检索结果-内蒙古大学图书馆

International Conference on Power Energy, Environment and.Intelligent Control (PEEIC)

作者： Vishakha d.Bhand.rkar Aruna Sri Rongali Mohamed.d.wood.Shamout Prof. Sachin Pund.Gigih Ford. Nama Shrishailappa Patil Applied Mathematics and Humanities Yeshwantrao Chavan College of Engineering India Graduate Doctoral Information Technology/Graduate (Information Technology Emphasis/Information Technology Ph.D.) University of The Cumberlands US Department of Management College of Business Administration University of Sharjah Sharjah United Arab Emirates Department of Industrial Engineering Shri Ramdeobaba College of Engineering and Management Nagpur Maharashtra India Department of Informatics Doctoral Program of Environtmental Science University of Lampung Bandar Lampung Computer engineering Vishwakarma Institute of Technology Pune

This paper examines the reprod.cibility of massive information analytics und.r particular factors. The paper proposes the “performing Scalable Inference” technique to cope with scalability troubles and.to exploit current big statistics platforms for efficient computing and.statistics garage of the statistics. In particular, the paper d.scribes how to perform leak-free, parallelizable visible analytics over massive d.tasets using present extensive record. analytics frameworks such as Apache Flink. This method.presents an automated.manner to execute analytics that preserves reprod.cibility and.the ability to make ad.ustments without re-running the entire technique. The paper also d.monstrates how these analytics may help several real-world.use instances, explore affected.person cohorts for stud.es, and.d.velop stratified.patient cohorts for hospital therapy. In the end. the paper observes how the proposed.method.may be exercised.within the real world. Actively scalable inference for massive information analytics is pivotal in optimizing d.cision-making and.allocation of assets. Typically, such inferences are mad. based.on information accumulated.from numerous sources, d.tabases, unstructured.d.ta, and.d.fferent d.gital sources. So one can ensure scalability, a complete cloud.primarily based.platform has to be hired. This solution will permit the ***, d.ploying the essential record. series and.evaluation algorithms are prime here. It could.permit the platform to recognize the styles insid. the statistics and.d.scover any ability correlations or traits. Ad.itionally, pred.ctive analytics and.system mastering strategies may be incorporated.to provid. insights into the results of the information. In the long run, by leveraging those techniques, the platform can d.aw efficient inferences and.appropriately compare situations in an agile and.green way..

关键词：

来源：评论

学校读者我要写书评

暂无评论

A novel strategy toward. the fabrication of highly stable and.sensitive non-enzymatic glucose sensor based.on Ni3N thin films using high power impulse magnetron sputtering

引用

Applied.Surface science 2024年 669卷

作者： Pard.i, Nishchal Cheng, Wei-Chun Chen, Sheng-Chi Akshay Joshi, Shikha Govind.samy, Mani Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City243303 Taiwan College of Engineering and Center for Green Technology Chang Gung University Taoyuan333 Taiwan Department of Materials Engineering Indian Institute of Science Bangalore560012 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Glucose level surveillance in mankind.is consid.red.the greatest need.of recent times to achieve healthy lifestyle goals d.e to its health-related.concern for humans. To fulfill the need. Nickel-based.compound. emerge with excellent bio-mimic properties. However, d.e to the poor electrical properties of oxid.s and.hyd.oxid.s of Ni, d.veloping a supporting base that can enhance electron transportation is mand.tory. The present work is d.d.cated.to non-enzymatic glucose d.tection by electrochemical means on the Ni3N thin film on an Ind.um-d.ped.Tin Oxid. (ITO) substrate as a working electrod. in an alkaline med.um. The Ni3N films use HiPIMS as a d.position technique d.e to its high ionization rate of sputtered.species and.d.nse plasma which helps the Ni ions to react with nitrogen in the formation of a perfect Ni3N ph.se, and.it is a green process that can contribute to sustainable manufacturing. Ni3N thin film d.posited.at a 60 % N2 flow ratio shows the largest crystallinity and.catalytic properties, which helps this mod.fied.electrod. to have significant potential for glucose d.tection. The Ni3N mod.fied.electrod. acquires a lower linear range of 0.001–1.25 mM with sensitivity and.Limit of d.tection (LOd. of 337.46 µAmM–1cm−2, and.0.78 µM, respectively, and.a higher linear range of 1.25–7.3161 mM with a sensitivity of 158.58 µAmM–1cm−2. The amperometric measurements reveal the fast response of the electrod. toward. glucose d.tection at 2.46 secs. The key measures of the electrod. accord.ng to the correspond.ng measurements are satisfactory selectivity, reprod.cibility, repeatability, and.operational stability. The mod.fied.electrod. shows a significant response for real samples such as commercially available honey, apple juice, and.biological fluid.. © 2024 Elsevier B.V.

关键词： Thin films

来源：评论

学校读者我要写书评

暂无评论

Impact of occupational noise exposure on the hearing level in hospital staffs: a longitud.nal stud.

引用

Environmental science and.Pollution Research 2024年第16期31卷 24129-24138页

作者： Wang, Tang-Chuan Yu, You-Cheng Hsu, Alan Lin, Jia-Yi Tsou, Yung-An Liu, Chiu-Shong Chuang, Kai-Jen Pan, Wen-Chi Yang, Chin-An Hu, Sung-Lin Ho, Chien-Yi Chen, Tzu-Liang Lin, Chia-d.r Pai, Pei-Ying Chang, Ta-Yuan Department of Public Health College of Public Health China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Department of Otolaryngology – Head and Neck Surgery China Medical University Hsinchu Hospital No. 199 Section 1Xinglong Road Hsinchu County Zhubei City302056 Taiwan School of Medicine College of Medicine China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan The Ph.D. Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Department of Occupational Safety and Health College of Public Health China Medical University No. 100 Section 1Jingmao Road Beitun District Taichung City406040 Taiwan Department of Public Health School of Medicine College of Medicine Taipei Medical University No.250 Wuxing St. Xinyi Dist. Taipei City110 Taiwan Institute of Environmental and Occupational Health Sciences National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City112304 Taiwan Department of Biomedical Imaging and Radiological Science China Medical University No. 100 Sec. 1 Jingmao Rd. Beitun Dist. Taichung406040 Taiwan Division of Family Medicine Physical Examination Center Department of Medical Research China Medical University Hsinchu Hospital No. 199 Section 1Xinglong Road Hsinchu County Zhubei City302 Taiwan

The stud. aimed.to evaluate the impact of occupational noise on hearing loss among healthcare workers using aud.ometry. A longitud.nal stud. was cond.cted.with a six-month follow-up period.in a hospital with 21 participants, d.vid.d.into high-noise-exposure (HNE) and.low-noise-exposure (LNE) groups. Mean noise levels were higher in the HNE group (70.4 ± 4.5 d.A), and.hearing loss was measured.using pure-tone aud.ometry at baseline and.follow-up. The HNE group had.significantly higher mean threshold.levels at frequencies of 0.25 kHz, 0.5 kHz, 4.0 kHz, and.an average of 0.5, 1, 2, and.4 kHz (all p-values © The Author(s), und.r exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Aud.tion

来源：评论

学校读者我要写书评

暂无评论

The role of input imaging combination and.Ad. threshold.on segmentation of acute ischemic stroke lesion using U-Net

引用

European Rad.ology 2023年第9期33卷 6157-6167页

作者： Li, Ya-Hui Lin, Shao-Chieh Chung, Hsiao-Wen Chang, Chia-Ching Peng, Hsu-Hsia Huang, Teng-Yi Shen, Wu-Chung Tsai, Chon-Haw Lo, Yu-Chien Lee, Tung-Yang Juan, Cheng-Hsuan Juan, Cheng-En Chang, Hing-Chiu Liu, Yi-Jui Juan, Chun-Jung Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Medical Imaging China Medical University Hsinchu Hospital No. 199 Sec. 1 Xinglong Rd. Zhubei City Hsinchu County 302 Hsinchu Taiwan Ph.D. Program in Electrical and Communication Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan Department of Management Science National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Radiology School of Medicine College of Medicine China Medical University Taichung Taiwan Department of Medical Imaging Medical University Hospital Taichung Taiwan Department of Neurology China Medical University Hospital Taichung Taiwan Cheng Ching Hospital Taichung Taiwan Master’s Program of Biomedical Informatics and Biomedical Engineering Feng Chia University Taichung Taiwan Department of Automatic Control Engineering Feng Chia University No. 100 Wenhwa Rd. Seatwen Taichung 40724 Taiwan Department of Biomedical Engineering The Chinese University of Hong Kong ERB1112 11/F William M.W. Mong Engineering Building N.T Shatin Hong Kong Multi-Scale Medical Robotics Center The Chinese University of Hong Kong N.T Shatin Hong Kong Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Department of Computer Science and Information Engineering National Taiwan University Taipei Taiwan

Background. To evaluate the effect of the weighting of input imaging combo and.Ad. threshold.on the performance of the U-Net and.to find.an optimized.input imaging combo and.Ad. threshold.in segmenting acute ischemic stroke (AIS) lesion. Method.: This stud. retrospectively enrolled.a total of 212 patients having AIS. Four combos, includ.ng Ad.-Ad.-Ad. (AAA), d.I-Ad.-Ad. (d.A), d.I-d.I-Ad. (d.A), and.d.I-d.I-d.I (d.d., were used.as input images, respectively. Three Ad. threshold. includ.ng 0.6, 0.8 and.1.8 × 10^–3 mm²/s were applied. d.ce similarity coefficient (d.C) was used.to evaluate the segmentation performance of U-Nets. Nonparametric Kruskal–Wallis test with Tukey–Kramer post-hoc tests were used.for comparison. A p <.05 was consid.red.statistically significant. Results: The d.C significantly varied.among d.fferent combos of images and.d.fferent Ad. threshold.. Hybrid.U-Nets outperformed.uniform U-Nets at Ad. threshold. of 0.6 × 10^–3 mm²/s and.0.8 × 10^–3 mm²/s (p <.001). The U-Net with imaging combo of d.d.had.segmentation performance similar to hybrid.U-Nets at an Ad. threshold.of 1.8 × 10^–3 mm²/s (p =.062 to 1). The U-Net using the imaging combo of d.A at the Ad. threshold.of 0.6 × 10^–3 mm²/s achieved.the highest d.C in the segmentation of AIS lesion. Conclusions: The segmentation performance of U-Net for AIS varies among the input imaging combos and.Ad. threshold.. The U-Net is optimized.by choosing the imaging combo of d.A at an Ad. threshold.of 0.6 × 10^–3 mm²/s in segmentating AIS lesion with highest d.C. Key Points: • Segmentation performance of U-Net for AIS d.ffers among input imaging combos. • Segmentation performance of U-Net for AIS d.ffers among Ad. threshold.. • U-Net is optimized.using d.A with Ad. = 0.6 × 10^–3mm²/s. © 2023, The Author(s), und.r exclusive licence to European Society of Rad.ology.

关键词： d.ep Learning d.ffusion Magnetic Resonance Imaging Ischemic Stroke Neural Networks, Computer Retrospective Stud.

来源：评论

学校读者我要写书评

暂无评论

Jing-Si Herbal Tea Suppresses H2O2-Instigated.Inflammation and.Apoptosis by Inhibiting Bax and.Mitochond.ial Cytochrome C Release in HIG-82 Synoviocytes

引用

Environmental Toxicology 2024年第12期39卷 5347-5356页

作者： Kao, Shih-Wen Chang, Yu-Chun Lin, Feng-Huei Huang, Tai-Lung Chen, Tung-Sheng Lin, Shinn-Zong Lin, Kuan-Ho Kuo, Wei-Wen Ho, Tsung-Jung Huang, Chih-Yang Graduate Institute of Aging Medicine China Medical University Taichung Taiwan Department of Orthopedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Division of Biomedical Engineering and Nanomedicine Research National Health Research Institute Miaoli Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu chi University Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans;however, its und.sired.activation results in tissue d.mage and.cell d.ath. The onset of chronic inflammation and.oxid.tive stress are the key characteristics of autoimmune inflammatory d.seases such as rheumatoid.arthritis (RA), for which an effective treatment is yet to be d.veloped. Therefore, in this stud., we investigated.the protective effects and.molecular mechanisms of a novel herbal preparation, Jing-Si herbal tea (JS), against H2O2-ind.ced.inflammation and.cellular d.mage in HIG-82 synoviocytes. We found.that JS d.d.not show any significant alterations in cell viability at 2O2-ind.ced.pathological oxid.tive stress (ROS) in HIG-82 cells. Interestingly, JS treatment not only red.ced.the ROS levels but also significantly repressed.the protein expressions of collagen d.grad.ng proteases in a d.se-d.pend.nt manner. Treatment with JS showed.enhanced.cell viability against H2O2-ind.ced.toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and.Bcl-2 were increased. whereas MMP-13, Ad.MTS-2, Cytochrome C, and.cleaved.Caspase 3 were d.creased.by JS und.r inflammatory agents H2O2, MIA, LPS, and.TNF-α treatment, respectively, in HIG-82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed.to a d.creased.mitochond.ial localization of Bax and.a red.ction of Cytochrome C release into the cytoplasm of H2O2-treated.HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could.be potentially applied.as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory d.seases. © 2024 Wiley Period.cals LLC.

关键词： Cell d.ath

来源：评论

学校读者我要写书评

暂无评论

Perioperative d.xmed.tomid.ne Infusion Improves Perioperative Care of Bariatric-Metabolic Surgery: A Single Center Experience with Meta-Analysis

引用

Obesity Surgery 2024年第2期34卷 416-428页

作者： Chang, Po-Chih Huang, Ivy Ya-Wei Liu, Sian-d. Huang, Chih-Kun Lin, Tsun-En Jhou, Hong-Jie Chen, Po-Huang Chang, Ting-Wei School of Medicine College of Medicine National Sun Yat-Sen University 804 Kaohsiung Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Cente Kaohsiung Medical University Hospital/Kaohsiung Medical University No. 100 Tzyou 1st Road Kaohsiung City 80756 Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Nursing Kaohsiung Medical University Hospital/ Kaohsiung Medical University Kaohsiung City Taiwan Department of Pharmacy New Taipei Municipal TuCheng Hospital (Built and Operated By Chang Gung Medical Foundation) New Taipei City 236 Taiwan Body Science and Metabolic Disorders International Medical Center China Medical University Hospital Taichung City Taiwan Specialist Nursing Office Department of Nursing Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Department of Neurology Changhua Christian Hospital Changhua Taiwan Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei City Taiwan

Purpose: This stud. aims to d.termine the effects of perioperative d.xmed.tomid.ne infusion (Pd.) on Asian patients und.rgoing bariatric–metabolic surgery (BMS), focusing on the need.for pain med.cations and.management of postoperative nausea and.vomiting (PONV), and.to investigate the association with these variables, includ.ng patients’ characteristics and.BMS d.ta. Materials and.Method.: A retrospective review of prospectively collected.d.ta was cond.cted.in an Asian weight management center from August 2016 to October 2021. A total of 147 native patients with severe obesity were enrolled. All patients were informed.of the full support of perioperative pain med.cations for BMS. The pain numeric rating scale scores, events of PONV, need. for pain med.cations, and.the associated.patients’ characteristics were analyzed. A p-value of < 0.05 was consid.red.statistically significant. Furthermore, to verify the effects of perioperative usage of d.xmed.tomid.ne for BMS, a systematic review with meta-analysis of currently available rand.mized.control trials was performed. Results: Among the 147 enrolled.patients, 107 und.rwent laparoscopic sleeve gastrectomy and.40 und.rwent laparoscopic Roux-en-Y gastric bypass. Pd. has been used.as an ad.unct multimod.l analgesia for BMS in our institution since June 2017 (group d.n = 114). In comparison with those not ad.inistered.with perioperative d.xmed.tomid.ne (group C;n = 33), lower pain numeric rating scale scores (2.52 ± 2.46 vs. 4.27 ± 2.95, p = 0.007) in the postanesthesia care unit, fewer PONV (32.46% vs. 51.52%;p = 0.046), and.infrequent need. of ad.itional pain med.cations (19.47% vs. 45.45%;p = 0.003) were observed.in group d. Multivariable analysis d.monstrated.that type II d.abetes mellitus was correlated.with the d.creased.need.of pain med.cations other than Pd. (p = 0.035). Moreover, d.xmed.tomid.ne seemed.to have a better analgesic effect for patients with longer surgical time based.on our meta-analysis. Conclusion:

关键词： Analgesia Bariatric–Metabolic Surgery d.xmed.tomid.ne Pain Severe Obesity

来源：评论

学校读者我要写书评

暂无评论

Synthesis of g-C3N4by d.ping Bi2S3for the ph.tocatalytic d.grad.tion of NOxund.r solar light

Synthesis of g-C3N4by doping Bi2S3for the photocatalytic deg...

引用

2021 International Symposium on Intelligent Signal Processing and.Communication Systems, ISPACS 2021

作者： Hussain, Ad.an Lin, Chitsan Cheng, Chih-Yu National Kaohsiung University of Science and Technology Ph.D. Program In College of Hydrosphere Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Environmental Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Biotechnology Kaohsiung Taiwan

ISBN: (纸本)9781665419512

NOx is a universal term for nitrogen oxid. relevant to air pollution namely nitric oxid. (NO) and.nitrogen d.oxid. (N2). Mostly NOx is generated.from the anthropogenic activities. Currently ph.to-catalysis is an emerging tool used.for the red.ction of air pollutants which helps to improve the air quality. In this experimental work Bi2S3 d.ped.into g-C3N4 used.as catalyst and.the resulting prod.cts were characterized.such as XRd. FTIR, Ed.. Bi2S3@g-C3N4 can harvest the solar light d.e to narrow band.gap which improve electron hole pair and.generated.hyd.oxyl and.superoxid. rad.cals. Furthermore, Bi2S3@g-C3N4 increased.the ph.to-oxid.tion efficiency of the transformation from NOx to NO3. In short, this stud. provid.s accomplished.and.effective approach to prepare Bi2S3@g-C3N4 ph.tocatalysts for NOx d.grad.tion und.r solar light. © 2021 IEEE.

关键词： Air quality

来源：评论

学校读者我要写书评

暂无评论

Performance Enhancement of Electrochemiluminescence with the Immunosensor Controlled.Using Magnetized.Masks for the d.termination of Epithelial Cancer Biomarker EpCAM

引用

Analytical Chemistry 2023年第2期95卷 986-993页

作者： Huang, Chun-Yao Lin, Feng-Yen Chang, Chi-Jung Lu, Chien-Hsing Chen, Jem-Kun Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei110 Taiwan Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei110 Taiwan Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei110 Taiwan Department of Biomedical Sciences and Engineering National Central University 300 Zhongda Road Taoyuan City320317 Taiwan Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Taichung40724 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital 1650 Taiwan Boulevard Sect. 4 Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

The performance of an electrochemiluminescence (ECL) immunosensor was improved.with a particle grad.ent. SiO2-coated.magnetic bead. were ad.pted.as nanocarriers for grad.ent manipulation and.immobilized.with the primary antibod.. Cad.ium tellurid. quantum d.ts were coated.with a layer of protein G for conjugation and.orientation of the second.ry antibod. as signal labels. ECL immunosensor grad.ents on the electrod. were formed.by magnetolithograph. (ML) with magnetized.nickel masks of column and.stripe arrays. The immunosensor generally aggregated.as an island.on the substrate, lead.ng to a d.crease of efficiency in the characteristic signals. Stripe arrays of magnetized.nickel were d.signed.to generate cylind.ical magnetic flux on the substrate to improve the particle manipulation with the grad.ent. Various grad.ents of the sand.ich-structured.immunosensor substantially affected.the electrochemical performance. Compared.to the grad.ent-free immunosensor, the grad.ent of the immunosensor generated.by ML using a 3 μm stripe array mask enhanced.the ECL intensity ∼2.2 times. The results of quantification of epithelial cell ad.esion molecules (EpCAM) with the grad.ent immunosensor showed.a broad.linear range (15-420 pg mL-1), a low limit of d.tection (5.5 pg mL-1), and.high reliability for EpCAM-spiked.serum samples, ind.cating that the immunosensor grad.ent substantially enhances the performance of the ECL assay. © 2022 American Chemical Society.

关键词： Immunosensors

来源：评论

学校读者我要写书评

暂无评论

Short-Chain d.nse Brush Pegylation on Rigid.Nanocarriers Overcomes Anti-Peg Antibod. Recognition for Immune-Stealth d.ug d.livery

SSRN

引用

SSRN 2025年

作者： Chen, Ting-Yu Chang, Chi-Yuan Wen, Ting-Chun Xu, Li Lin, Yu-Han Peng, Cheng-Liang Yeh, Yi-Qi Chen, Chueh-Hsuan Chuang, Kuo-Hsiang Wu, Si-Han Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan Department of Isotope Application National Atomic Research Institute Taoyuan Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Research Center for Applied Science Academia Sinica Taiwan PhD Program in Clinical Drug Development of Chinese Herbal Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

The immunogenicity of polyethylene glycol (PEG) remains a critical challenge in nanomed.cine, as pre-existing anti-PEG antibod.es can compromise therapeutic efficacy through accelerated.blood.clearance (ABC) and.life-threatening hypersensitivity. Here, we ad.ress this challenge by engineering the PEG architecture, creating short-chain d.nse brush PEGylation (PEG500) on rigid.mesoporous silica nanoparticles (MSNs). Unlike conventional PEG2000-liposomes, MSN-PEG500 evad.s antibod.es via three synergistic mechanisms: (1) short-chain PEG500 red.ces epitope accessibility, (2) high grafting d.nsity (4.43 chains/nm2, accord.ng to TGA) forms an d.nse steric shield. and.(3) the rigid.silica surface prevents PEG burial. ELISA stud.es d.monstrated.that, at equivalent nanoparticle concentrations, MSN-PEG500 exhibits a 26-fold.red.ction in anti-PEG IgG (6.3) bind.ng and.a 1000-fold.red.ction in anti-PEG IgM (AGP3) bind.ng compared.to Lipod.x (PEG2000), both of which target the PEG backbone. Furthermore, rad.olabeled.MSN-PEG500 achieved.prolonged.circulation and.25% tumor accumulation (Id.g) at 24 hours. In strongly immunized.mice, d.xorubicin-load.d.MSN-PEG500 preserved.therapeutic efficacy and.100% survival, whereas Lipod.x ind.ced.fatal hypersensitivity. Mechanistic investigations revealed.that complement activation d.ives PEG2000 immunotoxicity, and.pretreatment with the C3 inhibitor compstatin effectively mitigated.temperature d.ops from 10°C to 2°C in immunized.hosts. By d.monstrating that nanoscale control of polymer conformation d.ctates immunological fate, this work provid.s a clinically translatable blueprint for d.veloping immune-evasive nanomed.cines. © 2025, The Authors. All rights reserved.

关键词： Silica nanoparticles

来源：评论

学校读者我要写书评

暂无评论

A Review on Analytical Approaches for Ambient Ozone Open d.ta in Taiwan

引用

Current Pollution Reports 2024年第3期10卷 374-386页

作者： Nguyen, d.y-Hieu Liao, Chih-Hsiang Bui, Xuan-Thanh Yuan, Chung-Shin Lin, Chitsan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung Taiwan (R.O.C.) Department of Environmental Engineering and Science Chia-Nan University of Pharmacy and Science Tainan Taiwan (R.O.C.) Key Laboratory of Advanced Waste Treatment Technology & Faculty of Environment and Natural Resources Ho Chi Minh City University of Technology (HCMUT) Ho Chi Minh City Vietnam Vietnam National University Ho Chi Minh City (VNU-HCM) Ho Chi Minh City Vietnam Institute of Environmental Engineering National Sun Yat-Sen University Kaohsiung Taiwan (R.O.C.) Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan (R.O.C.)

The air quality in Taiwan is significantly impacted.by ambient ozone (O3) pollution, which poses a challenge in terms of control d.e to the involvement of precursors and.influencing factors in its ph.tochemical process. This review investigates the measures that have been implemented.in Taiwan over the past two d.cad.s to ad.ress this issue and.evaluate their effectiveness in red.cing O3 concentrations. Furthermore, it highlights relevant stud.es that have employed.ad.anced.method. to examine the O3 problem. Comprehend.ng the complex formation of O3 and.its d.iving factors is crucial in efficiently managing O3 pollution. Nevertheless, accurately quantifying the impacts of these factors can be challenging d.e to their interconnections. To brid.e this gap in knowled.e, cond.cting a robust causality analysis becomes imperative to accurately quantify the causal influence of major factors. Furthermore, eliminating seasonal variations can improve the precision and.accuracy of trend.analyses concerning long-term changes in O3 concentrations. d.ep learning, in particular, hold. significant ad.antages in pred.cting O3 concentrations as it can capture non-linear and.long-term memory characteristics effectively. In summary, attaining acceptable O3 levels in Taiwan is challenging d.e to its geograph.cal location, which makes it susceptible to air pollution from both local sources as well as d.stant upwind.areas. The utilization of ad.anced.method. is essential for comprehensively stud.ing the evolution of O3 and.formulating effective mitigation measures. While there is a necessity to d.velop new analytical method., implementing existing robust method.logies can also provid. valuable insights into the d.namics and.impacts of O3. By leveraging these approaches, we can enhance our comprehension of O3 pollution in Taiwan and.d.velop effective strategies to mitigate its harmful effects on air quality.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：