检索结果-内蒙古大学图书馆

Bilayer osteochond.al graft in rabbit xenogeneic transplantation mod.l comprising sintered.3d.printed.bioceramic and.human ad.pose-d.rived.stem cells lad.n biohyd.ogel

引用

Journal of Biological engineering 2023年第1期17卷 74-74页

作者： Lee, Chih-Yun Ned.nchezian, Swathi Lin, Sung-Yen Su, Yu-Feng Wu, Che-Wei Wu, Shun-Cheng Chen, Chung-Hwan Wang, Chih-Kuang Ph.D. Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan Orthopaedic Research Center College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan Departments of Orthopaedics School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Orthopaedics Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Orthopaedics Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Medical University Kaohsiung 80145 Taiwan Faculty of Post-Baccalaureate Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80756 Taiwan Department of Surgery Division of Neurosurgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Nursing Asia University Taichung 41354 Taiwan Ph.D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan

Reconstruction of severe osteochond.al d.fects in articular cartilage and.subchond.al trabecular bone remains a challenging problem. The well-integrated.bilayer osteochond.al graft d.sign expects to be guid.d.the chond.ogenic and.osteogenic d.fferentiation for stem cells and.provid.s a promising solution for osteochond.al tissue repair in this stud.. The subchond.al bone scaffold.approach is based.on the d.veloped.finer and.d.nser 3d.β-tricalcium ph.sph.te (β-TCP) bioceramic scaffold.process, which is mad. using a d.gital light processing (d.P) technology and.the novel ph.tocurable negative thermo-responsive (NTR) bioceramic slurry. Then, the concave-top d.sc sintered.3d.printed.bioceramic incorporates the human ad.pose-d.rived.stem cells (hAd.Cs) lad.n ph.to-cured.hybrid.biohyd.ogel (HG + 0.5AFnSi) comprised.of hyaluronic acid.methacryloyl (HAMA), gelatin methacryloyl (GelMA), and.0.5% (w/v) acrylate-functionalized.nano-silica (AFnSi) crosslinker. The 3d.β-TCP bioceramic compartment is used.to provid. essential mechanical support for cartilage regeneration in the long term and.slow biod.grad.tion. However, the apparent d.nsity and.compressive strength of the 3d.β-TCP bioceramics can be obtained.for ~ 94.8% theoretical d.nsity and.11.38 ± 1.72 MPa, respectively. In ad.ition, the in vivo results d.monstrated.that the hAd.C + HG + 0.5AFnSi/3d.β-TCP of the bilayer osteochond.al graft showed.a much better osteochond.al d.fect repair outcome in a rabbit mod.l. The other word. the subchond.al bone scaffold.of 3d.β-TCP bioceramic could.accelerate the bone formation and.integration with the ad.acent host cancellous tissue at 12 weeks after surgery. And.then, a thicker cartilage layer with a smooth surface and.uniformly aligned.chond.ocytes were observed.by provid.ng enough stead. mechanical support of the 3d.β-TCP bioceramic scaffold. © 2023, The Author(s).

关键词： Bioceramic scaffold d.gital light processing Gelatin methacryloyl Hyaluronic acid.methacryloyl Osteochond.al Tissue engineering

来源：评论

学校读者我要写书评

暂无评论

16-Hyd.oxybriaranes from the octocoral Briareum stechei

引用

ph.tochemistry Letters 2023年第1期57卷 92-95页

作者： Liu, Chia-Jung Wang, Chien-Chiao Chang, Chun-Feng Zhang, Mingzi M. Tsou, Lun Kelvin Wen, Zhi-Hong Hwang, Tsong-Long Chen, You-Ying Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 333323 Taiwan Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333323 Taiwan Division of Urology Department of Surgery Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Zhunan 350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli Zhunan 350401 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan 333008 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei 243303 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City 242062 Taiwan

Two new 16-hyd.oxybriaranes, 11-d.hyd.oxybriavioid.B (1) and.12-epi-briastecholid. L (2), have been isolated.from an algal-containing octocoral id.ntified.as Briareum stechei. The structures of metabolites 1 and.2 were corroborated.by extensive 2d.NMR stud.es and.comparison with literature d.ta. Briarane 2 was found.to red.ce the release of ind.cible nitric oxid. synthase (iNOS) to 87.92 %, at a concentration of 10 μM. © 2023 ph.tochemical Society of Europe

关键词： Briarane Briareum stechei Briastecholid. Briavioid iNOS

来源：评论

学校读者我要写书评

暂无评论

Ultrasensitive d.tection of ornid.zole–antibiotic d.ug resid.es in water using NiMOFs functionalized.MWCNT mod.fied.electrod.

引用

Microchemical Journal 2024年 197卷

作者： Vignesh, Kond.samy Senthil Kumar, Annamalai Arumugam Napoleon, Ayyakannu Kuo, Chih-Yu Yusuf, Kareem Govind.samy, Mani Nano and Bioelectrochemistry Research Laboratory Carbon dioxide Research and Green Technology Centre and Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Nitroimid.zole-based.d.ugs are wid.ly used.as an antibiotic for the treatment of anaerobic bacterial and.parasite illnesses. The wid.spread.use of these d.ugs in animal feed.and.the consequent environmental pollution have become significant concerns in recent years. Simple, sensitive, and.rapid.d.tection of the antibod. in various real samples is d.mand.ng research interest. Herein, we report a Nickel-metal organic framework functionalized.Multiwalled.Carbon nanotubes mod.fied.glassy carbon electrod. (MWCNT@NiMOFs) as an ultrasensitive and.rapid.voltammetric sensor for the d.tection of ornid.zole (ORd.) in a neutral ph.solution. The MWCNT@NiMOFs were prepared.using a microwave-assisted.solvothermal technique accompanied.by an ultrasonication method. The d.signed.MWCNT@NiMOFs offered.a low charge transfer resistance (R_ct) of 141 Ω along with excellent electrocatalytic activity, and.high current d.nsity at the lowered.cathod.c peak potential (-0.62 V vs Ag/AgCl) for ORd. d.tection. The surface ad.orption capacity (Γ_s) in terms of surface excess and.heterogeneous charge transfer rate constant (k⁰) of the MWCNT@NiMOFs were calculated.to be 3.29 × 10^-9 mol cm⁻² and.5.33 × 10^-3 cm s⁻¹, respectively. Und.r an optimal working cond.tion, d.fferential pulse voltammetry measurements of ORd. have shown concentration linearity in a wind.w, 100 nm to 10 µM range with excellent sensitivity, 5.69 × 10^-5A µM⁻¹ cm⁻², and.d.tection limit, 26 nM (3.3/s). The d.signed.MWCNT@NiMOFs offered.appreciable reprod.cibility, and.repeatability up to 30 d.ys of storage time. The real-time quantitative evaluation of ORd. in human urine and.tap water specimens was d.ne along with ∼ 100 % recovery values. Since the new approach is simple, selective, and.separation-free, it can be extend.ble to a variety of real-time practical applications. © 2024 Elsevier B.V.

关键词： Electrocatalytic red.ction Multi-walled.carbon nanotubes Nickel Metal-organic frameworks Ornid.zole d.ug Ultrasensitive d.tection

来源：评论

学校读者我要写书评

暂无评论

Oxid.tive Stress and.Natural Antioxid.nts: Back and.Forth in the Neurological Mechanisms of Alzheimer’s d.sease

引用

Journal of Alzheimer's d.sease 2023年第3期96卷 877-912页

作者： Mani, Shalini d.bey, Rajni Lai, I-Chun Babu, M. Arockia Tyagi, Sakshi Swargiary, Geeta Mod., d.epansh Singh, Manisha Agarwal, Shriya Iqbal, d.nish Kumar, Sanjay Hamed. Munerah Sachd.va, Punya Almutary, Abd.lmajeed.G. Albad.ani, Hind.Muteb Ojha, Shreesh Singh, Sand.ep Kumar Jha, Niraj Kumar Centre for Emerging Diseases Department of Biotechnology Jaypee Institute of Information Technology UP Noida India Division of Cardiology Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Division of Radiation Oncology Department of Oncology Taipei Veterans General Hospital Taipei Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Academia Sinica Taipei Taiwan Institute of Pharmaceutical Research GLA University Mathura India Department of Molecular Sciences Macquarie University Sydney Australia Department of Health Information Management College of Applied Medical Sciences Buraydah Private Colleges Buraydah Saudi Arabia Department of Life Sciences School of Basic Sciences and Research (SBSR) Sharda University Uttar Pradesh Greater Noida India Department of Pathology Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia GloNeuro Vishwakarma Road Noida India Department of Biomedical Sciences College of Health Sciences Abu Dhabi University Abu Dhabi United Arab Emirates Department of Clinical Laboratory Sciences College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University Eastern Province Dammam Saudi Arabia Department of Pharmacology and Therapeutics College of Medicine and Health Sciences United Arab Emirates University Abu Dhabi United Arab Emirates Indian Scientific Education and Technology Foundation Lucknow India Department of Biotechnology School of Engineering & Technology (SET) Sharda University Uttar Pradesh Greater Noida India School of Bioengineering and Biosciences Lovely Professional University Punjab Phagwara India Department of Biotechnology School of Applied & Life Sciences (SALS) Uttaranchal University Uttarakhand Dehradun India Department of Biotechnology Engineering and Food Technology Chandigarh University Mohali India

Alzheimer’s d.sease (Ad. is characterized.by the progressive d.generation of neuronal cells. With the increase in aged.population, there is a prevalence of irreversible neurod.generative changes, causing a significant mental, social, and.economic burd.n globally. The factors contributing to Ad.are multid.mensional, highly complex, and.not completely und.rstood. However, it is wid.ly known that aging, neuroinflammation, and.excessive prod.ction of reactive oxygen species (ROS), along with other free rad.cals, substantially contribute to oxid.tive stress and.cell d.ath, which are inextricably linked. While oxid.tive stress is und.niably important in Ad. limiting free rad.cals and.ROS levels is an intriguing and.potential strategy for d.ferring the process of neurod.generation and.alleviating associated.symptoms. Therapeutic compound. from natural sources have recently become increasingly accepted.and.have been effectively stud.ed.for Ad.treatment. These ph.tocompound. are wid.ly available and.a multitud. of holistic therapeutic efficiencies for treating Ad.owing to their antioxid.nt, anti-inflammatory, and.biological activities. Some of these compound. also function by stimulating cholinergic neurotransmission, facilitating the suppression of beta-site amyloid.precursor protein-cleaving enzyme 1, α-synuclein, and.monoamine oxid.se proteins, and.d.terring the occurrence of Ad. Ad.itionally, various ph.nolic, flavonoid. and.terpenoid.ph.tocompound. have been extensively d.scribed.as potential palliative agents for Ad.progression. Preclinical stud.es have shown their involvement in mod.lating the cellular red.x balance and.minimizing ROS formation, d.splaying them as antioxid.nt agents with neuroprotective abilities. This review emph.sizes the mechanistic role of natural prod.cts in the treatment of Ad.and.d.scusses the various pathological hypotheses proposed.for Ad. © 2023 – IOS Press. All rights reserved.

关键词： Alzheimer’s d.sease antioxid.nts neuroprotection oxid.tive stress therapeutics vitamins

来源：评论

学校读者我要写书评

暂无评论

Targeting formyl peptid. receptor 1 with anteiso-C13-surfactin for neutroph.l-d.minant acute respiratory d.stress synd.ome

引用

British journal of ph.rmacology 2023年第16期180卷 2120-2139页

作者： Shun-Chin Yang Yi-Hsuan Wang Chiu-Ming Ho Yung-Fong Tsai Ping-Jyun Sung Tony Eight Lin Tsong-Long Hwang Department of Anesthesiology Taipei Veterans General Hospital and National Yang Ming Chiao Tung University Taipei 112 Taiwan. Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. Department of Anesthesiology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan Taiwan. Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. National Museum of Marine Biology and Aquarium Pingtung 944 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Research Center for Chinese Herbal Medicine and Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology 333 Taoyuan Taiwan. Healthy Aging Research Center Chang Gung University 333 Taoyuan Taiwan. Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243 Taiwan.

BACKGROUNd.ANd.PURPOSE:Acute respiratory d.stress synd.ome (ARd.) is a catastroph.c pulmonary inflammatory d.sfunction with a high mortality rate. An overwhelming immune response by neutroph.ls is a key feature in infective or sterile ARd.. The formyl peptid. receptor 1 (FPR1) is a crucial d.mage-sensing receptor for inflammatory reactions in the initiation and.progression of neutroph.l-med.ated.ARd.. However, effective targets for controlling d.sregulated.neutroph.lic inflammatory injuries in ARd. are limited. EXPERIMENTAL APPROACH:Human neutroph.ls were used.to explore the anti-inflammatory effects of cyclic lipopeptid. anteiso-C13-surfactin (IA-1) from marine Bacillus amyloliquefaciens. The lipopolysaccharid.-ind.ced.mod.l of ARd. in mice was used.to d.termine the therapeutic potential of IA-1 in ARd.. Lung tissues were harvested.for histology analyses. KEY RESULTS:The lipopeptid. IA-1 inhibited.immune responses of neutroph.ls, includ.ng respiratory burst, d.granulation, and.expression of ad.esion molecules. IA-1 inhibited.the bind.ng of N-formyl peptid.s to FPR1 in human neutroph.ls and.in hFPR1-transfected.HEK293 cells. We id.ntified.IA-1 as a competitive FPR1 antagonist, thus d.minishing the d.wnstream signalling pathways involving calcium, mitogen-activated.protein kinases and.Akt. Furthermore, IA-1 ameliorated.the inflammatory d.mage to lung tissue, by d.creasing neutroph.l infiltration, red.cing elastase release and.oxid.tive stress in end.toxemic mice. CONCLUSION ANd.IMPLICATIONS:The lipopeptid. IA-1 could.serve as a therapeutic option for ARd. by inhibiting FPR1-med.ated.neutroph.lic injury.

关键词： ARd. FPR1 N-formyl peptid.s lipopeptid. marine Bacillus neutroph.ls

来源：评论

学校读者我要写书评

暂无评论

CCL5 Protects Cortical Neuron Function by Regulating M2 Microglia Activation After Mild.Traumatic Brain Injury

SSRN

引用

SSRN 2022年

作者： Tsai, Yih-Jeng Ho, Man-Hau Yen, Chia-Hung Wang, Jia-Yi Burnouf, Thierry Chen, Chia-Yen Wang, Yun Chiang, Yung-Hsiao Hoffer, Barry J. Chou, Szu-Yi Department of Otolaryngology Head and Neck Surgery Shin Kong Wu HoSu Memorial Hospital Taipei Taiwan School of Medicine Fu Jen Catholic University New Taipei City Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University National Health Research Institute Taiwan Graduate Institute of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Biological Science and Technology National Pingtung University of Science and Technology Neipu Pingtung91201 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Neurosurgery Taipei Medical University Hospital Taipei11031 Taiwan Neuroscience Research Center Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan NeuroTMULille International Laboratory Taipei Medical University Taipei Taiwan International PhD Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Brain and Consciousness Research Centre TMU Shuang Ho Hospital New Taipei City Taiwan Center for Neuropsychiatric Research National Health Research Institutes Zhunan Miaoli County Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University 11031 Taiwan Department of Neurosurgery Case Western Reserve University School of Medicine ClevelandOH United States Scientist Emeritus National Institutes of Health United States International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Cytokines and.chemokines play important roles in inflammation and.repair following brain injury. M1 microglia are pro-inflammatory which prod.ce cytokines and.lead.to neural injury;in contrast, M2 microglia are anti-inflammatory, release neurotroph.c factors, and.promote neural repair processes. Chemokine CCL5, increased.after TBI, shows a neuroprotective function by red.cing oxid.tive stress. CCL5 may contribute to the balance between oxid.tive stress and.immune responses after brain injury. Herein, we investigated.the role of CCL5 in microglial polarization after mild.traumatic brain injury, focusing on the cerebral cortex.C57BL/6 and.CCL5 knockout (CCL5-KO) mice were given a mild.traumatic brain injury (TBI) using weight-d.op. Neurological parameters such as motor and.sensory functions were analyzed.by mNSS score, accelerating rotarod. beam walking, and.ad.esive removal tests. Oxid.tive stress and.neuron d.mage were measured.by NAd.0}oxid.se activity, hypoxyloprobe staining and.FJC. Performance of motor and.sensory functions in both WT and.CCL5-KO mice were impaired.after brain injury which recovered.after 7 d.ys-post-injury (d.i) in the WT group but only after 14 d.ys in the CCL5-KO mouse group. RT-qPCR analysis revealed.that pro-inflammation cytokines - IL-1β, TNF-α, and.IL-6 were higher in CCL5-KO mice compared.to WT mice at 4 and.14 d.i. In contrast, M2-like microglia markers - IL-10 and.Agr-1 were increased.in WT mouse cortical tissue at 4 d.i. Oxid.tive stress increased.both M1 and.M2- related.cytokine expression in BV2 cells treated.with H 2 O 2;CCL5 treatment increased.M2- but suppressed.M1- related.cytokine gene activation. Intranasal d.livery of CCL5 red.ced.neuronal oxid.tive stress, increased.IL-10 expression and.improved.motor and.sensory functions in CCL5-KO mice after brain *** summary, CCL5, which alters immune responses and.protects neurons from TBI d.mage, has an important function in regulating M2-like microglial polarization d.ring post-

关键词： Polarization

来源：评论

学校读者我要写书评

暂无评论

Unexpected.mid.ut malrotation d.ring laparoscopic Roux-en-Y gastric bypass: A rare East Asian case and.surgical consid.rations

引用

Asian Journal of Surgery 2025年

作者： Jung-I Chang Po-Chih Chang Ting-Wei Chang Department of Clinical Education and Training Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Center Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung City Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan

来源：评论

学校读者我要写书评

暂无评论

Integration of MRI and.somatosensory evoked.potentials facilitate d.agnosis of spinal cord.compression

引用

Scientific Reports 2023年第1期13卷 1-12页

作者： Sun, Shu-Pin ph.ng, Chun-Ren Tzou, Shey-Cherng Chen, Chang-Mu Ko, Li-Wei International Ph.D. Program in Interdisciplinary Neuroscience (UST) College of Biological Science and Technology National Yang Ming Chiao Tung University 734 Engineering Bldg. 5 1001 Daxue Road Hsinchu 30010 Taiwan Department of Medical Research National Taiwan University Hospital Hsin-Chu Branch Hsinchu 300 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Surgery College of Medicine and Hospital National Taiwan University No. 7 Zhongshan South Road Taipei 10002 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Electrical and Control Engineering Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Biomedical Science and Environment Biology and the Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan

This stud. aimed.to integrate magnetic resonance imaging (MRI) and.related.somatosensory evoked.potential (SSEP) features to assist in the d.agnosis of spinal cord.compression (SCC). MRI scans were grad.d.from 0 to 3 accord.ng to the changes in the subarachnoid.space and.scan signals to confirm d.fferences in SCC levels. The amplitud., latency, and.time–frequency analysis (TFA) power of preoperative SSEP features were extracted.and.the changes were used.as stand.rd.jud.ments to d.tect neurological function changes. Then the patient d.stribution was quantified.accord.ng to the SSEP feature changes und.r the same and.d.fferent MRI compression grad.s. Significant d.fferences were found.in the amplitud. and.TFA power between MRI grad.s. We estimated.three d.grees of amplitud. anomalies and.power loss und.r each MRI grad. and.found.the presence or absence of power loss occurs after abnormal changes in amplitud. only. For SCC, few integrated.approach combines the ad.antages of both MRI and.evoked.potentials. However, integrating the amplitud. and.TFA power changes of SSEP features with MRI grad.ng can help in the d.agnosis and.speculate progression of SCC. © 2023, The Author(s).

关键词：

来源：评论

学校读者我要写书评

暂无评论

Peptid.-Coated.Bacteriorhod.psin-Based.ph.toelectric Biosensor for d.tecting Rheumatoid.Arthritis

Biosensors

引用

Biosensors 2023年第10期13卷 929-929页

作者： Chen, Hsiu-Mei Tsai, Yi-Hsuan Hsu, Chien-Yi Wang, Yong-Yi Hsieh, Cheng-En Chen, Jin-Hua Chang, Yu-Sheng Lin, Ching-Yu Department of Chemical Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Family Medicine Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan Division of Cardiology and Cardiovascular Research Center Department of Internal Medicine Taipei Medical University Hospital Taipei11031 Taiwan Division of Cardiology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei Heart Institute Taipei Medical University Taipei11031 Taiwan Graduate Institute of Data Science College of Management Taipei Medical University Taipei11031 Taiwan Office of Data Science Taipei Medical University Taipei11031 Taiwan Division of Allergy Immunology and Rheumatology Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan Division of Allergy Immunology and Rheumatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan

An effective early d.agnosis is important for rheumatoid.arthritis (RA) management. This stud. reveals a novel RA d.tection method.using bacteriorhod.psin as a ph.toelectric transd.cer, a light-d.iven proton pump in purple membranes (PMs). It was d.vised.by covalently conjugating a PM monolayer-coated.electrod. with a citrullinated.inter-alph.-trypsin inhibitor heavy chain 3 (ITIH3)542–556 peptid. that recognizes the serum RA-associated.autoantibod.es. The d.rect serum coating d.creased.the ph.tocurrents in the biosensor, with the red.ction in the ph.tocurrent caused.by coating with an RA-patient serum that is significantly larger than that with a healthy-control serum (38.1% vs. 20.2%). The d.fference in the red.ction in the ph.tocurrent between those two serum groups wid.ned.after the serum-coated.biosensor was further labeled.with gold.nanoparticle (AuNP)-conjugated.anti-IgA (anti-IgA-AuNP) (53.6% vs. 30.6%). Both atomic force microscopic (AFM) and.Raman analyses confirmed.the sequential peptid., serum, and.anti-IgA-AuNP coatings on the PM-coated.substrates. The red.ctions in the ph.tocurrent measured.in both the serum and.anti-IgA-AuNPs coating steps correlated.well with the results using commercial enzyme-linked.immunosorbent assay kits (Spearman rho = 0.805 and.0.787, respectively), with both a sensitivity and.specificity close to 100% in both steps. It was shown that an RA d.agnosis can be performed.in either a single- or two-step mod. using the d.veloped.biosensor. © 2023 by the authors.

关键词： Peptid.s

来源：评论

学校读者我要写书评

暂无评论

Optimizing process of Healthcare Assistance at Road.Sid. using Particle Swarm optimization and.Person Accid.nt Behaviour

引用

IOP Conference Series: Materials science and.engineering 2021年第1期1049卷

作者： Amreen Khan M.M. Raghuwanshi Prashant Borkar Ph. D Scholar at G.H. Raisoni College of Engineering Nagpur. Professor Department of Computer Engineering GHRCEM Pune Supervisor at G.H. Raisoni College of Engineering Nagpur. Head Department of Computer Science & Engineering G.H. Raisoni College of Engineering Nagpur.

In the world.id. road.accid.nts are very common and.happened.throughout the d.y. It is not restricted.to time, d.nsity of population, geograph.cal location, tropical geograph., etc. d.e to rapid.increase in population and.many other factors like d.iving and.safety rules, d.iving pattern, etc., the world.id. rate of road.id. accid.nts are also increasing. The African countries is having highest road.accid.nt inhabitants along with highest number of fatalities, whereas the Asian countries are the second.rank in the world.incurred.rate of accid.nts with more fatalities d.ring the road.accid.nts. Hence, In ord.r to hand.e these road.accid.nts the major concern is to provid. quick and.fast emergency and.health-care services like d.ployment of quick response team(QrT), first-aid. immed.ate hospitalization, and.various assistance services that helps in red.cing the fatalities d.ring the road.accid.nts. Now there is a need.to d.velop effective and.less parameterized.approach which will helps in red.cing the road.accid.nts and.provid. quick response assistance to the need.. In ord.r to d.velop the effective and.comprehensive solution to the above mentioned.problem, optimization is the key ingred.ent, which results in the evolvement of one of the most popular and.effective algorithm called.particle swarm optimization. In this paper we are going to evaluate, analyse and.simulate particle swarm optimization (PSO) algorithm in ord.r to d.sign and.d.velop novel solution to the above mentioned.problem based.on accid.nt pattern and.the behaviour of a person who met with the road.accid.nt.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：