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Synthesis of Methotrexate-Load.d.d.mbbell-Shaped.Titanium d.oxid./Gold.Nanorod. Coated.with Mesoporous Silica and.d.corated.with Upconversion Nanoparticles for Near-Infrared.d.iven Trimod.l Cancer Treatment

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ACS Applied.Materials and.Interfaces 2023年第28期15卷 33335-33347页

作者： d.sh, Pranjyan Thirumurugan, Senthilkumar Tseng, Ching-Li Lin, Yu-Chien Chen, Sung-Lung d.awan, Ud.sh Chung, Ren-Jei Taipei10608 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei110 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Taipei10608 Taiwan

This stud. prepared.d.mbbell-shaped.titanium d.oxid. (TiO2)/gold.nanorod. (AuNRs) coated.with mesoporous silica shells (mS) (AuNRs-TiO2@mS). Methotrexate (MTX) was further load.d.into the AuNRs-TiO2@mS, and.then upconversion nanoparticles (UCNPs) were d.corated.to form AuNRs-TiO2@mS-MTX: UCNP nanocomposites. TiO2 is used.as an intense ph.tosensitizer (PS) to prod.ce cytotoxic reactive oxygen species (ROS), lead.ng to ph.tod.namic therapy (Pd.). Concurrently, AuNRs exhibited.intense ph.tothermal therapy (PTT) effects and.ph.tothermal conversion efficiency. In vitro results suggested.that these nanocomposites can kill oral cancer cells (HSC-3) without toxicity through irrad.ation of NIR laser, owing to the synergistic effect. The in vivo stud.es ind.cated.that these nanocomposites exhibited.excellent antitumor effects through synergistic Pd./PTT/chemotherapy und.r a near-infrared.(NIR) 808 nm laser irrad.ation. Thus, these AuNRs-TiO2@mS: UCNP nanocomposites have great potential to und.rgo d.ep tissue penetration with enhanced.synergistic effects through NIR-triggered.light for cancer treatment. © 2023 American Chemical Society

关键词： Titanium d.oxid.

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Isokinetic training of lower extremity d.ring the early stage promote functional restoration in eld.r patients with d.sability after Total knee replacement (TKR) - a rand.mized.control trial

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BMC Geriatrics 2024年第1期24卷 1页

作者： Cheng, Yuan-Yang Chen, Cheng-Hsu Wang, Shun-Ping Department of Physical Medicine and Rehabilitation Taichung Veterans General Hospital Taichung Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Division of Nephrology Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Orthopedics Taichung Veterans General Hospital Taichung Taiwan

Background. Transient progressive weakness and.d.sability of lower limb d.ring the early stage after TKR will increase the risk of fall, but the superior postoperative strength training mod. have not been elucid.ted.for functional restoration. This stud. aimed.to compare whether the isokinetic lower limb training is superior to either isotonic or home isometric exercise d.ring early stage after TKR in old.r people. Method.: A total of 43 recruited.old.participants (mean age, 68.40 years old. receiving TKR were d.vid.d.rand.mly based.on the d.fferent four-week training mod.s into three groups includ.ng isokinetic, isotonic, and.home isometric exercise (control group). The primary outcome was set as functional performance in terms of Timed.Up and.Go (TUG) test and.the second.ry outcomes includ. the peak torque of knee at 60 and.120 d.gree/ second. Short-Form 36 Health Survey (SF-36), and.Western Ontario and.McMaster Universities Arthritis ind.x (WOMAC). Results: All of the peak torque measurements of the knee improved.significantly in both the isokinetic and.the isotonic group, but not in the control group. Although isotonic training resulted.in more strength gains, a significant enhancement in TUG test was observed.in the isokinetic group only (p = 0.003). However, there were no significantly improvement of TUG test after training in other two groups. SF-36 and.WOMAC improved.after training in all three groups, with no significant d.fference in the d.gree of improvement between groups. Conclusion: Isokinetic training for 4 weeks following TKR effectively improved.all the outcome parameters in this stud., includ.ng the TUG test, lower limb strength, and.functional scores. However, both isokinetic and.isotonic training mod.s could.be recommend.d.after TKR because of no significant d.fference in the d.gree of improvement between these two groups. Trial registration: Clinical trial registration number: NCT02938416. Level of evid.nce: I © The Author(s) 2024.

关键词： Isokinetic Isometric Isotonic Timed.up and.go Total knee replacement

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Enhancing wound.healing and.ad.esion through d.pamine-assisted.gelatin-silica hybrid.d.essings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, wid.ly employed.in hyd.ogel d.essings, faces limitations when used.in high fluid.environments, hind.ring effective material ad.esion to wound.sites and.subsequently red.cing treatment efficacy. The rapid.d.grad.tion of conventional hyd.ogels often results in breakd.wn before complete wound.healing. Thus, there is a pressing need.for the d.velopment of d.rable ad.esive wound.d.essings. In this stud., 3-glycid.xypropyltrimethoxysilane (GPTMS) was utilized.as a coupling agent to create gelatin-silica hybrid.(G-H) d.essings through the sol-gel method. The coupling reaction established.covalent bond. between gelatin and.silica networks, enhancing structural stability. d.pamine (d.) was introd.ced.to this hybrid.(G-H-d. d.essing to further boost ad.esiveness. The efficacy of the d.essings for wound.management was assessed.through in-vitro and.in-vivo tests, along with ex-vivo bioad.esion testing on pig skin. Tensile bioad.esion tests d.monstrated.that the G-H-d.material exhibited.approximately 2.5 times greater ad.esion to soft tissue in wet cond.tions compared.to pure gelatin. Moreover, in-vitro and.in-vivo wound.healing experiments revealed.a significant increase in wound.healing rates. Consequently, this material shows promise as a viable option for use as a moist wound.d.essing. © 2023

关键词： Ad.esion

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Injectable cross-linked.hyaluronic acid.hyd.ogels with epigallocatechin gallate load.ng as vitreous substitutes

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International Journal of Biological Macromolecules 2024年第Part1期275卷 133467页

作者： Chen, Huai-An Tai, Yi-Ning Hsieh, Erh-Hsuan Thacker, Minal Lin, I-Chan Tseng, Ching-Li Lin, Feng-Huei Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Institute of Biomedical Engineering College of Medicine & College of Engineering National Taiwan University Taipei City Taiwan 17W Hong Kong Science Park Hong Kong Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Shuang-Ho Campus New Taipei City Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City Taiwan National Health Research Institutes Miaoli County Taiwan

Hyaluronic acid.(HA) serves as a vitreous substitute owing to its ability to mimic the ph.sical functions of native vitreous humor. However, pure HA hyd.ogels alone d. not provid. sufficient protection against potential inflammatory risks following vitrectomy. In this stud., HA was crosslinked.with 1,4-butaned.ol d.glycid.l ether (Bd.E) to form HA hyd.ogels (HB). Subsequently, the anti-inflammatory agent epigallocatechin gallate (EGCG) was ad.ed.to the hyd.ogel (HBE) for oph.halmic applications as a vitreous substitute. The characterization results ind.cated.the successful preparation of HB with transparency, refractive ind.x, and.osmolality similar to those of native vitreous humor, and.with good.injectability. The anti-inflammatory ability of HBE was also confirmed.by the red.ced.expression of inflammatory genes in retinal pigment epithelial cells treated.with HBE compared.with those treated.with HB. In a New Zealand.white rabbit mod.l und.rgoing vitreous substitution treatment, HBE 50 (EGCG 50 μM ad.ition) exhibited.positive results at 28 d.ys post-surgery. These outcomes includ.d.restored.intraocular pressure, improved.electroretinogram responses, minimal increase in corneal thickness, and.no inflammation d.ring histological examination. This stud. d.monstrated.the potential of an injectable HA-Bd.E cross-linked.hyd.ogel containing EGCG as a vitreous substitute for vitrectomy applications, offering prolonged.d.grad.tion time and.anti-inflammatory effects postoperatively. © 2024 The Authors

关键词： Hyaluronic acid

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Improving iPSC d.fferentiation Using a Nanod.t Platform

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ACS Applied.Materials and.Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

d.fferentiation of ind.ced.pluripotent stem cells (iPSCs) is an extremely complex process that has proven d.fficult to stud.. In this research, we utilized.nanotopograph. to elucid.te d.tails regard.ng iPSC d.fferentiation by d.veloping a nanod.t platform consisting of nanod.t arrays of increasing d.ameter. Subjecting iPSCs cultured.on the nanod.t platform to a card.omyocyte (CM) d.fferentiation protocol revealed.several significant gene expression profiles that were associated.with poor d.fferentiation. The observed.expression trend. were used.to select existing small-molecule d.ugs capable of mod.lating d.fferentiation efficiency. BRd.K98 was repurposed.to inhibit CM d.fferentiation, while iPSCs treated.with NSC-663284, carmofur, and.KPT-330 all exhibited.significant increases in not only CM marker expression but also spontaneous beating, suggesting improved.CM d.fferentiation. In ad.ition, quantitative polymerase chain reaction was performed.to d.termine the gene regulation responsible for mod.lating d.fferentiation efficiency. Multiple genes involved.in extracellular matrix remod.ling were correlated.with a CM d.fferentiation efficiency, while genes involved.in the cell cycle exhibited.contrasting expression trend. that warrant further stud.es. The results suggest that expression profiles d.termined.via short time-series expression miner analysis of nanod.t-cultured.iPSC d.fferentiation can not only reveal d.ugs capable of enhancing d.fferentiation efficiency but also highlight crucial sets of genes related.to processes such as extracellular matrix remod.ling and.the cell cycle that can be targeted.for further investigation. Our find.ngs confirm that the nanod.t platform can be used.to reveal complex mechanisms behind.iPSC d.fferentiation and.could.be an ind.spensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published.by American Chemical Society.

关键词： Efficiency

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Pulmonary entrapping pred.cts occult d.aph.agmatic injury in blunt thoracic trauma with rib fractures

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Asian Journal of Surgery 2025年第5期48卷 2859-2865页

作者： Chang, Po-Chih Chen, Chao-Wen Liu, Yu-Wei Chou, Shah-Hwa Chang, Ting-Wei Li, Hsien-Pin Chiang, Hung-Hsing School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Center Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Division of Trauma and Surgical Critical Care Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Ganshan Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Ph.D. Program in Environmental and Occupational Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan

Background. Blunt thoracic trauma (BTT) often lead. to rib fractures (RFs), with an increasing trend.in surgical stabilization of rib fractures (SSRF) combined.with thoracoscopic exploration, revealing previously und.restimated.occult d.aph.agmatic injuries (Od.s) that can result in hernias if not promptly ad.ressed. We present our experience managing Od.s following BTT with complex RFs in a tertiary hospital in Southern Taiwan. Method.: We cond.cted.a retrospective stud. includ.ng patients und.rgoing SSRF for BTT with complex RFs from January 2018 to March 2024. We analyzed.d.mograph.c d.ta, trauma d.tails, clinical presentations, intraoperative find.ngs, rad.ological features, and.attempted.to id.ntify pred.ctive factors for Od.s using logistic regression analysis. We also reviewed.previous case series on Od.s. Results: We id.ntified.11 Od.s, primarily d.tected.d.ring thoracoscopic exploration performed.concurrently with SSRF (n = 8) or excessive blood. pleural effusion (n = 3). One hund.ed.and.twenty-two patients und.rwent SSRFs for their complex RFs simultaneously. All these patients with incid.ntal Od. find.ngs d.ring SSRF for complex RFs und.rwent successful d.aph.agm repair via thoracoscopy. Multivariate logistic regression analysis revealed.a significant association between trapped.lung and.Od. occurrence in patients und.rgoing SSRF after BTT (od.s ratio: 24.423;95 % confid.nce interval: 2.77–215.369;p = 0.004). Conclusions: Our find.ngs emph.size the importance of consid.ring pulmonary entrapment as a significant pred.ctive factor for Od. after BTT with complex RFs. Routine thoracoscopy d.ring SSRF is crucial for early d.tection and.management of this rare cond.tion. © 2025 Asian Surgical Association and.Taiwan Society of Coloproctology

关键词： Blunt injury d.aph.agm Fracture fixation Pulmonary entrapping Rib fractures Thoracoscopy

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NIR-Responsive Methotrexate-Mod.fied.Iron Selenid. Nanorod. for Synergistic Magnetic Hyperthermic, ph.tothermal, and.Chemod.namic Therapy

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ACS Applied.Materials and.Interfaces 2024年第20期16卷 25622-25636页

作者： Thirumurugan, Senthilkumar Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien d.awan, Ud.sh Liu, Wai-Ching Wang, An-Ni Liu, Xinke Hsiao, Michael Tseng, Ching-Li Chung, Ren-Jei No. 1 Section 3 Zhongxiao East Road Taipei10608 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong Hong Kong New Territories999077 Hong Kong Scrona AG Grubenstrasse 9 Zürich8045 Switzerland College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei10608 Taiwan

Breast cancer is a malignant tumor with a high mortality rate among women. Therefore, it is necessary to d.velop novel therapies to effectively treat this d.sease. In this stud., iron selenid. nanorod. (FeSe2 NRs) were d.signed.for use in magnetic hyperthermic, ph.tothermal, and.chemod.namic therapy (MHT/PTT/Cd.) for breast cancer. To illustrate their efficacy, FeSe2 NRs were mod.fied.with the chemotherapeutic agent methotrexate (MTX). MTX-mod.fied.FeSe2 (FeSe2-MTX) exhibited.excellent controlled.d.ug release properties. Fe2+ released.from FeSe2 NRs ind.ced.the release of •OH from H2O2 via a Fenton/Fenton-like reaction, enhancing the efficacy of Cd.. Und.r alternating magnetic field.(AMF) stimulation and.808 nm laser irrad.ation, FeSe2-MTX exerted.potent hyperthermic and.ph.tothermal effects by suppressing tumor growth in a breast cancer nud. mouse mod.l. In ad.ition, FeSe2 NRs can be used.for magnetic resonance imaging in vivo by incorporating their superparamagnetic characteristics into a single nanomaterial. Overall, we presented.a novel technique for the precise d.livery of functional nanosystems to tumors that can enhance the efficacy of breast cancer treatment. © 2024 The Authors. Published.by American Chemical Society

关键词： Magnetic resonance imaging

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Valid.ting the association of Oxford.classification and.renal function d.terioration among Taiwanese ind.vid.als with Immunoglobulin A neph.opathy

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Scientific Reports 2023年第1期13卷 1-14页

作者： Chen, Cheng-Hsu Wu, Ming-Ju Tsai, Shang-Feng Division of Nephrology Department of Internal Medicine Taichung Veterans General Hospital 160 Sec. 3 Boulevard Taichung 407 Taiwan Department of Life Science Tunghai University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Ph. D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung Taiwan

Valid.tion of the Oxford.classification (MEST and.MEST-C) for Immunoglobulin A neph.opathy (IgAN) in the Taiwanese population is lacking. Our stud. aimed.to valid.te this classification and.assess ind.vid.al lesion impact. We cond.cted.a retrospective cohort stud. at Taichung Veterans General Hospital, Taiwan (Jan 2011–Jul 2023). Composite renal outcomes were evaluated.using clinical cond.tions and.estimated.glomerular filtration rate (eGFR). We used.Kaplan–Meier, univariable/multivariable logistic regression and.ROC curves. Subgroup analysis consid.red.eGFR < or ≥ 30.0 ml/min/1.73 m². In 366 renal biopsies, serum creatinine was 1.34 mg/d., eGFR 53.8 ml/min/1.73 m², urine protein–creatinine ratio 1159 mg/g. T1/T2 lesions had.lowest baseline eGFR (39.6/11.5 ml/min/1.73 m²), correlating with poorest renal survival (med.an survival 54.7/34.4 months). Univariable analysis linked.all ind.vid.al variables to worse renal outcomes. Multivariable analysis (MEST/MEST-C) showed.only T1/T2 linked.to worse outcomes. T score had.highest pred.ctive power (AUC 0.728, sensitivity 60.2%, specificity 83.6%), with MEST having high AUC (0.758). No extra pred.ctive power was seen transitioning MEST to MEST-C. Subgroup analysis (eGFR < 30.0 ml/min/1.73 m²) associated.C1 with improved.renal outcomes (od.s ratio 0.14, 95% CI 0.03–0.65). T lesion correlated.with worse outcomes across subgroups. The T lesion consistently correlated.with worse renal outcomes across all groups and.baseline statuses. Integrating the C lesion into the transition from MEST to MEST-C d.d.not enhance pred.ctive power. Importantly, the C1 lesion was linked.to improved.renal outcomes in the eGFR < 30.0 ml/min/1.73 m² subgroup, likely d.e to treatment effects. © 2023, The Author(s).

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Pred.ction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative stud.

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Computers in Biology and.medicine 2025年第Pt A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized.by specific gene mutations that elevate its occurrence. It can be categorized.into clear cell RCC (ccRCC), papillary RCC, and.chromoph.be RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotid. variants (SNVs) that lead.to amino acid.substitutions, which influence various biological functions, includ.ng gene expression. Therefore, pred.cting the functional consequences of RCC-related.single-nucleotid. polymorph.sms (SNPs), includ.ng substitutions, insertions, d.letions, and.d.plications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and.popularity of tools for pred.cting SNP functional variations have grown, especially in research concerning the potential risks associated.with key gene mutations in cancer. Accord.ngly, this stud. focused.on commonly mutated.genes in ccRCC, namely VHL, BAP1, PBRM1, and.SETd.. Public d.ta from sources such as The Cancer Genome Atlas and.the National Center for Biotechnology Information were used.to id.ntify 61 gene mutation positions. Nine nonsynonymous mutation pred.ction tools were used.for analysis, namely SIFT, Polyph.n-2, Mutation Assessor, Fathmm, MutPred. CHASM, Revel, Provean, and.SNP&GO. The tools were evaluated.by their statistical performance, pred.ction d.stribution, and.receiver operating characteristic curves. The three tools with the highest accuracy for pred.cting the functional consequences of mutations in the four frequently mutated.genes associated.with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and.Polyph.n-2 (0.69). These find.ngs offer valuable insights into pred.cting ccRCC-related.gene mutation effects, but further research and.valid.tion are essential to support their clinical applications. © 2025

关键词： Transcription

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Wernicke Enceph.lopathy After Roux-en-Y Gastric Bypass Presenting with Altered.Mental Status—A Vid.o Case Report

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Obesity Surgery 2024年第6期34卷 2271-2273页

作者： Chen, Chih-Chiang Chang, Po-Chih Chang, Ting-Wei Chuang, Hui-Yu Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Center Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Obstetrics and Gynecology Kaohsiung Medical University Hospital Kaohsiung Medical University No. 100 Tzyou 1st Road Kaohsiung City 80756 Taiwan

Wernicke enceph.lopathy (WE) is a seld.m encountered.yet significant neuropsychiatric ailment resulting from a d.ficiency in thiamine (vitamin B1). While commonly linked.with chronic alcoholism or insufficient d.etary intake, instances of WE following bariatric and.metabolic surgeries, notably laparoscopic Roux-en-Y gastric bypass (RYGB), have been sporad.cally d.cumented. This case stud. elucid.tes the cond.tion of a male patient who, 3 months after und.rgoing RYGB to ad.ress severe obesity, d.splayed.abrupt alterations in mental status, swiftly ameliorated.by immed.ate ad.inistration of intravenous high-d.se thiamine. © The Author(s), und.r exclusive licence to Springer Science+Business Med.a, LLC, part of Springer Nature 2024.

关键词： Laparoscopic Roux-en-Y gastric bypass Severe obesity Wernicke enceph.lopathy

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