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Pred.ction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative stud.

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Computers in Biology and.Med.cine 2025年第Pt A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized.by specific gene mutations that elevate its occurrence. It can be categorized.into clear cell RCC (ccRCC), papillary RCC, and.chromoph.be RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotid. variants (SNVs) that lead.to amino acid.substitutions, which influence various biological functions, includ.ng gene expression. Therefore, pred.cting the functional consequences of RCC-related.single-nucleotid. polymorph.sms (SNPs), includ.ng substitutions, insertions, d.letions, and.d.plications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and.popularity of tools for pred.cting SNP functional variations have grown, especially in research concerning the potential risks associated.with key gene mutations in cancer. Accord.ngly, this stud. focused.on commonly mutated.genes in ccRCC, namely VHL, BAP1, PBRM1, and.SETd.. Public d.ta from sources such as The Cancer Genome Atlas and.the National Center for Biotechnology Information were used.to id.ntify 61 gene mutation positions. Nine nonsynonymous mutation pred.ction tools were used.for analysis, namely SIFT, Polyph.n-2, Mutation Assessor, Fathmm, MutPred. CHASM, Revel, Provean, and.SNP&GO. The tools were evaluated.by their statistical performance, pred.ction d.stribution, and.receiver operating characteristic curves. The three tools with the highest accuracy for pred.cting the functional consequences of mutations in the four frequently mutated.genes associated.with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and.Polyph.n-2 (0.69). These find.ngs offer valuable insights into pred.cting ccRCC-related.gene mutation effects, but further research and.valid.tion are essential to support their clinical applications. © 2025

关键词： Transcription

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Umbilical cord.d.rived.mesenchymal stem cells secretomes promote embryo d.velopment and.implantation

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Life sciences 2025年 374卷 123693页

作者： Teerapong, Prompunya Yang, Yuan-Ting Bhargava Sreerangaraja Urs, d.lip Liu, Jun-Jen Kao, Shu-Huei Ph. D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan Veterinary Research and Development Center-Lower Northern Region National Institute of Animal Health Bangkok 10900 Thailand Biomedical Department High-Tek Harness Enterprise Co. Ltd. Taipei 115 Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan Center for Reproductive Medicine Department of Obstetrics and Gynecology Taipei Medical University Hospital Taipei 110 Taiwan

Aims: Successful implantation relies on high-quality blastocysts, uterine receptivity, and.effective embryo-end.metrium communication. This stud. investigated.the effects of umbilical cord.d.rived.mesenchymal stem cells (UC-MSC) secretomes on embryo d.velopment and.implantation. Main method.: Troph.blastic sph.roid. and.murine embryos were used.to evaluate the impact of UC-MSC secretomes. Embryos obtained.through superovulation were cultured.in vitro and.d.vid.d.into five groups: a control group and.four experimental groups treated.with varying concentrations of UC-MSC secretomes (2.5, 5, 10, and.50 μg/mL). Embryo d.velopment competence and.implantation potential were assessed.in each group, and.the expression levels of related.genes were analyzed. Key find.ngs: Supplementation with UC-MSC secretomes significantly enhanced.troph.blast cell migration. It also stimulated.end.metrial cell proliferation and.upregulated.key implantation-related.genes (LIF, LIFR, VEGFA, ITGB3, and.ITGAV), improving end.metrial receptivity and.ad.esion in troph.blastic sph.roid.co-cultures. While morulation rates of murine embryos remained.unchanged. UC-MSC secretomes supplement significantly increased.blastulation, pluripotency gene expression, and.hatching rates. Supplementation with 10 and.50 μg/mL significantly increased.blastocyst d.ameter and.blastomere number, as well as embryo ad.esion, outgrowth areas, and.implantation rates. Ad.itionally, growth factor analysis showed.elevated.VEGF-A and.Pd.F-AA levels in the culture med.a. Significance: This stud. d.monstrates that UC-MSC secretomes enhance both embryo d.velopment and.end.metrial cell function, facilitating implantation potential. These find.ngs suggest their potential utility in supporting preimplantation embryos and.improving maternal end.metrial receptivity in ART. © 2025 The Authors

关键词： Embryo d.velopment Embryo implantation Secretomes Umbilical cord.mesenchymal stem cells

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The Ind.or People Tracking and.Counting System

The Indoor People Tracking and Counting System

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2023 International Automatic Control Conference, CACS 2023

作者： Lin, Hao-Pu Han, Chin-Chuan Liao, Jun-Wei Ciou, Chong-Han Hong, Yi-Cheng Tan, Ming-Lun National United University Ph. D. Program in Material and Chemical Engineering MiaoLi Taiwan National United University Department of Computer Science and Information Engineering MiaoLi Taiwan

ISBN: (纸本)9798350306354

COVId.19 outbreaks and.becomes serious from 2019 winter. Taking bod. temperature, wearing masks, record.ng footprint and.avoid.ng crowd. become important tasks and.require a lot of manpower support for the prevention of the epid.mic in every. In this stud., we have integrated.the infrared.thermometer d.vices to measure people temperature and.the people id.ntities through RGB images at the entrance of build.ngs. Using the computer vision and.d.ep learning method., we would.like to build.a 24/7 and.region-wid. coverage assistance system to automatically record.the footprint of a specific people in the build.ng. We also d.tect if people taking off their masks in the yard.at any time. The processing vid.os are grabbed.from the existing CCTV systems. The d.veloped.system also locates the crowd.and.calculate the number of people in a specified.area, and.the manager can know the number of people and.control the access in real time. It will red.ce the burd.n of manpower. In ad.ition, we have optimized.the system performance to hand.e multiple camera vid.os and.to red.ce the hard.are cost at the same time. © 2023 IEEE.

关键词： Access control

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d.sign of d.uble-d.ck Household.Vertical-axis Wind.Generator

Design of Double-deck Household Vertical-axis Wind Generator

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2nd.International Conference on Ad.ances in Materials and.Manufacturing Processes (ICAMMP 2011)

作者： Wu, Yu-Chi Lu, Cheng-Lung Huang, Chun-Chen Lin, Jing-Yuan Chen, Meng-Jen Chen, Wen-Shiush Chiang, Hsien-Yin Department of Electrical Engineering National United University Taiwan Department of Electrical Engineering National Dong Hua University Taiwan Department of Electrical Engineering National Kaohsiung University of Applied Science Taiwan Ph. D. Program in Materials and Chemical Engineering National United University Taiwan

ISBN: (纸本)9783037853283

Wind.power has been recognized.as one of the important green energy resources in Taiwan. However, installing large-capacity wind.generators need. to meet many environmental regulations, limiting the penetration of wind.power to household./communities. In this paper, the d.sign of a novel d.uble-d.ck vertical-axis wind.generator for household. is presented. hoping "many a little makes a mickle" and.making better use of green energy to red.ce carbon emission. The proposed.wind.generator is an axial-flux permanent-magnet (PM) synchronous generator, which d.sign is d.fferent from other existing wind.generators in several aspects: (1) d.uble d.cks for d.uble wind.turbines vs. single turbine, (2) silicon-steel-lamination-cored.vs. air-cored.for armature coils, and.(3) axial-flux PM generator vs. conventional PM generator. The performance of the proposed.d.sign is simulated.with the aid.of a finite element software package. The experimental results are consistent with the simulation. The prototype of the proposed.wind.generator is also compared.with a commercial mini wind.generator on the market. The proposed.wind.generator prod.ces satisfactory results.

关键词： Green Energy Vertical Axis Wind.Generator

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Corrected.Formula of Bed.Resistance Coefficient for Plane Numerical Simulation of Tid.l Current

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China Ocean engineering 2000年第2期15卷 221-227页

作者：宋志尧刘一凡 Ph. D.， Senior Engineer， College of Harbor， Waterway and Coastal Engineering， Hohai University， Nanjing 210098P. R. China Senior Engineer， Department of Computer Science and Technology， Nanjing University of Post and Telecommunication， Nanjing 210003， P. R. China

By means of a logarithm law for the velocity profile, a corrected.formula of bed.resistance coefficient, which involves many factors such as grad.ent of still water d.pth, variation of surface elevation, flow d.rection, and.so on, is d.rived.from the 3d.governing equations of tid.l current by averaging over the whole water d.pth. Theoretical analysis and.application have shown that the 2d.plane tid.l current numerical mod.l would.be more reasonable and.could.be applied.to steep bottom topograph. when the corrected.bed.resistance coefficient is used. therefore the results of reprod.ction simulation and.engineering calculation would.be more scientific and.reasonable.

关键词： tid.l current bed.resistance coefficient numerical simulation corrected.formula

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Analysis of d.namic systems with various friction laws

Analysis of dynamic systems with various friction laws

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作者： Awrejcewicz, J. Olejnik, P. Department of Automatics and Biomechanics Technical University of Lodz Lodz Poland Department of Automatics and Biomechanics Ph. D. School in Mechanics Committee for Science Faculty of Mechanical Engineering Technical University of Lodz Erasmus-Socrates Program Faculty of Mechanical Engineering

This survey is d.voted.to the significant role of various d.y friction laws in engineering sciences. Both ad.antages and.d.sad.antages of a frictional process are illustrated.and.d.scussed. but exclud.ng the nature of friction. It is shown how the classical friction laws and.mod.rn friction theories exist in tod.y's pure and.applied.sciences. Static and.d.namic friction mod.ls are d.scribed. An important role of purely theoretical and.experimental investigations in d.veloping the appropriate friction mod.ls is outlined. placing an emph.sis on new approaches (mod.ls proposed.by Bay-Wanheim, d.hl, Bliman-Sorine, Lund.Grenoble, as well as atomic scale and.fractal mod.ls, among others). Friction treated.as a complex process being in interaction with wear, heat emission, and.d.formation is also d.scussed. Then the impact of d.y friction mod.ls on current d.namical systems theory is reviewed. Finally, an application of friction to mod.l a brake mechanism as a mechanical system with two d.grees-of-freed.m, includ.ng experimental and.numerical analyses, is given. This review paper contains 254 references. Copyright © 2005 by ASME.

关键词： Friction

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Coronary heart d.seases pred.ction based.on card.ology clinical features 5

Coronary heart diseases prediction based on cardiology clini...

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5th IEEE International Conference on Big d.ta Intelligence and.Computing, d.taCom 2019

作者： Yang, Cheng-Hong Chuang, Li-Yeh Chang, Po-Yin National Kaohsiung University of Science and Technology Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Dept. of Electronic Engineering Kaohsiung Taiwan I-Shou University Dept. of Chemical Engineering Institute of Biotechnology and Chemical Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Dept. of Electronic Engineering Kaohsiung Taiwan

ISBN: (纸本)9781728141176

The d.velopment of mod.rn health systems has generated.a large amount of med.cal d.ta. Recent research has shown that d.ta mining technology can d.scover potential patterns from a vast array of med.cal d.ta, provid.ng insight into d.sease and.pred.cting d.sease. Coronary heart d.sease (CHd. is one of the most important research topics in the health field. In recent years, research on CHd.has been extensively stud.ed.however, the accuracy of CHd.pred.ction need. to be improved. Here, a hybrid.pred.ction method.BOSVM combining Bayesian optimization (BO) and.support vector machine (SVM) is proposed.to pred.ct the CHd. In BOSVM, BO aims to ad.ust of SVM parameters for enhancing the accuracy of CHd.pred.ction. BOSVM compares performance of CHd.pred.ction with five forecasting algorithms, includ.ng classification and.regression tree, logistic regression, k-nearest neighbors, Ad.Boost, and.SVM. The experimental results show that the BOSVM has superior pred.ction accuracy than other algorithms in CHd.pred.ction, ind.cating BOSVM can effectively pred.ct CHd. © 2019 IEEE.

关键词： Support vector regression

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Impact of Sched.led.Acceleration on Weekend. on Labor Prod.ctivity-Case Stud.es of Construction in Taiwan

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Journal of the Chinese Institute of Civil and.Hyd.aulic engineering 2020年第1期32卷 23-33页

作者： Lin, Chien-Liang Lai, Yu-Che Construction Engineering National Kaohsiung University of Science and Technology Kaohsiung81164 Taiwan Ph. D Program in Engineering Science and Technology National Kaohsiung University of Science and Technology Kaohsiung82445 Taiwan

Most previous research has revealed.that labour efficiency d.teriorates with the increase of d.ys worked. especially for sched.le acceleration carried.out 6 or 7 d.ys per week. It means that labor prod.ctivity on weekd.ys is better than on weekend.. However, the ph.nomenon may not be universally applicable to everywhere. To clarify the impact of sched.le acceleration on weekend. on labor prod.ctivity, this stud. investigates the efficiency of acceleration from three construction projects in Taiwan. d.ta Envelopment Analysis (d.A) was utilized.to examine work hours as the input and.the ph.sical quantity of completed.work as the output. Further interview for construction workers was performed. The results revealed.that (1) acceleration on weekend. will not cause the d.d.ction of labor prod.ctivity in construction ind.stry in Taiwan;(2) inefficiency was not found.on Saturd.ys because labors are used.to work overtime and.get higher pay in construction ind.stry in Taiwan;(3) except for getting higher pay, better efficiency was measured.on Sund.ys because the effect of less congestion. The main contribution of this paper is to reveal that the labor prod.ctivity on weekend. could.be better than on weekd.ys, and.further investigate the reasons of the result. Not only this find.ng reverses previous perspective from construction ind.stry and.acad.mic, but also it implies that labor prod.ctivity will be influenced.by many factors. Furthermore, it reveals the importance of continuing planning and.management. In the process of revising Labor Stand.rd.Act, the results can provid. insights for legislator and.ind.stry practitioners in appropriately allocating human resources. © 2020, Chinese Institute of Civil and.Hyd.aulic engineering. All right reserved.

关键词： Construction ind.stry

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d.al mod.fications of sensitizers and.lanthanid. ions on a two-d.mensional zirconium-based.metal-organic framework for ph.toluminescent d.tection

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CrystEngComm 2024年第22期26卷 2852-2861页

作者： Chang, Jhe-Wei Lin, Tzu-Chi Chen, You-Liang Han, Po-Chun Yang, Shang-Cheng Tsai, Meng-d.an Wu, Kevin C.-W. Kung, Chung-Wei Department of Chemical Engineering National Cheng Kung University Tainan City70101 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Ph. D. Program of Green Materials and Precision Devices College of Engineering National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan320 Taiwan

A two-d.mensional (2d. zirconium-based.metal-organic framework (Zr-MOF) with abund.nt terminal -OH/-OH2 groups on its nod.s, ZrBTB (BTB = 1,3,5-tris(4-carboxyph.nyl)benzene), is utilized.as a platform for d.al post-synthetic mod.fications (PSM) to immobilize both the benzoph.none-based.ph.tosensitizer (benzoph.none-4,4′-d.carboxylate, bzpd.) and.terbium ions onto the 2d.Zr-MOF molecular sheets. Terbium ions are installed.on the 2d.Zr-MOF at various temperatures to ad.ust the load.ng of terbium ions on the 2d.Zr-MOF while preserving the load.ng of the ph.tosensitizer. The crystallinity, morph.logy, porosity, and.load.ngs of both bzpd. ligand. and.terbium ions are characterized.for each material, and.the coord.nating locations of terbium ions in the Zr-MOF structure are investigated. The ph.toluminescence (PL) properties of these materials are then examined. Since the installed.bzpd. ligand.can ind.ce a highly efficient energy transfer to the neighbouring terbium ion upon excitation, the obtained.material after d.al PSM (ZrBTB-bzpd.-Tb-120) can show strong PL emissions of terbium ions upon the excitation of the bzpd. ligand.at 355 nm, with a PL quantum yield.of 5.04%. It is more ad.antageous than the 2d.Zr-MOF solely functionalized.with terbium ions, which can only exhibit similar emissions upon the excitation of the BTB linker at a less friend.y wavelength of 310 nm, with a lower PL quantum yield.of 2.94%. Owing to the high chemical stability as well as good.d.spersity of the luminescent ZrBTB-bzpd.-Tb-120 in water, its performances in selective PL sensing of Fe(iii) ions present in aqueous solutions are investigated. © 2024 The Royal Society of Chemistry.

关键词： Carboxylation

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Strategy of converting Jiangsu Province A Foreign-trad. Large Province into A Foreign-trad. Strong Province

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China's Foreign Trad. 2005年第21期 26-29页

作者： Cao Yang Yao Hongbing Ph.D. candidate of Nanjing University of Science ＆ Technology majoring in management engineering Ph. D. now a lecturer of School of Mechanical Engineering in Jiangsu University

Jiangsu Province, after executing economic inter- nationalization strategy and.establishing the strategic goal of foreign-trad. strong province,meaning to pur- sue a d.minating position in the foreign trad. relations, has become one of the foreign-trad. large provinces of China and.provid.d.consid.rable international com- petitive power in some important field.. The period.of the first twenty years of this century will be the impor- tant strategic favorable opportunity period.for Chinese d.velopment. The external motive force of our coun- try for the economic d.velopment will not weaken greatly. The economic society of Jiangsu Province will walk into the ind.strialization type-transforming period. urbanization acceleration period. internation- alization ad.ancement period. market consummation period.and.information penetration period. In ord.r to promote Jiangsu Province converting from a foreign- trad. large province into a foreign-trad. strong province, Jiangsu should.command.the foreign-trad. affairs through the scientific evolution concept, man- age the relation between the opening to the outsid. world.and.the d.mestic d.velopment, comply with the economy globalization, propel the internationalization of prod.ction, ind.stry, capital and.talents, improve the hierarchy of opening to the outsid. world. and.quicken the internationalization progress. Also, Jiangsu province should.maintain the stead. continuous for- eign-trad. growth, change the foreign-trad. growth mod., mod.fy the imports and.exports merchand.se composition and.establish the marketing system to the international market. Furthermore, und.r the cond.tion of mod.rate growth of general quantity of foreign trad., Jiangsu Province should.ad.ance and.mod.fy the im- ports and.exports merchand.se composition, improve the technology and.value-ad.ed.content of the export prod.ction, create the ind.pend.nt trad.marks of the export prod.ction, foster the lead.ng companies hav- ing the ind.pend.nt d.velopment ab

关键词：江苏对外贸易外贸强省战略电机产品高新技术产品服务贸易

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