检索结果-内蒙古大学图书馆

Exploration of anti-leukemic effect of soft coral-derived 13-acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II

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Kaohsiung Journal of medical Sciences 2023年第7期39卷 718-731页

作者： Chin, Hsien-Kuo Lu, Mei-Chin Hsu, Kai-Cheng El-Shazly, Mohamed Tsai, Tsen-Ni Lin, Tzu-Yung Shih, Shou-Ping Lin, Tony Eight Wen, Zhi-Hong Yang, Yu-Chen S. H. Liu, Yi-Chang Department of Marine Biotechnology and Resources National Sun Yat-Sen University Kaohsiung Taiwan Division of Cardiovascular Surgery Department of Surgery Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan Graduate Institute of Marine Biology National Dong Hwa University Hualien Taiwan National Museum of Marine Biology and Aquarium Pingtung Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Master Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan TMU Research Center of Drug Discovery Taipei Medical University Taipei Taiwan Department of Pharmacognosy Faculty of Pharmacy Ain-Shams University Cairo Egypt Division of Hematology-Oncology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department and Graduate Institute of Aquaculture National Kaohsiung University of Science and Technology Kaohsiung Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung Taiwan Doctoral Degree Program in Marine Biotechnology Academia Sinica Taipei Taiwan Joint Biobank Office of Human Research Taipei Medical University Taipei Taiwan Department of Internal Medicine Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Cellular Therapy and Research Center Kaohsiung Medical University Hospital Kaohsiung Taiwan

13-Acetoxysarcocrassolide (13-AC) is a marine cembranoid derived from the aquaculture soft coral of Loboph.tum crassum. The cytotoxic effect of 13-AC against leukemia cells was previously reported but its mechanism of action is still unexplored. In the current study, we showed that 13-AC induced apoptosis of human acute lymph.blastic leukemia Molt4 cells, as evidenced by the cleavage of PARP and caspases, ph.sph.tidylserine externalization, as well as the disruption of mitochondrial membrane potential. The use of N-acetylcysteine (NAC), a reactive oxygen species (ROS) scavenger, attenuated the cytotoxic effect induced by 13-AC. Molecular docking and thermal shift assay indicated that the cytotoxic mechanism of action of 13-AC involved the inhibition of heat shock protein 90 (Hsp 90) activity by eliciting the level of Hsp 70 and topoisomerase IIα in Molt4 cells. 13-AC also exhibited potent antitumor activity by reducing the tumor volume (48.3%) and weight (72.5%) in the in vivo Molt4 xenograft mice model. Our findings suggested that the marine cembranoid, 13-AC, acted as a dual inhibitor of Hsp 90 and topoisomerase IIα, exerting more potent apoptotic activity via the enhancement of ROS generation. © 2023 The Authors. The Kaohsiung Journal of medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Kaohsiung medical University.

关键词： 13-Acetoxysarcocrassolide heat shock protein 90 leukemia oxidative stress topoisomerase II

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Perioperative dexmedetomidine Infusion Improves Perioperative Care of Bariatric-Metabolic Surgery: A Single Center Experience with Meta-Analysis

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Obesity Surgery 2024年第2期34卷 416-428页

作者： Chang, Po-Chih Huang, Ivy Ya-Wei Liu, Sian-de Huang, Chih-Kun Lin, Tsun-En Jhou, Hong-Jie Chen, Po-Huang Chang, Ting-Wei School of Medicine College of Medicine National Sun Yat-Sen University 804 Kaohsiung Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Cente Kaohsiung Medical University Hospital/Kaohsiung Medical University No. 100 Tzyou 1st Road Kaohsiung City 80756 Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Nursing Kaohsiung Medical University Hospital/ Kaohsiung Medical University Kaohsiung City Taiwan Department of Pharmacy New Taipei Municipal TuCheng Hospital (Built and Operated By Chang Gung Medical Foundation) New Taipei City 236 Taiwan Body Science and Metabolic Disorders International Medical Center China Medical University Hospital Taichung City Taiwan Specialist Nursing Office Department of Nursing Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Department of Neurology Changhua Christian Hospital Changhua Taiwan Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei City Taiwan

Purpose: This study aims to determine the effects of perioperative dexmedetomidine infusion (PdI) on Asian patients undergoing bariatric–metabolic surgery (BMS), focusing on the need for pain medications and management of postoperative nausea and vomiting (PONV), and to investigate the association with these variables, including patients’ characteristics and BMS data. Materials and Methods: A retrospective review of prospectively collected data was conducted in an Asian weight management center from August 2016 to October 2021. A total of 147 native patients with severe obesity were enrolled. All patients were informed of the full support of perioperative pain medications for BMS. The pain numeric rating scale scores, events of PONV, needs for pain medications, and the associated patients’ characteristics were analyzed. A p-value of < 0.05 was considered statistically significant. Furthermore, to verify the effects of perioperative usage of dexmedetomidine for BMS, a systematic review with meta-analysis of currently available randomized control trials was performed. Results: Among the 147 enrolled patients, 107 underwent laparoscopic sleeve gastrectomy and 40 underwent laparoscopic Roux-en-Y gastric bypass. PdI has been used as an adjunct multimodal analgesia for BMS in our institution since June 2017 (group d;n = 114). In comparison with those not administered with perioperative dexmedetomidine (group C;n = 33), lower pain numeric rating scale scores (2.52 ± 2.46 vs. 4.27 ± 2.95, p = 0.007) in the postanesthesia care unit, fewer PONV (32.46% vs. 51.52%;p = 0.046), and infrequent needs of additional pain medications (19.47% vs. 45.45%;p = 0.003) were observed in group d. Multivariable analysis demonstrated that type II diabetes mellitus was correlated with the decreased need of pain medications other than PdI (p = 0.035). Moreover, dexmedetomidine seemed to have a better analgesic effect for patients with longer surgical time based on our meta-analysis. Conclusion:

关键词： Analgesia Bariatric–Metabolic Surgery dexmedetomidine Pain Severe Obesity

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Jing-Si Herbal Tea Suppresses H2O2-Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes

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Environmental Toxicology 2024年第12期39卷 5347-5356页

作者： Kao, Shih-Wen Chang, Yu-Chun Lin, Feng-Huei Huang, Tai-Lung Chen, Tung-Sheng Lin, Shinn-Zong Lin, Kuan-Ho Kuo, Wei-Wen Ho, Tsung-Jung Huang, Chih-Yang Graduate Institute of Aging Medicine China Medical University Taichung Taiwan Department of Orthopedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Division of Biomedical Engineering and Nanomedicine Research National Health Research Institute Miaoli Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu chi University Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans;however, its undesired activation results in tissue damage and cell death. The onset of chronic inflammation and oxidative stress are the key characteristics of autoimmune inflammatory diseases such as rheumatoid arthritis (RA), for which an effective treatment is yet to be developed. Therefore, in this study, we investigated the protective effects and molecular mechanisms of a novel herbal preparation, Jing-Si herbal tea (JS), against H2O2-induced inflammation and cellular damage in HIG-82 synoviocytes. We found that JS did not show any significant alterations in cell viability at 2O2-induced pathological oxidative stress (ROS) in HIG-82 cells. Interestingly, JS treatment not only reduced the ROS levels but also significantly repressed the protein expressions of collagen degrading proteases in a dose-dependent manner. Treatment with JS showed enhanced cell viability against H2O2-induced toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and Bcl-2 were increased, whereas MMP-13, AdAMTS-2, Cytochrome C, and cleaved Caspase 3 were decreased by JS under inflammatory agents H2O2, MIA, LPS, and TNF-α treatment, respectively, in HIG-82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2-treated HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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Using ensemble learning and hierarchical strategy to predict the outcomes of ESWL for upper ureteral stone treatment

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Computers in Biology and Medicine 2024年 179卷 108904-108904页

作者： Chen, Chi-Wei Liu, Wayne-Young Huang, Lan-Ying Chu, Yen-Wei Graduate Degree Program of Smart Healthcare & Bioinformatics I-Shou University Kaohsiung City Taiwan Department of Biomedical Engineering I-Shou University Kaohsiung City Taiwan Doctoral Program in Medical Biotechnology National Chung Hsing University Taichung City Taiwan Department of Urology Jen-Ai Hospital Taichung City Taiwan Graduate Institute of Genomics and Bioinformatics National Chung Hsing University Taichung City Taiwan Institute of Molecular Biology National Chung Hsing University Taichung City Taiwan Agricultural Biotechnology Center National Chung Hsing University Taichung City Taiwan Rong Hsing Research Center for Translational Medicine Taichung City Taiwan Ph. D Program in Medical Biotechnology National Chung Hsing University Taichung City Taiwan Taichung402 Taiwan

Urinary tract stones are a common and frequently recurring medical issue. Accurately predicting the success rate after surgery can help avoid ineffective medical procedures and reduce unnecessary healthcare costs. This study collected data from patients with upper ureter stones who underwent extracorporeal shock wave lithotripsy, including cases of successful as well as unsuccessful stone removal after the first and second lithotripsy procedures, and constructed prediction systems for the outcomes of the first and second lithotripsy procedures. Features were extracted from three categories of information: patient characteristics, stone characteristics, and extracorporeal shock wave lithotripsy machine data, and additional features were created using Feature Creation. Finally, the impact of features on the models was analyzed using six methods to calculate feature importance. Our prediction model for the first lithotripsy, selected from among 43 methods and seven ensemble learning techniques, achieves an AUC of 0.91. For the second lithotripsy, the AUC reaches 0.76. The results indicate that the detailed and binary information provided by patients regarding their history of stone experiences contributes differently to the predictive accuracy of the first and second lithotripsy procedures. The prediction tool is available at https://***/ks. © 2024

关键词： Machine learning

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AdAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atroph. through modulating serum amyloid A1

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Journal of Cachexia, Sarcopenia and Muscle 2024年第3期15卷 949-962页

作者： Kung, Mei-Lang Yang, Tai-Hua Lin, Chia-Chi Ho, Jia-Yun Hung, Tzu-Chi Chang, Chih-Hsiang Huang, Kuan-Wen Chen, Chien-Chin Chen, Yun-Wen Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan Department of Biomedical Engineering College of Engineering National Cheng Kung University Tainan Taiwan Department of Orthopedic Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Department of Pharmacology College of Medicine National Cheng Kung University Tainan Taiwan Department of Pathology Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi Taiwan Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan Taiwan Ph.D. Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan

Background: Non-alcoholic fatty liver disease (NAFLd) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLd. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (AdAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three AdAR gene family members, including AdAR1, AdAR2 and AdAR3, have been identified. However, the functional role of AdAR2 in obesity-associated NAFLd and sarcopenia remains unclear. Methods: AdAR2^+/+/GluR-B^R/R mice (wild type [WT]) and AdAR2^−/−/GluR-B^R/R mice (AdAR2 knockout [KO]) were subjected to feeding with standard chow or high-fat diet (HFd) for 20 weeks at the age of 5 weeks. The metabolic parameters, hepatic lipid droplet, grip strength test, rotarod test, muscle weight, fibre cross-sectional area (CSA), fibre types and protein associated with protein degradation were examined. Systemic and local tissues serum amyloid A1 (SAA1) were measured. The effects of SAA1 on C2C12 myotube atroph. were investigated. Results: AdAR2 KO mice fed with HFd exhibited lower body weight (−7.7%, P < 0.05), lower liver tissue weight (−20%, P < 0.05), reduced liver lipid droplets in concert with a decrease in hepatic triglyceride content (−24%, P < 0.001) and liver injury (P < 0.01). AdAR2 KO mice displayed protection against HFd-induced glucose intolerance, insulin resistance and dyslipidaemia. Skeletal muscle mass (P < 0.01), muscle strength (P < 0.05), muscle endurance (P < 0.001) and fibre size (CSA;P < 0.0001) were improved in AdAR2 KO mice fed with HFd compared with WT mice fed with HFd. Muscle atroph.-associated transcripts, such as forkhead box protein O1, muscle atroph. F-box/atrogin-1 and muscle RING finger 1/tripartite motif-containing 63, were decreased in AdAR2 KO mice fed with HFd compare

关键词： AdAR2 diabetes inflammation muscle atroph. NAFLd SAA1

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Understanding AdC variation by fat content effect using a dual-function MRI ph.ntom

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European Radiology Experimental 2024年第1期8卷 19页

作者： Liu, Yi-Jui Tsai, Tung-Sheng Li, Ya-Hui Peng, Jo-Hua Chang, Hing-Chiu Peng, Hsu-Hsia Lee, Ying-Chieh Lee, Tung-Yang Liou, Chang-Hsien Lin, Tz-Feng Chew, Fatt-Yang Chou, Ruey-Hwang Juan, Chun-Jung Department of Automatic Control Engineering Feng Chia University Taichung Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital 199 Sec. 1 Xinglong Rd. Hsinchu County Zhubei City 302 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Biomedical Engineering Chinese University of Hong Kong Hong Kong Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Institute of Nuclear Engineering and Science National Tsing Hua University Hsinchu Taiwan Department of Fiber and Composite Materials Feng Chia University Taichung Taiwan Department of Medical Imaging China Medical University Hospital Taichung Taiwan Department of Radiology School of Medicine China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 406 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung Taiwan Department of Medical Laboratory and Biotechnology Asia University Taichung Taiwan

Background: A dual-function ph.ntom designed to quantify the apparent diffusion coefficient (AdC) in different fat contents (FCs) and glass bead densities (GBds) to simulate the human tissues has not been documented yet. We propose a dual-function ph.ntom to quantify the FC and to measure the AdC at different FCs and different GBds. Methods: A fat-containing diffusion ph.ntom comprised by 30 glass-bead-containing fat-water emulsions consisting of six different FCs (0, 10, 20, 30, 40, and 50%) multiplied by five different GBds (0, 0.1, 0.25, 0.5, and 1.0 g/50 mL). The FC and AdC were measured by the “iterative decomposition of water and fat with echo asymmetry and least squares estimation-IQ,” IdEAL-IQ, and single-shot echo-planar diffusion-weighted imaging, SS-EP-dWI, sequences, respectively. Linear regression analysis was used to evaluate the relationship among the fat fraction (FF) measured by IdEAL-IQ, GBd, and AdC. Results: The AdC was significantly, negatively, and linearly associated with the FF (the linear slope ranged from -0.005 to -0.017, R² = 0.925 to 0.986, all p < 0.001). The slope of the linear relationship between the AdC and the FF, however, varied among different GBds (the higher the GBd, the lower the slope). AdCs among emulsions across different GBds and FFs were overlapped. Emulsions with low GBds plus high FFs shared a same lower AdC range with those with median or high GBds plus median or lower FFs. Conclusions: A novel dual-function ph.ntom simulating the human tissues allowed to quantify the influence of FC and GBd on AdC. Relevance statement: The study developed an innovative dual-function MRI ph.ntom to explore the impact of FC on AdC variation that can affect clinical results. The results revealed the superimposed effect on FF and GBd density on AdC measurements. Key points: • A dual-function ph.ntom made of glass bead density (GBd) and fat fraction (FF) emulsion has been developed. • Apparent diffusion coefficient (AdC) values

关键词： Adipose tissue diffusion magnetic resonance imaging ph.ntoms (imaging) Quality assurance (healthcare) Quality control

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tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle

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Cell Communication and Signaling 2024年第1期22卷 1-15页

作者： Chen, Yi-Ming Tang, Kuo-Tung Liu, Hung-Jen Huang, Shih-Ting Liao, Tsai-Ling Department of Medical Research Taichung Veterans General Hospital Rong Hsing Research Center for Translational Medicine National Chung Hsing University Ph.D. Program in Translational Medicine National Chung Hsing University Division of Allergy Immunology and Rheumatology Department of Internal Medicine Taichung Veterans General Hospital Institute of Molecular Biology National Chung Hsing University The iEGG and Animal Biotechnology Center National Chung Hsing University Division of Nephrology Department of Internal Medicine Taichung Veterans General Hospital Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University

Background: Hyperactive neutroph.l extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythematosus (SLE). However, what triggers the imbalance in dysregulated NETs formation in SLE is elusive. Transfer RNA-derived small RNAs (tsRNAs) are novel non-coding RNAs, which participate in various cellular processes. We explore the role of tsRNAs on NETs formation in SLE. Methods: We analyzed the levels of NETs dNA and platelet-derived extracellular vesicles (pEVs) from 50 SLE patients and 20 healthy control subjects. The effects of pEVs on NETs formation were evaluated by using immunofluorescence assay and myeloperoxidase-dNA PicoGreen assay. The regulatory mechanism of pEVs on NETs formation and inflammatory cytokines production were investigated using an in vitro cell-based assay. Results: Increased circulating NETs dNA and pEVs were shown in SLE patients and were associated with disease activity (P < 0.005). We demonstrated that SLE patient-derived immune complexes (ICs) induced platelet activation, followed by pEVs release. ICs-triggered NETs formation was significantly enhanced in the presence of pEVs through Toll-like receptor (TLR) 8 activation. Increased levels of tRF-His-GTG-1 in pEVs and neutroph.ls of SLE patients were associated with disease activity. tRF-His-GTG-1 interacted with TLR8 to prime p47ph.x ph.sph.rylation in neutroph.ls, resulting in reactive oxygen species production and NETs formation. Additionally, tRF-His-GTG-1 modulated NF-κB and IRF7 activation in neutroph.ls upon TLR8 engagement, resulting IL-1β, IL-8, and interferon-α upregulation, respectively. Conclusions: The level of tRF-His-GTG-1 was positively correlated with NETs formation in SLE patients;tRF-His-GTG-1 inhibitor could efficiently suppress ICs-triggered NETs formation/hyperactivation, which may become a potential therapeutic target. © The Author(s) 2024.

关键词： Extracellular vesicles Interferon-α Neutroph.l extracellular traps Platelet Systemic lupus erythematosus tRNA-derived small RNA

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Sinulariaone A: a novel diterpenoid with a 13-membered carbocyclic skeleton from an octocoral Sinularia species

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RSC Advances 2023年第15期13卷 10408-10413页

作者： Tseng, Hsuan-Jung Kuo, Liang-Mou Tsai, Yu-Chi Hu, Hao-Chun Chen, Po-Jen Chien, Su-Ying Sheu, Jyh-Horng Sung, Ping-Jyun Graduate Institute of Marine Biology National Dong Hwa University Pingtung944401 Taiwan National Museum of Marine Biology & Aquarium Pingtung944401 Taiwan Department of General Surgery Chang Gung Memorial Hospital at Chiayi Chiayi613016 Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung404333 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807378 Taiwan Clinical Immunology Laboratory Department of Medical Research E-Da Hospital I-Shou University Kaohsiung824005 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung404394 Taiwan Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City242062 Taiwan

Chemical composition screening of an octocoral identified as Sinularia species led to the isolation of a novel diterpenoid, sinulariaone A (1), featuring a 13-membered carbocyclic skeleton. The structure of 1 was established by spectroscopic elucidation, computed calculation, and X-ray diffraction analysis. Moreover, a single-crystal X-ray diffraction analysis of chlorofurancembranoid B (2), obtained in our previous study from the same octocoral species, was reported for the first time to demonstrate the absolute configuration. diterpenoid 1 showed cytotoxicity towards human promyelocytic leukemia HL-60 cells, with an IC50 value of 38.01 μM. © 2023 The Royal Society of Chemistry.

关键词： X ray powder diffraction

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Crystal structure revision of the natural 3β,11-dihydroxy-9,11-secosteroids bearing a 5,6-epoxy group by single-crystal X-ray diffraction and NMR data

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Journal of Molecular Structure 2025年 1342卷

作者： Sheu, Jyh-Horng Ahmed, Atallah F. Chen, You-Ying Zheng, Li-Guo Chien, Su-Ying Tseng, Yen-Ju Su, Jui-Hsin Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807378 Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung404394 Taiwan Department of Pharmacognosy College of Pharmacy King Saud University Riyadh11451 Saudi Arabia Department of Pharmacognosy Faculty of Pharmacy Mansoura University Mansoura35516 Egypt National Museum of Marine Biology and Aquarium Pingtung944401 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital China Medical University Taichung404394 Taiwan Ph. D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City242062 Taiwan Department of Biochemistry and Molecular Medicine National Dong Hwa University Hualien974301 Taiwan

A comprehensive structural analysis of a reported natural product, previously identified as 3β,11-dihydroxy-5β,6β-epoxy-24-methylene-9,11-secocholestan-9-one (1) and reisolated from the Taiwanese octocoral Sinularia lochmodes, was conducted. Reanalysis of the NMR spectra together with X-ray crystallograph.c data, led to the revision of this compound from structue 1 to its stereoisomer, 3β,11-dihydroxy-5α,6α-epoxy-24-methylene-9,11-secocholestan-9-one (2). Based on the NMR data of 2, several reported 3β,11-dihydroxy-9-oxo-9,11-secosteroids structures possessing 5,6-epoxy group should be revised. This study also provides the relationship between the 1H/13C NMR spectroscopic data and the absolute configurations of the 9,11-secosteroids possessing either 5α,6α- or 5β,6β-epoxy group. © 2025 Elsevier B.V.

关键词： Nuclear magnetic resonance spectroscopy

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Enhanced light-driven ph.toelectrochemical catalysis of water splitting by TiO2 nanotubes grown on acid-etched titanium foils

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International Journal of Hydrogen Energy 2024年第PartA期51卷 1483-1493页

作者： Hsiao, Yu-Cheng Lai, Jhih-Hong Fan, Yu-Min Chen, Hung-Ming Yougbaré, Sibidou Saukani, Muhammad Chen, Chih-Yu Wu, Yung-Fu Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

Titanium dioxide with suitable band edges is one of promising ph.tocatalysts for water splitting. Nanotubes with one-dimensional structure can induce efficient charge transfers and hollow centers can provide large surface area for surface reactions. Modifying Ti foils for anodization can enhance light utilization of TiO2 nanotube ph.toelectrodes. In this work, it is firstly to fabricate TiO2 nanotube ph.toelectrodes on acid-etched Ti foils by anodization (MNT) for ph.toelectrochemical catalyzing water splitting. different acid-etching durations are applied on Ti foils to induce various rugged surfaces. The resulting ph.toelectrodes present largely enhanced light utilization than that fabricated by the pristine Ti foil. The anodization duration is also optimized to find suitable lengths of MNT. The smallest overpotential of 524.7 mV at 10 mA/cm2 and Tafel slope of 167 mV/dec are obtained for the optimal MNT ph.toelectrode. The TiO2 nanotubes grown on the pristine Ti foil shows the overpotential of 679.3 mV at 10 mA/cm2 and Tafel slope of 285 mV/dec. This result opens a blueprint for raising the ph.tocatalytic ability by simply modifying the surface property of the conductive substrate. Other modifications may be applicable to enhance the roughness of Ti foils for growing more efficient MNT array as ph.tocatalysis of water splitting. © 2023 Hydrogen Energy Publications LLC

关键词： Titanium dioxide

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