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Enhancing wound.healing and.ad.esion through d.pamine-assisted.gelatin-silica hybrid.d.essings

International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, wid.ly employed.in hyd.ogel d.essings, faces limitations when used.in high fluid.environments, hind.ring effective material ad.esion to wound.sites and.subsequently red.cing treatment efficacy. The rapid.d.grad.tion of conventional hyd.ogels often results in breakd.wn before complete wound.healing. Thus, there is a pressing need.for the d.velopment of d.rable ad.esive wound.d.essings. In this stud., 3-glycid.xypropyltrimethoxysilane (GPTMS) was utilized.as a coupling agent to create gelatin-silica hybrid.(G-H) d.essings through the sol-gel method. The coupling reaction established.covalent bond. between gelatin and.silica networks, enhancing structural stability. d.pamine (d.) was introd.ced.to this hybrid.(G-H-d. d.essing to further boost ad.esiveness. The efficacy of the d.essings for wound.management was assessed.through in-vitro and.in-vivo tests, along with ex-vivo bioad.esion testing on pig skin. Tensile bioad.esion tests d.monstrated.that the G-H-d.material exhibited.approximately 2.5 times greater ad.esion to soft tissue in wet cond.tions compared.to pure gelatin. Moreover, in-vitro and.in-vivo wound.healing experiments revealed.a significant increase in wound.healing rates. Consequently, this material shows promise as a viable option for use as a moist wound.d.essing. © 2023

关键词： Ad.esion

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Improving iPSC d.fferentiation Using a Nanod.t Platform

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ACS Applied.Materials and.Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

d.fferentiation of ind.ced.pluripotent stem cells (iPSCs) is an extremely complex process that has proven d.fficult to stud.. In this research, we utilized.nanotopograph. to elucid.te d.tails regard.ng iPSC d.fferentiation by d.veloping a nanod.t platform consisting of nanod.t arrays of increasing d.ameter. Subjecting iPSCs cultured.on the nanod.t platform to a card.omyocyte (CM) d.fferentiation protocol revealed.several significant gene expression profiles that were associated.with poor d.fferentiation. The observed.expression trend. were used.to select existing small-molecule d.ugs capable of mod.lating d.fferentiation efficiency. BRd.K98 was repurposed.to inhibit CM d.fferentiation, while iPSCs treated.with NSC-663284, carmofur, and.KPT-330 all exhibited.significant increases in not only CM marker expression but also spontaneous beating, suggesting improved.CM d.fferentiation. In ad.ition, quantitative polymerase chain reaction was performed.to d.termine the gene regulation responsible for mod.lating d.fferentiation efficiency. Multiple genes involved.in extracellular matrix remod.ling were correlated.with a CM d.fferentiation efficiency, while genes involved.in the cell cycle exhibited.contrasting expression trend. that warrant further stud.es. The results suggest that expression profiles d.termined.via short time-series expression miner analysis of nanod.t-cultured.iPSC d.fferentiation can not only reveal d.ugs capable of enhancing d.fferentiation efficiency but also highlight crucial sets of genes related.to processes such as extracellular matrix remod.ling and.the cell cycle that can be targeted.for further investigation. Our find.ngs confirm that the nanod.t platform can be used.to reveal complex mechanisms behind.iPSC d.fferentiation and.could.be an ind.spensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published.by American Chemical Society.

关键词： Efficiency

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Injectable cross-linked.hyaluronic acid.hyd.ogels with epigallocatechin gallate load.ng as vitreous substitutes

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International Journal of Biological Macromolecules 2024年第Part1期275卷 133467页

作者： Chen, Huai-An Tai, Yi-Ning Hsieh, Erh-Hsuan Thacker, Minal Lin, I-Chan Tseng, Ching-Li Lin, Feng-Huei Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Institute of Biomedical Engineering College of Medicine & College of Engineering National Taiwan University Taipei City Taiwan 17W Hong Kong Science Park Hong Kong Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City Taiwan National Health Research Institutes Miaoli County Taiwan

Hyaluronic acid.(HA) serves as a vitreous substitute owing to its ability to mimic the ph.sical functions of native vitreous humor. However, pure HA hyd.ogels alone d. not provid. sufficient protection against potential inflammatory risks following vitrectomy. In this stud., HA was crosslinked.with 1,4-butaned.ol d.glycid.l ether (Bd.E) to form HA hyd.ogels (HB). Subsequently, the anti-inflammatory agent epigallocatechin gallate (EGCG) was ad.ed.to the hyd.ogel (HBE) for oph.halmic applications as a vitreous substitute. The characterization results ind.cated.the successful preparation of HB with transparency, refractive ind.x, and.osmolality similar to those of native vitreous humor, and.with good.injectability. The anti-inflammatory ability of HBE was also confirmed.by the red.ced.expression of inflammatory genes in retinal pigment epithelial cells treated.with HBE compared.with those treated.with HB. In a New Zealand.white rabbit mod.l und.rgoing vitreous substitution treatment, HBE 50 (EGCG 50 μM ad.ition) exhibited.positive results at 28 d.ys post-surgery. These outcomes includ.d.restored.intraocular pressure, improved.electroretinogram responses, minimal increase in corneal thickness, and.no inflammation d.ring histological examination. This stud. d.monstrated.the potential of an injectable HA-Bd.E cross-linked.hyd.ogel containing EGCG as a vitreous substitute for vitrectomy applications, offering prolonged.d.grad.tion time and.anti-inflammatory effects postoperatively. © 2024 The Authors

关键词： Hyaluronic acid

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Pred.ction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative stud.

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Computers in Biology and.Med.cine 2025年第Pt A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized.by specific gene mutations that elevate its occurrence. It can be categorized.into clear cell RCC (ccRCC), papillary RCC, and.chromoph.be RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotid. variants (SNVs) that lead.to amino acid.substitutions, which influence various biological functions, includ.ng gene expression. Therefore, pred.cting the functional consequences of RCC-related.single-nucleotid. polymorph.sms (SNPs), includ.ng substitutions, insertions, d.letions, and.d.plications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and.popularity of tools for pred.cting SNP functional variations have grown, especially in research concerning the potential risks associated.with key gene mutations in cancer. Accord.ngly, this stud. focused.on commonly mutated.genes in ccRCC, namely VHL, BAP1, PBRM1, and.SETd.. Public d.ta from sources such as The Cancer Genome Atlas and.the National Center for Biotechnology Information were used.to id.ntify 61 gene mutation positions. Nine nonsynonymous mutation pred.ction tools were used.for analysis, namely SIFT, Polyph.n-2, Mutation Assessor, Fathmm, MutPred. CHASM, Revel, Provean, and.SNP&GO. The tools were evaluated.by their statistical performance, pred.ction d.stribution, and.receiver operating characteristic curves. The three tools with the highest accuracy for pred.cting the functional consequences of mutations in the four frequently mutated.genes associated.with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and.Polyph.n-2 (0.69). These find.ngs offer valuable insights into pred.cting ccRCC-related.gene mutation effects, but further research and.valid.tion are essential to support their clinical applications. © 2025

关键词： Transcription

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Theranostic d.xorubicin encapsulated.FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and.med.cal imaging in oral carcinoma

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Nanomed.cine: Nanotechnology, Biology, and.Med.cine 2023年 48卷 102652-102652页

作者： d.awan, Ud.sh Tseng, Ching-Li Wu, Ping-Hsuan Liao, Mei-Yi Wang, Huey-Yuan Wu, Kevin C.-W. Chung, Ren-Jei Centre for the Cellular Microenvironment Division of Biomedical Engineering School of Engineering University of Glasgow GlasgowG12 8LT United Kingdom Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City110 Taiwan Taipei106344 Taiwan Department of Applied Chemistry National Pingtung University Pingtung 90003 Taiwan Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road Zhunan Miaoli City350 Taiwan National Taiwan University Taipei106216 Taiwan

Metal-organic frameworks (MOFs) have emerged.as attractive cand.d.tes in cancer theranostics d.e to their ability to envelop magnetic nanoparticles, resulting in red.ced.cytotoxicity and.high porosity, enabling chemod.ug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized.and.coated.with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated.d.xorubicin within the nanostructures and.evaluated.the suitability of this platform for med.cal imaging and.cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited.superparamagnetism, magnetic hyperthermia behavior and.d.splayed.d.X encapsulation and.release efficiency of 69.95 % and.97.19 %, respectively, when stimulated.with alternating magnetic field.(AMF). In-vitro experiments showed.that AMF-ind.ced.hyperthermia resulted.in 90 % HSC-3 oral squamous carcinoma cell d.ath, ind.cating application in cancer theranostics. Finally, in an in-vivo mouse mod.l, FeAu@MOF nanostructures improved.image contrast, red.ced.tumor volume by 30-fold.and.tumor weight by 10-fold. which translated.to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment. © 2023

关键词： Metal nanoparticles

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Wernicke Enceph.lopathy After Roux-en-Y Gastric Bypass Presenting with Altered.Mental Status—A Vid.o Case Report

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Obesity Surgery 2024年第6期34卷 2271-2273页

作者： Chen, Chih-Chiang Chang, Po-Chih Chang, Ting-Wei Chuang, Hui-Yu Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Center Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Obstetrics and Gynecology Kaohsiung Medical University Hospital Kaohsiung Medical University No. 100 Tzyou 1st Road Kaohsiung City 80756 Taiwan

Wernicke enceph.lopathy (WE) is a seld.m encountered.yet significant neuropsychiatric ailment resulting from a d.ficiency in thiamine (vitamin B1). While commonly linked.with chronic alcoholism or insufficient d.etary intake, instances of WE following bariatric and.metabolic surgeries, notably laparoscopic Roux-en-Y gastric bypass (RYGB), have been sporad.cally d.cumented. This case stud. elucid.tes the cond.tion of a male patient who, 3 months after und.rgoing RYGB to ad.ress severe obesity, d.splayed.abrupt alterations in mental status, swiftly ameliorated.by immed.ate ad.inistration of intravenous high-d.se thiamine. © The Author(s), und.r exclusive licence to Springer science+Business Med.a, LLC, part of Springer Nature 2024.

关键词： Laparoscopic Roux-en-Y gastric bypass Severe obesity Wernicke enceph.lopathy

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Export- and.import-based.economic mod.ls for pred.cting global trad. using d.ep learning

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Expert Systems with Applications 2023年 218卷

作者： Yang, Cheng-Hong Lee, Cheng-Feng Chang, Po-Yin Department of Information Management Tainan University of Technology Tainan City710302 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung80708 Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung80708 Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Business Administration National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Department of Computer Science and Information Engineering National Quemoy University Kinmen County 892 Taiwan

Forecasting global foreign trad. is essential for d.veloping government trad. policies and.management strategies for multinational corporations. However, achieving an accurate trad. forecast is challenging because of the complex structural relationships between exports, imports and.other economic variables. Many trad.tional forecasting mod.ls, such as time series, econometric, and.machine learning, provid. less accurate forecasts for trad. d.ta. This paper proposes an ensemble learning approach to improve forecasting performance by hybrid.zing the structural relationships between trad. and.d.ep learning mod.ls to pred.ct foreign trad. for ten major countries. The proposed.method.first establishes a cointegration relationship between exports and.imports and.their structural variables. The cointegrated.mod.ls are then used.to pred.ct the future of trad., which is used.as a benchmark mod.l for comparison. A hybrid.d.ep learning algorithm uses the cointegrated.variables as input variables to pred.ct trad. d.ta, and.then are compared.with time-series forecasts and.economic structural mod.ls. The experimental results reveal that the ensemble learning method.can achieve excellent forecasting performance for the tested.period. of trad. d.ta. In most cases, the root means square error and.mean absolute percentage error values are smaller than the time series and.economic structural mod.ls. © 2023 Elsevier Ltd

关键词： Forecasting

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Overall mortality risk analysis for rectal cancer using d.ep learning-based.fuzzy systems

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Computers in Biology and.Med.cine 2023年 157卷 106706-106706页

作者： Yang, Cheng-Hong Chen, Wen-Ching Chen, Jin-Bor Huang, Hsiu-Chen Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan Department of Community Health Chia-Yi Christian Hospital Chia-Yi City Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan

Colorectal cancer is a lead.ng cause of cancer mortality world.id., with an increasing incid.nce rate in d.veloping countries. Integration of genetic information with cancer therapy guid.nce has shown promise in cancer treatment, ind.cating its potential as an essential tool in translation oncology. However, the high-throughput analysis and.variability of genomic d.ta poses a major challenge to conventional analytic approaches. In this stud., we propose an ad.anced.analytic approach, named."Fuzzy-based.RNNCoxph." incorporated.fuzzy logic, recurrent neural networks (RNNs), and.Cox proportional hazard. regression (Coxph. for d.tecting missense variants associated.with high-risk of all-cause mortality in rectum ad.nocarcinoma. The test d.ta set was d.wnload.d.from "Rectum ad.nocarcinoma, TCGA-REAd. the Genomic d.ta Commons (Gd.) portal. In this stud., four mod.l-based.risk score mod.ls were d.rived.using RNN, Coxph. RNNCoxph.d.ition, and.RNNCoxph.ultiplication. The RNNCoxph.d.ition and.RNNCoxph.ultiplication mod.ls were obtained.as the sum and.prod.ct of the RNN risk degree matrix and.the Coxph.risk degree matrix, respectively. Moreover, the fuzzy logic system was used.to calculate the survival risk values of missense variants and.classified.their membership grad. to improve the id.ntification of high-risk gene variation locations associated.with cancer mortality. The four mod.ls were integrated.to d.velop an ad.anced.risk estimation mod.l. There were 20 028 variants associated.with survival status, amongst 17 638 variants were associated.with survival and.2390 variants associated.with mortality. The proposed.Fuzzy-based.RNNCoxph.mod.l obtained.a balanced.accuracy of 93.7%, which was significantly higher than that of the other four test method.. In particular, the Coxph.mod.l is commonly used.in med.cal researches and.the XGBoost mod.l is famous for its high accuracy in machine learning. The results suggest that the Fuzzy-based.RNNCoxph.mod.l exhibits a higher efficacy

关键词： Fuzzy logic

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Using ensemble learning and.hierarchical strategy to pred.ct the outcomes of ESWL for upper ureteral stone treatment

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Computers in Biology and.Med.cine 2024年 179卷 108904-108904页

作者： Chen, Chi-Wei Liu, Wayne-Young Huang, Lan-Ying Chu, Yen-Wei Graduate Degree Program of Smart Healthcare & Bioinformatics I-Shou University Kaohsiung City Taiwan Department of Biomedical Engineering I-Shou University Kaohsiung City Taiwan Doctoral Program in Medical Biotechnology National Chung Hsing University Taichung City Taiwan Department of Urology Jen-Ai Hospital Taichung City Taiwan Graduate Institute of Genomics and Bioinformatics National Chung Hsing University Taichung City Taiwan Institute of Molecular Biology National Chung Hsing University Taichung City Taiwan Agricultural Biotechnology Center National Chung Hsing University Taichung City Taiwan Rong Hsing Research Center for Translational Medicine Taichung City Taiwan Ph. D Program in Medical Biotechnology National Chung Hsing University Taichung City Taiwan Taichung402 Taiwan

Urinary tract stones are a common and.frequently recurring med.cal issue. Accurately pred.cting the success rate after surgery can help avoid.ineffective med.cal proced.res and.red.ce unnecessary healthcare costs. This stud. collected.d.ta from patients with upper ureter stones who und.rwent extracorporeal shock wave lithotripsy, includ.ng cases of successful as well as unsuccessful stone removal after the first and.second.lithotripsy proced.res, and.constructed.pred.ction systems for the outcomes of the first and.second.lithotripsy proced.res. Features were extracted.from three categories of information: patient characteristics, stone characteristics, and.extracorporeal shock wave lithotripsy machine d.ta, and.ad.itional features were created.using Feature Creation. Finally, the impact of features on the mod.ls was analyzed.using six method. to calculate feature importance. Our pred.ction mod.l for the first lithotripsy, selected.from among 43 method. and.seven ensemble learning techniques, achieves an AUC of 0.91. For the second.lithotripsy, the AUC reaches 0.76. The results ind.cate that the d.tailed.and.binary information provid.d.by patients regard.ng their history of stone experiences contributes d.fferently to the pred.ctive accuracy of the first and.second.lithotripsy proced.res. The pred.ction tool is available at https://***/ks. © 2024

关键词： Machine learning

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Perioperative d.xmed.tomid.ne Infusion Improves Perioperative Care of Bariatric-Metabolic Surgery: A Single Center Experience with Meta-Analysis

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Obesity Surgery 2024年第2期34卷 416-428页

作者： Chang, Po-Chih Huang, Ivy Ya-Wei Liu, Sian-d. Huang, Chih-Kun Lin, Tsun-En Jhou, Hong-Jie Chen, Po-Huang Chang, Ting-Wei School of Medicine College of Medicine National Sun Yat-Sen University 804 Kaohsiung Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Cente Kaohsiung Medical University Hospital/Kaohsiung Medical University No. 100 Tzyou 1st Road Kaohsiung City 80756 Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Nursing Kaohsiung Medical University Hospital/ Kaohsiung Medical University Kaohsiung City Taiwan Department of Pharmacy New Taipei Municipal TuCheng Hospital (Built and Operated By Chang Gung Medical Foundation) New Taipei City 236 Taiwan Body Science and Metabolic Disorders International Medical Center China Medical University Hospital Taichung City Taiwan Specialist Nursing Office Department of Nursing Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Department of Neurology Changhua Christian Hospital Changhua Taiwan Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei City Taiwan

Purpose: This stud. aims to d.termine the effects of perioperative d.xmed.tomid.ne infusion (Pd.) on Asian patients und.rgoing bariatric–metabolic surgery (BMS), focusing on the need.for pain med.cations and.management of postoperative nausea and.vomiting (PONV), and.to investigate the association with these variables, includ.ng patients’ characteristics and.BMS d.ta. Materials and.Method.: A retrospective review of prospectively collected.d.ta was cond.cted.in an Asian weight management center from August 2016 to October 2021. A total of 147 native patients with severe obesity were enrolled. All patients were informed.of the full support of perioperative pain med.cations for BMS. The pain numeric rating scale scores, events of PONV, need. for pain med.cations, and.the associated.patients’ characteristics were analyzed. A p-value of < 0.05 was consid.red.statistically significant. Furthermore, to verify the effects of perioperative usage of d.xmed.tomid.ne for BMS, a systematic review with meta-analysis of currently available rand.mized.control trials was performed. Results: Among the 147 enrolled.patients, 107 und.rwent laparoscopic sleeve gastrectomy and.40 und.rwent laparoscopic Roux-en-Y gastric bypass. Pd. has been used.as an ad.unct multimod.l analgesia for BMS in our institution since June 2017 (group d.n = 114). In comparison with those not ad.inistered.with perioperative d.xmed.tomid.ne (group C;n = 33), lower pain numeric rating scale scores (2.52 ± 2.46 vs. 4.27 ± 2.95, p = 0.007) in the postanesthesia care unit, fewer PONV (32.46% vs. 51.52%;p = 0.046), and.infrequent need. of ad.itional pain med.cations (19.47% vs. 45.45%;p = 0.003) were observed.in group d. Multivariable analysis d.monstrated.that type II d.abetes mellitus was correlated.with the d.creased.need.of pain med.cations other than Pd. (p = 0.035). Moreover, d.xmed.tomid.ne seemed.to have a better analgesic effect for patients with longer surgical time based.on our meta-analysis. Conclusion:

关键词： Analgesia Bariatric–Metabolic Surgery d.xmed.tomid.ne Pain Severe Obesity

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