montreal H3A 1M8 Canada Was born in Montreal Canada on 14 September 1966. He received the B. Eng. degree in electrical engineering from Concordia University Montreal Canada in 1989. He is at present completing the M.A.Sc. degree in electrical engineering at Concordia University. (S'75–S'79–M'79–SM'86) received the Ph.D. degree from Southern Methodist University Dallas TX in 1979. He spent the next two years working as a Visiting Professor in Egypt after which he moved to Ottawa Canada in 1982. He assumed teaching and research positions in Carleton and Manitoba Univerities and later moved to Concordia University Montreal Canada in 1983 where he is now a Professor in the Electrical and Computer Engineering Department. He has published numerous papers in IEEE and international journals in the areas of spread spectrum and networking. He is a well-known expert in these areas and serves as a consultant to many companies. His current research interests include wide-band metropolitan networks switching architectures and performance of on-board multibeam satellites acquisitionless CDMA networks code distribution and orthogonalization of CDMA signals responsive congestion control for ATM-based networks ARQ techniques and investigation of the novel SUGAR CDMA systems in fading channels. Dr. Elhakeem is a Senior Member of the Canadian Electrical Engineering Society and Armed Forces Association. He has chaired numerous technical sessions in IEEE Conferences was the Technical Program Chairman for IEEE Montech 1986 Montreal Canada. Dr. Elhakeem is the key guest editor of theIEEE Journal of Selected Areas in Communicationsfor the May June issues 1993 covering CDMA networks. Advanced Technology & Networks VISTAR Telecommunications Inc. Ottawa Ontario K1G 3J4 Canada An Associate Director of Advanced Technology & Networks Group VISTAR Telecommunications Inc. Ottawa Canada. He is also an Adjunct Pr

In this paper, we study the performance of a prioritized on-board baseband switch in conjunction with a multibeam satellite handling integrated services. The services considered for the analysis include voice, video, file transfer and interactive data. The prioritized switch uses both input and output buffering, switch speed-up as well as a two-ph.se head-of-line resolution algorithm, in order to reduce the buffer loss while maintaining acceptable user delays. The minimum required buffer capacity and switch speed-up for each service in a prioritized environment are found under uniform traffic conditions. It is shown that under uniform traffic conditions, only minimal buffering and switch speed-up are needed even for the lowest priority users. The performance dependence on the switch size is also substantially reduced with head of line resolution and buffering even in a prioritized environment.

关键词： SWITCH ON-BOARd BASEBANd MULTIBEAM PRIORITIZEd HEAd-OF-LINE UNIFORM LOAd SPEEd-UP

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AN AdVANCEd METHOdOLOGY FOR PRELIMINARY HULL FORM dEVELOPMENT

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NAVAL ENGINEERS JOURNAL 1984年第4期96卷 147-161页

作者： LIN, WC dAY, WG HOUGH, JJ KEANE, RG WALdEN, dA KOH, IY Wen-Chin Lin:heads the Ship Powering Division at the David Taylor Naval Ship R&D Center (DTNSRDC). Dr. Lin received his B.S. degree in mechanical engineering from the National Taiwan University in 1957. He was awarded his M.S. degree in naval architecture and Ph.D. in engineering science from the University of California at Berkeley in 1963 and 1966 respectively. From 1966 to 1969 he was employed by ESSO Research and Engineering Company to conduct marine hydrodynamic research for oil tankers and offshore structures. Since joining DTNSRDC in 1969 he has actively conducted and directed hydrodynamic research to advance naval ship design technology and improve ship performance. Active in national and international symposia on ship hydrodynamic research he is recognized for contributions to the ship research community. For the past six years he has been a member of the Performance Committee of the ITTC and currently serves as secretary of the committee. He is a member of SNAME and the Society of Naval Architects of Japan. William G. Day Jr:. has been employed as a naval architect at the David Taylor Naval Ship R&D Center since receiving a B.E.S. degree from the Johns Hopkins University in 1966. He obtained an M.S. E. degree from George Washington University in 1971. As Head Design Evaluation Branch of the Ship Performance Department he is responsible for model experiments to evaluate the hydrodynamic performance of ships and propulsors. He is a member of ASNE and SNAME. In-Young Koh:received his B.S. and M.S. degrees in electrical engineering from Lowell University in 1969 and 1971 respectively and his Ph.D. in applied mechanics from Rensselaer Polytechnic Institute in 1976. Dr. Koh joined DTNSRDC as an electronic engineer specializing in the application of advanced instrumentation and computer techniques to ship research and design. He is currently engaged in research and development of active control systems for naval ship applications. Dr. Koh is a member of ASNE SNAME and IEEE. David Andrew Walden:is

A ship design methodology is presented for developing hull forms that attain improved performance in both seakeeping and resistance. Contrary to traditional practice, the methodology starts with developing a seakeeping-optimized hull form without making concessions to other performance considerations, such as resistance. The seakeeping-optimized hull is then modified to improve other performance characteristics without degrading the seakeeping. Presented is a point-design example produced by this methodology. Merits of the methodology and the point design are assessed on the basis of theoretical calculations and model experiments. This methodology is an integral part of the Hull Form design System (HFdS) being developed for computer-supported naval ship design. The modularized character of HFdS and its application to hull form development are discussed.

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COMPUTER-SYSTEM ARCHITECTURE CONCEPTS FOR FUTURE COMBAT SYSTEMS

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NAVAL ENGINEERS JOURNAL 1990年第3期102卷 43-62页

作者： ZITZMAN, LH FALATKO, SM PAPACH, JL Dr. Lewis H. Zitzman:is the group supervisor of the Advanced Systems Design Group Fleet Systems Department The Johns Hopkins University Applied Physics Laboratory (JHU/APL). He has been employed at JHU/APL since 1972 performing applied research in computer science and in investigating and applying advanced computer technologies to Navy shipboard systems. He is currently chairman of Aegis Computer Architecture Data Bus and Fiber Optics Working Group from which many concepts for this paper were generated. Dr. Zitzman received his B.S. degree in physics from Brigham Young University in 1963 and his M.S. and Ph.D. degrees in physics from the University of Illinois in 1967 and 1972 respectively. Stephen M. Falatko:was a senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated for the majority of this effort. He is currently employed at ManTech Services Corporation. During his eight-year career first at The Johns Hopkins University Applied Physics Laboratory and currently with ManTech Mr. Falatko's work has centered around the development of requirements and specifications for future Navy systems and the application of advanced technology to Navy command and control systems. He is a member of both the Computer Architecture Fiber Optics and Data Bus Working Group and the Aegis Fiber Optics Working Group. Mr. Falatko received his B.S. degree in aerospace engineering with high distinction from the University of Virginia in 1982 and his M.S. degree in applied physics from The Johns Hopkins University in 1985. Mr. Falatko is a member of Tau Beta Pi Sigma Gamma Tau the American Society of Naval Engineers and the U.S. Naval Institute. Janet L. Papach:is a section leader and senior engineering analyst in the Combat Systems Engineering Department Comptek Research Incorporated. She has ten years' experience as an analyst supporting NavSea Spa War and the U.S. Department of State. She currently participates in working group efforts under Aegis Combat System Doctrin

This paper sets forth computer systems architecture concepts for the combat system of the 2010–2030 timeframe that satisfy the needs of the next generation of surface combatants. It builds upon the current Aegis computer systems architecture, expanding that architecture while preserving, and adhering to, the Aegis fundamental principle of thorough systems engineering, dedicated to maintaining a well integrated, highly reliable, and easily operable combat system. The implementation of these proposed computer systems concepts in a coherent architecture would support the future battle force capable combat system and allow the expansion necessary to accommodate evolutionary changes in both the threat environment and the technology then available to effectively counter that threat. Changes to the current Aegis computer architecture must be carefully and effectively managed such that the fleet will retain its combat readiness capability at all times. This paper describes a possible transition approach for evolving the current Aegis computer architecture to a general architecture for the future. The proposed computer systems architecture concepts encompass the use of combinations of ph.sically distributed, microprocessor-based computers, collocated with the equipment they support or embedded within the equipment itself. They draw heavily on widely used and available industry standards, including instruction set architectures (ISAs), backplane busses, microprocessors, computer programming languages and development environments, and local area networks (LANs). In this proposal, LANs, based on fiber optics, will provide the interconnection to support system expandability, redundancy, and higher data throughput rates. A system of cross connected LANs will support a high level of combat system integration, spanning the major warfare areas, and will facilitate the coordination and development of a coherent multi-warfare tactical picture supporting the future combatant command st

关键词： Computer Architecture

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