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determinants of Household Earnings in Rural Economy of Thailand

Asia-Pacific Journal of Rural development 2000年第1期10卷 27 - 42页

作者： Rajendra P. Shrestha Apisit Eiumnoh Research Scientist and Associate Professor respectively of the Rural Development Gender and Resources Program School of Environment Resources and Development Asian Institute of Technology Bangkok Thailand. The study is the part of the Ph.D work of the first author. The authors would like to extend their sincere appreciation to Prof. Dr. Karl E. Weber Dr. Kaew Nualchawee of Asian Institute of Technology Bangkok Dr. Sornthep Tumwasorn of Kasetsart University Bangkok and Prof. Dr. Ulrich Freitag of Freie University of Berlin Germany for their constructive comments during the study period.

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RESOLVING dIFFERENCES WITHIN THE REHABILITATION TEAM

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Rehabilitation Nursing 1984年第3期9卷 38-40页

作者： Margolis, Howard Fiorelli, Joseph S. Leonard, H. Skipton Howard Margolis received his EdD from Hofstra University. He is currently director of program development for Star Systems Consultation and Training in Philadelphia PA. He specializes in assisting health organizations improve productivity and service through the judicious use of their human resources. Joseph S. Fiorelli received his PhD in organizational development and training from Temple University and is currently director of education for Moss Rehabilitation Hospital in Philadelphia PA. He specializes in organizational problem solving psycho-educational processes and adult education. He is a frequent presenter and author in the areas of training and inter-disciplinary teamwork. H. Skipton Leonard Ph.D received his doctorate from the Research Center For Human Development NY University. He was a post doctoral fellow in group processes at the National Institute of Mental Health. He is currently a clinical psychologist in private practice in the Washington DC area and has just co-authored a text on nursing management.

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16-Hydroxybriaranes from the octocoral Briareum stechei

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phytochemistry Letters 2023年第1期57卷 92-95页

作者： Liu, Chia-Jung Wang, Chien-Chiao Chang, Chun-Feng Zhang, Mingzi M. Tsou, Lun Kelvin Wen, Zhi-Hong Hwang, Tsong-Long Chen, You-Ying Sung, Ping-Jyun Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung 804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan Graduate Institute of Natural Products College of Medicine Chang Gung University Taoyuan 333323 Taiwan Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333323 Taiwan Division of Urology Department of Surgery Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Zhunan 350401 Taiwan Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Miaoli Zhunan 350401 Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Taoyuan 333008 Taiwan Research Center for Chinese Herbal Medicine Graduate Institute of Healthy Industry Technology College of Human Ecology Chang Gung University of Science and Technology Taoyuan 333324 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei 243303 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807378 Taiwan Ph.D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City 242062 Taiwan

Two new 16-hydroxybriaranes, 11-dehydroxybriavioid B (1) and 12-epi-briastecholide L (2), have been isolated from an algal-containing octocoral identified as Briareum stechei. The structures of metabolites 1 and 2 were corroborated by extensive 2d-NMR studies and comparison with literature data. Briarane 2 was found to reduce the release of inducible nitric oxide synthase (iNOS) to 87.92 %, at a concentration of 10 μM. © 2023 phytochemical Society of Europe

关键词： Briarane Briareum stechei Briastecholide Briavioid iNOS

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Total synthesis and metabolic stability of hispidulin and its d-Labelled derivative

Total synthesis and metabolic stability of hispidulin and it...

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第11届世界华人药物化学研讨会（ISCMC 2018）

作者： Liangchi Chen Kaicheng Hsu Lihchu Chiou Huiju Tseng Weijan Huang Graduate Institute of Pharmacognosy College of PharmacyTaipei Medical University School of Pharmacy College of PharmacyTaipei Medical University Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical University Graduate Institute of Brain and Mind Sciences College of MedicineTaiwan University Graduate Institute of Pharmacology College of MedicineTaiwan University Ph.D.Program in Biotechnology Research and Development College of PharmacyTaipei Medical University Ph.D.Program for the Clinical Drug Discovery from Botanical Herbs College of PharmacyTaipei Medical University School of Pharmacy “Defense Medical Center”

Hispidulin is a naturally occurring flavone known to have various central nervous system(CNS) *** synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall *** solve these problems,this study developed a novel scheme for synthesizing hispidulin,which had an improved overall yield as well as more concise reaction steps compared to previous methods ***,using the same synthetic strategy,d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver *** work may produce *** entities for enriching the library of hispidulin-derived compounds.

关键词： hispidulin total synthesis flavone microsome stability deuterium-labelled compound

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INTERCOMPARTMENTAL FLUId SHIFTS IN HEMOdIALYSIS-PATIENTS

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biotechnology PROGRESS 1987年第2期3卷 69-73页

作者： HEINEKEN, FG EVANS, MC KEEN, ML GOTCH, FA COBE Laboratories Inc. Lakewood Colorado Fred G. Heineken is currently Program Director for Biotechnology within the Emerging Engineering Technologies Division of the Engineering Directorate of the National Science Foundation. He received his B.Sc. degree in Chemical Engineering from Northwestern University and his Ph.D. degree in the same discipline from the University of Minnesota. His work experience includes fermentation research at Monsanto teaching and research in respiration physiology at the University of Colorado and hemodialysis product design and evaluation at COBE Laboratories. Hemodialysis Treatment and Research Center Franklin Hospital Ralph K. Davis Medical Center San Francisco California Mary C. Evans has a BS degree in Chemistry from the University of Florida. She has held positions in the artificial kidney development group at Dow Chemical Company and the new product development group of Cordis-Dow Corporation. She is currently working in clinical research in the Hemodialysis Treatment & Research Center at Franklin Hospital in San Francisco. Marcia Keen is currently a doctoral student at the University of California San Francisco and serves as Clinical Research Supervisor at the Hemodialysis Treatment & Research Center at Franklin Hospital in San Francisco. She received her MS at the University of California San Francisco. Her thesis research developed a non-invasive Doppler technique to quantitate vascular access graft flow in hemodialysis patients. Her research interests include physiologic responses to dialysis therapy manipulations. Frank Gotch is an Associate Clinical Professor of Medicine at the University of California San Francisco. He received his BA and MD from the University of California and is currently Medical Director of the Hemodialysis Treatment & Research Center at Franklin Hospital in San Francisco. His research has addressed such issues as adequacy of dialysis and mathematical modeling of hemodialysis and associated therapies. He is a past president of the American

Hemodialysis is a therapeutic procedure for replacing some functions of the natural kidney. As such, it is capable of allowing people with little or no residual kidney function to survive and in some cases to lead productive lives. There are, unfortunately, a number of side effects associated with this procedure (shock, muscle cramps, fatigue, etc.). In order to minimize these side effects, we have undertaken to model shifts of fluid between the intracellular and extracellular fluid spaces in hemodialysis patients. Fluid shifts are primarily a function of osmolality differences between these fluid spaces. Changes in osmolality are caused mainly by changes in urea and salt concentrations. Least squares analysis of patient data has been used to estimate the appropriate ultrafiltration and urea mass transfer coefficients for each patient. The model has then been used to find a dialysate sodium concentration profile that will minimize fluid shifts into and out of the intracellular fluid space.

关键词： BIOMEdICAL EQUIPMENT

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design of diarylheptanoid derivatives as dual inhibitors against class Ⅱa histone deacetylase and β-amyloid aggregation

Design of diarylheptanoid derivatives as dual inhibitors aga...

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第11届世界华人药物化学研讨会（ISCMC 2018）

作者： Huiju Tseng Liangchieh Chen Changyi Liu Yunyi Huang Chengchung Yen Jingru Weng Yehlin Lu Wenchi Hou Tony Eight Lin Ihorng Pan Kuokuei Huang Weijan Huang Kaicheng Hsu Program in Biotechnology Research and Development College of PharmacyTaipei Medical University Graduate Institute of Pharmacognosy College of PharmacyTaipei Medical University School of Pharmacy College of PharmacyTaipei Medical University Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical University Department of Marine Technology and Resources College of Marine SciencesSun Yat-sen University Herbal Medicinal Product Div. Industrial Technology Research Institute Ph.D.Program for the Clinical Drug Discovery from Botanical Herbs College of PharmacyTaipei Medical University School of Pharmacy “Defense Medical Center”

Alzheimer's disease(Ad) is a progressive neurodegenerative disorder with multiple ***-amyloid(AB) self-aggregation and overexpression of class IIa histone deacetylases(HdACs) are strongly implicated with Ad *** this study,a series of novel diarylheptanoid derivatives were designed,synthesized and evaluated for use as dual Aβ self-aggregation and class IIa HdAC *** these compounds,4 j,5 c and Se displayed effective inhibitions for AB self-aggregation,HdACS activity and HdAC7 activity with IC50 values of < 10 μ*** compounds contain three common features:(1) a catechol or pyrogallol moiety,(2) a carbonyl linker and(3) an aromatic ring that can function as an HdAC cap and create hydrophobic interactions with Aβ***,compounds 4 j,5 c and 5 e showed no significant cytotoxicity to human neuroblastoma SH-SY5 Y cells and also exhibited neuroprotective effect against H2O2-induced ***,these promising in vitro data highlighted compounds 4 j,5 c and 5 e as lead compounds that are worthy for further investigation.

关键词： Alzheimer's disease Aβ aggregation Histone deacetylase Isoform-selective inhibitors dual inhibitors

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Briastecholides G–J, New Polyoxygenated Briaranes from the Octocoral Briareum Stechei

SSRN

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SSRN 2022年

作者： Sung, Ping-Jyun Huynh, Thanh-Hao Chien, Su-Ying Wen, Zhi-Hong Liaw, Chih-Chuang Tsai, Yu-Chi Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung804201 Taiwan National Museum of Marine Biology and Aquarium Pingtung944401 Taiwan Instrumentation Center National Taiwan University Taipei106319 Taiwan Institute of Biopharmaceutical Sciences National Sun Yat-sen University Kaohsiung804201 Taiwan Chinese Medicine Research and Development Center China Medical University Hospital Taichung404394 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung807378 Taiwan Ph. D. Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City242062 Taiwan

Chemical composition screening of octocoral Briareum stechei , collected from Okinawan waters, led to the isolation of 10 briarane-type diterpenoids, including four previously-undescribed metabolites, briastecholides G–J ( 1 – 4 ), in addition to six known analogues, brianodin A ( 5 ), briarlides G ( 6 ) and P ( 7 ), and violides G, O, and P ( 8 – 10 ). The structures of 1 – 10 were elucidated by spectroscopic methods. Briastecholide d ( 1 ) was found to possess an unprecedented 10/6/5/5-fused tetracyclic scaffold. Furthermore, the absolute configuration of brianodin A ( 5 ) was elucidated for the first time in this study by single-crystal X-ray diffraction analysis. Briaranes 2 and 5 – 8 reduced the release of iNOS to 17.01, 37.95, 28.76, 1.21 and 26.66%, respectively, at a concentration of 10 µM. © 2022, The Authors. All rights reserved.

关键词： Spectroscopic analysis

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GENETIC-ENGINEERING ANd ENVIRONMENTAL-POLLUTION - POTENTIAL ANd UNCERTAINTIES

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BIO-TECHNOLOGY 1983年第8期1卷 670-673页

作者： ZABORSKY, OR Oskar R. Zaborsky Ph.D. is a program director in the Division of Chemical and Process Engineering of the National Science Foundation 1800 G Street Washington DC 20550. The views conclusions and recommendations expressed herein are those of the author and do not necessarily reflect the views and policies of the National Science Foundation.REFERENCES Conference on "Genetic Control of Environmental Pollutants" July 31-August 3 1983 University of Washington School of Public Health & Community Medicine and Department of Environmental Health Seattle WA. The proceedings are to be published by Plenum Press.Recent reports covering the handling of hazardous industrial wastes including biological processes are (a) "Management of Hazardous Industrial Wastes: Research and Development Needs" National Research Council National Academy Press Washington D.C. 1983 (b) "Technologies and Management Strategies for Hazardous Waste Control " Congress of the United States Office of Technology Assessment Washington D.C. 1983.An expanded report on the technology market analysis regulatory and legislative factors dealing with biotechnology applications to hazardous wastes has been produced by Dr. Thomas O.Peyton AmTech Consultants Vienna VA for the OTA study.Baross J.A. and Deming J.W.1983. Growth of 'black smoker' bacteria at temperatures of at least 250C. Nature303: 423-426.|Article|ISI|ChemPort|

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Biological Evaluation of Sulfonate and Sulfate Analogues of Lithocholic Acid: A Bioisosterism-Guided Approach Towards the discovery of Potential Sialyltransferase Inhibitors for Antimetastatic Study

SSRN

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SSRN 2023年

作者： Perez, Ser John Lynon P. Chen, Chia-Ling Chang, Tzu-Ting Li, Wen-Shan Institute of Chemistry Academia Sinica Taipei115 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu300 Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Biomedical Translation Research Center Academia Sinica Taipei115 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung807 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung804 Taiwan Department of Chemistry College of Science Tamkang University New Taipei City251 Taiwan

The naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impact of the terminal carboxyl acid substituent of LCA on its ST inhibition, in this present study, we report the (bio)isosteric replacement-based design and synthesis of sulfonate and sulfate analogues of LCA. Among these compounds, the sulfate analogue SPP-002 was found to selectively inhibit N-glycan sialylation by at least an order of magnitude, indicating a substantial improvement in both potency and selectivity when compared to the unmodified parent bile acid. Molecular docking analysis supported the stronger binding of the synthetic analogue in the enzyme active site. Treatment with SPP-002 also hampered the migration, adhesion, and invasion of MdA-MB-231 cells in vitro by suppressing the expression of signaling proteins involved in the cancer metastasis-associated FAK/paxillin pathway. In totality, these findings offer not only a novel structural scaffold but also valuable insights for the future development of more potent and selective ST inhibitors with potential therapeutic effects against tumor cancer metastasis. © 2023, The Authors. All rights reserved.

关键词： Sulfur compounds

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diterpenoids and Their Glycosides from the Stems ofTinospora crispawith Beta-Cell Protective Activity

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Journal of Natural Products 2023年第6期86卷 1437-1448页

作者： Sio-Hong Lam Hui-Kang Liu Shih-Yuan Chung Jia-Ling Chang Mao-Xuan Hong Sheng-Chu Kuo Chih-Chuang Liaw School of Pharmacy College of Medicine National Cheng Kung University Tainan 70101 Taiwan Division of Basic Chinese Medicine National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei 112 Taiwan Ph.D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei 11031 Taiwan Graduate Institute of Pharmaceutical Chemistry China Medical University Taichung 404 Taiwan Department of Marine Biotechnology and Resource National Sun Yat-sen University Kaohsiung 80424 Taiwan Department of Science Application and Dissemination National Taichung University of Education Taichung 403 Taiwan Graduate Institute of Natural Products Kaohsiung Medical University Kaohsiung 807 Taiwan Graduate Institute of Pharmacognosy Taipei Medical University Taipei 11031 Taiwan

Seven previously undescribed diterpenoids, tinocrisposides A–d (1–4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem ofTinospora crispa(Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-Bd11 cells under dexamethasone treatment. diterpene glycosides12,14–16, and18presented a substantial protective effect on BRIN-Bd11 cells treated with dexamethasone in a dose-dependent manner. Compounds4and17with two sugar moieties exhibited clear protective effects on β-cells.

关键词： Alkyls Carbohydrates Carbon Chemical structure Nuclear magnetic resonance spectroscopy

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