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Anti-Inflammatory Glycosid.s from Gomph.nd.a mollis Merr.: Structural Elucid.tion and.Mechanistic Insights

ph.tochemistry 2025年 239卷 114583页

作者： Quoc-d.ng Tran Huynh Thuy-Tien Thi ph.n Man-Hsiu Chu Thanh-Vu Nguyen Truc-Ly Thi d.ong Su-Jung Hsu Yun-Han Wang Ngoc-Thac ph.m Bien-Thuy Nguyen Bui d.ng-Khoa Nguyen Thanh-Hoa Vo Ta-Wei Liu Ching-Kuo Lee Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam. Institute of Pharmaceutical Education and Research Binh Duong University Thu Dau Mot 820000 Binh Duong Vietnam Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan. School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan. Biotechnology Center Of Ho Chi Minh City Ho Chi Minh 700000 Vietnam. Faculty of Traditional medicine Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam Faculty of Pharmacy Can Tho University of Medicine and Pharmacy Can Tho 900000 Vietnam. School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Institute of Fisheries Science National Taiwan University Taipei 106 Taiwan. Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 11221 Taiwan University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam. School of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Vietnam. University of Health Sciences Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam Center for Discovery and Development of Healthcare Product Vietnam National University Ho Chi Minh City Ho Chi Minh 700000 Vietnam. Institute of Pharmaceutical Sciences Department of Pharmacognosy University of Graz Universitätsplatz 4 8010 Graz Austria. Electronic address: d301110010@tmu.edu.tw. Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Department of Chemistry Chung Yuan Christ

Eight previously unreported.glycosid.s, d.signated.gomph.nd.anosid.s I-VIII, along with nine known compound., were isolated.from the roots of Gomph.nd.a mollis Merr. Their structures were elucid.ted.through comprehensive spectroscopic analyses, includ.ng NMR, HR-ESI-MS, Cd. d.4+ probability, and.ECd.calculations. The anti-inflammatory activities of the isolated.compound. were assessed.using nitric oxid. inhibition assays in LPS-stimulated.RAW264.7 macroph.ges. Compound. 5, 10, and.16 exhibited.significant anti-inflammatory activity with IC values of 7.56 ± 0.9, 15.0 ± 1.2, and.14.2 ± 0.9 μM, respectively. Network ph.rmacology, gene ontology, Kyoto Encycloped.a of Genes and.Genomes analysis, and.molecular d.cking stud.es id.ntified.IL-6, TNF-α, MMP9, PTGS2, and.HIF1A as key targets, with potentially involved.in the NF-κB and.IL-17 signaling pathways. These find.ngs highlight G. mollis as a promising cand.d.te for the treatment of inflammation-related.d.seases.

关键词： Gomph.nd.a mollis Stemonuraceae anti-inflammatory activity molecular d.cking network ph.rmacology

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Corrigend.m to "Ultrafast absorption mechanism of oil-emulsified.micelles onto ferrous absorbents with d.electroph.resis force in the presence of polarization" [J Hazard.Mater 460 (2023) 132436]

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Journal of hazard.us materials 2024年 464卷 132601页

作者： Chun-Yao Huang Feng-Yen Lin Chien-Hsing Lu Jem-Kun Chen Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Section 4 Keelung Road Taipei 106 Taiwan ROC Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei 110 Taiwan ROC Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei 110 Taiwan ROC Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 110 Taiwan ROC Department of Biomedical Sciences and Engineering National Central University 300 Zhongda Road Taoyuan City 320317 Taiwan ROC. Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei 110 Taiwan ROC. Department of Obstetrics and Gynecology Taichung Veterans General Hospital 1650 Taiwan Boulevard Sect. 4 Taichung 40705 Taiwan ROC Ph.D. Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan ROC. Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei 110 Taiwan ROC. Electronic address: jkchen@mail.ntust.edu.tw.

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Med.ation analysis for TNF-α as a med.ator between multiple metal exposure and.kid.ey function

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Ecotoxicology and.environmental safety 2024年 283卷 116837页

作者： Kuei-Hau Luo Hung-Pin Tu Huang-Chih Chang Chen-Cheng Yang Wei-Chun Weng Tzu-Hua Chen Cheng-Hong Yang Hung-Yi Chuang Graduate Institute of Medicine College of Medicine Kaohsiung Medicine University Kaohsiung City 807 Taiwan. Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Divisions of Pulmonary & Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan. Graduate Institute of Medicine College of Medicine Kaohsiung Medicine University Kaohsiung City 807 Taiwan Department of Occupational Medicine Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University Kaohsiung 812 Taiwan. Division of Gastroenterology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung 802 Taiwan. Department of Family Medicine Kaohsiung Municipal Ta-Tung Hospital Kaohsiung 801 Taiwan. Department of Information Management Tainan University of Technology Tainan 71002 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung 80778 Taiwan. Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan Department of Occupational and Environmental Medicine Kaohsiung Medicine University Hospital Kaohsiung Medicine University Kaohsiung 807 Taiwan Ph.D. Program in Environmental and Occupational Medicine College of Medicine and Research Center for Precision Environmental Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Electronic address: ericch@kmu.edu.tw.

The association between metal mixtures and.kid.ey function has been reported. However, reports on the mechanism of metal toxicity were limited. Oxid.tive stress was reported.as a possible cause. This stud. aimed.to d.termine the association between of kid.ey function and.metals, such as arsenic (As), cad.ium (Cd., cobalt (Co), copper (Cu), lead.(Pb), selenium (Se), and.zinc (Zn), and.to explore the possible med.ating role of tumor necrosis factor alph. (TNF-α) between metal toxicity and.kid.ey function. In this stud., we recruited.421 ad.lts from a health examination. The concentration of blood.metals was analyzed.using ind.ctively coupled.plasma mass spectrometry. We used.linear regression mod.ls to assess the association between metals and.TNF-α. Then, med.ation analysis was applied.to investigate the relationship between metal exposure, TNF-α, and.kid.ey function. In univariate linear regression, blood.As, Cd. Co, Cu, Pb, and.Zn levels significantly increased.TNF-α and.d.creased.kid.ey function. Higher blood.As and.Pb levels significantly increased.TNF-α in multivariable linear regressions after ad.usting for covariates. We found.that blood.levels of As (coefficients = -0.021, p = 0.011), Pb (coefficients = -0.060, p < 0.001), and.Zn (coefficients = -0.230, p < 0.001) showed.a significant negative association with eGFR in the multiple-metal mod.l. Furthermore, med.ation analysis showed.that TNF-α med.ated.41.7 %, 38.8 %, and.20.8 % of blood.Cd. As and.Pb, respectively. Among the essential elements, TNF-α med.ated.24.5 %, 21.5 % and.19.9 % in the effects of blood.Co, Cu, and.Zn on kid.ey function, respectively. TNF-α, acting as a med.ator, accounted.for 20.1 % of the contribution between the WQS score of metal mixtures and.the eGFR (p < 0.001). This stud. suggested.that TNF-α may be a persuasive pathway med.ating the association between metals and.kid.ey function. Inflammation and.kid.ey injury could.be the und.rlying mechanisms of metal exposure. However, there i

关键词： Kid.ey function Med.ation analysis Metals Pb TNF-α

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The Application of Last Observation Carried.Forward.Method.for Missing d.ta Estimation in the Context of Ind.strial Wireless Sensor Networks

The Application of Last Observation Carried Forward Method f...

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IEEE Asia-Pacific Conference on Antennas and.Propagation (APCAP)

作者： Hong Zhou Kun-Ming Yu Ming-Gong Lee Chin-Chuan Han Ph.D. Program in Engineering Science College of Engineering Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering Chung Hua University Hsinchu Taiwan Leisure and Recreation Management Chung Hua University Hsinchu Taiwan Department of Computer Science and Information Engineering National United University Miaoli Taiwan

Thanks to ad.ances in wireless communication technologies, the wireless sensor network (WSNs) have been attracting a lot of attention from acad.mic communities and.successfully applied.to various d.mains. Along with d.velopments of the Ind.stry 4.0, the WSNs start to play a vital role in the construction of smart factories and.realization of intelligent manufacturing. Although, the ind.strial WSNs (IWSNs) presents great quantity of ad.antages, there still have some d.awbacks to overcome such as challenges of the quality of d.ta for IWSNs. In ord.r to resolve the d.ta missing problems in the context of IWSNs, the Last Observation Carried.Forward.method.is ad.pted.to estimate the missing value and.reconstruct the sensing d.taset which takes into account the temporal characteristics of sensing d.ta in IWSNs. Through experiments, this method.is proved.to be an easy and.effective measurement for missing value imputation of the large multi-d.mensional sensing d.ta achieved.by the IWSNs.

关键词： Wireless sensor networks Estimation Ind.stries Temperature sensors Smart manufacturing

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Id.ntification of gene expression signatures for psoriasis classification using machine learning techniques

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Med.cine in Omics 2021年 1卷

作者： Nguyen Quoc Khanh Le d.yen Thi d. Trinh-Trung-d.ong Nguyen Ngan Thi Kim Nguyen Truong Nguyen Khanh Hung Nguyen Thi Thu Trang Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei City 106 Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei City 106 Taiwan Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City 106 Taiwan Department of Computer Science and Engineering Yuan Ze University Chung-Li 32003 Taiwan School of Nutrition and Health Sciences Taipei Medical University Taipei City 110 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Orthopedic and Trauma Department Cho Ray Hospital Ho Chi Minh City Viet Nam International PhD Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan

Psoriasis classification requires the accurate id.ntification of the lesional types for the early and.effective d.agnosis and.it is worth interesting that the normal and.psoriasis cell tissues exhibit d.fferent gene expression. Therefore, gene expression d.ta is an effective source for psoriasis classification and.there is a challenge regard.ng the selection of suitable gene signatures for its purpose. In this present stud., the gene expression-based.microarray d.ta were used.and.35 expression features linked.with psoriasis were utilized.to feed.into our machine learning mod.l. Overall, the performance of our mod.l based.on 35 mentioned.above features surpassed.that of other state-of-the-art classifiers with an average accuracy of 98.3%, recall of 98.6%, and.precision of 98% in 5-fold.cross-valid.tion tests. We also valid.te our mod.l on two d.fferent sets of psoriasis and.the performance results are significant. These results have suggested.that our 35 expression signatures have been id.ntified.as key features for classifying samples between lesion and.non-lesion. More specifically, the expression levels of few genes i.e., FABP5 , TGM1 , or BCAR3 are d.scovered.as newly potential biomarkers for psoriasis classification and.treatment with high confid.nce. This stud., therefore, could.shed.light on d.veloping the pred.ction mod.ls for psoriasis classification and.treatment using gene expression profiles.

关键词： Psoriasis classification Rand.m forest Gene expression Feature selection Machine learning FABP5 d.rmatology

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Non-d.structive evaluation of a city road.ay for pavement rehabilitation: A case stud.

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International Journal of Pavement Research and.Technology 2017年第7期11卷 667-678页

作者： Chao, Chien-Chiao Lin, d.ng-Fong Luo, Huan-Lin Wang, Yu-Kai Lo, Wei Ph. D. Program in Engineering Science and Technology College of Engineering National Kaohsiung First University of Science and Technology Kaohsiung City Taiwan Department of Civil and Ecological Engineering I-Shou University Kaohsiung City Taiwan Department of Construction Engineering National Kaohsiung First University of Science and Technology Kaohsiung City Taiwan

In this stud., a pavement evaluation was carried.out on a corrid.r that carried.heavy truck traffic, connecting a harbor, a major high-way, an airport, and.ind.stries. The pavement of the corrid.r was d.stressed.frequently, requiring constant maintenance. With tight maintenance bud.et and.intention to minimize the effects on traffic, full reconstruction or major rehabilitation of the corrid.r was not practical. To d.velop proper pavement rehabilitation d.sign within the practical constrains, pavement evaluation was performed.in this stud. using non-d.structive techniques, such as visual cond.tion survey, falling weight d.flectometer (FWd., ground.penetrating rad.r (GPR), and.d.namic cone penetrometer (d.P), and.pavement coring. It is d.monstrated.that appropriate pavement rehabilitation d.sign can be d.veloped.to offer practical solution to the repair/maintenance for city streets. © 2017 Chinese Society of Pavement engineering.

关键词： Ground.penetrating rad.r systems

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Ovatod.olid. and.antrocin synergistically inhibit the stemness and.metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and.mod.lating ERK/Akt-mTOR signaling axis

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ph.tomed.cine : international journal of ph.totherapy and.ph.toph.rmacology 2023年 108卷 154478页

作者： Ming-Yao Chen Chia-Hung Hsu Syahru Agung Setiawan d.vid.T W Tzeng Hon-Ping Ma Jiann Ruey Ong Yi Cheng Chu Ming-Shou Hsieh Alexand.r T H Wu Yew-Min Tzeng Chi-Tai Yeh Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan. Department of Emergency Medicine Taipei Medical University-Shuang Ho Hospital New Taipei City 235 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 110 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei City 110 Taiwan. International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan. School of Life Sciences The Chinese University of Hong Kong Hong Kong SAR 999077 China Lifebit Mindspace Shoreditch London England EC2A 2AP UK. Department of Medicine St. George's University School of Medicine St. George Grenada. Department of Applied Science National Taitung University Taitung 95092 Taiwan. Electronic address: ymtzeng@nttu.edu.tw. Department of Medical Research & Education Taipei Medical University - Shuang-Ho Hospital New Taipei City 235 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan. Electronic address: ctyeh@s.tmu.edu.tw.

Activation of mitogen-activated.protein kinase (MAPK) and.PI3K signaling confers resistance against sorafenib, a mainstay treatment for ad.anced.hepatocellular carcinoma (HCC). Antrocin and.ovatod.olid. constitute as the most potent second.ry metabolites isolated.from Antrod.a camph.rata and.Anisomeles ind.ca, respectively. Both natural compound. have recently gained.a lot of attention d.e to their putative inhibition of MAPK and.PI3K signaling in various solid.cancers. However, whether their combination is effective in HCC remains unknown. Here, we investigated.their effect, alone or in various combinations, on MAPK and.PI3K signaling pathways in HCC cells. An array of in vitro stud. were used.to investigate anticancer and.stemness effects to treat HCC, such as cytotoxicity, d.ug combination ind.x, migration, invasion, colony formation, and.tumor sph.re formation. d.ug effect in vivo was evaluated.using mouse xenograft mod.ls. In this stud., antrocin and.ovatod.olid. synergistically inhibited.the SNU387, Hep3B, Mahlavu, and.Huh7 cell lines. Sequential combination treatment of Huh7 and.Mahlavu with ovatod.olid. followed.by antrocin resulted.stronger cytotoxic effect than d.d.treatment with antrocin followed.by ovatod.olid., their simultaneous ad.inistration, antrocin alone, or ovatod.olid. alone. In the Huh7 and.Mahlavu cell lines, ovatod.olid.→antrocin significantly suppressed.colony formation and.proliferation as well as marked.y d.wnregulated.ERK1/2, Akt, and.mTOR expression. Inhibition of ERK1/2 and.Akt/mTOR signaling by ovatod.olid.→antrocin suppressed.ribosomal biogenesis, autoph.gy, and.cancer stem cell-like ph.notypes and.promoted.apoptosis in Huh7 and.Mahlavu cells. The sorafenib-resistant clone of Huh7 was effectively inhibited.by synergistic combination of both compound.in vitro. Eventually, the ovatod.olid.→antrocin combination synergistically suppressed.the growth of HCC xenografts. Taken together, our find.ngs suggested.that ovatod.olid.→antrocin combi

关键词： Ad.anced.HCC Antrocin (ANC) MAPK Ovatod.olid. (OVA) PI3K

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MATLAB-based.analysis of labor d.spatch and.work d.stribution: An example involving caseworkers in central Taiwan

MATLAB-based analysis of labor dispatch and work distributio...

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2017 IEEE International Conference on Applied.System Innovation, ICASI 2017

作者： Oh, Chin-Yu Hsu, Meng-Chueh Tsai, Chang-Ming Jhang, Jyun-Yao Chen, Yu-Ren Chen, Bo-Xiang Chen, Yi-Chung Teng, Chun-Wen Chen, Shu-Hui Department of Information Engineering and Computer Science Feng Chia University Taichung40724 Taiwan Ph. D. Program of Business Feng Chia University Taichung40724 Taiwan Graduate Institute of Public Policy and social innovation Feng Chia University Taichung40724 Taiwan General Education Center Feng Chia University Taichung40724 Taiwan

ISBN: (纸本)9781509048977

The d.spatching of labor and.d.stribution of tasks among workers are important aspects of corporate operations. Labor d.spatch refers to the d.spatching of employees to meet with clients;however, d.spatches commonly vary with time. This means that any analysis pertaining to labor d.spatch and.work d.stribution should.also vary with time. In this stud., MATLAB was used.to analyze d.ta from anonymous caseworkers in central Taiwan in ord.r to id.ntify relationships between the location of their offices and.the homes of their clients. Our aim was to d.termine the rationality behind.labor d.spatch and.work d.stribution. This led.us to d.velop a novel method.by which to d.spatch labor in ord.r to achieve a more equitable d.stribution of work. Simulations d.monstrate the efficacy of the proposed.scheme in improving labor d.spatch and.work d.stribution. © 2017 IEEE.

关键词： MATLAB

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Erratum for Wang et al., "Clinically Applicable System for Rapid.y Pred.cting Enterococcus faecium Susceptibility to Vancomycin"

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Microbiology spectrum 2022年第1期10卷 e0261021页

作者： Hsin-Yao Wang Chia-Ru Chung Chao-Jung Chen Ko-Pei Lu Yi-Ju Tseng Tzu-Hao Chang Min-Hsien Wu Wan-Ting Huang Ting-Wei Lin Tsui-Ping Liu Tzong-Yi Lee Jorng-Tzong Horng Jang-Jih Lu Department of Laboratory Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Ph.D. Program in Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Computer Science and Information Engineering National Central Universitygrid.37589.30 Taoyuan City Taiwan. Graduate Institute of Integrated Medicine China Medical Universitygrid.254145.3 Taichung Taiwan. Proteomics Core Laboratory China Medical Universitygrid.254145.3 Hospital Taichung Taiwan. Graduate Program in Biomedical Information Yuan-Ze University Taoyuan City Taiwan. Department of Information Management Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei City Taiwan. Graduate Institute of Biomedical Engineering Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Division of Haematology/Oncology Department of Internal Medicine Chang Gung Memorial Hospitalgrid.413801.f at Linkou Taoyuan City Taiwan. Biosensor Group Biomedical Engineering Research Center Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Pathology Kaohsiung Chang Gung Memorial Hospitalgrid.413801.f and Chang Gung University College of Medicine Kaohsiung Taiwan. School of Life and Health Sciences The Chinese University of Hong Kong Shenzhen China. Warshel Institute for Computational Biology The Chinese University of Hong Kong Shenzhen China. Department of Bioinformatics and Medical Engineering Asia University Taichung City Taiwan. School of Medicine Chang Gung Universitygrid.145695.a Taoyuan City Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung Universitygrid.145695.a Taoyuan City Taiwan.

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International Scientific Collaboration Is Need.d.to Brid.e science to Society: USERN2020 Consensus Statement

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SN comprehensive clinical med.cine 2021年第8期3卷 1699-1703页

作者： Sara Momtazmanesh Amene Saghazad.h Juan Carlos Ald.ve Becerra Kiarash Aramesh Francisco J Barba Fed.rico Bella Anna Blakney Massimo Capaccioli Rossella Castagna Umberto Crisanti Tigran d.vtyan Tommaso d.rigo Julie Ealy Mehd. Farokhnia Giulia Grancini Manoj Gupta Amine Harbi Wojciech Krysztofiak Arutha Kulasinghe Chi-Ming Lam Alexand.r Leemans Brian Lighthill Vittorio Limongelli Paola Lopreiato Livio Luongo Christoph.r Ryan Maboloc Reza Malekzad.h Orland. Costa Gomes Milos Milosevic Jan Nouwen d.lfín Ortega-Sánchez John Pawelek Surapati Pramanik Seeram Ramakrishna Ortwin Renn Serena Sanseviero d.niel Sauter Michael Schreiber Frank W Sellke Mohammad.Ali Shahbazi Natalya Shelkovaya Wayne H Slater d.d.er Snoeck Slawomir Sztajer Lucina Q Ud.in Liz Veramend.-Espinoza Ricard. Vinuesa Walter C Willett d.ngrui Wu Karolina Żyniewicz Nima Rezaei http://***. School of Medicine Tehran University of Medical Sciences Tehran Iran. Research Center for Immunodeficiencies Children's Medical Center Hospital Tehran University of Medical Sciences Tehran Iran. Division of Allergy and Immunology Hospital Nacional Edgardo Rebagliati Martins Lima Lima Peru. Department of Biology and Health Sciences College of Science and Health Professions Edinboro University of Pennsylvania Edinboro USA. Nutrition and Food Science Area Preventive Medicine and Public Health Food Science Toxicology and Forensic Medicine Department Faculty of Pharmacy Universitat de València Avda. Vicent Andrés Estellés S/n València 46100 Burjassot Spain. Department of Applied Science and Technology - DISAT Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy. Department of Infectious Diseases Imperial College London Norfolk Place London W2 1PG UK. Physics Department "Ettore Pancini" University of Naples Federico II Monte Sant'Angelo Campus via Cinthia 21 80121 Naples Italy. Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute for Science and Technology Barcelona 08028 Spain. Latvian Institute of Organic Synthesis (LIOS) Riga LV-1006 Latvia. Psychotherapist in Private Practice Canterbury Kent England. Analytical Laboratory Branch Scientific Centre of Drug and Medical Technology Expertise after Academician E. Gabrielyan CJSC Yerevan 0051 Armenia. INFN Sezione di Padova Padova Italy. Penn State Lehigh Valley 2809 Saucon Valley Road Center Valley PA 18034 USA. National Health Institutes of Health (NIH) Intramural Research Program (IRP) Bethesda USA. Department of Chemistry & INSTM University of Pavia Via Taramelli 14 Pavia I-27100 Italy. Department of Mechanical Engineering National University of Singapore Singapore Singapore. Souk Ahras University Souk Ahras Algeria. The Institute of Philosophy University of Szczecin Ul. Krakowska 71-79 Szczecin 71-004 Poland. Translational Research Institute Woolloongabba

Scientific collaboration has been a critical aspect of the d.velopment of all field. of science, particularly clinical med.cine. It is well und.rstood.that myriad. of benefits can be yield.d.by interd.sciplinary and.international collaboration. For instance, our rapid.y growing knowled.e on COVId.19 and.vaccine d.velopment could.not be attained.without expand.d.collaborative activities. However, achieving fruitful results requires mastering specific tactics in collaborative efforts. These activities can enhance our knowled.e, which ultimately benefits society. In ad.ition to tackling the issue of the invisible bord.r between d.fferent countries, institutes, and.d.sciplines, the bord.r between the scientific community and.society need. to be ad.ressed.as well. International and.transd.sciplinary approaches can potentially be the best solution for brid.ing science and.society. The Universal Scientific Ed.cation and.Research Network (USERN) is a non-governmental, non-profit organization and.network to promote professional, scientific research and.ed.cation world.id.. The fifth annual congress of USERN was held.in Tehran, Iran, in a hybrid.manner on November 7-10, 2020, with key aims of brid.ing science to society and.facilitating bord.rless science. Among speakers of the congress, a group of top scientists unanimously agreed.on The USERN 2020 consensus, which is d.afted.with the goal of connecting society with scientific scholars and.facilitating international and.interd.sciplinary scientific activities in all field., includ.ng clinical med.cine.

关键词： Collaboration International Policy Research science Society

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