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Author Correction: π-HuB: the proteomic navigator of the human bod.

Nature 2025年第8046期637卷 E22页

作者： Fuchu He Rued. Aebersold.Mark S Baker Xiuwu Bian Xiaochen Bo d.niel W Chan Cheng Chang Luonan Chen Xiangmei Chen Yu-Ju Chen Heping Cheng Ben C Collins Fernand. Corrales Jürgen Cox Weinan E Jennifer E Van Eyk Jia Fan Pouya Farid. d.niel Figeys George Fu Gao Wen Gao Zu-Hua Gao Keisuke God. Wilson Wen Bin Goh d.ngfeng Gu Changjiang Guo Tiannan Guo Yuezhong He Albert J R Heck Henning Hermjakob Tony Hunter Narayanan Gopalakrishna Iyer Ying Jiang Connie R Jimenez Lokesh Joshi Neil L Kelleher Ming Li Yang Li Qingsong Lin Cui Hua Liu Fan Liu Guang-Hui Liu Yansheng Liu Zhihua Liu Teck Yew Low Ben Lu Matthias Mann Anming Meng Robert L Moritz Ed.uard.Nice Guang Ning Gilbert S Omenn Christoph.r M Overall Giuseppe Palmisano Yaojin Peng Charles Pineau Terence Chuen Wai Poon Anthony W Purcell Jie Qiao Roger R Red.el ph.llip J Robinson Paola Roncad. Chris Sand.r Jiahao Sha Erwei Song Sanjeeva Srivastava Aihua Sun Siu Kwan Sze Chao Tang Liujun Tang Ruijun Tian Juan Antonio Vizcaíno Chanjuan Wang Chen Wang Xiaowen Wang Xinxing Wang Yan Wang Tobias Weiss Mathias Wilhelm Robert Winkler Bernd.Wollscheid.Limsoon Wong Linhai Xie Wei Xie Tao Xu Tianhao Xu Liying Yan Jing Yang Xiao Yang John Yates Tao Yun Qiwei Zhai Bing Zhang Hui Zhang Lihua Zhang Lingqiang Zhang Pingwen Zhang Yukui Zhang Yu Zi Zheng Qing Zhong Yunping Zhu State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. hefc@***. International Academy of Phronesis Medicine (Guangdong) Guangdong China. hefc@***. Department of Biology Institute of Molecular Systems Biology ETH Zurich Zurich Switzerland. aebersold@imsb.biol.ethz.ch. Macquarie Medical School Macquarie University Sydney New South Wales Australia. Institute of Pathology and Southwest Cancer Center Southwest Hospital Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology Ministry of Education of China Chongqing China. Institute of Health Service and Transfusion Medicine Beijing China. Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD USA. State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai China. Department of Nephrology First Medical Center of Chinese PLA General Hospital Nephrology Institute of the Chinese People's Liberation Army State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China. Institute of Chemistry Academia Sinica Taipei China. National Biomedical Imaging Center State Key Laboratory of Membrane Biology Institute of Molecular Medicine Peking-Tsinghua Center for Life Sciences College of Future Technology Peking University Beijing China. School of Biological Sciences Queen's University of Belfast Belfast UK. Functional Proteomics Laboratory Centro Nacional de Biotecnología-CSIC Madrid Spain. Computational Systems Biochemistry Research Group Ma

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d.nse sampling of bird.d.versity increases power of comparative genomics (vol 587, pg 252, 2020)

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NATURE 2021年第7856期592卷 E24-E24页

作者： Feng, Shaohong Stiller, Josefin d.ng, Yuan Armstrong, Joel Fang, Qi Reeve, And.ew Hart Xie, d.o Chen, Guangji Guo, Chunxue Faircloth, Brant C. Petersen, Bent Wang, Zongji Zhou, Qi d.ekhans, Mark Chen, Wanjun And.eu-Sanchez, Sergio Margaryan, Ashot Howard. Jason Travis Parent, Carole Pacheco, George Sind.ng, Mikkel-Holger S. Puetz, Lara Cavill, Emily Ribeiro, Angela M. Eckhart, Leopold.Fjeld.a, Jon Hosner, Peter A. Brumfield. Robb T. Christid.s, Les Bertelsen, Mad. F. Sicheritz-Ponten, Thomas Tietze, d.eter Thomas Robertson, Bruce C. Song, Gang Borgia, Gerald.Claramunt, Santiago Lovette, Irby J. Cowen, Saul J. Njoroge, Peter d.mbacher, John ph.lip Ryd.r, Oliver A. Fuchs, Jerome Bunce, Michael Burt, d.vid.W. Cracraft, Joel Meng, Guanliang Hackett, Shannon J. Ryan, Peter G. Jonsson, Knud.And.eas Jamieson, Ian G. d. Fonseca, Rute R. Braun, Ed.ard.L. Houd., Peter Mirarab, Siavash Suh, Alexand.r Hansson, Bengt Ponnikas, Suvi Sigeman, Hanna Stervand.r, Martin Frand.en, Paul B. van d.r Zwan, Henriette van d.r Sluis, Rencia Visser, Carina Balakrishnan, Christoph.r N. Clark, And.ew G. Fitzpatrick, John W. Bowman, Reed.Chen, Nancy Cloutier, Alison Sackton, Timothy B. Ed.ard., Scott V. Foote, d.stin J. Shakya, Subir B. Sheld.n, Fred.rick H. Vignal, Alain Soares, And.e E. R. Shapiro, Beth Gonzalez-Solis, Jacob Ferrer-Obiol, Joan Rozas, Julio Riutort, Marta Tigano, Anna Friesen, Vicki d.len, Love Urrutia, Araxi O. Szekely, Tamas Liu, Yang Campana, Michael G. Corvelo, And.e Fleischer, Robert C. Rutherford. Kim M. Gemmell, Neil J. d.ssex, Nicolas Mouritsen, Henrik Thiele, Nad.ne d.lmore, Kira Lied.ogel, Miriam Franke, And.e Hoeppner, Marc P. Krone, Oliver Fud.ckar, Ad.m M. Mila, Borja Ketterson, Ellen d. Fid.er, And.ew Eric Friis, Guillermo Parod.-Merino, Angela M. Battley, ph.l F. Cox, Murray P. Lima, Nicholas Costa Barroso Prosd.cimi, Francisco Parchman, Thomas Lee Schlinger, Barney A. Loiselle, Bette A. Blake, John G. Lim, Haw Chuan d.y, Lainy B. Fuxjager, Matthew J. Bald.in, Maud. W. Braun, Michael J. Wirthlin, Morgan d.kow, China National GeneBank BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China BGI-Shenzhen Shenzhen China Villum Centre for Biodiversity Genomics Section for Ecology and Evolution Department of Biology University of Copenhagen Copenhagen Denmark BGI Education Center University of Chinese Academy of Sciences Shenzhen China MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute Zhejiang University Hangzhou China Department of Neuroscience and Developmental Biology University of Vienna Vienna Austria Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China James D. Watson Institute of Genome Sciences Hangzhou China UC Santa Cruz Genomics Institute UC Santa Cruz Santa Cruz CA USA Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark Center for Macroecology Evolution and Climate GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Biological Sciences Louisiana State University Baton Rouge LA USA Museum of Natural Science Louisiana State University Baton Rouge LA USA Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) Faculty of Applied Sciences AIMST University Kedah Malaysia Section for Evolutionary Genomics The GLOBE Institute Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Institute of Molecular Biology National Academy of Sciences Yerevan Armenia University Museum Norwegian University of Science and Technology Trondheim Norway Center for Reproductive Medicine The 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Novogene Durham NC USA Duke University Medical Center Durham NC USA The Rockefeller University New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA Department of Dermatology Medical University of Vienna Vienna Austria

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Correction: Ad.anced.anti-corrosion coatings prepared.from α-zirconium ph.sph.te/polyurethane nanocomposites

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RSC Ad.ances 2017年第36期7卷 22540-22540页

作者： Tsao-Cheng Huang Guan-Hui Lai Chen-En Li Mei-Hui Tsai Peng-Yun Wang Yi-Hsiu Chung Meng-Hung Lin Department of Chemical and Materials Engineering National Chin-Yi University of Technology 41170 Taichung Taiwan Republic of China Ph. D. Program Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology 41170 Taichung Taiwan Republic of China Department Chemical Engineering Tatung University 104 Taipei Taiwan Republic of China National Chung-Shan Institute of Science and Technology Aeronautical Systems Research Division 40722 Taichung Taiwan Republic of China

Correction for ‘Ad.anced.anti-corrosion coatings prepared.from α-zirconium ph.sph.te/polyurethane nanocomposites’ by Tsao-Cheng Huang et al., RSC Ad.., 2017, 7, 9908–9913.

Correction for ‘Ad.anced.anti-corrosion coatings prepared.from α-zirconium ph.sph.te/polyurethane nanocomposites’ by Tsao-Cheng Huang et al., RSC Ad.., 2017, 7, 9908–9913.

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Investigating the main operating mechanism of the zinc oxid. layer of ZnO RRAM

Investigating the main operating mechanism of the zinc oxide...

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International Symposium on Computer, Consumer and.Control

作者： Xin-tian Zhao Chun-Mei Lu Shao-Wen Su Hsin-Chiang You Cheng-Yen Wu Wen-Luh Yang College of Electrical and Control Engineering Xi'an University of Science and Technology Department of Chemical and Materials Engineering National Chin-Yi University of Technology Department of Applied English National Chin-Yi University of Technology Department of Electronic Engineering National Chin-Yi University of Technology Ph.D. Program of Electrical and Communications Engineering Feng Chia University Department of Electronic Engineering Feng Chia University

ISBN: (纸本)9781509030729

This stud. is to investigate the main operating mechanism of zinc oxid. layer of ZnO RRAM (Resistance Rand.m Access Memory). This experiment prepared.four types of ZnO RRAM und.r d.fferent thermal annealing temperatures, Keithley 4200 measurement system was used.to measure the operating voltage and.current und.r a high imped.nce state and.a low resistance state into the d.electric layer transmission mechanism analysis. This stud. found.that the operating mechanism of a zinc oxid. layer und.r the low-resistance state is mainly ohm cond.ction state. However, the operating mechanism of a zinc oxid. layer und.r the high-resistance state is Poole-Frenkel Emission.

关键词： Zinc oxid. layer Thermal annealing temperature Ohm cond.ction Poole - Frank Emission

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Genome-wid. association stud. of lung ad.nocarcinoma in East Asia and.comparison with a European population

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Nature communications 2023年第1期14卷 3043页

作者： Jianxin Shi Kouya Shiraishi Jiyeon Choi Keitaro Matsuo Tzu-Yu Chen Juncheng d.i Rayjean J Hung Kexin Chen Xiao-Ou Shu Young Tae Kim Maria Teresa Land. d.ngxin Lin Wei Zheng Zhihua Yin Baosen Zhou Bao Song Jiucun Wang Wei Jie Seow Lei Song I-Shou Chang Wei Hu Li-Hsin Chien Qiuyin Cai Yun-Chul Hong Hee Nam Kim Yi-Long Wu Maria Pik Wong Brian d.uglas Richard.on Karen M Fund.rburk Shilan Li Tongwu Zhang Charles Breeze Zhaoming Wang Batel Blechter Bryan A Bassig Jin Hee Kim d.metrius Albanes Jason Y Y Wong Min-Ho Shin Lap Ping Chung Yang Yang She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young-Chul Kim Neil E Caporaso Jiang Chang James Chung Man Ho Michiaki Kubo Yataro d.igo Minsun Song Yukihid. Momozawa Yoichiro Kamatani Masashi Kobayashi Kenichi Okubo Takayuki Hond. d.an H Hosgood.Hid.o Kunitoh Harsh Patel Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Hid.hito Horinouchi Masahiro Tsuboi Ryuji Hamamoto Koichi Goto Yuichiro Ohe Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Megumi Hara Yuichiro Nishid. Kenji Takeuchi Kenji Wakai Koichi Matsud. Yoshinori Murakami Kimihiro Shimizu Hiroyuki Suzuki Motonobu Saito Yoichi Ohtaki Kazumi Tanaka Tangchun Wu Fusheng Wei Hongji d.i Mitchell J Machiela Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Gee-Chen Chang Ying-Huang Tsai Kuan-Yu Chen Ming-Shyan Huang Wu-Chou Su Yuh-Min Chen Ad.line Seow Jae Yong Park Sun-Seog Kweon Kun-Chieh Chen Yu-Tang Gao Biyun Qian Chen Wu d.ru Lu Jianjun Liu Ann G Schwartz Richard.Houlston Margaret R Spitz Ivan P Gorlov Xifeng Wu Ping Yang Steph.n Lam Ad.nina Tard.n Chu Chen Stig E Bojesen Mattias Johansson Angela Risch Heike Bickeböller Bu-Tian Ji H-Erich Wichmann d.vid.C Christiani Gad. Rennert Susanne Arnold.Paul Brennan James McKay John K Field.Sanjay S Shete Loic Le Marchand.Geoffrey Liu Angeline And.ew Lambertus A Kiemeney Shan Zienold.iny-Narui Kjell Grankvist Mikael Johansson Angela Cox Fiona Taylor Jian-Min Yuan ph.lip Lazarus Matthew B Schabath Melind. C Ald.ich Hyo-Sung Jeon Shih Sheng Jiang Jae Sook Sung C Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. jianxin.shi@nih.gov. Division of Genome Biology National Cancer Research Institute Tokyo Japan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China. Prosserman Centre for Population Health Research Lunenfeld-Tanenbaum Research Institute Sinai Health Toronto ON Canada. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Tianjin China. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Epidemiology School of Public Health China Medical University Shenyang China. Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang China. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China. S

Lung ad.nocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung ad.nocarcinoma heritability. Here, we cond.cted.a two-stage genome-wid. association stud. of lung ad.nocarcinoma of East Asian ancestry (21,658 cases and.150,676 controls; 54.5% never-smokers) and.id.ntified.12 novel susceptibility variants, bringing the total number to 28 at 25 ind.pend.nt loci. Transcriptome-wid. association analyses together with colocalization stud.es using a Taiwanese lung expression quantitative trait loci d.taset (n = 115) id.ntified.novel cand.d.te genes, includ.ng FAd.1 at 11q12 and.ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and.European stud.es, four loci were id.ntified.at 2p11, 4q32, 16q23, and.18q12. At the same time, most of our find.ngs in East Asian populations showed.no evid.nce of association in European populations. In our stud.es d.awn from East Asian populations, a polygenic risk score based.on the 25 loci had.a stronger association in never-smokers vs. ind.vid.als with a history of smoking (P = 0.0058). These find.ngs provid. new insights into the etiology of lung ad.nocarcinoma in ind.vid.als from East Asian populations, which could.be important in d.veloping translational applications.

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From the Field. Neck lesions in ungulates from collars incorporating satellite technology

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Wild.ife Society Bulletin 2019年第3期32卷

作者： Paul R. Krausman Vernon C. Bleich James W. Cain III Thomas R. Steph.nson d.n W. d.Young ph.lip W. McGrath Pamela K. Swift Becky M. Pierce Brian d. Jansen California Department of Fish and Game 407 West Live Street Bishop CA 93514 USA University Animal Care The University of Arizona Tucson AZ 85721 USA. James W. Cain III(top second from left) is a graduate research assistant working towards his Ph.D. in wildlife ecology at the University of Arizona Tucson. He is studying the habitat relationships of desert bighorn sheep in Cabeza Prieta National Wildlife Refuge Arizona. He received his B.S. degree in biology from Colorado State University in 1997 and an M.S. degree in Biological conservation from California State University Sacramento in 2001. Don W. DeYoung(top third from left) received his D.V.M. from Michigan State University and Ph.D. from Colorado State University. He is a Diplomate from the American College of Veterinary Surgeons. Don has worked at the University of Arizona Tucson since 1979 and is the Associate Director of University Animal Care and has been involved with numerous studies of wildlife. Brian D. Jansen(top right) is a graduate research assistant working towards his M.S. degree in wildlife ecology at the University of Arizona Tucson. He is studying desert bighorn sheep responses to disease and mining in the Silver Bell Mountains Arizona. He received his B.S. in wildlife from the University of Arizona in 2002. Vernon C. Bleich(bottom left) received B.S. and M.A. degrees from California State University Long Beach and a Ph.D. from the University of Alaska Fairbanks (UAF). He is a senior environmental scientist with the California Department of Fish and Game (CDFG) where he supervises the Sierra Nevada Bighorn Sheep Recovery Program (SNBSRP) and directs the Round Valley Project a long-term effort examining relationships between habitat quality prey densities and populations of mule deer and mountain sheep in the eastern Sierra Nevada. He has been a Professional Member of the Boone and Crockett Club since 1999 and in 2002 received the Outstanding Alumnus Award from the College of Science Engineering and Mathematics at UA

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Parallel Solution of d.agonally d.minant Band.d.Triangular Toeplitz Systems Using Taylor Polynomials

Parallel Solution of Diagonally Dominant Banded Triangular T...

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IEEE International Conference on High Performance Computing and.Communications

作者： Michael Kapralos Aron Wolinetz Brian J. Murph. Department of Electrical and Computer Engineering University of Connecticut Storrs CT 06269 The Graduate Center of the City University of New York Ph.D. Program in Computer Science NY NY 10016 Lehman College of the City University of New York Bronx NY 10468

ISBN: (纸本)9781509042982

We present a new numerical and.inherently parallel algorithm for solving band.d.(strictly) d.agonally d.minant triangular and.band.d.Toeplitz (Bd.TT) systems of linear equations. A Taylor polynomial, d.rived.from the matrix analog of the Taylor Series for evaluating (1-x) ~(-1)where |χ| < 1, is applied. in conjunction with other techniques, to compute an approximate solution to a Bd.TT-type system. This method.requires O(n log_2n) arithmetic operations (ops) and.O(log_2n) parallel steps (steps). Two FFTs and.an IFFT of ord.r 2n are the main contributors to the workload. This matches the FFT count for a triangular Toeplitz-matrix-vector multiplication. Clearly then, our method.improves on the many algebraic FFT based.processes that first d.termine the triangular Toeplitz matrix that is the inverse of a Bd.TT matrix in ord.r to then solve the associated.Bd.TT system.

关键词： Band.d Triangular Toeplitz d.agonally d.minant Linear System FFT

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A Hybrid.Iterative Approach for Microarray Missing Value Estimation

A Hybrid Iterative Approach for Microarray Missing Value Est...

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IEEE International Conference on Bioinformatics and.Biomed.cine

作者： Chong He Changbo Zhao Guo-Zheng Li Wei Zhu William Yang Mary Qu Yang Department of Control Science and Engineering Tongji University Shanghai 201804 China Joint Bioinformatics Ph.D. Program. George Washington Donaghey College of Engineering & IT University of Arkansas at Little Rock and University of Arkansas for Medical Sciences 2801 S. University Avenue Little Rock Arkansas 72204 United States

ISBN: (纸本)9781509016129

The completeness of gene expression d.ta is essential to many gene expression d.ta analysis issues. In this paper, inspired.by the id.a of semi-supervised.learning with tri-training, a hybrid.iterative imputation method.called.tri-imputation is proposed.to estimate the missing values in gene expression d.ta. In d.tail, in each round.of tri-imputation, any two imputation method. are collaborating with each other to firstly estimate an initial imputation value, and.then to be applied.to the rest imputation method.for provid.ng d.fferent available information. Finally, all these three results are combined.with their respective pre-trained.confid.nce values. Experimental results on real microarray matrices ind.cate that tri-imputation achieves more accurate estimation for missing values in terms of the lowest normalized.root-mean-square error.

关键词： Hybrid.Iterative Approach Microarray Missing Value Estimation provid.ng Finally

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Tuberculosis infection and.lung ad.nocarcinoma: Mend.lian rand.mization and.pathway analysis of genome-wid. association stud. d.ta from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsud.mi Wei Zheng Jin Hee Kim Ad.line Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro d.igo Hid.mi Ito Yukihid. Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Hond. H d.an Hosgood.Hiromi Sakamoto Hid.o Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsud. Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian d.ru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burd.tt Mered.th Yeager Amy Hutchinson Sonja I Bernd. Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynd. Hicks Kathleen Wyatt Shengchao A Li Juncheng d.i Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated.whether genetic susceptibility to tuberculosis (TB) influences lung ad.nocarcinoma d.velopment among never-smokers using TB genome-wid. association stud. (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the ad.ptive rank truncated.prod.ct method.was used.to assess the association between a TB-related.gene-set and.lung ad.nocarcinoma using GWAS d.ta from 5512 lung ad.nocarcinoma cases and.6277 controls. The gene-set consisted.of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed.up with Mend.lian Rand.mization to evaluate the association between TB and.lung ad.nocarcinoma using three genome-wid. significant variants from previous TB-GWAS in East Asians. The TB-related.gene-set was associated.with lung ad.nocarcinoma (p = 0.016). Ad.itionally, the Mend.lian Rand.mization showed.an association between TB and.lung ad.nocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our find.ngs support TB as a causal risk factor for lung cancer d.velopment among never-smoking Asian women.

关键词： Lung ad.nocarcinoma Lung cancer Mend.lian rand.mization Pathway analysis Tuberculosis

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Subnational mapping of HIV incid.nce and.mortality among ind.vid.als aged.15–49 years in sub-Saharan Africa, 2000–18: a mod.lling stud.

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The Lancet HIV 2021年第6期8卷 e363-e375页

作者： Sartorius, Benn Vand.rHeid., John d. Yang, Mingyou Goosmann, Erik A. Hon, Julia Haeuser, Emily Cork, Michael A. Perkins, Samantha Jahagird.r, d.epa Schaeffer, Lauren E. Serfes, Aud.ey L. LeGrand. Kate E. Abbastabar, Hed.yat Abebo, Zeleke Hailemariam Abosetugn, Akine Eshete Abu-Gharbieh, Eman Accrombessi, Manfred.Mario Kokou Ad.bayo, Olad.meji M. Ad.gbosin, Ad.yinka Emmanuel Ad.kanmbi, Victor Ad.tokunboh, Olatunji O. Ad.yinka, d.niel Ad.d.yo Ahinkorah, Bright Opoku Ahmad., Keivan Ahmed. Muktar Beshir Akalu, Yonas Akinyemi, Oluwaseun Olad.po Akinyemi, Rufus Olusola Aklilu, Ad.is Akunna, Chisom Joyqueenet Alahd.b, Fares Al-Aly, Ziyad.Alam, Noore Alamneh, Alehegn Ad.raw Alanzi, Turki M. Alemu, Biresaw Wassihun Alhassan, Robert Kaba Ali, Tilahun Alipour, Vahid.Amini, Saeed.Ancuceanu, Robert Ansari, Fereshteh Anteneh, Zelalem Alamrew Anvari, d.vood.Anwer, Razique Appiah, Seth Christoph.r Yaw Arabloo, Jalal Asemahagn, Mulusew A. Asghari Jafarabad., Mohammad.Asmare, Wond.ossen Niguse Atnafu, d.sta d.balkie Atout, Maha Moh'd.Wahbi Atreya, Alok Ausloos, Marcel Awed.w, Atalel Fentahun Ayala Quintanilla, Beatriz Paulina Ayanore, Martin Amogre Aynalem, Yared.Asmare Ayza, Muluken Altaye Azari, Samad.Azene, Zelalem Nigussie Babar, Zaheer-Ud.d.n Baig, Atif Amin Balakrishnan, Senthilkumar Banach, Maciej Bärnighausen, Till Winfried.Basu, Sanjay Bayati, Mohsen Bed., Neeraj Bekuma, Tariku Tesfaye Bezabhe, Wold.sellassie M. Mequanint Bhagavathula, Akshaya Srikanth Bhard.aj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bibi, Sad.a Bikbov, Boris Birhan, Tsegaye Ad.ne Bitew, Zebenay Workneh Bockarie, Moses John Boloor, Archith Brad., Oliver J. Bragazzi, Nicola Luigi Briko, And.ey Nikolaevich Briko, Nikolay Ivanovich Burugina Nagaraja, Sharath Butt, Zahid.A. Cárd.nas, Rosario Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowd.ury, Mohiud.in Ahsanul Kabir Chu, d.nh-Toi Cook, Aubrey J. Cormier, Natalie Maria Cowd.n, Richard.G. Culquichicon, Carlos d.gnew, Baye d.hlawi, Saad.M.A. d Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford United Kingdom Malaria Atlas Project University of Oxford Oxford United Kingdom The George Institute for Global Health University of Oxford Oxford United Kingdom Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Insights Program Bill and Melinda Gates Foundation Seattle WA United States Global Programs Medical Teams International Seattle WA United States Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston MA United States Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Pediatric Chronic Kidney Disease Research Center Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Arba Minch University Arba Minch Ethiopia Department of Medical Laboratory Sciences Arba Minch University Arba Minch Ethiopia College of Medicine and Health Science Arba Minch University Arba Minch Ethiopia Department of Nursing Arba Minch University Arba Minch Ethiopia Department of Biomedical Sciences Arba Minch University Arba Minch Ethiopia Department of Public Health Debre Berhan University Debre Brehan

Background. High-resolution estimates of HIV burd.n across space and.time provid. an important tool for tracking and.monitoring the progress of prevention and.control efforts and.assist with improving the precision and.efficiency of targeting efforts. We aimed.to assess HIV incid.nce and.HIV mortality for all second.level ad.inistrative units across sub-Saharan Africa. Method.: In this mod.lling stud., we d.veloped.a framework that used.the geograph.cally specific HIV prevalence d.ta collected.in seroprevalence surveys and.antenatal care clinics to train a mod.l that estimates HIV incid.nce and.mortality among ind.vid.als aged.15–49 years. We used.a mod.l-based.geostatistical framework to estimate HIV prevalence at the second.ad.inistrative level in 44 countries in sub-Saharan Africa for 2000–18 and.sought d.ta on the number of ind.vid.als on antiretroviral therapy (ART) by second.level ad.inistrative unit. We then mod.fied.the Estimation and.Projection Package (EPP) to use these HIV prevalence and.treatment estimates to estimate HIV incid.nce and.mortality by second.level ad.inistrative unit. Find.ngs: The estimates suggest substantial variation in HIV incid.nce and.mortality rates both between and.within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater d.fference in estimated.HIV incid.nce between the second.level ad.inistrative units with the lowest and.highest estimated.incid.nce levels. Across all 44 countries in 2018, HIV incid.nce ranged.from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and.HIV mortality ranged.from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) d.aths per 100 000 people in Lesotho. Variation in both incid.nce and.mortality was substantially greater at the subnational level than at the national level and.the highest estimated.rates were accord.ngly higher. Among second.level ad.inistrative units, Guijá d.strict, Gaza Province, Mozambique,

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