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第11届世界华人药物化学研讨会（ISCMC 2018）

作者： Huiju Tseng Liangchieh Chen Changyi Liu Yunyi Huang Chengchung Yen Jingru Weng Yehlin Lu Wenchi Hou Tony Eight Lin Ihorng Pan Kuokuei Huang Weijan Huang Kaicheng Hsu Program in Biotechnology Research and Development College of PharmacyTaipei Medical University Graduate Institute of Pharmacognosy College of PharmacyTaipei Medical University School of Pharmacy College of PharmacyTaipei Medical University Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical University Department of Marine Technology and Resources College of Marine SciencesSun Yat-sen University Herbal Medicinal Product Div. Industrial Technology Research Institute Ph.D.Program for the Clinical Drug Discovery from Botanical Herbs College of PharmacyTaipei Medical University School of Pharmacy “Defense Medical Center”

Alzheimer's disease(Ad) is a progressive neurodegenerative disorder with multiple ***-amyloid(AB) self-aggregation and overexpression of class IIa histone deacetylases(HdACs) are strongly implicated with Ad *** this study,a series of novel diarylheptanoid derivatives were designed,synthesized and evaluated for use as dual Aβ self-aggregation and class IIa HdAC *** these compounds,4 j,5 c and Se displayed effective inhibitions for AB self-aggregation,HdACS activity and HdAC7 activity with IC50 values of < 10 μ*** compounds contain three common features:(1) a catechol or pyrogallol moiety,(2) a carbonyl linker and(3) an aromatic ring that can function as an HdAC cap and create hydroph.bic interactions with Aβ***,compounds 4 j,5 c and 5 e showed no significant cytotoxicity to human neuroblastoma SH-SY5 Y cells and also exhibited neuroprotective effect against H2O2-induced ***,these promising in vitro data highlighted compounds 4 j,5 c and 5 e as lead compounds that are worthy for further investigation.

关键词： Alzheimer's disease Aβ aggregation Histone deacetylase Isoform-selective inhibitors dual inhibitors

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Corrigendum to “Application of an optically induced dielectroph.resis (OdEP)-based microfluidic system for the detection and isolation of bacteria with heterogeneity of antibiotic susceptibility” [Sens. Actuators B: Chem. 307 (15 March) (2020) 127540]

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Sensors and Actuators B: Chemical 2020年 323卷

作者： Hsin-Yao Wang Chih-Yu Chen Po-Yu Chu Yu-Xian Zhu Chia-Hsun Hsieh Jang-Jih Lu Min-Hsien Wu Department of Laboratory Medicine Chang Gung Memorial Hospital at Linkou Taoyuan City Taiwan ROC Ph.D. Program in Biomedical Engineering Chang Gung University Taoyuan City Taiwan Graduate Institute of Biomedical Engineering Chang Gung University Taoyuan City Taiwan ROC Division of Haematology/Oncology Department of Internal Medicine Chang Gung Memorial Hospital at Linkou Taoyuan City Taiwan ROC School of Medicine Chang Gung University Taoyuan City Taiwan ROC Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan City Taiwan ROC

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Author Correction: ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin d-dependent and p53-independent manner

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Scientific reports 2019年第1期9卷 17457页

作者： Fat-Moon Suk Chi-Ching Chang Ren-Jye Lin Shyr-Yi Lin Shih-Chen Liu Chia-Feng Jau Yu-Chih Liang Division of Gastroenterology Department of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan. Division of Allergy Immunology and Rheumatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Division of Rheumatology Immunology and Allergy Taipei Medical University Hospital Taipei Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Primary Care Medicine Taipei Medical University Hospital Taipei Taiwan. Department of General Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. ycliang@tmu.edu.tw. Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei Taiwan. ycliang@tmu.edu.tw. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. ycliang@tmu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

关键词： Lung adenocarcinoma Lung cancer Mendelian randomization Pathway analysis Tuberculosis

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Author Correction: Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays

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Scientific reports 2018年第1期8卷 4256页

作者： Wen-Rui Hao Michael Chen Yi-Jou Chen Yu-Cheng Su Chiu-Min Cheng Hsiang-Yin Hsueh An-Pei Kao Yuan-Chin Hsieh Johny Chang Ming-Yang Tseng Kuo-Hsiang Chuang Division of Cardiovascular Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. Ph.D. program for the Clinical Drug Discovery from Botanical Herbs Taipei Medical University Taipei Taiwan. Institute of Biomedical Sciences Academia Sinica Taipei Taiwan. Department of Aquaculture National Kaohsiung Marine University Kaohsiung Taiwan. School of Pharmacy Taipei Medical University Taipei Taiwan. Stemforce Biotechnology Co. Ltd Chiayi City Taiwan. Graduate Institute of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Graduate Institute of Pharmacognosy Taipei Medical University Taipei Taiwan. Ph.D. program for the Clinical Drug Discovery from Botanical Herbs Taipei Medical University Taipei Taiwan. khchuang@tmu.edu.tw. Graduate Institute of Pharmacognosy Taipei Medical University Taipei Taiwan. khchuang@tmu.edu.tw.

A correction to this article has been published and is linked from the HTML and PdF versions of this paper. The error has been fixed in the paper.

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Erratum: "Polygonum multiflorum decreases Airway Allergic Symptoms in a Murine Model of Asthma"

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The American journal of Chinese medicine 2017年第5期45卷 1125页

作者： Chen-Chen Lee Yueh-Lun Lee Chien-N Wang Hsing-Chuan Tsai Chun-Lung Chiu Leroy F Liu Hung-Yun Lin Reen Wu * Department of Microbiology and Immunology School of Medicine China Medicine University Taichung Taiwan. † Graduate Institute of Basic Medical Science China Medicine University Taichung Taiwan. ‡ Graduate Institute of Immunology China Medicine University Taichung Taiwan. ∥ Department of Health and Nutrition Biotechnology Asia University Taichung Taiwan. § Center for Comparative Respiratory Biology and Medicine Internal Medicine College of Medicine University of California at Davis Davis California 95616 USA. ¶ The Ph.D. Program for Cancer Biology and Drug Discovery Taipei Medical University College of Medicine Taipei Medical University Taipei Taiwan.

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing dong Christoph.r Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph.F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorph.sms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/dCBLd1) and rs2179920 (HLA-dPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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The nerve branches between the dorsal penile nerves and the cavernous nerves should be the determinant of erectile function

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Urological Science 2015年第4期26卷 296-296页

作者： Yen-Lin Chen Yi-No Wu Ying-Hung Lin Han-Sun Chiang Department of Pathology Cardinal Tien Hospital Taiwan Department of Chemistry Fu-Jen Catholic University Taiwan Graduate Institute of Basic Medicine Fu-Jen Catholic University Taiwan Ph. D Program in Nutrition & Food science Fu Jen Catholic University Taiwan Department of Urology Taipei Medical University Hospital Taipei Taiwan

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Effects of Needle-Punch depth on Properties of PET/LPET/Kevlar Nonwoven Geotextiles

Effects of Needle-Punch Depth on Properties of PET/LPET/Kevl...

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2nd International Conference on Advanced Composite Materials and Manufacturing Engineering, CMME 2014

作者： Lin, Jia Horng Hsieh, Jing Chzi Li, Jia Hsun Hsing, Wen Hao Lou, Ching Wen Laboratory of Fiber Application and Manufacturing Department of Fiber and Composite Materials Feng Chia University Taichung City 40724 Taiwan School of Chinese Medicine China Medical University Taichung 40402 Taiwan Department of Fashion Design Asia University Taichung 41354 Taiwan Department of Land Management Feng Chia University Taichung City 40724 Taiwan Department of Ph. D Program in Civil and Hydraulic Engineering Feng Chia University Taichung City 40724 Taiwan The Department of Textile Engineering Chinese Culture University Taipei 11114 Taiwan Institute of Biomedical Engineering and Materials Science Central Taiwan University of Science and Technology Taichung 40601 Taiwan

ISBN: (纸本)9783038350651

Geotextile has been commonly used in civil and geotechnical engineering applications, and the majority of geotextiles is made of nonwoven fabrics. Therefore, this study combines crimped polyester (PET) fibers, recycled Kevlar unidirectional selvage fibers, and low-melting-point PET (LPET) fibers to form PET/Kevlar/LPET nonwoven geotextiles, and then examines how various neelde-punch depths influence mechanical properties of the resulting nonwoven geotextiles. The tensile strength, tearing strength, bursting strength, and static puncture resistance of the nonwoven fabrics increase as a result of an increase of 0.3 cm to 0.5 cm in needle-punch depth. However, an increase of 0.5 cm to 0.7 cm causes a slight decrease in all aforementioned properties. © (2014) Trans Tech Publications, Switzerland.

关键词： Needles

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Effects of needle-punch rate on properties of PET/Kevlar/LPET nonwoven geotextiles 4

Effects of needle-punch rate on properties of PET/Kevlar/LPE...

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4th International Workshop on Computer Science and Engineering-Winter, WCSE 2014

作者： Lin, Jia-Horng Li, Jia-Hsun Hsieh, Jing-Chzi Hsing, Wen-Hao Lou, Ching-Wen Laboratory of Fiber Application and Manufacturing Department of Fiber and Composite Materials Feng Chia University Taichung City40724 Taiwan School of Chinese Medicine China Medical University Taichung40402 Taiwan Department of Fashion Design Asia University Taichung41354 Taiwan Department of Ph. D Program in Civil and Hydraulic Engineering Feng Chia University Taichung City40724 Taiwan Department of Land Management Feng Chia University Taichung City40724 Taiwan Department of Textile Engineering Chinese Culture University Taipei11114 Taiwan Institute of Biomedical Engineering and Materials Science Central Taiwan University of Science and Technology Taichung40601 Taiwan

Geotextiles feature reinforcement, drainage, filtration, separation, and act as a moisture barrier, and are commonly used in civil and geotechnical engineering applications. Using nonwoven fabrics as geotextiles has become a recent trend;therefore, this study combines crimped polyester (PET) fibers, recycled Kevlar unidirectional selvage fibers, and low-melting-point PET (LPET) fiber to make PET/Kevlar/LPET nonwoven geotextiles, the mechanical properties of which are then examined. The test results show that the tensile strength and tearing strength of the PET/Kevlar/LPET nonwoven geotextiles increases as a result of an increasing needle-punch rate from 150 punches/min to 200 punches/min. The mechanical properties along the cross machine direciton (Cd) of the nonwoven geotextiles is greater than that along the machine direction (Md). When the needle-punching rate exceeds 200 punches/min, the mechanical properties of the nonwoven geotextiles slightly decrease.

关键词： Needles

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