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Epidemiologic Study of Enterobius vermicularis Infection among Schoolchildren in the Republic of Marshall Islands

Journal of Tropical Medicine 2021年第1期2021卷 6273954页

作者： Fan, Chia-Kwung Sonko, Pasaikou Lee, Yueh-Lun Yin, Ai-Wen Chuang, Ting-Wu Kios, Ramson Wang, Ying-Ting Chou, Chia-Mei Hsu, Shao-Lun Wu, Mai-Szu Lin, Jia-Wei Tu, Chia-Ying Department of Molecular Parasitology and Tropical Diseases School of Medicine Taipei Medical University No. 250 Wu-Xing Street Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University No. 250 Wu-Xing Street Taipei Taiwan International Master/Ph. D. Program in Medicine College of Medicine Taipei Medical University No. 250 Wu-Xing Street Taipei Taiwan Research Center of International Tropical Medicine College of Medicine Taipei Medical University No. 250 Wu-Xing Street Taipei Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Xinglong Road Taipei Taiwan Department of Microbiology and Immunology School of Medicine Taipei Medical University No. 250 Wu-Xing Street Taipei Taiwan Department of Public Health Ministry of Health PO. Box 3885 Majuro Mh96960 Marshall Islands Taiwan Health Center in Majuro Ministry of Health PO. Box 3885 Majuro Mh96960 Marshall Islands Superintendent Office Taipei Medical University-Shuang-Ho Hospital No. 291 Zhongzheng Rd Taipei 23561 Taiwan Department of International Medical Affairs Taipei Medical University-Shuang-Ho Hospital No. 291 Zhongzheng Rd. Zhonghe District Taipei City 23561 Taiwan

The prevalence and risk factors of Enterobius vermicularis (pinworm) infection among primary schoolchildren (PSC) in the Marshall Islands remain unknown;thus, investigation on the status of pinworm infection rate is necessary to establish baseline data. After parents'/guardians' consent, a total of 346 children (179 boys and 167 girls) participated in this study. Individual's perianal area and thumbs were inspected by using the Scotch tape technique and celloph.ne tape method, respectively. For each child, demograph.c and risk factor data were collected by a structured questionnaire and statistically analyzed. The overall prevalence of pinworm infection was 12.14% (42/346). Univariate analysis indicated significant differences in PSC who live in an urban area compared to those who live in the rural area p=0.01. Multivariate analysis still found that PSC who live in the rural area had higher chances to acquire pinworm infection. However, no risk factors were identified to be associated with personal hygiene, sibling number, and parent's educational level or occupation. Nevertheless, a pinworm-like egg was detected on the thumb of one male participant. Children living in the rural area and thumb-sucking behavior are two of the important risk factors of transmitting pinworm infection in the PSC in the Marshall Islands. We suggested an urgent and continuous provision of adequate hygienic sensitization in the school and the community. © 2021 Chia-Kwung Fan et al.

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Application of impulse oscillometry to detect interstitial lung disease and airway disease in adults with rheumatoid arthritis

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BMC pulmonary medicine 2023年第1期23卷 331页

作者： Wen-Chien Cheng Shih-Hsin Chang Wei-Chun Chen Bing-Ru Wu Chia-Hung Chen Chi-Chien Lin Wu-Huei Hsu Joung-Liang Lan der-Yuan Chen Division of Pulmonary and Critical Care Department of Internal Medicine China Medical University Hospital Taichung Taiwan. Department of Life Science National Chung Hsing University Taichung Taiwan. Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan. Department of Life Science National Chung Hsing University Taichung Taiwan. sherry61976@***. Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan. sherry61976@***. Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan. sherry61976@***. Rheumatology and Immunology Center China Medical University Hospital Taichung Taiwan. sherry61976@***. and Animal Biotechnology Center Institute of Biomedical Science the iEGG National Chung-Hsing University Taichung Taiwan. Department of Life Science National Chung Hsing University Taichung Taiwan. dychen1957@***. College of Medicine China Medical University Taichung Taiwan. dychen1957@***. College of Medicine National Chung Hsing University Taichung Taiwan. dychen1957@***.

BACKGROUNd:We conducted a retrospective observational study to explore the potential application of impulse oscillometry (IOS) as an alternative to high-resolution computed tomograph. (HRCT) for detecting pulmonary involvement in patients with rheumatoid arthritis (RA) because clinically evident interstitial lung disease (ILd) and airway involvement are common in this population. METHOdS:We enrolled 72 patients with RA who underwent pulmonary function tests (PFTs) and IOS between September 2021 and September 2022. We aimed to identify the PFT and IOS variables associated with lung diseases shown on HRCT images. RESULTS:In our cohort of 72 patients, 48 underwent HRCT; of these, 35 had airway disease or ILd and 13 showed no obvious abnormalities on HRCT. Abnormal IOS and PFT parameters were observed in 34 and 23 patients, respectively, with abnormal HRCT images. The predicted percentages for forced vital capacity, the ratio of forced expiratory volume in the first one second to forced vital capacity, and forced mid-expiratory flow value were significantly lower in patients with abnormal HRCT. Lung resistance at 5 Hz, difference in resistance between 5 and 20 Hz, resonant frequency (Fres), and reactance area were higher in these patients and reactance at 5 Hz was lower. Compared to other parameters, Fres > 14.14 was significantly associated with alterations in HRCT and may be used as an indicator for monitoring disease. CONCLUSION:Fres > 14.14 is significantly associated with lung involvement in RA patients. Performance of spirometry with IOS is more beneficial than spirometry alone for evaluating lung involvement in RA patients.

关键词： Impulse Oscillometry Interstitial lung disease Rheumatoid arthritis Small airway disease

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Mitochondrial activation via calcium peroxide/carrageenan/soybean lecithin-derived polypyrrole ph.totherapeutic microparticles

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Colloids and Surfaces B: Biointerfaces 2025年 254卷 114787页

作者： Chuang, Sih-Chi Yu, Shih-An Hung, Pei-Chia Chuang, Andrew E.-Y. Liang, Jia-Wei Sun, Chia-Lu Rethi, Lekshmi Fang, Hsu-Wei Nguyen, Hieu Trung Tsai, Yao-Tung Weng, Pei-Wei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei10608 Taiwan Taipei Medical University Derived Company-Hsuan Chen Technology CO. LTD. New Taipei City22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan WELLCARE Health Care Supply Co. Ltd. Taipei Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh city Ho Chi Minh City700000 Viet Nam Department of Orthopaedic Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Division of Traumatology Department of Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan

Mitochondria, often referred to as the "powerhouses" of eukaryotic cells, play a critical role in maintaining cellular homeostasis and supporting essential life functions, particularly in cell survival and apoptosis. This study introduces a composite formulation—combining carrageenan (Car), calcium peroxide (CaO2), and microparticles, derived from soybean oil lecithin, enhanced with ph.tothermally active polypyrrole (PPy)—to create Car-Lec-PPy MP, aimed at promoting mitochondrial activation in cells. The investigation focuses on intercellular mitochondrial transfer and activation as a therapeutic strategy. The formulation seeks to stimulate mitochondrial biogenesis and enhance cellular resilience through targeted mitochondrial activation, leveraging the synergistic effects of near-infrared (NIR) therapy. In the in vivo experiment, ph.totherapeutic Car-Lec-PPy MP was administered to rodent muscle tissue. The results showed increased expression of heat-shock proteins and reduced oxidative stress in the treated muscle. Preliminary findings suggest that this approach not only boosts mitochondrial activity but also improves cell proliferation and survival, presenting significant potential for applications in regenerative medicine and cellular therapy. © 2025 Elsevier B.V.

关键词： Mitochondria

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Melatonin Enhanced Microglia M2 Polarization in Rat Model of Neuro-inflammation Via Regulating ER Stress/PPARδ/SIRT1 Signaling Axis

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Journal of neuroimmune ph.rmacology : the official journal of the Society on NeuroImmune ph.rmacology 2024年第1期19卷 11页

作者： Hung-Chuan Pan Cheng-Ning Yang Wen-Jane Lee Jason Sheehan Sheng-Mao Wu Hong-Shiu Chen Mao-Hsun Lin Li-Wei Shen Shu-Hua Lee Chin-Chang Shen Liang-Yi Pan Shing-Hwa Liu Meei-Ling Sheu Neurological Institute Taichung Veterans General Hospital Taichung Taiwan. Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan. Ph.D. Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan. Doctoral Program in Biotechnology Industrial Management and Innovation National Chung Hsing University Taichung Taiwan. College of Medicine and Life Science Chung Hwa University of Medical Technology Tainan Taiwan. Department of Dentistry School of Dentistry College of Medicine National Taiwan University Taipei Taiwan. Department of Neurosurgery University of Virginia Charlottesville VA USA. Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan. Department of Neurosurgery Tungs' Taichung MetroHarbor Hospital Taichung Taiwan. Division of Neurology Department of Internal Medicine Ditmanson Medical Foundation Chia-Yi Christian Hospital Chia-Yi Taiwan. Institute of Nuclear Energy Research Atomic Energy Council Taoyuan Taiwan. School of Medicine Kaohsiung Medical University Taichung Taiwan. Institute of Toxicology College of Medicine National Taiwan University Taipei 100 Taiwan. Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan. mlsheu@nchu.edu.tw. Ph.D. Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan. mlsheu@nchu.edu.tw. Institute of Biomedical Sciences National Chung Hsing University Taichung Taiwan. mlsheu@nchu.edu.tw. Institute of Biomedical Sciences College of Life Sciences National Chung Hsing University 250 Kuo Kuang Road Taichung 402 Taiwan. mlsheu@nchu.edu.tw.

Neuro-inflammation involves distinct alterations of microglial ph.notypes, containing nocuous pro-inflammatory M1-ph.notype and neuroprotective anti-inflammatory M-ph.notype. Currently, there is no effective treatment for modulating such alterations. M1/M2 marker of primary microglia influenced by Melatonin were detected via qPCR. Functional activities were explored by western blotting, luciferase activity, EMSA, and ChIP assay. Structure interaction was assessed by molecular docking and LIGPLOT analysis. ER-stress detection was examined by ultrastructure TEM, calapin activity, and ERSE assay. The functional neurobehavioral evaluations were used for investigation of Melatonin on the neuroinflammation in vivo. Melatonin had targeted on Peroxisome Proliferator Activated Receptor delta (PPARδ) activity, boosted LPS-stimulated alterations in polarization from the M1 to the M2 ph.notype, and thereby inhibited NFκB-IKKβ activation in primary microglia. The PPARδ agonist L-165,041 or over-expression of PPARδ plasmid (ov-PPARδ) showed similar results. Molecular docking screening, dynamic simulation approaches, and biological studies of Melatonin showed that the activated site was located at PPARδ (ph.sph.-Thr256-PPARδ). Activated microglia had lowered PPARδ activity as well as the downstream SIRT1 formation via enhancing ER-stress. Melatonin, PPARδ agonist and ov-PPARδ all effectively reversed the above-mentioned effects. Melatonin blocked ER-stress by regulating calapin activity and expression in LPS-activated microglia. Additionally, Melatonin or L-165,041 ameliorated the neurobehavioral deficits in LPS-aggravated neuroinflammatory mice through blocking microglia activities, and also promoted ph.notype changes to M2-predominant microglia. Melatonin suppressed neuro-inflammation in vitro and in vivo by tuning microglial activation through the ER-stress-dependent PPARδ/SIRT1 signaling cascade. This treatment strategy is an encouraging ph.rmacological approach for the remedy

关键词： Melatonin Microglia, Neuro-inflammation PPARδ SIRT1

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Unlocking the potential of bacterial cellulose: synthesis, functionalization, and industrial impact

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International Journal of Biological Macromolecules 2025年第Pt 3期311卷 143951页

作者： Kumaravel, Ashokkumar Lin, Shin-Ping Santoso, Shella Permatasari Shanmugasundaram, Saranya Hsu, Hsien-Yi Hsieh, Chang-Wei Chou, Yu-Chieh Lin, Hui-Wen Cheng, Kuan-Chen Institute of Food Science and Technology National Taiwan University Daan District Taipei10617 Taiwan School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Chemical Engineering Master Program Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Department of Chemical Engineering Faculty of Engineering Widya Mandala Catholic University Surabaya Kalijudan 37 Surabaya60114 Indonesia Department of Chemical Engineering University of Ulsan 93 Daehak-ro Nam-gu Ulsan44610 Korea Republic of City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Food Science and Biotechnology National Chung-Hsing University Taichung City40227 Taiwan Department of Food Science National Ilan University Yilan City260007 Taiwan Institute of Medicine Chung Shan Medical University Taichung40201 Taiwan Department of Medical Research Chung Shan Medical University Hospital Taichung40201 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei10607 Taiwan Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung41350 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung40402 Taiwan Department of Food Science Fu Jen Catholic University 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City242062 Taiwan

In recent years, bacterial cellulose (BC), a crystalline and nanoscale fibrillar polymer, has garnered significant interest due to its superior ph.sical, chemical, and mechanical properties compared to plant cellulose. Inherent features of BC, which include high biodegradability, mechanical strength, and biocompatibility, make it a suitable material for use in a wide variety of applications, particularly in the domains of biomedicine and environmental science. However, realizing its full potential requires targeted chemical or ph.sical modifications. Recent developments have focused on in-situ and ex-situ BC modification for various applications. Incorporating functional compounds into cellulose during BC synthesis enhances its strength and functional properties. Additionally, the material properties of BC, such as water content, thermal stability, and antibacterial capabilities, can be enhanced through post-synthesis modifications, including chemical acetylation, ph.sph.rylation, and integration with other biopolymers. Currently, the applicability of BC is being improved using new modification techniques, which involve genetically engineered strains to enhance polymer characteristics and market potential. The review highlights recent advancements in BC research and novel modification strategies that enhance its applications in advanced biomedical engineering and sustainable packaging. © 2025

关键词： Acetylation

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Co-MOF-67/carbon black composite: A novel electrochemical platform for furazolidone detection for food analysis

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Food chemistry 2025年 489卷 145023页

作者： Arunkumar Selvam Meenakumari Gopakumar Gopika Chih-Yu Kuo Beena Saraswathyamma Kareem Yusuf Mani Govindasamy International Graduate Program in Energy and Optoelectronic Materials (EOMP) National Taipei University of Technology Taipei 10608 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan. Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kollam Kerala 690525 India Department of Chemistry Korea University Seongbuk-gu Seoul Republic of Korea. Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology Taipei 106 Taiwan. Electronic address: chihyukuo@ntut.edu.tw. Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kollam Kerala 690525 India. Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia. International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Electronic address: manymany2025@mail.mcut.edu.tw.

Furazolidone (FZd), a nitrofuran antibiotic used for the treatment of bacterial and protozoal illnesses, generates apprehensions about its potential toxicity and mutagenicity. The swift and dependable identification of FZd in food and biological specimens is essential for public health and regulatory adherence. This study presents a novel electrochemical sensor using a glassy carbon electrode (GCE) modified with a cobalt-based metal-organic framework (Co-MOF) and carbon black (CB) composite (Co-MOF@CB/GCE) for the sensitive detection of FZd. The Co-MOF@CB composite enhances electron transport and expands the electroactive surface area. Characterization investigations confirmed the successful fabrication of the Co-MOF@CB/GCE sensor. Electrochemical analyses revealed an extensive detection range (0.4-610 μmolL) and a minimal detection limit (0.0875 μmolL). The sensor exhibited great repeatability, stability, and selectivity, demonstrating efficient FZd detection in milk, honey, and chicken. This sensor provides a reliable, economical tool for FZd detection in regulatory and public health contexts.

关键词： Biological analysis Carbon black Cobalt metal-organic framework Electrochemical detection Furazolidone Health care test

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Correction: Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAd+/ SIRT1 axis

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Journal of biomedical science 2024年第1期31卷 61页

作者： B Linju Yen Li-Tzu Wang Hsiu-Huang Wang Chin-Pao Hung Pei-Ju Hsu Chia-Chi Chang Chien-Yu Liao Huey-Kang Sytwu Men-Luh Yen Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. blyen@nhri.edu.tw. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University No. 250 Wuxing Street Taipei 11042 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University No.250 Wuxing Street Taipei 11042 Taiwan. Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Life Sciences National Defense Medical Center (NDMC) No.161 Section Minquan East Road Taipei 11490 Taiwan. National Institute of Infectious Diseases & Vaccinology NHRI No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Microbiology & Immunology NDMC No.161 Section 6 Minquan East Road Taipei 11490 Taiwan. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. mlyen@ntu.edu.tw.

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Sensitization of hepatocellular carcinoma cells to HdACi is regulated through hsa-miR-342-5p/CFL1

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Cancer cell international 2024年第1期24卷 291页

作者： Parvathi Nakka Chikondi Jassi Ming-Cheng Chen Yi-Sheng Liu Jer-Yuh Liu Chung-Min Yeh Chi-Cheng Li Yu-Chun Chang Wei-Wen Kuo Chih-Yang Huang Graduate Institute of Biomedical Sciences China Medical University Taichung 404 Taiwan. Department of Biological Science and Technology China Medical University Taichung 406 Taiwan. Division of Colorectal Surgery Department of Surgery Taichung Veterans General Hospital Taichung 40705 Taiwan. Faculty of Medicine National Yang-Ming University Taipei Taiwan. Division of Hematology and Oncology Department of Medicine Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan. School of Medicine National Defense Medical Center Taipei Taiwan. Center for Molecular Medicine China Medical University Hospital Taichung Taiwan. Department of Pathology Changhua Christian Hospital Changhua 500 Taiwan. School of Medicine Tzu Chi University 701 Section 3 Chung-Yang Road Hualien 97004 Taiwan. Department of Hematology and Oncology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. Ph.D. Program for Biotechnology Industry China Medical University Taichung 406 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung 404 Taiwan. cyhuang@mail.cmu.edu.tw. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan. cyhuang@mail.cmu.edu.tw. Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien 970 Taiwan. cyhuang@mail.cmu.edu.tw. Department of Medical Research China Medical University Hospital China Medical University Taichung 404 Taiwan. cyhuang@mail.cmu.edu.tw. Department of Biotechnology Asia University Taichung 413 Taiwan. cyhuang@mail.cmu.edu.tw.

BACKGROUNd:Increased prevalence of hepatocellular carcinoma (HCC) remains a global health challenge. HCC chemoresistance is a clinical obstacle for its management. Aberrant miRNA expression is a hallmark for both cancer progression and drug resistance. However, it is unclear which miRNAs are involved in HCC chemoresistance. METHOdS:MicroRNA microarray analysis revealed a differential expression profile of microRNAs between the hepatocellular carcinoma HA22T cell line and the HdACi-R cell line, which was validated by quantitative real-time PCR (qRT-PCR). To determine the biological function of miR-342-5p and the mechanism of the microRNA-342-5p/CFL1 axis in hepatocellular carcinoma HdACi resistance, loss- and gain-of-function studies were conducted in vitro. RESULTS:Here we demonstrated the molecular mechanism of histone deacetylase inhibitor (HdACi) resistance in HCC. differential miRNA expression analysis showed significant down regulation of miR-342-5p in HdACi-R cells than in parental HA22T cells. Mimics of miR-342-5p enhanced apoptosis through upregulation of Bax, cyto-C, cleaved-caspase-3 expressions with concomitant decline in anti-apoptotic protein (Bcl-2) in HdACi-R cells. Although HdACi did not increase cell viability of HdACi-R, overexpression of miR-342-5p decreased cofilin-1 expression, upregulated reactive oxygen species (ROS) mediated apoptosis, and sensitized HdACi-R to HdACi in a dose-dependent manner. CONCLUSION:Our findings demonstrated the critical role of miR-342-5p in HdACi resistance of HCC and that this mechanism might be attributed to miR-342-5p/cofilin-1 regulation.

关键词： CFL-1 HA22T HCC HdACi HdACi-R ROS SAHA miR-342-5p miRNA

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Corrigendum to "WNK1 kinase signaling in metastasis and angiogenesis"

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Cellular signalling 2022年 96卷 110377页

作者： Chia-Ying Hou Chung-Yung Ma Chiou-Hwa Yuh Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu Taiwan. Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Taiwan. Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu Taiwan Department of Biological Science and Technology National Chiao Tung University Hsinchu Taiwan Ph.D. Program in Environmental and Occupational Medicine Kaohsiung Medical University Kaohsiung Taiwan. Electronic address: chyuh@nhri.edu.tw.

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198 The effect of magnolol on the TNF-α/IL-23/Th-17 axis of the imiquimod induced psoriasis-like dermatitis mice

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Journal of Investigative dermatology 2020年第7期140卷 S23-S23页

作者： J. Guo Y. Cheng Y. Ro Z. Wu S. Jee Medical Research Institute Cathay General Hospital New Taipei City Taiwan Fu Jen Catholic University Ph.D. Program in Pharmaceutical Biotechnology New Taipei City Taiwan Department of Dermatology Cathay General Hospital Taipei Taiwan

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