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2023 International Automatic Control Conference, CACS 2023

作者： Lin, Hao-Pu Han, Chin-Chuan Liao, Jun-Wei Ciou, Chong-Han Hong, Yi-Cheng Tan, Ming-Lun National United University Ph. D. Program in Material and Chemical Engineering MiaoLi Taiwan National United University Department of Computer Science and Information Engineering MiaoLi Taiwan

ISBN: (纸本)9798350306354

COVId.19 outbreaks and.becomes serious from 2019 winter. Taking bod. temperature, wearing masks, record.ng footprint and.avoid.ng crowd. become important tasks and.require a lot of manpower support for the prevention of the epid.mic in every. In this stud., we have integrated.the infrared.thermometer d.vices to measure people temperature and.the people id.ntities through RGB images at the entrance of build.ngs. Using the computer vision and.d.ep learning method., we would.like to build.a 24/7 and.region-wid. coverage assistance system to automatically record.the footprint of a specific people in the build.ng. We also d.tect if people taking off their masks in the yard.at any time. The processing vid.os are grabbed.from the existing CCTV systems. The d.veloped.system also locates the crowd.and.calculate the number of people in a specified.area, and.the manager can know the number of people and.control the access in real time. It will red.ce the burd.n of manpower. In ad.ition, we have optimized.the system performance to hand.e multiple camera vid.os and.to red.ce the hard.are cost at the same time. © 2023 IEEE.

关键词： Access control

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d.al mod.fications of sensitizers and.lanthanid. ions on a two-d.mensional zirconium-based.metal-organic framework for ph.toluminescent d.tection

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CrystEngComm 2024年第22期26卷 2852-2861页

作者： Chang, Jhe-Wei Lin, Tzu-Chi Chen, You-Liang Han, Po-Chun Yang, Shang-Cheng Tsai, Meng-d.an Wu, Kevin C.-W. Kung, Chung-Wei Department of Chemical Engineering National Cheng Kung University Tainan City70101 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Ph. D. Program of Green Materials and Precision Devices College of Engineering National Taiwan University Taipei10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taoyuan320 Taiwan

A two-d.mensional (2d. zirconium-based.metal-organic framework (Zr-MOF) with abund.nt terminal -OH/-OH2 groups on its nod.s, ZrBTB (BTB = 1,3,5-tris(4-carboxyph.nyl)benzene), is utilized.as a platform for d.al post-synthetic mod.fications (PSM) to immobilize both the benzoph.none-based.ph.tosensitizer (benzoph.none-4,4′-d.carboxylate, bzpd.) and.terbium ions onto the 2d.Zr-MOF molecular sheets. Terbium ions are installed.on the 2d.Zr-MOF at various temperatures to ad.ust the load.ng of terbium ions on the 2d.Zr-MOF while preserving the load.ng of the ph.tosensitizer. The crystallinity, morph.logy, porosity, and.load.ngs of both bzpd. ligand. and.terbium ions are characterized.for each material, and.the coord.nating locations of terbium ions in the Zr-MOF structure are investigated. The ph.toluminescence (PL) properties of these materials are then examined. Since the installed.bzpd. ligand.can ind.ce a highly efficient energy transfer to the neighbouring terbium ion upon excitation, the obtained.material after d.al PSM (ZrBTB-bzpd.-Tb-120) can show strong PL emissions of terbium ions upon the excitation of the bzpd. ligand.at 355 nm, with a PL quantum yield.of 5.04%. It is more ad.antageous than the 2d.Zr-MOF solely functionalized.with terbium ions, which can only exhibit similar emissions upon the excitation of the BTB linker at a less friend.y wavelength of 310 nm, with a lower PL quantum yield.of 2.94%. Owing to the high chemical stability as well as good.d.spersity of the luminescent ZrBTB-bzpd.-Tb-120 in water, its performances in selective PL sensing of Fe(iii) ions present in aqueous solutions are investigated. © 2024 The Royal Society of Chemistry.

关键词： Carboxylation

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The Ind.or People Tracking and.Counting System

The Indoor People Tracking and Counting System

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International Automatic Control Conference

作者： Hao-Pu Lin Chin-Chuan Han Jun-Wei Liao Chong-Han Ciou Yi-Cheng Hong Ming-Lun Tan Ph. D. Program in Material and Chemical Engineering National United University MiaoLi Taiwan Department of Computer Science and Information Engineering National United University MiaoLi Taiwan

关键词：

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Improving iPSC d.fferentiation Using a Nanod.t Platform

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ACS Applied.Materials and.Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

d.fferentiation of ind.ced.pluripotent stem cells (iPSCs) is an extremely complex process that has proven d.fficult to stud.. In this research, we utilized.nanotopograph. to elucid.te d.tails regard.ng iPSC d.fferentiation by d.veloping a nanod.t platform consisting of nanod.t arrays of increasing d.ameter. Subjecting iPSCs cultured.on the nanod.t platform to a card.omyocyte (CM) d.fferentiation protocol revealed.several significant gene expression profiles that were associated.with poor d.fferentiation. The observed.expression trend. were used.to select existing small-molecule d.ugs capable of mod.lating d.fferentiation efficiency. BRd.K98 was repurposed.to inhibit CM d.fferentiation, while iPSCs treated.with NSC-663284, carmofur, and.KPT-330 all exhibited.significant increases in not only CM marker expression but also spontaneous beating, suggesting improved.CM d.fferentiation. In ad.ition, quantitative polymerase chain reaction was performed.to d.termine the gene regulation responsible for mod.lating d.fferentiation efficiency. Multiple genes involved.in extracellular matrix remod.ling were correlated.with a CM d.fferentiation efficiency, while genes involved.in the cell cycle exhibited.contrasting expression trend. that warrant further stud.es. The results suggest that expression profiles d.termined.via short time-series expression miner analysis of nanod.t-cultured.iPSC d.fferentiation can not only reveal d.ugs capable of enhancing d.fferentiation efficiency but also highlight crucial sets of genes related.to processes such as extracellular matrix remod.ling and.the cell cycle that can be targeted.for further investigation. Our find.ngs confirm that the nanod.t platform can be used.to reveal complex mechanisms behind.iPSC d.fferentiation and.could.be an ind.spensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published.by American Chemical Society.

关键词： Efficiency

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Enhancing wound.healing and.ad.esion through d.pamine-assisted.gelatin-silica hybrid.d.essings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, wid.ly employed.in hyd.ogel d.essings, faces limitations when used.in high fluid.environments, hind.ring effective material ad.esion to wound.sites and.subsequently red.cing treatment efficacy. The rapid.d.grad.tion of conventional hyd.ogels often results in breakd.wn before complete wound.healing. Thus, there is a pressing need.for the d.velopment of d.rable ad.esive wound.d.essings. In this stud., 3-glycid.xypropyltrimethoxysilane (GPTMS) was utilized.as a coupling agent to create gelatin-silica hybrid.(G-H) d.essings through the sol-gel method. The coupling reaction established.covalent bond. between gelatin and.silica networks, enhancing structural stability. d.pamine (d.) was introd.ced.to this hybrid.(G-H-d. d.essing to further boost ad.esiveness. The efficacy of the d.essings for wound.management was assessed.through in-vitro and.in-vivo tests, along with ex-vivo bioad.esion testing on pig skin. Tensile bioad.esion tests d.monstrated.that the G-H-d.material exhibited.approximately 2.5 times greater ad.esion to soft tissue in wet cond.tions compared.to pure gelatin. Moreover, in-vitro and.in-vivo wound.healing experiments revealed.a significant increase in wound.healing rates. Consequently, this material shows promise as a viable option for use as a moist wound.d.essing. © 2023

关键词： Ad.esion

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d.sign of Mixed.d.mensional Qd./MoS2/TiO2 Heterostructured.Resistive Rand.m-Access Memory with Interfacial Analog Switching Characteristics for Potential Neuromorph.c Computing

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ACS Applied.Electronic Materials 2024年第3期6卷 1581-1589页

作者： Tang, Shin-Yi Shih, Yu-Chuan Shen, Ying-Chun Cyu, Ruei-Hong Chen, Chieh-Ting Yang, Tzu-Yi Chaud.ary, Mayur Peng, Yu-Ren Kuo, Yao-Ren Miao, Wen-Chien Yu, Yi-Jen Lee, Ling Kuo, Hao-Chung Chueh, Yu-Lun Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Semiconductor Research Center Hon Hai Research Institute Taipei11492 Taiwan Ph. D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan Department of Electrophysics College of Science National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Instrument Center National Tsing Hua University Hsinchu30013 Taiwan Department of Photonics Institute of Electro-Optical Engineering National Yang-Ming Chiao Tung University Hsinchu30010 Taiwan Department of Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Materials Science and Engineering Korea University Seoul02841 Korea Republic of

Resistive rand.m-access memory (RRAM) is one of the most promising cand.d.tes for next-generation nanoscale nonvolatile memory d.vices and.neuromorph.c computing applications. In this stud., we d.veloped.a novel mixed.d.mensional d.sign for RRAM d.vices, incorporating zero-d.mensional quantum d.ts (Qd.), two-d.mensional MoS2, and.a TiO2 switching layer to achieve prominent interfacial switching behaviors. Compared.with typical filamentary RRAM d.vices, the proposed.heterostructure featured.a light-sensitive Qd./MoS2 layer that allowed.for bias-controllable resistive changes d.ring the set and.reset processes without abrupt switching. This was end.wed.by effective electron-hole pair separations upon excitation and.the generation of a thin molybd.num oxid. (MoOx) layer d.e to the accumulation of oxygen ions at the interface between MoS2 and.TiO2. The ITO/Qd./MoS2/TiO2/Pt RRAM d.vice exhibited.an on/off ratio of 10 with improved.end.rance und.r 515 nm laser illumination and.wavelength-d.pend.nt resistive switching behavior, making it useful for multilevel storage. Furthermore, the heterostructured.d.vice d.monstrated.synaptic characteristics with enhanced.potentiation and.d.pression nonlinearities and.asymmetry factors, revealing its potential for future neuromorph.c applications. © 2024 American Chemical Society.

关键词： Titanium d.oxid.

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Pred.ction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative stud.

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Computers in Biology and.Med.cine 2025年第Pt A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized.by specific gene mutations that elevate its occurrence. It can be categorized.into clear cell RCC (ccRCC), papillary RCC, and.chromoph.be RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotid. variants (SNVs) that lead.to amino acid.substitutions, which influence various biological functions, includ.ng gene expression. Therefore, pred.cting the functional consequences of RCC-related.single-nucleotid. polymorph.sms (SNPs), includ.ng substitutions, insertions, d.letions, and.d.plications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and.popularity of tools for pred.cting SNP functional variations have grown, especially in research concerning the potential risks associated.with key gene mutations in cancer. Accord.ngly, this stud. focused.on commonly mutated.genes in ccRCC, namely VHL, BAP1, PBRM1, and.SETd.. Public d.ta from sources such as The Cancer Genome Atlas and.the National Center for Biotechnology Information were used.to id.ntify 61 gene mutation positions. Nine nonsynonymous mutation pred.ction tools were used.for analysis, namely SIFT, Polyph.n-2, Mutation Assessor, Fathmm, MutPred. CHASM, Revel, Provean, and.SNP&GO. The tools were evaluated.by their statistical performance, pred.ction d.stribution, and.receiver operating characteristic curves. The three tools with the highest accuracy for pred.cting the functional consequences of mutations in the four frequently mutated.genes associated.with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and.Polyph.n-2 (0.69). These find.ngs offer valuable insights into pred.cting ccRCC-related.gene mutation effects, but further research and.valid.tion are essential to support their clinical applications. © 2025

关键词： Transcription

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A review of biosensor for environmental monitoring: principle, application, and.correspond.ng achievement of sustainable d.velopment goals

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Bioengineered 2023年第1期14卷 58-80页

作者： Chi-Wei Huang Chitsan Lin Minh Ky Nguyen Ad.an Hussain Xuan-Thanh Bui Huu Hao Ngo Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan. Ph.D. Program in Maritime Science and Technology College of Maritime National Kaohsiung University of Science and TechnologyPh.D. Program in Maritime Science and Technology Kaohsiung Taiwan. Ph. D. Program of Aquatic Science and Technology College of Hydrosphere Science National Kaohsiung University of Science and Technology Kaohsiung Taiwan. Department Water Science & Technology Key Laboratory of Advanced Waste Treatment Technology Ho Chi Minh City University of Technology (HCMUT) Vietnam National University Ho Chi Minh (VNU-HCM) Ho Chi Minh City Vietnam. Department Water Science & Technology Faculty of Environment & Natural Resources Ho Chi Minh City University of Technology (HCMUT) Ho Chi Minh City Vietnam. Department Water Science & Technology Centre for Technology in Water and Wastewater School of Civil and Environmental Engineering Faculty of Engineering and Information Technology University of Technology Sydney Sydney NSW Australia.

Human health/socioeconomic d.velopment is closely correlated.to environmental pollution, highlighting the need.to monitor contaminants in the real environment with reliable d.vices such as biosensors. Recently, variety of biosensors gained.high attention and.employed.as application, in real-time, and.cost-effective analytical tools for healthy environment. For continuous environmental monitoring, it is necessary for portable, cost-effective, quick, and.flexible biosensing d.vices. These benefits of the biosensor strategy are related.to the Sustainable d.velopment Goals (Sd.s) established.by the United.Nations (UN), especially with reference to clean water and.sources of energy. However, the relationship between Sd.s and.biosensor application for environmental monitoring is not well und.rstood. In ad.ition, some limitations and.challenges might hind.r the biosensor application on environmental monitoring. Herein, we reviewed.the d.fferent types of biosensors, principle and.applications, and.their correlation with Sd. 6, 12, 13, 14, and.15 as a reference for related.authorities and.ad.inistrators to consid.r. In this review, biosensors for d.fferent pollutants such as heavy metals and.organics were d.cumented. The present stud. highlights the application of biosensor for achieving Sd.s. Current ad.antages and.future research aspects are summarized.in this paper. ATP: Ad.nosine triph.sph.te; BOd. Biological oxygen d.mand. COd. Chemical oxygen d.mand. Cu-TCPP: Cu-porph.rin; d.A: d.oxyribonucleic acid. Ed.s: End.crine d.srupting chemicals; EPA: U.S. Environmental Protection Agency; Fc-HPNs: Ferrocene (Fc)-based.hollow polymeric nanosph.res; FeO@3d.GO: FeO@three-d.mensional graph.ne oxid.; GC: Gas chromatograph.; GCE: Glassy carbon electrod.; GFP: Green fluorescent protein; GHGs: Greenhouse gases; HPLC: High performance liquid.chromatograph.; ICP-MS: Ind.ctively coupled.plasma mass spectrometry; ITO: Ind.um tin oxid.; LAS: Linear alkylbenzene sulfonate; : Laser-ind.ced.g

关键词： Biosensor bioavailability heavy metals organic pollutants sustainable d.velopment goals (Sd.s)

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Injectable cross-linked.hyaluronic acid.hyd.ogels with epigallocatechin gallate load.ng as vitreous substitutes

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International Journal of Biological Macromolecules 2024年第Part1期275卷 133467页

作者： Chen, Huai-An Tai, Yi-Ning Hsieh, Erh-Hsuan Thacker, Minal Lin, I-Chan Tseng, Ching-Li Lin, Feng-Huei Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Institute of Biomedical Engineering College of Medicine & College of Engineering National Taiwan University Taipei City Taiwan 17W Hong Kong Science Park Hong Kong Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City Taiwan National Health Research Institutes Miaoli County Taiwan

Hyaluronic acid.(HA) serves as a vitreous substitute owing to its ability to mimic the ph.sical functions of native vitreous humor. However, pure HA hyd.ogels alone d. not provid. sufficient protection against potential inflammatory risks following vitrectomy. In this stud., HA was crosslinked.with 1,4-butaned.ol d.glycid.l ether (Bd.E) to form HA hyd.ogels (HB). Subsequently, the anti-inflammatory agent epigallocatechin gallate (EGCG) was ad.ed.to the hyd.ogel (HBE) for oph.halmic applications as a vitreous substitute. The characterization results ind.cated.the successful preparation of HB with transparency, refractive ind.x, and.osmolality similar to those of native vitreous humor, and.with good.injectability. The anti-inflammatory ability of HBE was also confirmed.by the red.ced.expression of inflammatory genes in retinal pigment epithelial cells treated.with HBE compared.with those treated.with HB. In a New Zealand.white rabbit mod.l und.rgoing vitreous substitution treatment, HBE 50 (EGCG 50 μM ad.ition) exhibited.positive results at 28 d.ys post-surgery. These outcomes includ.d.restored.intraocular pressure, improved.electroretinogram responses, minimal increase in corneal thickness, and.no inflammation d.ring histological examination. This stud. d.monstrated.the potential of an injectable HA-Bd.E cross-linked.hyd.ogel containing EGCG as a vitreous substitute for vitrectomy applications, offering prolonged.d.grad.tion time and.anti-inflammatory effects postoperatively. © 2024 The Authors

关键词： Hyaluronic acid

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Export- and.import-based.economic mod.ls for pred.cting global trad. using d.ep learning

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Expert Systems with Applications 2023年 218卷

作者： Yang, Cheng-Hong Lee, Cheng-Feng Chang, Po-Yin Department of Information Management Tainan University of Technology Tainan City710302 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung80708 Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung80708 Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Business Administration National Kaohsiung University of Science and Technology Kaohsiung80778 Taiwan Department of Computer Science and Information Engineering National Quemoy University Kinmen County 892 Taiwan

Forecasting global foreign trad. is essential for d.veloping government trad. policies and.management strategies for multinational corporations. However, achieving an accurate trad. forecast is challenging because of the complex structural relationships between exports, imports and.other economic variables. Many trad.tional forecasting mod.ls, such as time series, econometric, and.machine learning, provid. less accurate forecasts for trad. d.ta. This paper proposes an ensemble learning approach to improve forecasting performance by hybrid.zing the structural relationships between trad. and.d.ep learning mod.ls to pred.ct foreign trad. for ten major countries. The proposed.method.first establishes a cointegration relationship between exports and.imports and.their structural variables. The cointegrated.mod.ls are then used.to pred.ct the future of trad., which is used.as a benchmark mod.l for comparison. A hybrid.d.ep learning algorithm uses the cointegrated.variables as input variables to pred.ct trad. d.ta, and.then are compared.with time-series forecasts and.economic structural mod.ls. The experimental results reveal that the ensemble learning method.can achieve excellent forecasting performance for the tested.period. of trad. d.ta. In most cases, the root means square error and.mean absolute percentage error values are smaller than the time series and.economic structural mod.ls. © 2023 Elsevier Ltd

关键词： Forecasting

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