检索结果-内蒙古大学图书馆

A self-powered multifunctional dressing for active infection prevention and accelerated wound healing

Science Advances 2023年第4期9卷 eadc8758页

作者： Barman, Snigdha Roy Chan, Shuen-Wen Kao, Fu-Cheng Ho, Hsuan-Yu Khan, Imran Pal, Arnab Huang, Chih-Ching Lin, Zong-Hong Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan Department of Orthopaedic Surgery Spine Section Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Department of Bioscience and Biotechnology National Taiwan Ocean University Keelung202301 Taiwan Center of Excellence for the Oceans National Taiwan Ocean University Keelung202301 Taiwan School of Pharmacy College of Pharmacy Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Chemistry National Tsing Hua University Hsinchu30013 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan

Interruption of the wound healing process due to pathogenic infection remains a major health care challenge. The existing methods for wound management require power sources that hinder their utilization outside of clinical settings. Here, a next generation of wearable self-powered wound dressing is developed, which can be activated by diverse stimuli from the patient’s body and provide on-demand treatment for both normal and infected wounds. The highly tunable dressing is composed of thermocatalytic bismuth telluride nanoplates (Bi2Te3 NPs) functionalized onto carbon fiber fabric electrodes and triggered by the surrounding temperature difference to controllably generate hydrogen peroxide to effectively inhibit bacterial growth at the wound site. The integrated electrodes are connected to a wearable triboelectric nanogenerator (TENG) to provide electrical stimulation for accelerated wound closure by enhancing cellular proliferation, migration, and angiogenesis. The reported self-powered dressing holds great potential in facilitating personalized and user-friendly wound care with improved healing outcomes. Copyright © 2023 The Authors, some rights reserved.

关键词： Patient treatment

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Correction to: Biological synthesis and characterization of iron oxide (FeO) nanoparticles using Pleurotus citrinopileatus extract and its biomedical applications

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Biomass Conversion and Biorefinery 2023年第11期14卷 12587-12587页

作者： Manimaran, Kumar Yanto, dede Heri Yuli Govindasamy, Mani Karunanithi, Bogeshwaran Alasmary, Fatmah Ali Habab, Reem Abdulrahman Research Center for Applied Microbiology National Research and Innovation Agency (BRIN) Cibinong Republic of Indonesia Department of Product Development Institute of Biotechnology Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India Faculty International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Korea University Seongbuk-gu Republic of Korea Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam India Department of Petroleum Engineering Dhaanish Ahmed College of Engineering Chennai India Department of Chemistry College of Science King Saud University Riyadh Saudi Arabia

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Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases

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Life sciences 2023年 317卷 121411页

作者： Kai-Cheng Chuang Yun-Wen Lai Chi-Hua Ko Chih-Ching Yen Hsiao-Ling Chen Ying-Wei Lan Chien-Fu Chen Wei Chen Chuan-Mu Chen Department of Life Sciences Ph.D. Program in Translational Medicine National Chung Hsing University Taichung 402 Taiwan. Department of Life Sciences Ph.D. Program in Translational Medicine National Chung Hsing University Taichung 402 Taiwan Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Yunlin 638 Taiwan. Department of Internal Medicine China Medical University Hospital College of Health Care China Medical University Taichung 404 Taiwan. Department of Biomedical Sciences Department of Bioresources Da-Yeh University Changhwa 515 Taiwan. Division of Pulmonary Biology Cincinnati Children's Hospital Medical Center University of Cincinnati OH USA. Department of Orthopedic Surgery Taichung Armed Forces General Hospital Taichung 411 Taiwan. Division of Pulmonary and Critical Care Medicine Chia-Yi Christian Hospital Chiayi Taiwan. The iEGG and Animal Biotechnology Center The Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung 402 Taiwan. Electronic address: chchen1@dragon.nchu.edu.tw.

AIMS:Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its pathological features are synovial inflammation, bone erosion, and joint structural damages. Our previous studies have shown that kefir peptides (KPs) can reduce cardiovascular disease, osteoporosis and renal inflammation. In this study, we further evaluate the efficacy of KPs on adjuvant-induced arthritis (AIA) in a rat model. MAIN METHOdS:After the 14th day of adjuvant induction, rats were subsequently orally administered KPs (83 or 166 mg/day/kg) or tofacitinib (6.2 mg/day/kg) for 14 days. On the 28th day, the rats were anesthetized with isoflurane for ultrasonic, in vivo imaging system (IVIS), and radiograph.c imaging and then sacrificed for ankle tissues collection and analysis. In vitro, IL-1β-treated human synovial cells (SW982) were subjected to anti-arthritis mechanism study in the presence of KPs. KEY FINdINGS:The results of ultrasonograph., radiograph. histology, the expression of matrix metalloproteinases (MMPs), inflammatory cytokines and RANKL/OPG ratio demonstrated decreasing severity of synovitis and bone erosion in the ankle joints after KPs treatment. Activation of the NF-κB and MAPK pathways was significantly reduced in KPs treated AIA group. Furthermore, KPs attenuated IL-1β-induced inflammatory cytokine production and the expression of MMPs in a human synovial cell line SW982. These results demonstrated that KPs alleviated adjuvant-induced arthritis in rats by inhibiting IL-1β-related inflammation and MMPs production. SIGNIFICANCE:We concluded that KPs can exhibit anti-inflammatory effects by reducing the levels of macroph.ge-related inflammatory cytokines and MMPs, thus alleviating bone erosion in the ankle joint and constituting a potential therapeutic strategy for rheumatoid arthritis.

关键词： Adjuvant-induced arthritis (AIA) Inflammatory cytokines Kefir peptides (KPs) Matrix metalloproteinases (MMPs) Rheumatoid arthritis (RA) Ultrasound imaging

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HER2 amplification in colorectal cancer with brain metastasis: A propensity score matching study

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European journal of cancer (Oxford, England : 1990) 2023年 181卷 62-69页

作者： Po-Chuan Chen Yu-Min Yeh Chun-Ting Chu Pei-Fang Su Pin-Hsuan Chiu Bo-Wen Lin Shang-Hung Chen Peng-Chan Lin Chung-Ta Lee Helen H W Chen Chien-Chin Chen Division of Colorectal Surgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan. Division of Colorectal Surgery Department of Surgery Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi 600 Taiwan. Department of Statistics National Cheng Kung University Tainan 701 Taiwan. The Center of Quantitative Sciences Clinical Medicine Research Center National Cheng Kung University Hospital Tainan 704 Taiwan. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan National Institute of Cancer Research National Health Research Institute Tainan 704 Taiwan. Department of Genomic Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan Department of Computer Science and Information Engineering College of Electrical Engineering and Computer Science National Cheng Kung University Tainan 704 Taiwan. Department of Pathology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 704 Taiwan. Electronic address: helen@mail.ncku.edu.tw. Department of Pathology Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi 600 Taiwan Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan 717 Taiwan Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan 701 Taiwan Ph.D. Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung 40227 Taiwan. Electronic address: hlmarkc@gmail.c

BACKGROUNd:The association between human epidermal growth factor receptor-2 (HER2) amplification and brain metastasis (BM) in patients having colorectal cancer (CRC) has been suggested but not yet established. This study investigated the expression patterns of HER2, its association with BM, and its prognostic value in patients having CRC. METHOdS:We retrospectively identified 99 patients having metastatic CRC (mCRC) and BM (the BM cohort) and compared them with a cohort of 249 patients having mCRC and without BM (the stage IV cohort) by propensity score matching. Immunohistochemical studies of HER2 on all available paraffin-embedded tumour samples, either from the primary tumour, the metastasis (brain and/or extracranial sites) or both, were performed and analysed. HER2 fluorescent in situ hybridisation was applied when necessary. The expression of HER2 was compared and correlated with survival. RESULTS:HER2 amplifications were detected in 16 (18.4%) of 87 and 9 (3.6%) of 249 patients who had specimens available in the BM and stage IV cohorts, respectively (P < .001). After propensity score matching, HER2 amplification was significantly associated with BM (odds ratio: 5.38, P = .003). HER2 heterogeneity was frequently observed not only at the single tumour level but also in paired tumour samples. A marginally significant longer survival since BM was found in patients having HER2-amplified mCRC than in those without (P = .07). CONCLUSIONS:HER2 amplification was significantly associated with BM in patients having mCRC and might have prognostic value for survival since BM. Given the heterogeneity of HER2 expression, the testing of HER2 status on available tissues from both primary and metastatic tumours should be encouraged.

关键词： Brain metastasis Colorectal cancer HER2 amplification Heterogeneity Propensity score matching

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data-driven Two-Stage Framework for Identification and Characterization of different Antibiotic-Resistant Escherichia coli Isolates Based on Mass Spectrometry data

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Microbiology spectrum 2023年第3期11卷 e0347922页

作者： Chia-Ru Chung Hsin-Yao Wang Chun-Han Yao Li-Ching Wu Jang-Jih Lu Jorng-Tzong Horng Tzong-Yi Lee Department of Computer Science and Information Engineering National Central University Taoyuan Taiwan. Department of Laboratory Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. Ph.D. Program in Biomedical Engineering Chang Gung University Taoyuan Taiwan. Department of Biomedical Sciences and Engineering National Central University Taoyuan Taiwan. College of Medicine Chang Gung University Taoyuan Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan. Department of Bioinformatics and Medical Engineering Asia University Taichung Taiwan. Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan.

In clinical microbiology, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALdI-TOF MS) is frequently employed for rapid microbial identification. However, rapid identification of antimicrobial resistance (AMR) in Escherichia coli based on a large amount of MALdI-TOF MS data has not yet been reported. This may be because building a prediction model to cover all E. coli isolates would be challenging given the high diversity of the E. coli population. This study aimed to develop a MALdI-TOF MS-based, data-driven, two-stage framework for characterizing different AMRs in E. coli. Specifically, amoxicillin (AMC), ceftazidime (CAZ), ciprofloxacin (CIP), ceftriaxone (CRO), and cefuroxime (CXM) were used. In the first stage, we split the data into two groups based on informative peaks according to the importance of the random forest. In the second stage, prediction models were constructed using four different machine learning algorithms-logistic regression, support vector machine, random forest, and extreme gradient boosting (XGBoost). The findings demonstrate that XGBoost outperformed the other four machine learning models. The values of the area under the receiver operating characteristic curve were 0.62, 0.72, 0.87, 0.72, and 0.72 for AMC, CAZ, CIP, CRO, and CXM, respectively. This implies that a data-driven, two-stage framework could improve accuracy by approximately 2.8%. As a result, we developed AMR prediction models for E. coli using a data-driven two-stage framework, which is promising for assisting ph.sicians in making decisions. Further, the analysis of informative peaks in future studies could potentially reveal new insights. Based on a large amount of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALdI-TOF MS) clinical data, comprising 37,918 Escherichia coli isolates, a data-driven two-stage framework was established to evaluate the antimicrobial resistance of E. coli. Five antibiotics, including a

关键词： MALdI-TOF MS antimicrobial resistance ceph.losporin ceph.losporins fluoroquinolones machine learning matrix-assisted laser desorption ionization–time of flight mass spectrometry penicillin penicillins

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Cell Entry of Avian Reovirus Modulated by Cell-Surface Annexin A2 and Adhesion G Protein-Coupled Receptor Latroph.lin-2 Triggers Src and p38 MAPK Signaling Enhancing Caveolin-1- and dynamin 2-dependent Endocytosis

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Microbiology spectrum 2023年第3期11卷 e0000923页

作者： Wei-Ru Huang Yi-Ying Wu Tsai-Ling Liao Brent L Nielsen Hung-Jen Liu Institute of Molecular Biology National Chung Hsing University Taichung Taiwan. iEGG and Animal Biotechnology Center National Chung Hsing University Taichung Taiwan. Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan. Ph.D Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan. Department of Microbiology and Molecular Biology Brigham Young University Provo Utah USA. Department of Life Sciences National Chung Hsing University Taichung Taiwan.

The specifics of cell receptor-modulated avian reovirus (ARV) entry remain unknown. By using a viral overlay protein-binding assay (VOPBA) and an in-gel digestion coupled with liquid chromatograph.-tandem mass spectrometry (LC-MS/MS), we determined that cell-surface annexin A2 (AnxA2) and adhesion G protein-coupled receptor Latroph.lin-2 (AdGRL2) modulate ARV entry. direct interaction between the ARV σC protein and AnxA2 and AdGRL2 in Vero and dF-1 cells was demonstrated by proximity ligation assays. By using short hairpin RNAs (shRNAs) to silence the endogenous AnxA2 and AdGRL2 genes, ARV entry could be efficiently blocked. A significant decrease in virus yields and the intracellular specific signal for σC protein was observed in Vero cells preincubated with the specific AnxA2 and AdGRL2 monoclonal antibodies, indicating that AnxA2 and AdGRL2 are involved in modulating ARV entry. Furthermore, we found that cells pretreated with the AnxA2/S100A10 heterotetramer (A2t) inhibitor A2ti-1 suppressed ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK), demonstrating that Src and p38 MAPK serve as downstream molecules of cell-surface AnxA2 signaling. Our results reveal that suppression of cell-surface AnxA2 with the A2ti-1 inhibitor increased Csk-Cbp interaction, suggesting that ARV entry suppresses Cbp-mediated relocation of Csk to the membrane, thereby activating Src. Furthermore, reciprocal coimmunoprecipitation assays revealed that σC can interact with signaling molecules, lipid raft, and vimentin. The current study provides novel insights into cell-surface AnxA2- and AdGRL2-modulated cell entry of ARV which triggers Src and p38 MAPK signaling to enhance caveolin-1-, dynamin 2-, and lipid raft-dependent endocytosis. By analyzing results from VOPBA and LC-MS/MS, we have determined that cell-surface AnxA2 and AdGRL2 modulate ARV entry. After ARV binding to receptors, Src and p38 MAPK signaling were triggered and, in turn, increased the ph.sph

关键词： AdGRL2 Csk-Cbp interaction Src annexin A2 avian reovirus caveolin-1 dynamin 2 p38 MAPK σC

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Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autoph.gy in Retinal Pigment Epithelial Cells

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Archivum immunologiae et therapiae experimentalis 2023年第1期71卷 21页

作者： Chien-Chih Chiu Kai-Chun Cheng Yi-Hsiung Lin Chen-Xi He Yung-ding Bow Chia-Yang Li Chang-Yi Wu Hui-Min david Wang Shwu-Jiuan Sheu Department of Biotechnology Kaohsiung Medical University Kaohsiung 807 Taiwan. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Biological Sciences National Sun Yat-Sen University Kaohsiung 804 Taiwan. Center for Cancer Research Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Department of Ophthalmology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Department of Ophthalmology Kaohsiung Municipal Siaogang Hospital Kaohsiung 807 Taiwan. Department of Ophthalmology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Division of Cardiology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Center for Lipid Biosciences Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Lipid Science and Aging Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan. Ph.D. Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Ophthalmology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. sjiuansheu@***. Department of Ophthalmology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. sjiuansheu@***.

Chronic hyperglycemia involves persistent high-glucose exposure and correlates with retinal degeneration. It causes various diseases, including diabetic retinopathy (dR), a major cause of adult vision loss. Most in vitro studies have investigated the damaging short-term effects of high glucose exposure on retinal pigment epithelial (RPE) cells. dR is also a severe complication of diabetes. In this study, we established a model with prolonged high-glucose exposure (15 and 75 mM exogenous glucose for two months) to mimic RPE tissue pathoph.siology in patients with hyperglycemia. Prolonged high-glucose exposure attenuated glucose uptake and clonogenicity in ARPE-19 cells. It also significantly increased reactive oxygen species levels and decreased antioxidant protein (superoxide dismutase 2) levels in RPE cells, possibly causing oxidative stress and dNA damage and impairing proliferation. Western blotting showed that autoph.gic stress, endoplasmic reticulum stress, and genotoxic stress were induced by prolonged high-glucose exposure in RPE cells. despite a moderate apoptotic cell population detected using the Annexin V-staining assay, the increases in the senescence-associated proteins p53 and p21 and SA-β-gal-positive cells suggest that prolonged high-glucose exposure dominantly sensitized RPE cells to premature senescence. Comprehensive next-generation sequencing suggested that upregulation of oxidative stress and dNA damage-associated pathways contributed to stress-induced premature senescence of ARPE-19 cells. Our findings elucidate the pathoph.siology of hyperglycemia-associated retinal diseases and should benefit the future development of preventive drugs. Prolonged high-glucose exposure downregulates glucose uptake and oxidative stress by increasing reactive oxygen species (ROS) production through regulation of superoxide dismutase 2 (SOd2) expression. Autoph.gic stress, ER stress, and dNA damage stress (genotoxic stress) are also induced by prolonged high-gluco

关键词： Autoph.gy diabetic retinopathy Hyperglycemia Oxidative stress Premature senescence

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disulfiram inhibits coronaviral main protease by conjugating to its substrate entry site

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International journal of biological macromolecules 2024年第PT 2期276卷 133955页

作者： Ying Kuan Hsu-Feng Chu Pang-Hung Hsu Kai-Cheng Hsu Ta-Hsien Lin Chun-Hsiang Huang Wei-Yi Chen Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan. Biomedical Industry Ph.D. Program National Yang Ming Chiao Tung University Taipei Taiwan. Department of Bioscience and Biotechnology National Taiwan Ocean University Keelung 20224 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Division of Basic Research Department of Medical Research Taipei Veterans General Hospital Taipei 112 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Taipei 112 Taiwan. National Synchrotron Radiation Research Center Hsinchu City 30076 Taiwan. Electronic address: huang.conann@nsrrc.org.tw. Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Taipei 112 Taiwan Cancer and Immunology Research Center National Yang Ming Chiao Tung University Taipei Taiwan. Electronic address: chenwy@nycu.edu.tw.

Coronaviruses (CoV) are highly pathogenic single-strand RNA viruses. CoV infections cause fatal respiratory symptoms and lung injuries in humans and significant economic losses in livestock. Since the SARS-2 outbreak in 2019, the highly conserved main protease (M), also termed 3-chymotrypsin-like protease (3CL), has been considered an attractive drug target for treating CoV infections. M mediates the proteolytic cleavage of eleven sites in viral polypeptides necessary for virus replication. Here, we report that disulfiram, an FdA-approved drug for alcoholic treatment, exhibits a broad-spectrum inhibitory effect on CoV Ms. Analytical ultracentrifugation and circular dichroism analyses indicated that disulfiram treatment blocks the dimeric formation of SARS and PEdV Ms and decreases the thermostability of SARS, SARS-2, and PEdV Ms, whereas it facilitates the dimerization and stability of MERS M. Furthermore, mass spectrometry and structural alignment revealed that disulfiram targets the Cys44 residue of Ms, which is located at the substrate entrance and close to the catalytic His41. In addition, molecular docking analysis suggests that disulfiram conjugation interferes with substrate entry to the catalytic center. In agreement, mutation of Cys44 modulates the disulfiram sensitivity of CoV Ms. Our study suggests a broad-spectrum inhibitory function of disulfiram against CoV Ms.

关键词： 3C-like protease (3CL(pro)) disulfiram (dSF) Main protease (M(pro))

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Briavioid d, a rare 7β,8β-epoxybriarane from Briareum violaceum

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Tetrahedron Letters 2023年 118卷

作者： Thanh Hao Huynh Chou-Yuan Ko Hsin-Tzu Liu Yen-Po Chen Mingzi M. Zhang Lun Kelvin Tsou Zhi-Hong Wen Su-Ying Chien Ping-Jyun Sung Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung 804201 Taiwan Department of Medical Research Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 970473 Taiwan Department of Obstetrics and Gynecology Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Zhunan Miaoli 350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Zhunan Miaoli 350401 Taiwan Institute of BioPharmaceutical Sciences National Sun Yat-sen University Kaohsiung 804201 Taiwan Instrumentation Center National Taiwan University Taipei 106319 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City 242062 Taiwan

A rare 7β,8β-epoxybriarane, briavioid d ( 1 ), has been isolated from a cultured octocoral Briareum violaceum . The structure of 1 was deduced by extensive 2d NMR studies. Single-crystal X-ray diffraction analysis was performed to identify the structure of 1 and this compound was found to reduce the release of iNOS to 85.77 %, at a concentration of 10 μM.

关键词： Briareum violaceum Briavioid Briarane X-ray iNOS

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Novel design of NiS 2 and V 3 Ni(SO 4 ) 4 · 24H 2 O composites with controllable synthetic temperature and duration as an efficient active material for battery supercapacitor hybrids

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Journal of Energy Storage 2025年 130卷

作者： Tsung-Rong Kuo Wei-Lun Huang Chutima Kongvarhodom Muhammad Saukani Sibidou Yougbaré Hung-Ming Chen Lu-Yin Lin Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei 11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok 10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin 70124 Indonesia Institut de Recherche en Sciences de la Santé (IRSS-DRCO)/Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei 11054 Taiwan

Nickel–vanadium (Ni V) composites are considered as promising active materials for battery supercapacitor hybrids (BSHs), owing to multiple oxidation states, high theoretical capacitance, and tunable redox activity. Structural optimization and sulfur incorporation are effective strategies to improve conductivity and structural stability. Hydrothermal parameters such as temperature and duration significantly influence the material and electrochemical properties. In this study, novel Ni V composites are synthesized via a hydrothermal process at different temperatures and durations as the active material of BSHs. The Ni V composites primarily consist of NiS 2 and V 3 Ni(SO 4 ) 4 · 24H 2 O. The Ni V composites synthesized using 150 °C and 10 h (Ni-V150@10) shows the largest specific capacitance (C F ) of 1381.3 F/g (621.6 C/g) at 20 mV/s, owing to its favorable twisted layered structure and abundant electroactive NiS 2 . A BSH constructed with Ni-V150@10 and reduced graph.ne oxide electrodes shows a maximum energy density of 9.6 Wh/kg at the power density of 857 W/kg. The capacitance retention of 96.6% and a Coulombic efficiency of 96.9% are also attained after 10,000 charge/discharge cycles. This study provides a clear approach for designing high-performance active materials with controllable hydrothermal temperature and duration, which can be extended to improve the electrochemical performance of other bimetallic composites in the future.

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