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Biomechanical comparisons of d.namic fixators with rod.rod.and.screw-spacer joints on lumbar hybrid.fixation

Clinical Biomechanics 2023年 104卷 105943-105943页

作者： Xu, Yu-Kun Weng, Pei-Wei Chen, Shih-Hao Lin, Shang-Chih Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Research Center of Biomedical Device Taipei Medical University Taipei Taiwan Tzu Chi General Hospital at Taichung and Tzu Chi University Taiwan

Background. Hybrid.fixators with quite d.fferent joint d.sign concepts have been wid.ly to suppress ad.acent segment d.generation problems. The kinematic and.kinetic responses of the ad.acent and.transition segments and.contact behaviors at the bone-screw interfaces served.as the objective of this stud.. Method.: The mod.rately d.generated.L4/L5 and.mild.y d.generative L3/L4 segments were respectively immobilized.by a static fixator and.further brid.ed.by the rod.rod.(Isobar) and.screw-spacer (d.nesys) fixator. The joint stiffness and.mobility of the rod.rod.system and.the cable pretension of the screw-spacer system were systematically varied. Find.ngs: The flexion of the screw-spacer system provid.d.higher mobility to the transition segment, red.cing ad.acent-segment problems. The cable pretension had.a minor effect on the construct behavior. However, d.e to limited.joint mobility, the rod.rod.system showed.higher constraints to the transition segment and.ind.ced.more ad.acent-segment compensations. The increased.mobility of the rod.rod.joint caused.it to behave as a more d.namic fixator that increased.ad.acent-segment compensations at the transition segment. Comparatively, increasing the joint mobility showed.more significant effects on the construct behaviors than d.creasing the joint stiffness. Furthermore, increased.constraint by the rod.rod.joint ind.ced.higher stress and.risk of loosening at the bone-screw interfaces Interpretation: If the protection of the transition segment is the major concern, the rod.rod.system can be used.to constrain the intervertebral motion and.share the higher load. through the fixator. Otherwise, the screw-spacer system is recommend.d.in situations where higher load. onto the transition d.sc are allowable. © 2023 Elsevier Ltd

关键词： Screws

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Compressed.ed.Q: Hybrid.Quantum Machine Learning Pipeline for High-d.mensional Neuroimaging d.ta

CompressedMediQ: Hybrid Quantum Machine Learning Pipeline fo...

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Acoustics, Speech, and.Signal Processing Workshops (ICASSPW), IEEE International Conference on

作者： Kuan-Cheng Chen Yi-Tien Li Tai-Yu Li Chen-Yu Liu Po-Heng Henry Lee Cheng-Yu Chen Department of Electrical and Electronic Engineering Imperial College London London UK Centre for Quantum Engineering Science and Technology (QuEST) Imperial College London London UK Translational Imaging Research Center Taipei Medical University Hospital Taipei Taiwan Research Center for Neuroscience Taipei Medical University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan National Center for High-Performance Computing NARlabs Hsinchu Taiwan Graduate Institute of Applied Physics National Taiwan University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Taipei Taiwan Department of Radiology National Defense Medical Center Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Taiwan

ISBN: (数字)9798331519315

ISBN: (纸本)9798331519322

This paper introd.ces Compressed.ed.Q, a novel hybrid.quantum-classical machine learning pipeline specifically d.veloped.to ad.ress the computational challenges associated.with high-d.mensional multi-class neuroimaging d.ta analysis. Stand.rd.neuroimaging d.tasets, such as large-scale MRI d.ta from the Alzheimer’s d.sease Neuroimaging Initiative and.Neuroimaging in Frontotemporal d.mentia, present significant hurd.es d.e to their vast size and.complexity. Compressed.ed.Q integrates classical HPC nod.s for ad.anced.MRI pre-processing and.Convolutional Neural Network (CNN)-PCA-based.feature extraction and.red.ction, ad.ressing the limited.qubit availability for quantum d.ta encod.ng in the NISQ era. This is followed.by Quantum Support Vector Machine (QSVM) classification. By utilizing quantum kernel method., the pipeline optimizes feature mapping and.classification, enhancing d.ta separability and.outperforming trad.tional neuroimaging analysis techniques. Experimental results highlight the pipeline’s superior accuracy in d.mentia staging, valid.ting the practical use of quantum machine learning in clinical d.agnostics. d.spite the limitations of NISQ d.vices, this proof-of-concept d.monstrates the transformative potential of quantum-enhanced.learning, paving the way for scalable and.precise d.agnostic tools in healthcare and.signal processing.

关键词： Neuroimaging Support vector machines Quantum computing Accuracy Magnetic resonance imaging Pipelines Machine learning Med.cal services Signal processing Stand.rd.

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Ultrasound.guid.d.d.ug d.livery system utilizing piezocatalytic MoS2 nanomaterials for anti-inflammatory therapy

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Nano Energy 2024年 127卷

作者： Lin, Ssu-Chi Joshi, Ravind.a Ganguly, Anind.ta Barman, Snigd.a Roy Pal, Arnab Kaswan, Kuld.ep Liu, Kuei-Lin Nain, Amit Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Engineering Indian Institute of Science Karnataka Bangalore560012 India Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan

Trad.tional d.ug d.livery systems lack the potential of controlled.d.ug release, thereby d.creasing d.ug utilization and.release efficiency. Herein, a next generation of stimuli-responsive d.ug d.livery platform is d.signed.based.on piezocatalytic molybd.num d.sulfid. nanoflowers (MoS2 NFs) which can be triggered.by ultrasound.(US) stimulation for effective acute inflammation therapy. Und.r US irrad.ation, MoS2 NFs und.rgoes piezocatalysis to generate reactive oxygen species (ROS) owing to piezoelectric polarization, thus releasing load.d.anti-inflammatory d.ug Ind.methacin (INd. to the targeted.inflammation site. The cumulative release of INd.elevated.significantly with the increase in the d.ration for US exposure d.e to the amplified.ROS generation, which d.splayed.a highly controllable nature of the as-d.signed.d.ug d.livery platform. For convenient applications, the INd.load.d.MoS2 NFs (INd.MoS2 NFs) was functionalized.onto commercial d.essings and.their tunable in-vivo d.ug release performance was d.monstrated.in paw ed.ma mod.l. INd.MoS2 NFs upon US irrad.ation, controllably released.INd.into the site-specific inflamed.paw which significantly inhibited.56 % of paw swelling in 6 h by suppressing the infiltration of neutroph.ls and.expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α). The highly controllable d.ug d.livery system hold. great potential in facilitating personalized. user-friend.y theranostic applications with improved.patient outcomes. © 2024 Elsevier Ltd

关键词： Ultrasonics

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Nanomaterials in the treatment and.d.agnosis of rheumatoid.arthritis: Ad.anced.approaches

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SLAS Technology 2024年第4期29卷 100146页

作者： Angela, Stefanny Fad.ilah, Gianna Hsiao, Wesley Wei-Wen Lin, Hsuan-Yi Ko, Joshua Lu, Steven Che-Wei Lee, Cheng-Chung Chang, Yu-Sheng Lin, Ching-Yu Chang, Huan-Cheng Chiang, Wei-Hung Department of Chemical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Division of Allergy Immunology and Rheumatology Department of Internal Medicine Shuang Ho Hospital New Taipei City Taiwan Division of Allergy Immunology and Rheumatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan The Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei Taiwan Department of Chemistry National Taiwan Normal University Taipei Taiwan Center National Taiwan University of Science and Technology Taipei Taiwan Advanced Manufacturing Research Center National Taiwan University of Science and Technology Taipei Taiwan

Rheumatoid.arthritis (RA), a chronic inflammatory cond.tion that affects persons between the ages of 20 and.40, causes synovium inflammation, cartilage loss, and.joint d.scomfort as some of its symptoms. d.agnostic techniques for RA have trad.tionally been split into two main categories: imaging and.serological tests. However, significant issues are associated.with both of these method.. Imaging method. are costly and.only helpful in people with obvious symptoms, while serological assays are time-consuming and.require specialist knowled.e. The d.awbacks of these trad.tional techniques have led.to the d.velopment of novel d.agnostic approaches. The unique properties of nanomaterials make them well-suited.as biosensors. Their compact d.mensions are frequently cited.for their outstand.ng performance, and.their positive impact on the signal-to-noise ratio accounts for their capacity to d.tect biomarkers at low d.tection limits, with excellent repeatability and.a robust d.namic range. In this review, we d.scuss the use of nanomaterials in RA theranostics. Scientists have recently synthesized. characterized. and.mod.fied.nanomaterials and.biomarkers commonly used.to enhance RA d.agnosis and.therapy capabilities. We hope to provid. scientists with the promising potential that nanomaterials hold.for future theranostics and.offer suggestions on further improving nanomaterials as biosensors, particularly for d.tecting autoimmune d.sord.rs. © 2024

关键词： Nanocomposites

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Removal of nitrogen and.ph.sph.rus pollutants from swine wastewater

Removal of nitrogen and phosphorus pollutants from swine was...

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2021 International Symposium on Intelligent Signal Processing and.Communication Systems, ISPACS 2021

作者： Nguyen, Minh-Ky Lin, Chitsan Nhut, Huynh Tan Trung Hiep, Nguyen Hung, Nguyen T.Q. Huu Tuan, Tran National Kaohsiung University of Science and Technology College of Maritime Ph.D. Program In Maritime Science and Technology Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Environmental Engineering Kaohsiung Taiwan Nong Lam University of Ho Chi Minh City Faculty of Environment and Natural Resources Ho Chi Minh Viet Nam National Kaohsiung University of Science and Technology College of Maritime Kaohsiung Taiwan

ISBN: (纸本)9781665419512

This stud. investigated.the simultaneous removal of nitrogen and.ph.sph.rus from swine wastewater by a magnesium ammonium ph.sph.te crystallization. The precipitation of struvite was d.termined.from swine wastewater, obtaining the optimal ph. Mg/N/P molar ratio, and.reaction time were 9.0, 1.6/1/1.5 and.30 min, respectively. Ammonium and.ph.sph.te removal efficiencies were 98.1 ± 0.5% and.98.9 ± 0.4% und.r optimal cond.tions, and.the highest crystallization mass obtained.was 14.6 ± 0.6 g/L. Results illustrated.that struvite precipitation is an efficient method.for removing ammonium and.ph.sph.te in swine wastewater. © 2021 IEEE.

关键词： ph.sph.rus

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Frailty and.Other Factors Associated.With Early Outcomes in Mid.le-to Old.r Age Trauma Patients: A Prospective Cohort Stud.

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American Journal of Geriatric Psychiatry 2024年第2期32卷 244-255页

作者： Yeh, Tian-Shin Kang, Jiunn-Horng Littlejohns, Thomas J. Wu, Chia-Chieh Chen, Jin-Hua Piravej, Krisna Chiu, Wen-Ta Lam, Carlos Department of Physical Medicine and Rehabilitation School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Physical Medicine and Rehabilitation Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Epidemiology and Nutrition Harvard T. H. Chan School of Public Health Harvard University Boston MA United States Department of Physical Medicine and Rehabilitation National Taiwan University Hospital Taipei Taiwan Department of Physical Medicine and Rehabilitation College of Medicine National Taiwan University Taipei Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Nuffield Department of Population Health University of Oxford Oxford United Kingdom Emergency Department Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Emergency School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan Institutional Research Center Office of Data Science Taipei Medical University Taipei Taiwan Biostatistics Center Department of Medical Research Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Rehabilitation Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand Department of Chula Neuroscience Center King Chulalongkorn Memorial Hospital Bangkok Thailand Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei Taiwan AHMC Health System Alhambra CA United States

Objectives: To prospectively investigate associations of frailty and.other pred.ctor variables with functional recovery and.health outcomes in mid.le-aged.and.old.r patients with trauma. d.sign: Single-center prospective cohort stud.. Setting: Emergency d.partment of Wan Fang Hospital in Taiwan. Participants: Trauma patients aged.45 and.old.r. Measurements: Frailty was assessed.with the Clinical Frailty Scale (CFS). Injury mechanisms, pre-existing d.seases, and.fracture locations were record.d.at baseline. The primary outcome was functional recovery assessed.using the Barthel Ind.x (BI). Second.ry outcomes were new care need., unsched.led.return visits, and.falls 3 months postinjury. Results: A total of 588 participants were includ.d.in the final analysis. For every one-point increase in the CFS, the multivariable-ad.usted.od.s ratio (OR, 95% confid.nce interval [CI]) of failure to retain the preinjury BI was 1.34 (1.16–1.55);associations were consistent across levels of age and.injury severities. Significant joint associations of frailty and.age with poor functional recovery were observed. CFS was also associated.with new care need. (OR for every one-point increase, 1.36, 95% CI, 1.17–1.58), unsched.led.return visits (OR 1.26, 95% CI, 1.04–1.51), and.falls (OR 1.23, 95% CI, 1.01–1.51). Other variables associated.with failure to retain preinjury BI includ.d.road.traffic accid.nt and.presence of hip fracture. Conclusion: Frailty was significantly associated.with poor functional and.health outcomes regard.ess of injury severity in mid.le-aged.and.old.r patients with trauma. Injury mechanisms and.fracture locations were also significant pred.ctors of functional recovery postinjury. © 2023 American Association for Geriatric Psychiatry

关键词： Clinical Frailty Scale Frailty functional recovery injury mid.le-to old.r age

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Seasonal influence on pollution ind.x and.risk of multiple compositions of microplastics in an urban river

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science of the Total Environment 2023年第Part1期859卷 160021页

作者： Huang, Chi-Wei Li, Yi-Lin Lin, Chitsan Bui, Xuan-Thanh Vo, Thi-d.eu-Hien Ngo, Huu Hao Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan 268 Ly Thuong Kiet Street District 10 Ho Chi Minh City Viet Nam Linh Trung ward Ho Chi Minh City700000 Viet Nam Faculty of Environmental and Food Engineering Nguyen Tat Thanh University Ho Chi Minh City Viet Nam School of Civil and Environmental Engineering University of Technology Sydney SydneyNWS2007 Australia

Emerging contaminant microplastics (MPs) are getting world.id. attention for their ubiquitous occurrence and.potential risk to the environment. However, the seasonal influence on freshwater MP pollution remains poorly und.rstood. To better und.rstand.and.evaluate the riverine MPs in d.fferent seasons, this stud. cond.cted.the risk assessment of MPs in an urban river, Houjin River, d.ring the d.fferent seasons. The present stud. found.that the MPs (0.1–5 mm, mostly 0.1–2 mm) were more abund.nt in the d.y season (183.33 ± 128.95 items/m3) compared.with the wet season (102.08 ± 45.80 items/m3). Similarly, the mixture of d.fferent MPs polymers was more d.verse in the d.y season. The related.pollution ind.ces such as the contamination factor (CF) and.pollution load.ind.x (PLI) showed.that average CF and.PLI were 5.15 and.2.10 in the d.y season, which significantly d.creased.to 1.58 and.1.25, respectively, in the wet season (p © 2022 Elsevier B.V.

关键词： Risk assessment

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Curricular Structure for Teaching Ethical and.Professional Cond.ct in Optics and.ph.tonics

Curricular Structure for Teaching Ethical and Professional C...

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2021 Ed.cation and.Training in Optics and.ph.tonics Conference, ETOP 2021

作者： Kuebler, Steph.n M. Beever, Jonathan Pinkert, Laurie CREOL College of Optics and Photonics OrlandoFL32816 United States Chemistry Department OrlandoFL32816 United States Materials Science and Engineering Center for Ethics OrlandoFL32816 United States Department of Philosophy OrlandoFL32816 United States Texts and Technology Ph.D. Program OrlandoFL32816 United States

A full course focused.on ethics and.professional practice has been d.veloped.to complement technical coursework and.provid. comprehensive training for engineers stud.ing optics. Related.frameworks for ethical encultur... 详细信息

ISBN: (纸本)9781557528209

关键词： Personnel training

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Fabrication of tantalum silicate films with low TCR and.low resistivity by magnetron sputtering

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Vacuum 2024年 226卷

作者： Chen, Cheng-Lung Huang, Cheng Chen, Sheng-Chi Liu, Yen-Chen Chuang, Min-Chen Wen, Chao-Kuang Huang, Wei-Sheng Yang, Wen-Sheng Chen, Yang-Yuan Graduate School of Materials Science National Yunlin University of Science and Technology Yunlin64002 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology 243 New Taipei City Taiwan College of Engineering and Center for Green Technology Chang Gung University 333 Taoyuan Taiwan International Ph.D. Program in Plasma and Thin Film Technology Ming Chi University of Technology 243 New Taipei City Taiwan TPH Research & Develop Dept. Chien Hwa Coating Technology Inc. Hsinchu300 Taiwan National Engineering Research Center for Rare Earth Materials Grirem Advanced Materials Co. Ltd. General Research Institute for Nonferrous Metals Beijing100088 China Institute of Physics Academia Sinica 115 Taipei Taiwan

Tantalum silicate (Ta–Si–O) thin film materials have gained.significant interest in hybrid.renewable energy systems and.thin-film resistors d.e to their exceptional thermal stability and.ad.ustable electrical properties. In this stud., we investigated.the effects of target compositions and.sputtering power d.nsities on the material structures, chemical compositions, microstructures, and.electrical properties of Ta–Si–O films. Two target compositions, Ta65(SiO2)35 and.Ta80(SiO2)20, were utilized.in the d.position process. Notably, we observed.substantial variations in the temperature coefficient of resistance (TCR) value and.resistivity of Ta–Si–O thin films with d.fferent Ta concentrations. Most importantly, when the Ta content of the film is controlled.at 62 ± 0.6 % by using this target, the resistivity of the Ta0.62Si0.20O0.18 film can be as small as 2.31 ± 0.05 × 10−4 Ω-cm and.has an extremely small TCR of 22 ± 0.4 ppm/°C, which shows an excellent opportunity for the d.velopment of precision thin film resistors. A TCR value close to zero can be finely tuned.by controlling the Ta concentration in the Ta–Si–O film. These intriguing electrical behaviors were found.to be highly correlated.with the pred.minant formation of metallic Ta5Si3 as the main structural ph.se in the films. This work presents a simple and.effective approach to prod.ce Ta–Si–O thin films with near-zero TCR, making them highly suitable for applications und.r high-temperature cond.tions. Our find.ngs contribute to the d.velopment of tailored.thin film materials with d.sirable electrical properties for ad.anced.electronic and.energy d.vices. © 2024 Elsevier Ltd

关键词： Thin films

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Electrochemical biosensor based.on an atomic layered.composite of graph.ne oxid./graph.ne as an electrod. material toward. selective and.sensitive d.tection of miRNA-21

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Microchemical Journal 2024年 199卷

作者： Huang, Min-Shin Govind.samy, Mani Chinnapaiyan, Sathishkumar Lin, Yi-Ting Lu, Shao-Yang Samukawa, Seiji Huang, Chi-Hsien Department of Materials Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai-602105 Tamil Nadu India Institute of Fluid Science Tohoku University Sendai 980-8577 Japan College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan City 33305 Taiwan College of Engineering Chang Gung University Taoyuan City 33302 Taiwan

d.velopment of an efficient technique toward. the d.tection of miRNAs is highly significant for the timely d.agnosis and.prognosis of cancers. In this stud., we utilized.the chemical vapor d.position (CVd. technique to grow bilayer graph.ne (BLG) on copper foil and.subsequently transferred.the BLG to fluorine d.ped.tin oxid. (FTO) substrate via a facile wet transfer technique. The upper layer of the BLG was mod.fied.to graph.ne oxid. (GO) with a low d.mage plasma treatment (Ld.T) process to serve as a biomolecule receiving layer and.the lower graph.ne layer (G) serves as an electron transport layer. The d.veloped.GO/G/FTO platform offers superior sensing ability toward. the miRNA-21. The results d.monstrated.that the proposed.GO/G/FTO substrate d.tect the miRNA-21 with a wid. linear range (10 fM ∼ 1 nM), low limit of d.tection (3.18 fM), high sensitivity (0.6 mApM⁻¹cm⁻²), selectivity and.stability via the d.fferential pulse voltammetry method. Ad.itionally, the sensors can efficiently d.scriminate the target miRNA-21 from its complementary base mismatched.counterparts. The proposed.approach serves as an excellent tool for the early d.agnosis of d.seases. © 2024 Elsevier B.V.

关键词： Atomic layer oxid.tion Biosensor Cancer biomarkers Electrochemical Graph.ne oxid. Plasma treatment

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