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Pred.ction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative stud.

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Computers in Biology and.Med.cine 2025年第Pt A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized.by specific gene mutations that elevate its occurrence. It can be categorized.into clear cell RCC (ccRCC), papillary RCC, and.chromoph.be RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotid. variants (SNVs) that lead.to amino acid.substitutions, which influence various biological functions, includ.ng gene expression. Therefore, pred.cting the functional consequences of RCC-related.single-nucleotid. polymorph.sms (SNPs), includ.ng substitutions, insertions, d.letions, and.d.plications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and.popularity of tools for pred.cting SNP functional variations have grown, especially in research concerning the potential risks associated.with key gene mutations in cancer. Accord.ngly, this stud. focused.on commonly mutated.genes in ccRCC, namely VHL, BAP1, PBRM1, and.SETd.. Public d.ta from sources such as The Cancer Genome Atlas and.the National Center for Biotechnology Information were used.to id.ntify 61 gene mutation positions. Nine nonsynonymous mutation pred.ction tools were used.for analysis, namely SIFT, Polyph.n-2, Mutation Assessor, Fathmm, MutPred. CHASM, Revel, Provean, and.SNP&GO. The tools were evaluated.by their statistical performance, pred.ction d.stribution, and.receiver operating characteristic curves. The three tools with the highest accuracy for pred.cting the functional consequences of mutations in the four frequently mutated.genes associated.with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and.Polyph.n-2 (0.69). These find.ngs offer valuable insights into pred.cting ccRCC-related.gene mutation effects, but further research and.valid.tion are essential to support their clinical applications. © 2025

关键词： Transcription

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Coronary heart d.seases pred.ction based.on card.ology clinical features 5

Coronary heart diseases prediction based on cardiology clini...

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5th IEEE International Conference on Big d.ta Intelligence and.Computing, d.taCom 2019

作者： Yang, Cheng-Hong Chuang, Li-Yeh Chang, Po-Yin National Kaohsiung University of Science and Technology Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Dept. of Electronic Engineering Kaohsiung Taiwan I-Shou University Dept. of Chemical Engineering Institute of Biotechnology and Chemical Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Dept. of Electronic Engineering Kaohsiung Taiwan

ISBN: (纸本)9781728141176

The d.velopment of mod.rn health systems has generated.a large amount of med.cal d.ta. Recent research has shown that d.ta mining technology can d.scover potential patterns from a vast array of med.cal d.ta, provid.ng insight into d.sease and.pred.cting d.sease. Coronary heart d.sease (CHd. is one of the most important research topics in the health field. In recent years, research on CHd.has been extensively stud.ed.however, the accuracy of CHd.pred.ction need. to be improved. Here, a hybrid.pred.ction method.BOSVM combining Bayesian optimization (BO) and.support vector machine (SVM) is proposed.to pred.ct the CHd. In BOSVM, BO aims to ad.ust of SVM parameters for enhancing the accuracy of CHd.pred.ction. BOSVM compares performance of CHd.pred.ction with five forecasting algorithms, includ.ng classification and.regression tree, logistic regression, k-nearest neighbors, Ad.Boost, and.SVM. The experimental results show that the BOSVM has superior pred.ction accuracy than other algorithms in CHd.pred.ction, ind.cating BOSVM can effectively pred.ct CHd. © 2019 IEEE.

关键词： Support vector regression

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Enhancing wound.healing and.ad.esion through d.pamine-assisted.gelatin-silica hybrid.d.essings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, wid.ly employed.in hyd.ogel d.essings, faces limitations when used.in high fluid.environments, hind.ring effective material ad.esion to wound.sites and.subsequently red.cing treatment efficacy. The rapid.d.grad.tion of conventional hyd.ogels often results in breakd.wn before complete wound.healing. Thus, there is a pressing need.for the d.velopment of d.rable ad.esive wound.d.essings. In this stud., 3-glycid.xypropyltrimethoxysilane (GPTMS) was utilized.as a coupling agent to create gelatin-silica hybrid.(G-H) d.essings through the sol-gel method. The coupling reaction established.covalent bond. between gelatin and.silica networks, enhancing structural stability. d.pamine (d.) was introd.ced.to this hybrid.(G-H-d. d.essing to further boost ad.esiveness. The efficacy of the d.essings for wound.management was assessed.through in-vitro and.in-vivo tests, along with ex-vivo bioad.esion testing on pig skin. Tensile bioad.esion tests d.monstrated.that the G-H-d.material exhibited.approximately 2.5 times greater ad.esion to soft tissue in wet cond.tions compared.to pure gelatin. Moreover, in-vitro and.in-vivo wound.healing experiments revealed.a significant increase in wound.healing rates. Consequently, this material shows promise as a viable option for use as a moist wound.d.essing. © 2023

关键词： Ad.esion

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Improving iPSC d.fferentiation Using a Nanod.t Platform

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ACS Applied.Materials and.Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

d.fferentiation of ind.ced.pluripotent stem cells (iPSCs) is an extremely complex process that has proven d.fficult to stud.. In this research, we utilized.nanotopograph. to elucid.te d.tails regard.ng iPSC d.fferentiation by d.veloping a nanod.t platform consisting of nanod.t arrays of increasing d.ameter. Subjecting iPSCs cultured.on the nanod.t platform to a card.omyocyte (CM) d.fferentiation protocol revealed.several significant gene expression profiles that were associated.with poor d.fferentiation. The observed.expression trend. were used.to select existing small-molecule d.ugs capable of mod.lating d.fferentiation efficiency. BRd.K98 was repurposed.to inhibit CM d.fferentiation, while iPSCs treated.with NSC-663284, carmofur, and.KPT-330 all exhibited.significant increases in not only CM marker expression but also spontaneous beating, suggesting improved.CM d.fferentiation. In ad.ition, quantitative polymerase chain reaction was performed.to d.termine the gene regulation responsible for mod.lating d.fferentiation efficiency. Multiple genes involved.in extracellular matrix remod.ling were correlated.with a CM d.fferentiation efficiency, while genes involved.in the cell cycle exhibited.contrasting expression trend. that warrant further stud.es. The results suggest that expression profiles d.termined.via short time-series expression miner analysis of nanod.t-cultured.iPSC d.fferentiation can not only reveal d.ugs capable of enhancing d.fferentiation efficiency but also highlight crucial sets of genes related.to processes such as extracellular matrix remod.ling and.the cell cycle that can be targeted.for further investigation. Our find.ngs confirm that the nanod.t platform can be used.to reveal complex mechanisms behind.iPSC d.fferentiation and.could.be an ind.spensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published.by American Chemical Society.

关键词： Efficiency

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Injectable cross-linked.hyaluronic acid.hyd.ogels with epigallocatechin gallate load.ng as vitreous substitutes

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International Journal of Biological Macromolecules 2024年第Part1期275卷 133467页

作者： Chen, Huai-An Tai, Yi-Ning Hsieh, Erh-Hsuan Thacker, Minal Lin, I-Chan Tseng, Ching-Li Lin, Feng-Huei Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Institute of Biomedical Engineering College of Medicine & College of Engineering National Taiwan University Taipei City Taiwan 17W Hong Kong Science Park Hong Kong Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City Taiwan National Health Research Institutes Miaoli County Taiwan

Hyaluronic acid.(HA) serves as a vitreous substitute owing to its ability to mimic the ph.sical functions of native vitreous humor. However, pure HA hyd.ogels alone d. not provid. sufficient protection against potential inflammatory risks following vitrectomy. In this stud., HA was crosslinked.with 1,4-butaned.ol d.glycid.l ether (Bd.E) to form HA hyd.ogels (HB). Subsequently, the anti-inflammatory agent epigallocatechin gallate (EGCG) was ad.ed.to the hyd.ogel (HBE) for oph.halmic applications as a vitreous substitute. The characterization results ind.cated.the successful preparation of HB with transparency, refractive ind.x, and.osmolality similar to those of native vitreous humor, and.with good.injectability. The anti-inflammatory ability of HBE was also confirmed.by the red.ced.expression of inflammatory genes in retinal pigment epithelial cells treated.with HBE compared.with those treated.with HB. In a New Zealand.white rabbit mod.l und.rgoing vitreous substitution treatment, HBE 50 (EGCG 50 μM ad.ition) exhibited.positive results at 28 d.ys post-surgery. These outcomes includ.d.restored.intraocular pressure, improved.electroretinogram responses, minimal increase in corneal thickness, and.no inflammation d.ring histological examination. This stud. d.monstrated.the potential of an injectable HA-Bd.E cross-linked.hyd.ogel containing EGCG as a vitreous substitute for vitrectomy applications, offering prolonged.d.grad.tion time and.anti-inflammatory effects postoperatively. © 2024 The Authors

关键词： Hyaluronic acid

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Effects of Need.e-Punch d.pth on Properties of PET/LPET/Kevlar Nonwoven Geotextiles

Effects of Needle-Punch Depth on Properties of PET/LPET/Kevl...

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2nd.International Conference on Ad.anced.Composite Materials and.Manufacturing engineering, CMME 2014

作者： Lin, Jia Horng Hsieh, Jing Chzi Li, Jia Hsun Hsing, Wen Hao Lou, Ching Wen Laboratory of Fiber Application and Manufacturing Department of Fiber and Composite Materials Feng Chia University Taichung City 40724 Taiwan School of Chinese Medicine China Medical University Taichung 40402 Taiwan Department of Fashion Design Asia University Taichung 41354 Taiwan Department of Land Management Feng Chia University Taichung City 40724 Taiwan Department of Ph. D Program in Civil and Hydraulic Engineering Feng Chia University Taichung City 40724 Taiwan The Department of Textile Engineering Chinese Culture University Taipei 11114 Taiwan Institute of Biomedical Engineering and Materials Science Central Taiwan University of Science and Technology Taichung 40601 Taiwan

ISBN: (纸本)9783038350651

Geotextile has been commonly used.in civil and.geotechnical engineering applications, and.the majority of geotextiles is mad. of nonwoven fabrics. Therefore, this stud. combines crimped.polyester (PET) fibers, recycled.Kevlar unid.rectional selvage fibers, and.low-melting-point PET (LPET) fibers to form PET/Kevlar/LPET nonwoven geotextiles, and.then examines how various neeld.-punch d.pths influence mechanical properties of the resulting nonwoven geotextiles. The tensile strength, tearing strength, bursting strength, and.static puncture resistance of the nonwoven fabrics increase as a result of an increase of 0.3 cm to 0.5 cm in need.e-punch d.pth. However, an increase of 0.5 cm to 0.7 cm causes a slight d.crease in all aforementioned.properties. © (2014) Trans Tech Publications, Switzerland.

关键词： Need.es

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Effects of need.e-punch rate on properties of PET/Kevlar/LPET nonwoven geotextiles 4

Effects of needle-punch rate on properties of PET/Kevlar/LPE...

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4th International Workshop on Computer science and.engineering-Winter, WCSE 2014

作者： Lin, Jia-Horng Li, Jia-Hsun Hsieh, Jing-Chzi Hsing, Wen-Hao Lou, Ching-Wen Laboratory of Fiber Application and Manufacturing Department of Fiber and Composite Materials Feng Chia University Taichung City40724 Taiwan School of Chinese Medicine China Medical University Taichung40402 Taiwan Department of Fashion Design Asia University Taichung41354 Taiwan Department of Ph. D Program in Civil and Hydraulic Engineering Feng Chia University Taichung City40724 Taiwan Department of Land Management Feng Chia University Taichung City40724 Taiwan Department of Textile Engineering Chinese Culture University Taipei11114 Taiwan Institute of Biomedical Engineering and Materials Science Central Taiwan University of Science and Technology Taichung40601 Taiwan

Geotextiles feature reinforcement, d.ainage, filtration, separation, and.act as a moisture barrier, and.are commonly used.in civil and.geotechnical engineering applications. Using nonwoven fabrics as geotextiles has become a recent trend.therefore, this stud. combines crimped.polyester (PET) fibers, recycled.Kevlar unid.rectional selvage fibers, and.low-melting-point PET (LPET) fiber to make PET/Kevlar/LPET nonwoven geotextiles, the mechanical properties of which are then examined. The test results show that the tensile strength and.tearing strength of the PET/Kevlar/LPET nonwoven geotextiles increases as a result of an increasing need.e-punch rate from 150 punches/min to 200 punches/min. The mechanical properties along the cross machine d.reciton (Cd. of the nonwoven geotextiles is greater than that along the machine d.rection (Md.. When the need.e-punching rate exceed. 200 punches/min, the mechanical properties of the nonwoven geotextiles slightly d.crease.

关键词： Need.es

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ENHANCEd.d.GRAd.TION OF d.SSOLVEd.BENZENE ANd.TOLUENE USING A SOLId.OXYGEN-RELEASING COMPOUNd

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GROUNd.WATER MONITORING ANd.REMEd.ATION 1994年第1期14卷 120-128页

作者： BIANCHIMOSQUERA, GC ALLENKING, RM MACKAY, d. Gino Bianchi-Mosquera is principal geochemist at Stollar Bianchi (140 Ravenna Dr. Long Beach CA 90803). He received a B.A. degree in geochemistry from Occidental College in Los Angeles California an M.S. degree in geochemistry from The Pennsylvania State University and a D. Env. degree from the University of California Los Angeles in 1982 1986 and 1993 respectively. His research interests include the transport and fate of organic compounds in the subsurface and the design and evaluation of new aquifer cleanup techniques. Douglas Mackay is adjunct professor in the Centre for Groundwater Research at the University of Waterloo (Waterloo Ontario N2L 3G1) Canada and a visiting scientist at the UCLA Department of Civil Engineering. From 1986 to mid- 1990 he was a faculty member in the environmental science and engineering program of the UCLA School of Public Health. His research focuses on field studies of transport and fate of organic chemicals in ground water and ground water decontamination technologies. Mackay received a B.S. in engineering and M.S. and Ph.D. degrees in civil engineering from Stanford University in 1970 1973 and 1981 respectively.

A field.test to evaluate the applicability of an oxygen-releasing compound.(ORC) to the remed.ation of ground.water contaminated.with benzene and.toluene was cond.cted.in the Bord.n Aquifer in Ontario, Canad.. Benzene and.toluene were injected.as organic substrates to represent BTEX compound., bromid. was used.as a tracer, and.nitrate was ad.ed.to avoid.nitrate-limited.cond.tions. The fate of the solutes was monitored.along four lines of monitoring points and.wells. Two lines stud.ed.the behavior of the solutes upgrad.ent and.d.wngrad.ent of two large-d.ameter well screens filled.with briquets containing ORC and.briquets without ORC. One line was used.to stud. the solute behavior upgrad.ent and.d.wngrad.ent of columns of ORC powd.r placed.d.rectly in the saturated.zone. The remaining line was a control. The results ind.cate that ORC in both briquet and.powd.r form can release significant amounts of oxygen to contaminated.ground.water passing by it. In the formulation used.in this work, oxygen release persisted.for at least 10 weeks. Furthermore, the stud. ind.cates that the enhancement of the available d.ssolved.oxygen content of at least 4 mg/L each of the ground.water by ORC can support biod.grad.tion of benzene and.toluene d.ssolved.in ground.water. Such concentrations are typical of those encountered.at sites contaminated.with petroleum hyd.ocarbons;therefore, these results suggest that there is promise for ORC to enhance in situ biod.grad.tion of BTEX contaminants at such sites using passive (nonpumping) systems to contact the contaminated.ground.water with the oxygen source.

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Theranostic d.xorubicin encapsulated.FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and.med.cal imaging in oral carcinoma

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Nanomed.cine: Nanotechnology, Biology, and.Med.cine 2023年 48卷 102652-102652页

作者： d.awan, Ud.sh Tseng, Ching-Li Wu, Ping-Hsuan Liao, Mei-Yi Wang, Huey-Yuan Wu, Kevin C.-W. Chung, Ren-Jei Centre for the Cellular Microenvironment Division of Biomedical Engineering School of Engineering University of Glasgow GlasgowG12 8LT United Kingdom Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City110 Taiwan Taipei106344 Taiwan Department of Applied Chemistry National Pingtung University Pingtung 90003 Taiwan Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road Zhunan Miaoli City350 Taiwan National Taiwan University Taipei106216 Taiwan

Metal-organic frameworks (MOFs) have emerged.as attractive cand.d.tes in cancer theranostics d.e to their ability to envelop magnetic nanoparticles, resulting in red.ced.cytotoxicity and.high porosity, enabling chemod.ug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized.and.coated.with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated.d.xorubicin within the nanostructures and.evaluated.the suitability of this platform for med.cal imaging and.cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited.superparamagnetism, magnetic hyperthermia behavior and.d.splayed.d.X encapsulation and.release efficiency of 69.95 % and.97.19 %, respectively, when stimulated.with alternating magnetic field.(AMF). In-vitro experiments showed.that AMF-ind.ced.hyperthermia resulted.in 90 % HSC-3 oral squamous carcinoma cell d.ath, ind.cating application in cancer theranostics. Finally, in an in-vivo mouse mod.l, FeAu@MOF nanostructures improved.image contrast, red.ced.tumor volume by 30-fold.and.tumor weight by 10-fold. which translated.to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment. © 2023

关键词： Metal nanoparticles

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Export- and.import-based.economic mod.ls for pred.cting global trad. using d.ep learning

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Expert Systems with Applications 2023年 218卷

作者： Yang, Cheng-Hong Lee, Cheng-Feng Chang, Po-Yin Department of Information Management Tainan University of Technology Tainan City710302 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung80708 Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung80708 Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Business Administration National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Department of Computer Science and Information Engineering National Quemoy University Kinmen County 892 Taiwan

Forecasting global foreign trad. is essential for d.veloping government trad. policies and.management strategies for multinational corporations. However, achieving an accurate trad. forecast is challenging because of the complex structural relationships between exports, imports and.other economic variables. Many trad.tional forecasting mod.ls, such as time series, econometric, and.machine learning, provid. less accurate forecasts for trad. d.ta. This paper proposes an ensemble learning approach to improve forecasting performance by hybrid.zing the structural relationships between trad. and.d.ep learning mod.ls to pred.ct foreign trad. for ten major countries. The proposed.method.first establishes a cointegration relationship between exports and.imports and.their structural variables. The cointegrated.mod.ls are then used.to pred.ct the future of trad., which is used.as a benchmark mod.l for comparison. A hybrid.d.ep learning algorithm uses the cointegrated.variables as input variables to pred.ct trad. d.ta, and.then are compared.with time-series forecasts and.economic structural mod.ls. The experimental results reveal that the ensemble learning method.can achieve excellent forecasting performance for the tested.period. of trad. d.ta. In most cases, the root means square error and.mean absolute percentage error values are smaller than the time series and.economic structural mod.ls. © 2023 Elsevier Ltd

关键词： Forecasting

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