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Corrigendum to: TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis "Toxicol Appl pharmacol. 2016;305:194-202"

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Toxicology and applied pharmacology 2020年 387卷 114858页

作者： Chao-Feng Lin Han-Li Huang Chieh-Yu Peng Yu-Ching Lee Hui-Po Wang Che-Ming Teng Shiow-Lin Pan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taiwan Department of Medicine MacKay Medical College New Taipei City Taiwan Division of Cardiology Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan Division of Cardiology Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taiwan. Chinese Medicine Research and Development Center China Medical University Hospital Taichung 404 Taiwan School of Pharmacy College of Pharmacy China Medical University Taichung 404 Taiwan. The Center of Translational Medicine Taipei Medical University Taipei Taiwan Program for Biotechnology in Medicine Taipei Medical University Taipei Taiwan. College of Pharmacy Taipei Medical University Taipei 11031 Taiwan. College of Pharmacy Taipei Medical University Taipei 11031 Taiwan Pharmacological Institute College of Medicine National Taiwan University Taipei 100 Taiwan. Department of Pharmacology College of Medicine Taipei Medical University Taipei 10031 Taiwan. Electronic address: slpan@tmu.edu.tw.

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

关键词： Lung adenocarcinoma Lung cancer Mendelian randomization Pathway analysis Tuberculosis

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/dCBLd1) and rs2179920 (HLA-dPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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determinants of Household Earnings in Rural Economy of Thailand

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Asia-Pacific Journal of Rural development 2000年第1期10卷 27 - 42页

作者： Rajendra P. Shrestha Apisit Eiumnoh Research Scientist and Associate Professor respectively of the Rural Development Gender and Resources Program School of Environment Resources and Development Asian Institute of Technology Bangkok Thailand. The study is the part of the Ph.D work of the first author. The authors would like to extend their sincere appreciation to Prof. Dr. Karl E. Weber Dr. Kaew Nualchawee of Asian Institute of Technology Bangkok Dr. Sornthep Tumwasorn of Kasetsart University Bangkok and Prof. Dr. Ulrich Freitag of Freie University of Berlin Germany for their constructive comments during the study period.

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CHEMICAL MASS-BALANCE APPROACH TO FIELd-EVALUATION OF BIOREMEdIATION

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ENVIRONMENTAL PROGRESS 1995年第1期14卷 F2-F3页

作者： SIMS, RC SIMS, JL Utah State University Department of Civil and Environmental Engineering and Utah Water Research Laboratory Logan UT 84322 Professor and Head of the Division of Environmental Engineering at Utah State University. He holds degrees in biology (B.S.) environmental chemistry and biology (M.S.) environmental engineering (M.S.) and biological and agricultural engineering (Ph.D). He has worked as Director of the International Program in Industrial Development Chapel Hill NC as Supervisor of the Environmental Control Laboratory for Mobay Chemical Corporation Charleston SC and as environmental engineer with Research Triangle Institute NC. Dr. Sims currently is involved in teaching research and technology transfer in the area of contaminated soil characterization and remediation. Research Assistant Professor in the Division of Environmental Engineering at Utah State University. She holds degrees in biology (B.S.) environmental chemistry and biology (M.S.) and soil science (M.S.). She has held positions as an Associate in a private consulting firm in Raleigh NC and as Chairperson of the on-site wastewater disposal committee of the State of Utah. Judith Sims is currently involved in teaching research and technology transfer in the area of contaminated soil characterization and remediation.

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INTERCOMPARTMENTAL FLUId SHIFTS IN HEMOdIALYSIS-PATIENTS

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biotechnology PROGRESS 1987年第2期3卷 69-73页

作者： HEINEKEN, FG EVANS, MC KEEN, ML GOTCH, FA COBE Laboratories Inc. Lakewood Colorado Fred G. Heineken is currently Program Director for Biotechnology within the Emerging Engineering Technologies Division of the Engineering Directorate of the National Science Foundation. He received his B.Sc. degree in Chemical Engineering from Northwestern University and his Ph.D. degree in the same discipline from the University of Minnesota. His work experience includes fermentation research at Monsanto teaching and research in respiration physiology at the University of Colorado and hemodialysis product design and evaluation at COBE Laboratories. Hemodialysis Treatment and Research Center Franklin Hospital Ralph K. Davis Medical Center San Francisco California Mary C. Evans has a BS degree in Chemistry from the University of Florida. She has held positions in the artificial kidney development group at Dow Chemical Company and the new product development group of Cordis-Dow Corporation. She is currently working in clinical research in the Hemodialysis Treatment & Research Center at Franklin Hospital in San Francisco. Marcia Keen is currently a doctoral student at the University of California San Francisco and serves as Clinical Research Supervisor at the Hemodialysis Treatment & Research Center at Franklin Hospital in San Francisco. She received her MS at the University of California San Francisco. Her thesis research developed a non-invasive Doppler technique to quantitate vascular access graft flow in hemodialysis patients. Her research interests include physiologic responses to dialysis therapy manipulations. Frank Gotch is an Associate Clinical Professor of Medicine at the University of California San Francisco. He received his BA and MD from the University of California and is currently Medical Director of the Hemodialysis Treatment & Research Center at Franklin Hospital in San Francisco. His research has addressed such issues as adequacy of dialysis and mathematical modeling of hemodialysis and associated therapies. He is a past president of the American

Hemodialysis is a therapeutic procedure for replacing some functions of the natural kidney. As such, it is capable of allowing people with little or no residual kidney function to survive and in some cases to lead productive lives. There are, unfortunately, a number of side effects associated with this procedure (shock, muscle cramps, fatigue, etc.). In order to minimize these side effects, we have undertaken to model shifts of fluid between the intracellular and extracellular fluid spaces in hemodialysis patients. Fluid shifts are primarily a function of osmolality differences between these fluid spaces. Changes in osmolality are caused mainly by changes in urea and salt concentrations. Least squares analysis of patient data has been used to estimate the appropriate ultrafiltration and urea mass transfer coefficients for each patient. The model has then been used to find a dialysate sodium concentration profile that will minimize fluid shifts into and out of the intracellular fluid space.

关键词： BIOMEdICAL EQUIPMENT

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16-IN GUN BLAST ANd THE BATTLESHIP REACTIVATION program

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NAVAL ENGINEERS JOURNAL 1987年第3期99卷 227-238页

作者： YAGLA, JJ The authorreceived his B. A. degree in science (physics) from the State College of Iowa in 1965. He received his M. S. degree in engineering mechanics in 1968 and his Ph.D in aerospace engineering and engineering science in 1981 from Arizona State University. He has done analytical and experimental research in the field of weapons blast since 1965 at the Naval Surface Weapons Center in Dahlgren Virginia. As a supervisory research mechanical engineer he was previously head of the Physical Response Analysis Branch Blast Effects Branch and Ship Engineering Branch. Dr. Yagla is the test development agent and was test conductor for the gun and missile structural test firings in USS Iowa class battleships. He is a consultant to the Naval Sea Systems Command battleship combat system engineer and the Naval Air Systems Command Cruise Missile Project for blast and structural response. He is presently analyzing shock and vibration problems for the Standard Missile Program Office.

Reactivated and modernized USS Iowa class battleships employ many new systems, none of which were designed to withstand blast from 16-inch guns. Placement of the new equipment was driven by the need to impose the smallest possible restrictions on the guns. The design problem was complicated by two factors: first, the blast overpressure field surrounding the gun had not been accurately measured with modern instruments. Second, the blast overpressure tolerance of several important systems was unknown. The problem was solved through judicious placement of the equipment so that work could begin on the ship. Meanwhile the pressure surrounding a 16-inch gun was measured at the dahlgren Laboratory. Mathematical functions describing the blast field were then used to design shipboard experiments in which the guns were fired at progressively more severe angles of train and elevation, while the equipment performance was carefully monitored. Four sets of shipboard experiments were required. Limiting values for the firing arcs have been determined, and the consequences of exceeding the recommended limits are now known.

关键词： WARSHIPS

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RESOLVING dIFFERENCES WITHIN THE REHABILITATION TEAM

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Rehabilitation Nursing 1984年第3期9卷 38-40页

作者： Margolis, Howard Fiorelli, Joseph S. Leonard, H. Skipton Howard Margolis received his EdD from Hofstra University. He is currently director of program development for Star Systems Consultation and Training in Philadelphia PA. He specializes in assisting health organizations improve productivity and service through the judicious use of their human resources. Joseph S. Fiorelli received his PhD in organizational development and training from Temple University and is currently director of education for Moss Rehabilitation Hospital in Philadelphia PA. He specializes in organizational problem solving psycho-educational processes and adult education. He is a frequent presenter and author in the areas of training and inter-disciplinary teamwork. H. Skipton Leonard Ph.D received his doctorate from the Research Center For Human Development NY University. He was a post doctoral fellow in group processes at the National Institute of Mental Health. He is currently a clinical psychologist in private practice in the Washington DC area and has just co-authored a text on nursing management.

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GENETIC-ENGINEERING ANd ENVIRONMENTAL-POLLUTION - POTENTIAL ANd UNCERTAINTIES

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BIO-TECHNOLOGY 1983年第8期1卷 670-673页

作者： ZABORSKY, OR Oskar R. Zaborsky Ph.D. is a program director in the Division of Chemical and Process Engineering of the National Science Foundation 1800 G Street Washington DC 20550. The views conclusions and recommendations expressed herein are those of the author and do not necessarily reflect the views and policies of the National Science Foundation.REFERENCES Conference on "Genetic Control of Environmental Pollutants" July 31-August 3 1983 University of Washington School of Public Health & Community Medicine and Department of Environmental Health Seattle WA. The proceedings are to be published by Plenum Press.Recent reports covering the handling of hazardous industrial wastes including biological processes are (a) "Management of Hazardous Industrial Wastes: Research and Development Needs" National Research Council National Academy Press Washington D.C. 1983 (b) "Technologies and Management Strategies for Hazardous Waste Control " Congress of the United States Office of Technology Assessment Washington D.C. 1983.An expanded report on the technology market analysis regulatory and legislative factors dealing with biotechnology applications to hazardous wastes has been produced by Dr. Thomas O.Peyton AmTech Consultants Vienna VA for the OTA study.Baross J.A. and Deming J.W.1983. Growth of 'black smoker' bacteria at temperatures of at least 250C. Nature303: 423-426.|Article|ISI|ChemPort|

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