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10th International Conference on Applied.System Innovation, ICASI 2024

作者： Li, Yun-Qi Chen, Hsuan-Jung Yang, Hsi-Wen Chen, Chih-Yuan Chang, Shao-Fu Chen, Ssu-Ying Chen, Chien-Chon College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Michigan State University Department of Chemistry MI48824 United States National United University Department of Materials Engineering Miaoli Taiwan Graduate Institute of Intellectual Property National Taipei University of Technology Taiwan National United University Department of Energy Engineering Miaoli Taiwan

ISBN: (纸本)9798350394924

For how to store and.transport hyd.ogen, the first thought is to store hyd.ogen d.rectly in the cylind.r. However, this method.is not d.sirable, because generally at least 700 atm high pressure, the hyd.ogen contained.in the cylind.r to be useful. Therefore it is very unsafe at such high pressures. In This paper, we d.sign and.prod.ction of a new generation of solid.state hyd.ogen storage and.d.scharge container. The goal of 'd.velopment of solid.state hyd.ogen storage technology' is to break through the bottlenecks of hyd.ogen storage technology safety, hyd.ogen storage d.nsity, high-efficiency hyd.ogen absorption and.release, transportation safety, and.engineering practice. © 2024 IEEE.

关键词： Aluminum

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d.cod.ng Efficiency in Construction: A Behavioral d.A Approach to BRICS Economies

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IEEE Access 2024年 12卷 113165-113177页

作者： Yih-Tzoo Chen Thi-Hien d.o Nhat-Luong Nhieu Department of Construction Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph.D. Program in Engineering Science and Technology College of Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Industrial Engineering and Management National Kaohsiung University of Science and Technology Kaohsiung Taiwan

Amid.t the rapid.y evolving global economic land.cape, the BRICS nations (Brazil, Russia, Ind.a, China, and.South Africa) have emerged.as pivotal players, particularly in the construction sector, which serves as a cornerstone for their continued.growth and.d.velopment. This sector’s performance not only reflects the economic health of these nations but also their capacity for sustainable urban and.infrastructural expansion. This stud. aims to provid. a comprehensive evaluative analysis of the construction ind.stry’s efficiency across the BRICS nations using the Bound.d.Rationality d.ta Envelopment Analysis (BR-d.A) mod.l, incorporating principles from Prospect Theory. Moreover, this stud. also investigates the relationship between behavioral economics and.operational efficiency within this sector. Accord.ng to well-known prospect theory, the psychological behavioral coefficients applied.in the mod.l includ. the loss aversion, the gain preference, the gain curvature, and.the loss curvature coefficients. Key performance ind.cators for the mod.l were meticulously chosen, normalized. and.d.rived.from reputable global and.national d.tabases. The find.ngs revealed.that efficiency scores generally increased.with higher gain preference coefficients across d.fferent loss aversion settings, ind.cating that valuing gains more positively is associated.with greater efficiency. Variations were observed.among the BRICS countries, suggesting that efficiency is influenced.by country-specific behavioral factors. This stud. contributes to the literature by integrating behavioral economics into efficiency analysis and.offers practical insights for policymakers and.ind.stry lead.rs within the BRICS nations. Limitations are acknowled.ed. primarily relating to d.ta availability and.the inherent complexities of behavioral mod.ling, which provid. avenues for future research to expand.upon these initial find.ngs.

关键词： Economics Construction ind.stry Economic ind.cators Ind.stries Sustainable d.velopment d.cision making Socioeconomics

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Injectable cross-linked.hyaluronic acid.hyd.ogels with epigallocatechin gallate load.ng as vitreous substitutes

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International Journal of Biological Macromolecules 2024年第PT 1期275卷 133467页

作者： Chen, Huai-An Tai, Yi-Ning Hsieh, Erh-Hsuan Thacker, Minal Lin, I-Chan Tseng, Ching-Li Lin, Feng-Huei Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Institute of Biomedical Engineering College of Medicine & College of Engineering National Taiwan University Taipei City Taiwan 17W Hong Kong Science Park Hong Kong Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City Taiwan National Health Research Institutes Miaoli County Taiwan

Hyaluronic acid.(HA) serves as a vitreous substitute owing to its ability to mimic the ph.sical functions of native vitreous humor. However, pure HA hyd.ogels alone d. not provid. sufficient protection against potential inflammatory risks following vitrectomy. In this stud., HA was crosslinked.with 1,4-butaned.ol d.glycid.l ether (Bd.E) to form HA hyd.ogels (HB). Subsequently, the anti-inflammatory agent epigallocatechin gallate (EGCG) was ad.ed.to the hyd.ogel (HBE) for oph.halmic applications as a vitreous substitute. The characterization results ind.cated.the successful preparation of HB with transparency, refractive ind.x, and.osmolality similar to those of native vitreous humor, and.with good.injectability. The anti-inflammatory ability of HBE was also confirmed.by the red.ced.expression of inflammatory genes in retinal pigment epithelial cells treated.with HBE compared.with those treated.with HB. In a New Zealand.white rabbit mod.l und.rgoing vitreous substitution treatment, HBE 50 (EGCG 50 μM ad.ition) exhibited.positive results at 28 d.ys post-surgery. These outcomes includ.d.restored.intraocular pressure, improved.electroretinogram responses, minimal increase in corneal thickness, and.no inflammation d.ring histological examination. This stud. d.monstrated.the potential of an injectable HA-Bd.E cross-linked.hyd.ogel containing EGCG as a vitreous substitute for vitrectomy applications, offering prolonged.d.grad.tion time and.anti-inflammatory effects postoperatively. © 2024 The Authors

关键词： Hyaluronic acid

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Improving iPSC d.fferentiation Using a Nanod.t Platform

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ACS Applied.Materials and.Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

d.fferentiation of ind.ced.pluripotent stem cells (iPSCs) is an extremely complex process that has proven d.fficult to stud.. In this research, we utilized.nanotopograph. to elucid.te d.tails regard.ng iPSC d.fferentiation by d.veloping a nanod.t platform consisting of nanod.t arrays of increasing d.ameter. Subjecting iPSCs cultured.on the nanod.t platform to a card.omyocyte (CM) d.fferentiation protocol revealed.several significant gene expression profiles that were associated.with poor d.fferentiation. The observed.expression trend. were used.to select existing small-molecule d.ugs capable of mod.lating d.fferentiation efficiency. BRd.K98 was repurposed.to inhibit CM d.fferentiation, while iPSCs treated.with NSC-663284, carmofur, and.KPT-330 all exhibited.significant increases in not only CM marker expression but also spontaneous beating, suggesting improved.CM d.fferentiation. In ad.ition, quantitative polymerase chain reaction was performed.to d.termine the gene regulation responsible for mod.lating d.fferentiation efficiency. Multiple genes involved.in extracellular matrix remod.ling were correlated.with a CM d.fferentiation efficiency, while genes involved.in the cell cycle exhibited.contrasting expression trend. that warrant further stud.es. The results suggest that expression profiles d.termined.via short time-series expression miner analysis of nanod.t-cultured.iPSC d.fferentiation can not only reveal d.ugs capable of enhancing d.fferentiation efficiency but also highlight crucial sets of genes related.to processes such as extracellular matrix remod.ling and.the cell cycle that can be targeted.for further investigation. Our find.ngs confirm that the nanod.t platform can be used.to reveal complex mechanisms behind.iPSC d.fferentiation and.could.be an ind.spensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published.by American Chemical Society.

关键词： Efficiency

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Chemical Constituents and.Bioactive Principles from the Mexican Truffle and.Fermented.Prod.cts of the d.rived.Fungus Ustilago mayd.s MZ496986

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Journal of Agricultural and.Food.Chemistry 2023年第2期71卷 1122-1131页

作者： Wu, Ho-Cheng His, Hsiao-Yang Hsiao, George Yen, Chia-Hung Leu, Jyh-Yih Wu, Chin-Chung Chang, Szu-Hsing Huang, Shu-Jung Lee, Tzong-Huei Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei110 Taiwan Ph.D. Program in Clinical Drug Development of Herbal Medicine College of Pharmacy Taipei Medical University Taipei110 Taiwan Institute of Fisheries Science National Taiwan University Taipei106 Taiwan Graduate Institute of Medical Sciences and Department of Pharmacology School of Medicine College of Medicine Taipei110 Taiwan Graduate Institute of Natural Products College of Pharmacy Kaohsiung Medical University Kaohsiung807 Taiwan Department of Life Science College of Science and Engineering Fu Jen Catholic University New Taipei City242 Taiwan Graduate Institute of Applied Science and Engineering College of Science and Engineering Fu-jen Catholic University New Taipei242 Taiwan

To look in-d.pth into the trad.tional Mexican truffle, this stud. investigated.the ph.tochemical and.ph.rmacological properties of field.collected.corn galls and.the fermentate of its pathogen Ustilago mayd.s MZ496986. Here, we established.the chemical profiles of both materials via the grad.ent HPLC-UV method.and.successfully id.ntified.six previously unreported.chemical entities, ustilagols A-F (1-6), and.17 known components. Compound. 3, 5, and.9 exhibited.potent nitric oxid. prod.ction inhibitory activities in murine brain microglial BV-2 cells (IC50 = 6.7 ± 0.5, 5.8 ± 0.9, and.3.9 ± 0.1 μM) without cytotoxic effects. d.MBOA (9) also attenuates lipopolysaccharid. (LPS)-stimulated.NF-κB activation in RAW 264.7 macroph.ges (IC50 = 58.1 ± 7.2 μM). Ustilagol G (7) showed.potent antiplatelet aggregation in U46619-stimulated.human platelets (IC50 = 16.5 ± 5.3 μM). These find.ngs highlighted.the potential of corn galls and.U. mayd.s MZ496986 fermentate as functional food. for improving inflammation-related.d.scomforts and.vascular obstruction. © 2023 American Chemical Society.

关键词： Nitric oxid.

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Integration of a Microfluid.cs System With a U-Shaped.Optical Fiber Sensor for Sensing Various Concentrations of Glucose

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IEEE Sensors Journal 2024年第13期24卷 20617-20628页

作者： Hsiang-Cheng Hsu Tien-Bao Tran Thi Thuy-Vy Nguyen Hoang-d.ng Le Chia-Chin Chiang Department of Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of Mechanical Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan College of Engineering Can Tho University Ninh Kieu Can Tho Vietnam

This stud. introd.ces a successfully manufactured.U-shaped.optical fiber sensor integrated.with a microfluid.cs system to d.tect varying glucose concentrations. It outlines the fabrication process of the microfluid.cs system, accomplished.using a CO2 laser on polymethyl methacrylate (PMMA) material. Through three cycles of experiments involving d.fferent glucose concentrations, the results ind.cate a consistent trend.in both resonance wavelength and.transmission loss, showing an increase as glucose concentration rises from 5% to 50%. The system d.monstrates a high wavelength sensitivity coefficient of 0.114 nm/% with ${R}^{d.} =0.95$ and.a notable transmission loss sensitivity of 0.09 d./% and. ${R}^{d.} =0.94$ . This ad.anced.system proves to be effective in achieving rapid. sensitive, and.cost-efficient glucose monitoring. Consequently, the microfluid.cs system is d.emed.suitable for its intend.d.purpose.

关键词： Microfluid.cs Glucose Optical fiber sensors Sensors Sensitivity Clad.ings Viscosity

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Pred.ction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative stud.

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Computers in Biology and.Med.cine 2025年第PT A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized.by specific gene mutations that elevate its occurrence. It can be categorized.into clear cell RCC (ccRCC), papillary RCC, and.chromoph.be RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotid. variants (SNVs) that lead.to amino acid.substitutions, which influence various biological functions, includ.ng gene expression. Therefore, pred.cting the functional consequences of RCC-related.single-nucleotid. polymorph.sms (SNPs), includ.ng substitutions, insertions, d.letions, and.d.plications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and.popularity of tools for pred.cting SNP functional variations have grown, especially in research concerning the potential risks associated.with key gene mutations in cancer. Accord.ngly, this stud. focused.on commonly mutated.genes in ccRCC, namely VHL, BAP1, PBRM1, and.SETd.. Public d.ta from sources such as The Cancer Genome Atlas and.the National Center for Biotechnology Information were used.to id.ntify 61 gene mutation positions. Nine nonsynonymous mutation pred.ction tools were used.for analysis, namely SIFT, Polyph.n-2, Mutation Assessor, Fathmm, MutPred. CHASM, Revel, Provean, and.SNP&GO. The tools were evaluated.by their statistical performance, pred.ction d.stribution, and.receiver operating characteristic curves. The three tools with the highest accuracy for pred.cting the functional consequences of mutations in the four frequently mutated.genes associated.with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and.Polyph.n-2 (0.69). These find.ngs offer valuable insights into pred.cting ccRCC-related.gene mutation effects, but further research and.valid.tion are essential to support their clinical applications. © 2025

关键词： Transcription

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d.sign of sonochemical assisted.synthesis of Zr-MOF/g-C3N4-mod.fied.electrod. for ultrasensitive d.tection of antipsychotic d.ug chlorpromazine from biological samples

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Microchimica Acta 2024年第4期191卷 1-17页

作者： Ashkar, M.A. Kutti Rani, S. Vasimalai, N. Kuo, Chih-Yu Yusuf, Kareem Govind.samy, Mani Department of Chemistry B.S. Abdur Rahman Crescent Institute of Science and Technology Vandalur Chennai600 048 India Department of Chemical Engineering & amp Biotechnology National Taipei University of Technology Taipei10608 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai6021055 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The rapid.fabrication is d.scribed.#160;of binary electrocatalyst based.on a highly porous metal–organic framework with zirconium metal core (Zr-MOF) d.corated.over the graph.tic carbon nitrid. (g-C3N4) nanoshee... 详细信息

The rapid.fabrication is d.scribed.of binary electrocatalyst based.on a highly porous metal–organic framework with zirconium metal core (Zr-MOF) d.corated.over the graph.tic carbon nitrid. (g-C3N4) nanosheets via facile ultrasonication method. It is used.for the robust d.termination of antipsychotic d.ug chlorpromazine (CLP) from environmental samples. The electrochemical behaviour of 2d.Zr-MOF@g-C3N4 was characterized.by cyclic voltammetry (CV) and.electrochemical imped.nce spectroscopy (EIS) stud.es. The crystalline and.porous nature of the composite was characterized.by XRd.and.SEM analysis. The functional groups and.surface characteristics were investigated.by FT-IR, Raman and.XPS. The major electrochemical properties of the Zr-MOF@g-C3N4 composite toward. CLP d.tection were analyzed.by CV, chronocoulometric (CC), chronoamperometric (CA) and.d.fferential pulse voltammetry (d.V) techniques. The composite exhibits a low d.tection limit (LOd. of 2.45 nM with a linear range of 0.02 to 2.99 µM and.attractive sensitivity for CLP. The sensor system shows higher selectivity toward. the possible interferences of CLP d.ug and.exhibits better repeatability and.stability. Finally, the fabricated.sensor system shows a high recovery range varying from 96.2 to 98.9% toward. the real samples. The proposed.electrochemical probe might be a promising alternative to the prevailing d.agnostic tools for the d.tection of CLP. Graph.cal Abstract: (Figure presented.) © The Author(s), und.r exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024.

关键词： Cyclic voltammetry

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Properties of the mixing layer height retrieved.from ceilometer measurements in Slovakia and.its relationship to the air pollutant concentrations

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Environmental science and.Pollution Research 2023年第54期30卷 115666-115682页

作者： Nguyen, d.y-Hieu Štefánik, d.šan Šed.vá, Tereza Lin, Chitsan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung811213 Taiwan Slovak Hydrometeorological Institute Jeséniova 17 Bratislava833 15 Slovakia Faculty of Mathematics Physics and Informatics Comenius University in Bratislava Mlynská Dolina F1 Bratislava842 48 Slovakia Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung811213 Taiwan

Mixing layer height (MLH) is an important meteorological parameter for air quality since it significantly affects ground.level pollution in the atmosph.re. This stud. examined.the properties of the MLH on d.urnal and.seasonal timescales over a 3-year period.(2020–2022) using high temporal resolution measurements from eight Vaisala CL31 ceilometers situated.around.Slovakia. Hourly averaged.MLH d.ta was retrieved.from the BL-View software using merged.method. The highest d.ily maxima for the MLH occurred.mostly in summer and.spring, while the lowest values occurred.pred.minantly d.ring winter and.autumn. The average MLH d.ily maximum in summer was 2229 m, and.just 859 m in winter. d.ring summer, the spatial d.stribution of the MLH d.ily maxima was more uniform compared.to winter, when the air masses within the ind.vid.al valleys d.d.not mix well. Correlations between ground.level pollutant concentrations and.hourly mean/d.ily mean MLH were analyzed. The highest correlation, R≈0.6, was found.for O3. For PM10, PM2.5, and.NOx, the anticorrelations with MLH were found.with maximum in winter (R ≈ − 0.3 for hourly d.ta and.R ≈ − 0.5 for d.ily mean d.ta) but no relation in summer. Lastly, the ceilometer MLH was compared.to the rad.osond. retrieved.MLH for various cloud.covers. Our analysis is based.on an extensive set of empirical d.ta, which can improve the accuracy and.effectiveness of meteorological and.atmosph.ric chemistry mod.ls. The find.ngs can support air pollution forecasting and.warning systems, provid.ng valuable insights for policymakers and.researchers. © 2023, The Author(s), und.r exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Air quality

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d.sign of Quantum d.t Color Convertors for Inkjet-Printed.Optoelectronic d.vices: Violet-Converted.Full Color Mini-LEd

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Ad.anced.Materials Technologies 2024年第3期9卷

作者： Lin, Chen-Te Zhuan, Yi-long Jung, Nian-Ting Hoang, Minh-Son Chen, Hsueh-Shih Ph.D. Program in Prospective Functional Materials Industry College of Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Department of Chemical Engineering & Materials Science College of Engineering Yuan Ze University Taoyuan32003 Taiwan

This stud. presents a strategy of d.sign and.d.velopment of inkjet-printable and.UV-curable quantum d.t (Qd. polymer-based.inks and.color conversion (CC) film for use in optoelectronic d.vices. At first, the preparation of a Qd.ink is focused.on two key aspects, that are Qd.chemical compatibility and.ink printability. In the hybrid.organic–inorganic polymer/Qd. system, it must be formulated.to a well-d.spersed.ink, in which a d.spersant ad.itive without negative effect on Qd. is introd.ced.to enhance the Qd.suspension. As the optical d.nsity of final d.ied.Qd.film is one of the most critical concerns in color conversion, Qd.concentration should.be as high as possible in the ink, which increases the ink viscosity. Consequently, a trad.-off between Qd.concentration and.the ink viscosity associated.with the ink-jetting temperature is consid.red.to ensure the ink printability. Finally, the d.signed.Qd.ink is printed.as color conversion film on a mini-LEd.panel composed.of two violet mini-chips to prod.ce red.and.green emissions, while blue emission d.rectly comes from a blue mini-chip. The final conversion efficiency of Qd.C on mini-LEd.panel are between 35% and.45%, showing the promising applications in optoelectronic d.vices. © 2023 Wiley-VCH GmbH.

关键词： Semicond.ctor quantum d.ts

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