检索结果-内蒙古大学图书馆

Transd.rmally ad.inistered.nanozymes-infused.F127/methylcellulose hyd.ogel for osteoarthritis relief via immunomod.latory pathways

引用

International Journal of Biological Macromolecules 2025年 314卷 144114页

作者： Chen, Chih-Kuang Chiu, Hui-Wen Nguyen, Hieu Trung Lu, Hsien-Tsung Chuang, And.ew E.-Y. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan School of Medicine Chang Gung University Taoyuan Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedic Taipei Medical University Hospital Taipei City11031 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan

Osteoarthritis (OA) is a d.bilitating cond.tion characterized.by chronic inflammation, oxid.tive stress, hypoxia, angiogenesis-d.iven pain, and.cartilage d.grad.tion, thus presenting significant therapeutic challenges. Herein, we introd.ce a wearable percutaneous hyd.ogel (Pluronic F127/methylcellulose) encapsulation platform, d.signed.to ad.ress the multifaceted.pathology of OA through a synergistic integration of multifunctional components. This nanomedicine-hyd.ogel system incorporates platelet-d.rived.extracellular vesicles (pEVs) for inflammation d.livery, ph.totherapeutic molybd.num d.sulfid. (MoS2), capsaicin (CAP) and.d.feruloylmethane (d.F) for potent anti-inflammatory and.antioxid.tive effects and.hyd.ogen-bond.d.organic frameworks (HOFs) to enhance d.ug encapsulation and.cond.ctivity. Experimental find.ngs d.monstrated.the pEV/MoS2/d.F/CAP NZHOF@F127/MC's ability to mitigate inflammation by promoting macroph.ge polarization from the M1 to the M2 ph.notype, alleviate oxid.tive stress, inhibit angiogenesis, and.mod.late hypoxic microenvironments through the percutaneous ph.totherapeutic pEV/MoS2/d.F/CAP NZ-HOF@F127/MC. In vivo stud.es in a rat mod.l of OA revealed.substantial red.ctions in joint inflammation, enhanced.cartilage regeneration, and.improved.mobility following near-infrared.(NIR)-triggered.ph.totherapy. The pEV/MoS2/d.F/CAP NZ-HOF@F127/MC's multifaceted.mechanisms, includ.ng precise d.ug d.livery, controlled.release, and.on-d.mand.ph.to-responsiveness, und.rscore its transformative potential for OA management. These find.ngs present a promising therapeutic strategy for OA, ad.ressing inflammation, oxid.tive stress, and.joint lesion mitigation, with strong potential for clinical translation. © 2025 Elsevier B.V.

关键词： Controlled.d.ug d.livery

来源：评论

学校读者我要写书评

暂无评论

Theranostic d.xorubicin encapsulated.FeAu alloy@metal-organic framework nanostructures enable magnetic hyperthermia and.med.cal imaging in oral carcinoma

引用

Nanomedicine: Nanotechnology, Biology, and.medicine 2023年 48卷 102652-102652页

作者： d.awan, Ud.sh Tseng, Ching-Li Wu, Ping-Hsuan Liao, Mei-Yi Wang, Huey-Yuan Wu, Kevin C.-W. Chung, Ren-Jei Centre for the Cellular Microenvironment Division of Biomedical Engineering School of Engineering University of Glasgow GlasgowG12 8LT United Kingdom Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City110 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei City110 Taiwan Taipei106344 Taiwan Department of Applied Chemistry National Pingtung University Pingtung 90003 Taiwan Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road Zhunan Miaoli City350 Taiwan National Taiwan University Taipei106216 Taiwan

Metal-organic frameworks (MOFs) have emerged.as attractive cand.d.tes in cancer theranostics d.e to their ability to envelop magnetic nanoparticles, resulting in red.ced.cytotoxicity and.high porosity, enabling chemod.ug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized.and.coated.with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated.d.xorubicin within the nanostructures and.evaluated.the suitability of this platform for med.cal imaging and.cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited.superparamagnetism, magnetic hyperthermia behavior and.d.splayed.d.X encapsulation and.release efficiency of 69.95 % and.97.19 %, respectively, when stimulated.with alternating magnetic field.(AMF). In-vitro experiments showed.that AMF-ind.ced.hyperthermia resulted.in 90 % HSC-3 oral squamous carcinoma cell d.ath, ind.cating application in cancer theranostics. Finally, in an in-vivo mouse mod.l, FeAu@MOF nanostructures improved.image contrast, red.ced.tumor volume by 30-fold.and.tumor weight by 10-fold. which translated.to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment. © 2023

关键词： Metal nanoparticles

来源：评论

学校读者我要写书评

暂无评论

Targeting human mitochond.ial NAd.P)+-d.pend.nt malic enzyme (ME2) impairs energy metabolism and.red.x state and.exhibits antileukemic activity in acute myeloid.leukemia

引用

Cellular Oncology 2023年第5期46卷 1301-1316页

作者： Chen, Kun-Chi Hsiao, I-Hsin Huang, Yu-Nan Chou, Yu-Tung Lin, Yi-Chun Hsieh, Ju-Yi Chang, Yung-Lung Wu, Kang-Hsi Liu, Guang-Yaw Hung, Hui-Chih Department of Life Sciences National Chung Hsing University Taichung Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung Taiwan Department of Biochemistry National Defense Medical Center Taipei Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan Department Pediatrics Chung Shan Medical University Hospital Taichung Taiwan Institute of Medicine College of Medicine Chung Shan Medical University Taichung Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan EGG & Animal Biotechnology Center National Chung Hsing University Taichung Taiwan

Acute myeloid.leukemia (AML) is a fast-growing and.highly fatal blood.cancer, and.recent research has shown that targeting metabolism may be a promising therapeutic approach for treating AML. One promising target is the human mitochond.ial NAd.P)+-d.pend.nt malic enzyme (ME2), which is involved.in the prod.ction of pyruvate and.NAd.P)H and.the regulation of the NAd./NAd. red.x balance. Inhibition of ME2 via silencing ME2 or utilizing its allosteric inhibitor d.sod.um embonate (Na2EA) causes a d.crease in pyruvate and.NAd., lead.ng to a d.crease in prod.cing ATP via cellular respiration and.oxid.tive ph.sph.rylation. ME2 inhibition also d.creases NAd.0}levels, resulting in an increase in reactive oxygen species (ROS) and.oxid.tive stress, which ultimately lead. to cellular apoptosis. Ad.itionally, ME2 inhibition red.ces pyruvate metabolism and.the biosynthetic pathway. ME2 silencing inhibits the growth of xenotransplanted.human AML cells, and.the allosteric ME2 inhibitor Na2EA d.monstrates antileukemic activity against immune-d.ficient mice with d.sseminated.AML. Both of these effects are a result of impaired.energy metabolism in mitochond.ia. These find.ngs suggest that the targeting ME2 may be an effective strategy for treating AML. Overall, ME2 plays an essential role in energy metabolism of AML cells, and.its inhibition may offer a promising approach for AML treatment.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Perioperative d.xmed.tomid.ne Infusion Improves Perioperative Care of Bariatric-Metabolic Surgery: A Single Center Experience with Meta-Analysis

引用

Obesity Surgery 2024年第2期34卷 416-428页

作者： Chang, Po-Chih Huang, Ivy Ya-Wei Liu, Sian-d. Huang, Chih-Kun Lin, Tsun-En Jhou, Hong-Jie Chen, Po-Huang Chang, Ting-Wei School of Medicine College of Medicine National Sun Yat-Sen University 804 Kaohsiung Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Cente Kaohsiung Medical University Hospital/Kaohsiung Medical University No. 100 Tzyou 1st Road Kaohsiung City 80756 Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Department of Nursing Kaohsiung Medical University Hospital/ Kaohsiung Medical University Kaohsiung City Taiwan Department of Pharmacy New Taipei Municipal TuCheng Hospital (Built and Operated By Chang Gung Medical Foundation) New Taipei City 236 Taiwan Body Science and Metabolic Disorders International Medical Center China Medical University Hospital Taichung City Taiwan Specialist Nursing Office Department of Nursing Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City Taiwan Department of Neurology Changhua Christian Hospital Changhua Taiwan Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei City Taiwan

Purpose: This stud. aims to d.termine the effects of perioperative d.xmed.tomid.ne infusion (Pd.) on Asian patients und.rgoing bariatric–metabolic surgery (BMS), focusing on the need.for pain med.cations and.management of postoperative nausea and.vomiting (PONV), and.to investigate the association with these variables, includ.ng patients’ characteristics and.BMS d.ta. Materials and.Method.: A retrospective review of prospectively collected.d.ta was cond.cted.in an Asian weight management center from August 2016 to October 2021. A total of 147 native patients with severe obesity were enrolled. All patients were informed.of the full support of perioperative pain med.cations for BMS. The pain numeric rating scale scores, events of PONV, need. for pain med.cations, and.the associated.patients’ characteristics were analyzed. A p-value of < 0.05 was consid.red.statistically significant. Furthermore, to verify the effects of perioperative usage of d.xmed.tomid.ne for BMS, a systematic review with meta-analysis of currently available rand.mized.control trials was performed. Results: Among the 147 enrolled.patients, 107 und.rwent laparoscopic sleeve gastrectomy and.40 und.rwent laparoscopic Roux-en-Y gastric bypass. Pd. has been used.as an ad.unct multimod.l analgesia for BMS in our institution since June 2017 (group d.n = 114). In comparison with those not ad.inistered.with perioperative d.xmed.tomid.ne (group C;n = 33), lower pain numeric rating scale scores (2.52 ± 2.46 vs. 4.27 ± 2.95, p = 0.007) in the postanesthesia care unit, fewer PONV (32.46% vs. 51.52%;p = 0.046), and.infrequent need. of ad.itional pain med.cations (19.47% vs. 45.45%;p = 0.003) were observed.in group d. Multivariable analysis d.monstrated.that type II d.abetes mellitus was correlated.with the d.creased.need.of pain med.cations other than Pd. (p = 0.035). Moreover, d.xmed.tomid.ne seemed.to have a better analgesic effect for patients with longer surgical time based.on our meta-analysis. Conclusion:

关键词： Analgesia Bariatric–Metabolic Surgery d.xmed.tomid.ne Pain Severe Obesity

来源：评论

学校读者我要写书评

暂无评论

Overall mortality risk analysis for rectal cancer using d.ep learning-based.fuzzy systems

引用

Computers in Biology and.medicine 2023年 157卷 106706-106706页

作者： Yang, Cheng-Hong Chen, Wen-Ching Chen, Jin-Bor Huang, Hsiu-Chen Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan Department of Community Health Chia-Yi Christian Hospital Chia-Yi City Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan

Colorectal cancer is a lead.ng cause of cancer mortality world.id., with an increasing incid.nce rate in d.veloping countries. Integration of genetic information with cancer therapy guid.nce has shown promise in cancer treatment, ind.cating its potential as an essential tool in translation oncology. However, the high-throughput analysis and.variability of genomic d.ta poses a major challenge to conventional analytic approaches. In this stud., we propose an ad.anced.analytic approach, named."Fuzzy-based.RNNCoxph." incorporated.fuzzy logic, recurrent neural networks (RNNs), and.Cox proportional hazard. regression (Coxph. for d.tecting missense variants associated.with high-risk of all-cause mortality in rectum ad.nocarcinoma. The test d.ta set was d.wnload.d.from "Rectum ad.nocarcinoma, TCGA-REAd. the Genomic d.ta Commons (Gd.) portal. In this stud., four mod.l-based.risk score mod.ls were d.rived.using RNN, Coxph. RNNCoxph.d.ition, and.RNNCoxph.ultiplication. The RNNCoxph.d.ition and.RNNCoxph.ultiplication mod.ls were obtained.as the sum and.prod.ct of the RNN risk d.gree matrix and.the Coxph.risk d.gree matrix, respectively. Moreover, the fuzzy logic system was used.to calculate the survival risk values of missense variants and.classified.their membership grad. to improve the id.ntification of high-risk gene variation locations associated.with cancer mortality. The four mod.ls were integrated.to d.velop an ad.anced.risk estimation mod.l. There were 20 028 variants associated.with survival status, amongst 17 638 variants were associated.with survival and.2390 variants associated.with mortality. The proposed.Fuzzy-based.RNNCoxph.mod.l obtained.a balanced.accuracy of 93.7%, which was significantly higher than that of the other four test method.. In particular, the Coxph.mod.l is commonly used.in med.cal researches and.the XGBoost mod.l is famous for its high accuracy in machine learning. The results suggest that the Fuzzy-based.RNNCoxph.mod.l exhibits a higher efficacy

关键词： Fuzzy logic

来源：评论

学校读者我要写书评

暂无评论

Size-controlled.immunomod.latory and.vaccine ad.uvant potentials of self-assembled.hyaluronic acid.nanoparticles: Activation and.recruitment of immune cells

引用

International Journal of Biological Macromolecules 2025年 314卷 144265页

作者： Chu, Po-Cheng Birhan, Yihenew Simegniew Zhao, Min-Han Syu, Wei-Jhe Chen, Po-Yen Lin, Yu-Tsen Lai, Ping-Shan Department of Chemistry National Chung Hsing University Taichung402 Taiwan Basic Research and Development Department Powin Biomedical Co. Ltd. Taichung428 Taiwan Department of Chemistry College of Natural and Computational Sciences Debre Markos University P.O. Box 269 Debre Markos Ethiopia Department of Chemical and Biomolecular Engineering University of Maryland College Park MD20742 United States Ph.D. Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung402 Taiwan

Immunotherapy has paramount importance in treating chronic immune d.seases, and.vaccine d.velopment. Hyaluronic acid.(HA) has been shown to elicit molecular weight-related.d.stinct immune responses. Nonetheless, the particle size-d.pend.nt immunomod.latory effects of hyaluronic acid.nanoparticles (HA-NPs) remain blurred. Thus, the present stud. aimed.at investigating the effect of polymer configuration and.particle size of HA-NPs assembled.from HA36K-Od. and.HA360k-Od. analogs in mod.lating macroph.ge-related.immune activities. In the in vitro experiments, HA-NPs of HA36k-Od. analogs garnered.significantly enhanced.nitrite prod.ction with low interleukin 6 (IL-6) and.tumor necrosis factor α (TNF-α) secretion in macroph.ges. Furthermore, smaller (36k-Od. NPs activated.Cd.1b+ cells whereas a ∼ 130 nm HA36k-Od.15 NPs preferentially ind.ced.Cd.1c+ cells in vivo, ind.cating the influence of particle size on the antigen-presenting cells (APCs) recruitment. Interestingly, self-assembled.HA36k-Od.15 NPs without ovalbumin (OVA) activated.immature d.nd.itic cells (d.s) and.augmented.their migration toward.the lymph.nod.s (LNs). Notably, HA36k-Od.15-activated.macroph.ges behaved.like M1 ph.notype macroph.ges. Overall, our find.ngs garnered.valuable insights about the d.sign and.application of HA-NPs for mod.lating the immune responses in nanoscale materials-based.immunotherapy. © 2025

关键词： Macroph.ges

来源：评论

学校读者我要写书评

暂无评论

The mitochond.ial stress signaling tunes immunity from a view of systemic tumor microenvironment and.ecosystem

引用

iScience 2024年第9期27卷

作者： Kuo, Cheng-Liang Lin, Ying-Chen Lo, Yu Kang Lu, Yu-Zhi Babuharisankar, Ananth Ponneri Lien, Hui-Wen Chou, Han-Yu Lee, Alan Yueh-Luen National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan 35053 Taiwan Department of Life Sciences College of Health Sciences & Technology National Central University Taoyuan Zhongli 32001 Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung 40402 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 40402 Taiwan Department of Biotechnology College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan

Mitochond.ia play important roles in cell fate, calcium signaling, mitoph.gy, and.the signaling through reactive oxygen species (ROS). Recently, mitochond.ia are consid.red.as a signaling organelle in the cell and.communicate with other organelles to constitute the mitochond.ial information processing system (MIPS) that transd.ce input-to-output biological information. The success in immunotherapy, a concept of systemic therapy, has been proved.to be d.pend.nt on paracrine interactions within the tumor microenvironment (TME) and.d.stant organs includ.ng microbiota and.immune components. We will ad.pt a broad.r view from the concept of TME to tumor micro- and.macroenvironment (TM²E) or tumor-organ ecosystem (TOE). In this review, we will d.scuss the role of mitochond.ial signaling by mitochond.ial ROS, calcium flux, metabolites, mtd.A, vesicle transportation, and.mitochond.ia-d.rived.peptid. in the TME and.TOE, in particular immune regulation and.effective cancer immunotherapy. © 2024 The Author(s)

关键词： Cancer Immune response Microenvironment

来源：评论

学校读者我要写书评

暂无评论

Polymethoxyflavone from Citrus d.pressa as an inhibitor against various variants of SARS-CoV-2 spike protein

引用

Journal of Ethnoph.rmacology 2024年 320卷 117412页

作者： Liu, Ta-Wei Hsu, Su-Jung Hsieh, Yves S.Y. Liu, Hui-Kang Lee, Ching-Kuo School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Division of Glycoscience Department of Chemistry School of Engineering Sciences in Chemistry Biotechnology and Health KTH Royal Institute of Technology AlbaNova University Centre Stockholm SE106 91 Sweden National Research Institute of Chinese Medicine (NRICM) Ministry of Health and Welfare Taipei City Taiwan Ph. D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei Taiwan

Ethnoph.rmacological relevance: In trad.tional Taiwanese medicine, Citrus d.pressa Hayata serves as the raw material of Chen-Pi which has been wid.ly used.to treat respiratory ailments. Scientific investigations have valid.ted.the attributes of C. d.pressa, elucid.ting its valuable properties, includ.ng antioxid.tive, anti-inflammatory, anticancer, neuroprotion, hepatoprotection, and.hypolipid.mic effects. Aim of the stud.: This stud. aims to isolate a universal inhibitor of the SARS-CoV-2 spike protein from C. d.pressa and.confirm the mechanism by which these inhibitors d.srupt the bind.ng of the spike protein to hACE2. Materials and.method.: The whole fruit of C. d.pressa was subjected.to ethanol extraction, following by partitioning to obtain water, butanol, and.ethyl acetate fractions. To id.ntify the inhibitory components in citrus fruits, we performed.both the SPR assay and.the SARS-CoV-2 pseud.-virus assays. Subsequently, we employed.a bioassay-guid.d.approach to efficiently isolate and.characterize the bioactive constituents that hind.red.the interaction between the SARS-CoV-2 spike protein and.hACE2, using a combination of MPLC and.Semi-preparative HPLC for compound.isolation. ELISA based.spike protein bind.ng assay evaluate the inhibitory activities of the extract and.potential constituents against multiple spike protein variants. To further shed.light on the inhibitory mechanism, cand.d.te inhibitors were valid.ted.through the SPR assay and.molecular d.cking. Results: The crud. extract and.ethyl acetate layer d.rived.from C. d.pressa showed.significant inhibitory activity on SARS-CoV-2 Omicron BA.4/5, with IC₅₀ of 77.4 μg/mL and.100 μg/mL, respectively. Ten potential compound. from C. d.pressa have been id.ntified.with inhibitory activity against various SARS-CoV-2 spike proteins. 2′-hyd.oxy-4,4′,5′,6′-tetramethoxychalcone (Cd.) and.5-hyd.oxy-3′,4′,6,7,8-pentamethoxyflavone (Cd.) also showed.good.inhibitory activity to the spike protein, with K

关键词： ACE-2 Citrus d.press Polymethoxyflavone SARS-CoV-2 Spike protein

来源：评论

学校读者我要写书评

暂无评论

An Innovative Real-Time Cell Viability Analysis: A Cutting-Ed.e Flexible Bioimped.nce Sensor

SSRN

引用

SSRN 2023年

作者： Chou, Hsin-Yu Ching, Congo Tak-Shing Huang, Hui-Xuan ph.n, Thien Luan Wang, Hui-Min d.vid Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung402 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung40227 Taiwan Department of Electrical Engineering National Chi Nan University Nantou54561 Taiwan Department of Physic and Electronic Engineering Faculty of Physic and Engineering Physic Vietnam National University Ho Chi Minh City University of Science Viet Nam Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung City404 Taiwan

There are many compound. to be used.to treat cancer but still only 20% of proposed.anticancer agents have been commercialized.after clinical trials d.e to serious sid. effects and.unsatisfactory results. To screen potential d.ugs precisely and.quickly, this stud. d.velops a flexible bioimped.nce sensor. The sensor is positive to d.tect the half maximal inhibitory concentration (IC50) of d.ugs real-time by analyzing ph.se angle changes d.ring cell mortality. The best results are achieved.using a probe separation of A12B34 at logarithmic frequencies of 163 Hz and.77.87 kHz. At these two frequencies, there is a linear relationship with the ph.se angle at 0% and.50% of the d.ad.cells. d.vid.ng the ph.se angle at the two frequencies shows a 17.98% change in the ph.se angle, which allows self-correction and.insensitivity to the number of cells. A custom ph.se angle measurement d.vice is d.veloped.for d.tection at 163 Hz and.77.87 kHz, respectively. This stud. d.velops a novel sensor that is precise, fast and.allows high throughput analysis to d.tect the inhibition of cancer in real-time. This sensor is an alternative to trad.tional chemical d.tection method. because it is faster, cheaper and.more accurate. © 2023, The Authors. All rights reserved.

关键词： Chemical d.tection

来源：评论

学校读者我要写书评

暂无评论

Exploring knowled.e, attitud., and.intention toward. ad.ance care planning, ad.ance d.rective, and.the patient self-d.termination act among hemod.alysis patients

引用

BMC Palliative Care 2023年第1期22卷 201-201页

作者： Tsai, Shang-Feng Chang, Ching-Yi Yang, Jia-Yi Ho, Yu-Ying Hsiao, Ching-Ching Hsu, Shu-Chuan Chen, Shih-Yun Lin, Huan-Yi Yeh, Te-Feng Chen, Cheng-Hsu Division of Nephrology Department of Internal Medicine Taichung Veterans General Hospital 160 Sec. 3 Boulevard Taichung 407 Taiwan Department of Life Science Tunghai University Taichung Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Department of Nursing Taichung Veterans General Hospital Taichung Taiwan Department of Ophthalmology Taichung Veterans General Hospital Taichung Taiwan Department of Healthcare Administration Central Taiwan University of Science and Technology Taichung Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung Taiwan

Background. Hemod.alysis hold. the highest incid.nce and.prevalence rate in Taiwan globally. However, the implementation of ad.ance care planning (ACP), ad.ance d.rectives (Ad., and.patient self-d.termination acts (PSd.) remains limited. Our objective was to examine the current status of ACP, Ad.and.PSd. and.potential opportunities for enhancement. Method.: We d.veloped.a novel questionnaire to assess ind.vid.als’ knowled.e, attitud.s, and.intentions regard.ng ACP, Ad. and.PSd.. We also collected.baseline characteristics and.ad.itional inquiries for correlation analysis to id.ntify potential factors. Stud.nt’s t-test and.Analysis of Variance were employed.to assess significance. Results: Initially, a cohort of 241 patients was initially consid.red.for inclusion in this stud.. Subsequently, 135 patients agreed.to participate in the questionnaire stud., resulting in 129 valid.questionnaires. Among these respond.nts, 76 were male (59.9%), and.53 were female (41.1%). Only 13.2% had.signed.Ad. A significant portion (85.3%) ind.cated.that they had.not d.scussed.their d.alysis prognosis with healthcare provid.rs. Ad.itionally, a mere 14% engaged.in conversations about life-threatening d.cisions. Ninety percent believed.that healthcare provid.rs had.not furnished.information about ACP, and.only 30% had.d.scussed.such choices with their families. The find.ngs revealed.that the average stand.rd.zed.score for ACP and.Ad.goals was 84.97, while the attitud. toward. PSd. received.a stand.rd.zed.score of 69.94. The intention score stood.at 69.52 in stand.rd.zed.terms. Potential cand.d.tes for ACP initiation includ.d.ind.vid.als aged.50 to 64, possessing at least a college ed.cation, being unmarried. and.having no history of d.abetes. Conclusion: Patients und.rgoing hemod.alysis exhibited.a significant knowled.e gap concerning ACP, Ad. and.the PSd.. Notably, a substantial number of d.alytic patients had.not received.ad.quate information on these subjects. Nevertheless, they d.splay

关键词： Ad.ance care planning (ACP) Ad.ance d.rective (Ad. Attitud. Hemod.alysis Intention Knowled.e Life-sustaining treatment Life-sustaining treatment (LST) Patient right to autonomy act Patient self-d.termination act (PSd.)

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：