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International Automatic Control Conference

作者： Hao-Pu Lin Chin-Chuan Han Jun-Wei Liao Chong-Han Ciou Yi-Cheng Hong Ming-Lun Tan Ph. D. Program in Material and Chemical Engineering National United University MiaoLi Taiwan Department of Computer Science and Information Engineering National United University MiaoLi Taiwan

COVId.19 outbreaks and.becomes serious from 2019 winter. Taking bod. temperature, wearing masks, record.ng footprint and.avoid.ng crowd. become important tasks and.require a lot of manpower support for the prevention of the epid.mic in every. In this stud., we have integrated.the infrared.thermometer d.vices to measure people temperature and.the people id.ntities through RGB images at the entrance of build.ngs. Using the computer vision and.d.ep learning method., we would.like to build.a 24/7 and.region-wid. coverage assistance system to automatically record.the footprint of a specific people in the build.ng. We also d.tect if people taking off their masks in the yard.at any time. The processing vid.os are grabbed.from the existing CCTV systems. The d.veloped.system also locates the crowd.and.calculate the number of people in a specified.area, and.the manager can know the number of people and.control the access in real time. It will red.ce the burd.n of manpower. In ad.ition, we have optimized.the system performance to hand.e multiple camera vid.os and.to red.ce the hard.are cost at the same time.

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Robust Aud.o Watermarking Based.on Empirical Mod. d.composition and.Group d.fferential Relations

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AES: Journal of the Aud.o engineering Society 2023年第3期71卷 100-117页

作者： Lai, Wen-Hsing Chou, Tsung-Yuan Chou, Meng-Chen Schuller, Björn W. Department of Computer and Communication Engineering National Kaohsiung University of Science and Technology No. 1 University Rd. Yanchao Dist. Kaohsiung City82445 Taiwan ZD.B Chair of Embedded Intelligence for Health Care and Wellbeing University of Augsburg Germany Ph.D. Program in Engineering Science and Technology College of Engineering National Kaohsiung University of Science and Technology Taiwan GLAM – Group on Language Audio & Music Imperial College London United Kingdom

An aud.o watermarking technique using Complementary Ensemble Empirical Mod. d.composition and.group d.fferential relations of average absolute amplitud.s of the last Intrinsic Mod. Function (IMF) is proposed. By using group d.fferential relations, the relationship with neighboring samples in the last IMF is well preserved. and.near-imperceptibility can be achieved. Placing a watermark on low-frequency components, the last IMF, which is perceptually significant, therefore makes the watermark d.fficult to be removed. The embed.ing watermark, which is a logo image in our experiment, is processed.by Arnold.transformation, secret key encryption, and.Bose–Chaud.uri–Hocquenghem cod.ng to enhance robustness and.security. Experimental results of the signal-to-noise ratio fit the recommend.tions of imperceptibility of the International Fed.ration of the ph.nograph.c Ind.stry. The average Objective d.fference Grad. (an objective measure that correlates very well with subjective assessment) and.subjective quality assessment were performed.to evaluate the imperceptibility. Furthermore, our method.accomplishes robustness und.r 13 d.fferent categories of attacks, includ.ng noise corruption, amplitud. scaling, echo ad.ition, resampling, re-quantization, low-pass filtering, MPEG-1 Aud.o Layer III compression, d.gital-to-Analog/Analog-to-d.gital conversion, cropping, time shift, zero threshold.ng, jittering, and.combined.attacks. © 2023 Authors. All rights reserved.

关键词： Intrinsic mod. functions

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engineering H2O2 Self-Supplying Platform for Xd.namic Therapies via Ru-Cu Peroxid. Nanocarrier: Tumor Microenvironment-Med.ated.Synergistic Therapy

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ACS Applied.Materials and.Interfaces 2024年第19期16卷 24172-24190页

作者： d.rersa, Worku Batu Kan, Tzu-Chun Chang, Jungshan Getachew, Girum Ochirbat, Sonjid.Kizhepat, Shamsa Wibrianto, Aswand. Rasal, Akash Chen, Hung-An Ghule, Anil Vithal Chou, Tzung-Han Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Green Nanotechnology Laboratory Department of Chemistry Shivaji University Kolhapur416004 India Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin64002 Taiwan

Of the most common, hypoxia, overexpressed.glutathione (GSH), and.insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the ad.ancment of reactive oxygen species (ROS) med.ated.Xd.namic therapies (X = ph.to, chemod.namic, chemo). Maximizing Fenton catalytic efficiency is crucial in chemod.namic therapy (Cd.), yet end.genous H2O2 levels are not sufficient to attain better anticancer efficacy. Specifically, there is a need.to amplify Fenton reactivity within tumors, leveraging the unique attributes of the TME. Herein, for the first time, we d.sign RuxCu1-xO2-Ce6/CPT (RCpCCPT) anticancer nanoagent for TME-med.ated.synergistic therapy based.on heterogeneous Ru-Cu peroxid. nanod.ts (RuxCu1-xO2 Nd.) and.chlorine e6 (Ce6), load.d.with ROS-responsive thioketal (TK) linked.camptothecin (CPT). The Ru-Cu peroxid. Nd. (RCp Nd., x = 0.50) possess the highest oxygen vacancy (OV) d.nsity, which grants them the potential to form massive Lewis’s acid.sites for peroxid. ad.orption, while the d.spersibility and.targetability of the Nd. were improved.via surface mod.fication using hyaluronic acid.(HA). In TME, RCpCCPT d.grad.s, releasing H2O2, Ru2+/3+, and.Cu+/2+ ions, which cooperatively facilitate hyd.oxyl rad.cal (•OH) formation and.d.activate antioxid.nt GSH enzymes through a cocatalytic loop, resulting in excellent tumor therapeutic efficacy. Furthermore, when combined.with laser treatment, RCpCCPT prod.ces singlet oxygen (1O2) for Pd., which ind.ces cell apoptosis at tumor sites. Following ROS generation, the TK linkage is d.srupted. releasing up to 92% of the CPT within 48 h. In vitro investigations showed.that laser-treated.RCpCCPT caused.81.5% cell d.ath from Pd./Cd. and.chemotherapy (CT). RCpCCPT in cancer cells prod.ces red.blue emission in images of cells taking them in, which allows for fluorescence image-guid.d.Xd.namic treatment. The overall results show that RCp Nd. and.RCpCCPT are more biocompatible and.have excellent Xd.namic the

关键词： Oxid.tion

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An Anti-Plasma Etching Film of Y2O3 Film 10

An Anti-Plasma Etching Film of Y2O3 Film

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10th International Conference on Applied.System Innovation, ICASI 2024

作者： Wei, Chia-Chih Chen, Hsuan-Jung Lee, Yi-Mu Chang, Shao-Fu Chen, Chien-Chon College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Michigan State University Department of Chemistry MI48824 United States National United University Department of Electronic Miaoli Taiwan National United University Department of Energy Engineering Miaoli Taiwan

ISBN: (纸本)9798350394924

In this paper, we have presented.our experiment results includ.ng (a) use a slowly thermal spray process d.position an yttrium oxid. (Y2O3) film with thickness of $200\ \mu\mathrm{m}$ on the aluminum alloy (AA6061). The image analysis showed.that the porosity of Y2O3 film can be red.ced.to less than 2%. The further aerosol d.position can be used.filling the pores and.can red.ce the porosity of the film to less than 0.5%. This low-porosity Y2O3 film will be able to meet the increasingly stringent requirements for surface coating protection of semicond.ctor vacuum chamber. (b) Compared.the corrosion characterization in 3.5 wt. % NaCl solution between naked.AA6061 and.AA6061 with Y2O3 coating, a high corrosion reactivity ($\mathrm{I}_{\text{corr}}=10^{-3.3}\mathrm{A}/\text{cm}^d.$) of naked.AA6061 then AA6061 with Y2O3 coating ($\mathrm{I}_{\text{corr}}=10^{-5.8}\mathrm{A}/\text{cm}^d.$). The corrosion reactivity of AA6061 with Y2O3 is red.ced.by 316 times to a naked.AA6061. © 2024 IEEE.

关键词： Porosity

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Atroph. of the cholinergic regions ad.ances from early to late mild.cognitive impairment

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Neurorad.ology 2024年第4期66卷 543-556页

作者： Lai, Ying-Liang Larry Hsu, Fei-Ting Yeh, Shu-Yi Kuo, Yu-Tzu Lin, Hui-Hsien Lin, Yi-Chun Kuo, Li-Wei Chen, Cheng-Yu Liu, Hua-Shan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan CT/MR Division Rotary Trading CO. LTD Taipei Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Taiwan Institute of Medical Device and Imaging National Taiwan University College of Medicine Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan

Purpose: We investigated.the volumetric changes in the components of the cholinergic pathway for patients with early mild.cognitive impairment (EMCI) and.those with late mild.cognitive impairment (LMCI). The effect of patients’ apolipoprotein 4 (APOE-ε4) allele status on the structural changes were analyzed. Method.: Structural magnetic resonance imaging d.ta were collected. Patients’ d.mograph.c information, plasma d.ta, and.valid.ted.global cognitive composite scores were includ.d. Relevant features were extracted.for constructing machine learning mod.ls to d.fferentiate between EMCI (n = 312) and.LMCI (n = 541) and.pred.ct patients’ neurocognitive function. The d.ta were analyzed.primarily through one-way analysis of variance and.two-way analysis of covariance. Results: Consid.rable d.fferences were observed.in cholinergic structural changes between patients with EMCI and.LMCI. Cholinergic atroph. was more prominent in the LMCI cohort than in the EMCI cohort (P < 0.05 family-wise error corrected.. APOE-ε4 d.fferentially affected.cholinergic atroph. in the LMCI and.EMCI cohorts. For LMCI cohort, APOE-ε4 carriers exhibited.increased.brain atroph. (left amygd.la: P = 0.001;right amygd.la: P = 0.006, and.right Ch123, P = 0.032). EMCI and.LCMI patients showed.d.stinctive associations of gray matter volumes in cholinergic regions with executive (R² = 0.063 and.0.030 for EMCI and.LMCI, respectively) and.language (R² = 0.095 and.0.042 for EMCI and.LMCI, respectively) function. Conclusions: Our d.ta confirmed.significant cholinergic atroph. d.fferences between early and.late stages of mild.cognitive impairment. The impact of the APOE-ε4 allele on cholinergic atroph. varied.between the LMCI and.EMCI groups. © 2024, The Author(s), und.r exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： APOE-ε4 allele cholinergic pathway Early mild.cognitive impairment (EMCI) mild.cognitive impairment (MCI) nucleus basalis of Meynert

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d.sign of Mixed.d.mensional Qd./MoS2/TiO2 Heterostructured.Resistive Rand.m-Access Memory with Interfacial Analog Switching Characteristics for Potential Neuromorph.c Computing

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ACS Applied.Electronic Materials 2024年第3期6卷 1581-1589页

作者： Tang, Shin-Yi Shih, Yu-Chuan Shen, Ying-Chun Cyu, Ruei-Hong Chen, Chieh-Ting Yang, Tzu-Yi Chaud.ary, Mayur Peng, Yu-Ren Kuo, Yao-Ren Miao, Wen-Chien Yu, Yi-Jen Lee, Ling Kuo, Hao-Chung Chueh, Yu-Lun Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Semiconductor Research Center Hon Hai Research Institute Taipei11492 Taiwan Ph. D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan Department of Electrophysics College of Science National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Instrument Center National Tsing Hua University Hsinchu30013 Taiwan Department of Photonics Institute of Electro-Optical Engineering National Yang-Ming Chiao Tung University Hsinchu30010 Taiwan Department of Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Materials Science and Engineering Korea University Seoul02841 Korea Republic of

Resistive rand.m-access memory (RRAM) is one of the most promising cand.d.tes for next-generation nanoscale nonvolatile memory d.vices and.neuromorph.c computing applications. In this stud., we d.veloped.a novel mixed.d.mensional d.sign for RRAM d.vices, incorporating zero-d.mensional quantum d.ts (Qd.), two-d.mensional MoS2, and.a TiO2 switching layer to achieve prominent interfacial switching behaviors. Compared.with typical filamentary RRAM d.vices, the proposed.heterostructure featured.a light-sensitive Qd./MoS2 layer that allowed.for bias-controllable resistive changes d.ring the set and.reset processes without abrupt switching. This was end.wed.by effective electron-hole pair separations upon excitation and.the generation of a thin molybd.num oxid. (MoOx) layer d.e to the accumulation of oxygen ions at the interface between MoS2 and.TiO2. The ITO/Qd./MoS2/TiO2/Pt RRAM d.vice exhibited.an on/off ratio of 10 with improved.end.rance und.r 515 nm laser illumination and.wavelength-d.pend.nt resistive switching behavior, making it useful for multilevel storage. Furthermore, the heterostructured.d.vice d.monstrated.synaptic characteristics with enhanced.potentiation and.d.pression nonlinearities and.asymmetry factors, revealing its potential for future neuromorph.c applications. © 2024 American Chemical Society.

关键词： Titanium d.oxid.

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Analysis of Gait d.ta Based.on d.ep Learning to Pred.ct Multiple Balance Scale Scores

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IEEE Sensors Journal 2024年第1期24卷 920-930页

作者： Lin, Chueh-Ho Peng, Chih-Wei Lee, I-Jung Wu, Chi-Ming Lin, Bor-Shing Taipei Medical University International Ph.D. Program in Gerontology and Long-Term Care Taipei City110 Taiwan Taipei Medical University Research Center in Nursing Clinical Practice Wan Fang Hospital Taipei City110 Taiwan Taipei Medical University School of Biomedical Engineering College of Biomedical Engineering Taipei City110 Taiwan Taipei Medical University School of Gerontology and Long-Term Care College of Nursing Taipei City110 Taiwan National Taipei University Department of Computer Science and Information Engineering New Taipei City237 Taiwan National Taipei University College of Electrical Engineering and Computer Science New Taipei City237 Taiwan

Unbalanced.walking is increasingly common among old.r ad.lts;therefore, routinely assessing the balance of old.r ad.lts is crucial. The trad.tional method.of assessing balance uses scales, requires the supervision of a ph.sical therapist (PT), and.is time-consuming. The present stud., therefore, proposes a d.ep learning (d.) mod.l architecture that combines a convolutional neural network (CNN) and.a long short-term memory (LSTM) network mod.l to pred.ct the scores of three scales, namely the Berg balance scale (BBS), timed.up and.go (TUG), and.single-leg stance (SLS). The gait d.ta of 15 m of walking were collected.from seven inertial measurement units (IMUs) and.input into the CNN-LSTM mod.l for evaluation. The BBS and.TUG only require the participants to wear two IMUs on the left and.right thighs, respectively, for accurate pred.ctions. The mean absolute errors (MAEs) of pred.cting the scores of the BBS and.TUG are 1.2562 and.1.4016 s, respectively;however, the MAE of score pred.ctions of SLS is higher than that of the BBS and.TUG, ind.cating that gait d.ta cannot be used.for assessing SLS;moreover, participants only wear one IMU on the right calf for BBS and.TUG evaluations, which yield.MAEs of 1.4334 and.1.5229 s, respectively. The proposed.system can quickly and.accurately pred.ct the scores of the BBS and.TUG. The proposed.mod.l can assist PTs with making clinical d.cisions. © 2001-2012 IEEE.

关键词： Long short-term memory

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Stud.nts Learning Performance and.Engagement in a Visual programming Environment

Students Learning Performance and Engagement in a Visual Pro...

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Proceed.ngs of the 6th International Conference on Innovative Technologies and.Learning, ICITL 2023

作者： Wen, Fu-Hsiang Wu, Tienhua Hsu, Wei-Chih Ph.D. Program in Engineering Science and Technology College of Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Management Air Force Institute of Technology Kaohsiung Taiwan Department of Computer and Communication Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan

ISBN: (纸本)9783031401121

This stud. employed.a quasi-experimental method.to explore d.fferences in stud.nts’ learning performance and.engagement between visual and.textual language programming environments. Specifically, this stud. examined.how strongly engagement d.mensions affect participants’ learning achievement in a Scratch experimental setting. One hund.ed.and.thirty-two und.rgrad.ate stud.nts participated. The results revealed.that participants with Scratch intervention outperformed.those with text-based.language instructions in terms of performance and.behavioral, emotional, cognitive, and.agentic engagement. The find.ngs ind.cated.that engagement significantly pred.cted.stud.nt acad.mic success in a visual learning environment. This stud. conclud.d.that visual programming tools such as Scratch help novices engaged.and.effectively learn core aspects of programming concepts. Ad.itionally, stud.nt engagement d.epens an und.rstand.ng of pred.ctions of programmers’ behaviors and.achievements and.mechanisms behind.the effectiveness of visualization intervention. © 2023, The Author(s), und.r exclusive license to Springer Nature Switzerland.AG.

关键词： Stud.nts

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NIR-Responsive Methotrexate-Mod.fied.Iron Selenid. Nanorod. for Synergistic Magnetic Hyperthermic, ph.tothermal, and.Chemod.namic Therapy

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ACS Applied.Materials and.Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien d.awan, Ud.sh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to d.velop novel therapies to effectively treat this d.sease. In this stud., iron selenid. nanorod. (FeSe2 NRs) were d.signed.for use in magnetic hyperthermic, ph.tothermal, and.chemod.namic therapy (MHT/PTT/Cd.) for breast cancer. To illustrate their efficacy, FeSe2 NRs were mod.fied.with the chemotherapeutic agent methotrexate (MTX). MTX-mod.fied.FeSe2 (FeSe2-MTX) exhibited.excellent controlled.d.ug release properties. Fe2+ released.from FeSe2 NRs ind.ced.the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of Cd.. Und.r alternating magnetic field.(AMF) stimulation and.808 nm laser irrad.ation, FeSe2-MTX exerted.potent hyperthermic and.ph.tothermal effects by suppressing tumor growth in a breast cancer nud. mouse mod.l. In ad.ition, FeSe2 NRs can be used.for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented.a novel technique for the precise d.livery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published.by American Chemical Society

关键词： Magnetic resonance imaging

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Enhancing wound.healing and.ad.esion through d.pamine-assisted.gelatin-silica hybrid.d.essings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, wid.ly employed.in hyd.ogel d.essings, faces limitations when used.in high fluid.environments, hind.ring effective material ad.esion to wound.sites and.subsequently red.cing treatment efficacy. The rapid.d.grad.tion of conventional hyd.ogels often results in breakd.wn before complete wound.healing. Thus, there is a pressing need.for the d.velopment of d.rable ad.esive wound.d.essings. In this stud., 3-glycid.xypropyltrimethoxysilane (GPTMS) was utilized.as a coupling agent to create gelatin-silica hybrid.(G-H) d.essings through the sol-gel method. The coupling reaction established.covalent bond. between gelatin and.silica networks, enhancing structural stability. d.pamine (d.) was introd.ced.to this hybrid.(G-H-d. d.essing to further boost ad.esiveness. The efficacy of the d.essings for wound.management was assessed.through in-vitro and.in-vivo tests, along with ex-vivo bioad.esion testing on pig skin. Tensile bioad.esion tests d.monstrated.that the G-H-d.material exhibited.approximately 2.5 times greater ad.esion to soft tissue in wet cond.tions compared.to pure gelatin. Moreover, in-vitro and.in-vivo wound.healing experiments revealed.a significant increase in wound.healing rates. Consequently, this material shows promise as a viable option for use as a moist wound.d.essing. © 2023

关键词： Ad.esion

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