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Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition (vol 9, 10205, 2019)

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SCIENTIFIC REPORTS 2019年第1期9卷 1-11页

作者： Mahalapbutr, Panupong darai, Nitchakan Panman, Wanwisa Opasmahakul, Aunchan Kungwan, Nawee Hannongbua, Supot Rungrotmongkol, Thanyada Structural and Computational Biology Research Unit Department of Biochemistry Faculty of Science Chulalongkorn University 10330 Bangkok Thailand Program in Biotechnology Faculty of Science Chulalongkorn University 10330 Bangkok Thailand Multidisciplinary Program of Petrochemistry and Polymer Science Faculty of Science Chulalongkorn University 10330 Bangkok Thailand Computational Chemistry Center of Excellent Department of Chemistry Faculty of Science Chulalongkorn University 10330 Bangkok Thailand Department of Chemistry Faculty of Science Chiang Mai University 50200 Chiang Mai Thailand Center of Excellence in Materials Science and Technology Chiang Mai University 50200 Chiang Mai Thailand Ph.D. Program in Bioinformatics and Computational Biology Faculty of Science Chulalongkorn University 10330 Bangkok Thailand Molecular Sensory Science Center Faculty of Science Chulalongkorn University 10330 Bangkok Thailand

The human T1R2-T1R3 sweet taste receptor (STR) plays an important role in recognizing various low-molecular-weight sweet-tasting sugars and proteins, resulting in the release of intracellular heterotrimeric G protein that in turn leads to the sweet taste perception. Xylitol and sorbitol, which are naturally occurring sugar alcohols (polyols) found in many fruits and vegetables, exhibit the potential caries-reducing effect and are widely used for diabetic patients as low-calorie sweeteners. In the present study, computational tools were applied to investigate the structural details of binary complexes formed between these two polyols and the T1R2-T1R3 heterodimeric STR. Principal component analysis revealed that the Venus flytrap domain (VFd) of T1R2 monomer was adapted by the induced-fit mechanism to accommodate the focused polyols, in which α-helical residues 233–268 moved significantly closer to stabilize ligands. This finding likely suggested that these structural transformations might be the important mechanisms underlying polyols-STR recognitions. The calculated free energies also supported the VFd of T1R2 monomer as the preferential binding site for such polyols, rather than T1R3 region, in accord with the lower number of accessible water molecules in the T1R2 pocket. The E302 amino acid residue in T1R2 was found to be the important recognition residue for polyols binding through a strongly formed hydrogen bond. Additionally, the binding affinity of xylitol toward the T1R2 monomer was significantly higher than that of sorbitol, making it a sweeter tasting molecule. [ABSTRACT FROM AUTHOR]

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Citrus fruits, vitamin d, and the RNA virus: A correlation and meta-analysis study in Taiwan and the USA

Food Chemistry Advances

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Food Chemistry Advances 2023年 2卷

作者： Peer, Gajala deethamvali Ghouse Leal, Elcio Raj, V. Samuel Chang, Chung-Ming Pandey, Ramendra Pati Centre for Drug Design Discovery and Development (C4D) SRM University Delhi-NCR Rajiv Gandhi Education City Haryana Sonepat 131 029 India Department of Biotechnology SRM University Delhi-NCR Rajiv Gandhi Education City Haryana Sonepat 131 029 India Laboratório de Diversidade Viral Instituto de Ciências Biológicas Universidade Federal do Pará Pará Belem 66075-000 Brazil Master & Ph.D. program in Biotechnology Industry Chang Gung University No.259 Wenhua 1st Rd. Guishan Dist. Taoyuan City 33302 Taiwan

Background: The main threat to human health is infectious disease. For the treatment of infections with RNA viruses, there are hardly any antiviral drugs in the market. This is especially concerning because RNA viruses continue to generate the majority of emerging and highly pathogenic viruses, and this trend is expected to continue. The use of phytochemicals in alternative therapies for viral infections is essential. Bioactive compounds of citrus are widely employed to treat a wide range of viral diseases, and calciferol (vitamin d) has been shown to have virucidal effects. According to various researchers from around the world such bioactive chemicals from citrus, along with calciferol, have the potential to have both an inhibitory and a complementary therapeutic effect against RNA viruses. Scope and approach: The purpose of this research is to find the therapeutic effects of vitamin d and citrus fruit to minimize RNA virus virulence by comparing the data and analyzing and by reviewing it and the data collected from the research/ review papers of Taiwan and the United States. Utilizing specified keywords and logical expressions, intensive online searches of pertinent open-access literature found in high-quality and dependable databases served as the foundation for the layout of this review study. Mostly this review is focused on the data of citrus fruit and vitamin d against RNA virus and compared the data from each country. Conclusion: The data information that is available in this paper suggests that consuming enough vitamin d and secondary metabolites from citrus fruits are linked to a much lower risk of contracting RNA virus infections. © 2023 The Author(s)

关键词： Citrus Taiwan United States Viral diseases Vitamin d

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Managing the transition in cervical screening methods for Taiwan: Policy recommendations and perspectives

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Journal of the Formosan Medical Association 2023年第11期122卷 1213-1218页

作者： Chen, Chien-Chin Lai, Chyong-Huey Chang, Chih-Long Cheng, Wen-Fang Pwu, Raoh-Fang Tsai, Jane Wang, Peng-Hui Whang-Peng, Jacqueline Lai, Gi-Ming Department of Pathology Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi 600 Taiwan Department of Cosmetic Science Chia Nan University of Pharmacy and Science Tainan 717 Taiwan Ph.D. Program in Translational Medicine Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung 402 Taiwan Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan 701 Taiwan Department of Obstetrics and Gynecology Chang Gung Memorial Hospital Linkou Branch Taoyuan 333 Taiwan Chang Gung University Taoyuan 333 Taiwan Department of Medicine MacKay Medical College New Taipei City 252 Taiwan Department of Obstetrics and Gynecology MacKay Memorial Hospital Taipei 104 Taiwan Department of Obstetrics and Gynecology College of Medicine National Taiwan University Taipei 100 Taiwan School of Health Care Administration Taipei Medical University Taipei 110 Taiwan Data Science Center Fu Jen Catholic University New Taipei City 242 Taiwan Formosa Cancer Foundation Taipei 105 Taiwan Department of Obstetrics and Gynecology Taipei Veterans General Hospital Taipei 112 Taiwan National Yang Ming Chiao Tung University Taipei 112 Taiwan

Since government-provided annual cervical cytology testing for all Taiwanese women aged 30 years or older became available in 1995, both cervical cancer incidence and death have decreased significantly. However, with the 2018 introduction of the national immunization program for human papillomavirus (HPV) vaccination in all schoolgirls aged 13–15 years old, the positive predictive value of cytology testing is expected to decrease with rising vaccination rates, and therefore a transition to more sensitive HPV-based testing may be needed. This position paper, derived from discussions by a panel of experts in cervical cancer screening, provides short-, medium-, and long-term policy recommendations to manage the transition between cervical screening methods for Taiwan. The recommendations include concrete suggestions regarding testing procedures, standards, accreditation, monitoring, promotion, and implementation. It is hoped that comprehensive preparation and management of this transition will enable Taiwan to repeat the previous successes of the cervical cytology testing program. © 2023 Formosan Medical Association

关键词： Cervical cancer Cervical cytology HPV-based testing Human papillomavirus Pap smear

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Jing-Si Herbal Tea Suppresses H2O2-Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes

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Environmental Toxicology 2024年第12期39卷 5347-5356页

作者： Kao, Shih-Wen Chang, Yu-Chun Lin, Feng-Huei Huang, Tai-Lung Chen, Tung-Sheng Lin, Shinn-Zong Lin, Kuan-Ho Kuo, Wei-Wen Ho, Tsung-Jung Huang, Chih-Yang Graduate Institute of Aging Medicine China Medical University Taichung Taiwan Department of Orthopedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Division of Biomedical Engineering and Nanomedicine Research National Health Research Institute Miaoli Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu chi University Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans;however, its undesired activation results in tissue damage and cell death. The onset of chronic inflammation and oxidative stress are the key characteristics of autoimmune inflammatory diseases such as rheumatoid arthritis (RA), for which an effective treatment is yet to be developed. Therefore, in this study, we investigated the protective effects and molecular mechanisms of a novel herbal preparation, Jing-Si herbal tea (JS), against H2O2-induced inflammation and cellular damage in HIG-82 synoviocytes. We found that JS did not show any significant alterations in cell viability at 2O2-induced pathological oxidative stress (ROS) in HIG-82 cells. Interestingly, JS treatment not only reduced the ROS levels but also significantly repressed the protein expressions of collagen degrading proteases in a dose-dependent manner. Treatment with JS showed enhanced cell viability against H2O2-induced toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and Bcl-2 were increased, whereas MMP-13, AdAMTS-2, Cytochrome C, and cleaved Caspase 3 were decreased by JS under inflammatory agents H2O2, MIA, LPS, and TNF-α treatment, respectively, in HIG-82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2-treated HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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Psychological Thriving Among Latinas With Chronic Illness

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Journal of Social Issues 2010年第2期54卷 405-424页

作者： Ana F. Abraído-Lanza Carolina Guier Rose Marie Colón Columbia School of Public Health ANA ABRAÍDO-LANZA is an Assistant Professor in the Division of Sociomedical Sciences of Columbia University's School of Public Health. She received her Ph.D. in Social-Personality Psychology with a concentration in Health Psychology from the City University of New York in 1994. Her research focuses on cultural psychosocial and socioeconomic processes that affect psychological well-being adjustment to chronic illness and mortality among Latinos. New York NY CAROLINA GUIER holds a B.S. in Psychology from the University of Costa Rica. Her research interests include ethnic minority and children's health issues. She plans to pursue graduate training in psychology and eventually work in a health care setting in her homeland Costa Rica. Veterans Affairs Medical Center and Baylor College of Medicine ROSE COLÓN is a postdoctoral fellow at the Houston Center for Quality of Care and Utilization Studies a Veterans Affairs health services research and development field program. She received her Ph.D. in Social Psychology from the University of Houston in 1997. Her research centers on acculturation processes chronic illness and health care services for Latino populations.

This study utilizes a 3-year longitudinal design to explore factors that promote thriving among Latinas facing multiple adversity: poverty and chronic illness (specifically, arthritis). From a thriving paradigm, focus is placed on understanding the positive growth and thriving experiences reported by respondents, as well as the social, cultural, and personal resources that promote thriving. In the baseline interview, we employed a qualitative methodology to understand women's experiences of thriving. Women reported a variety of such experiences, the most frequent being enhanced appreciation of life. In the follow-up study, we created a thriving scale based on responses generated at the initial interview and prior research, then examined which of a number of social/cultural and personal factors predicted thriving 3 years after the initial assessment. Only measures of competence (self-esteem and self- efficacy) and psychological well-being were related to thriving. Path analyses testing the causal sequence of these variables revealed that negative affect contributed to decreased self-efficacy and self-esteem, but it did not have a direct or indirect effect on thriving. Greater self-esteem positively predicted thriving. In contrast, positive affect did not contribute to either measure of competence, but had a direct effect on thriving. Results suggest that psychological well-being (not ill-being) promotes thriving.

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ALGINATE-POLYLYSINE MICROCAPSULES OF CONTROLLEd MEMBRANE MOLECULAR-WEIGHT CUTOFF FOR MAMMALIAN-CELL CULTURE ENGINEERING

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biotechnology PROGRESS 1987年第4期3卷 231-240页

作者： KING, GA dAUGULIS, AJ FAULKNER, P GOOSEN, MFA Departments of Chemical Engineering and Microbiology and Immunology Queen's University Kingston Ontario Canada K7L 3N6 Glenn A. King:earned his B.Sc. in Chemical Engineering at Queen's University at Kingston and is currently completing his M.Sc. in the same department. His areas of specialization are animal and insect cell culture engineering and microencapsulation technology Andrew J. Daugulis:is Associate Professor of Chemical Engineering at Queen's University. He received his M.Sc. from the University of Western Ontario and his doctorate from Queen's University. From 1984–86 he was the Coordinator of the Queen's Biotechnology Board. His research interests lie in extractive fermentation bioseparation the production of biochemicals and biologicals from immobilized microbial animal and insect cells and the design and scale-up of continuous packed-bed and batch stirred-tank bioreactors Peter Faulkner:is Professor of Microbiology and Immunology at Queen's University. He obtained his Ph.D. from McGill University and is presently an MRC Career Investigator. Much of his research is in the field of molecular genetics where nucleic acid and monoclonal antibody probes are used to track products of gene expression. He also has experience in the production and characterization of sets of mouse monoclonal antibodies directed against viral antigens Mattheus F. A. Goosen:is Associate Professor of Chemical Engineering at Queen's University. After obtaining his doctorate in chemical-biomedical engineering from the University of Toronto he spent several years at the Connaught Research Institute in Toronto as an NSERC Industrial Research Fellow. His research interests are in the areas of animal and insect cell culture engineering microencapsulation technology bioseparation processes the development of polymeric vaccine and agrochemical delivery systems and biomaterials

The search for more productive mammalian cell culture techniques has been primarily driven by the need to increase both the cell density and product concentration. In the technique used in our laboratory, microencapsulation, hybridoma cells were grown and monoclonal antibody was entrapped within microcapsules, which had a controlled membrane molecular weight cutoff. In our studies it was shown that using the alginate-poly-l-lysine (PLL) microcapsule system and protein diffusion experiments, the capsule membrane molecular weight cutoff could be controlled from 20 .times. 103 to 300 .times. 103. This was achieved by increasing the viscosity average molecular weight (.***) of the PLL, used in the encapsulation procedure, from 14 .times. 103 to 525 .times. 103 and by decreasing the alginate -PLL reaction time from 40 minutes to 6 minutes. Cell culture studies with microencapsulated mouse hybridoma cells indicated that while the conventional (single-membrane) microcapsules produced a maximum intracapsular cell density of about 2 .times. 107 cells/mL and a monoclonal antibody concentration of 1250 .mu.g/mL, a modified (multiple-membrane) capsule resulted in intracapsular cell densities of about 6 .times. 107 cells/mL and monoclonal antibody concentration 5300 .mu.g/mL. These significant improvements in cell density and monoclonal antibody concentration were attributed to a lower (22%) intracapsular alginate content as well as better retention of the cell product by the modified capsule membrane.

关键词： BIOMEdICAL ENGINEERING

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design of diarylheptanoid derivatives as dual inhibitors against class Ⅱa histone deacetylase and β-amyloid aggregation

Design of diarylheptanoid derivatives as dual inhibitors aga...

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第11届世界华人药物化学研讨会（ISCMC 2018）

作者： Huiju Tseng Liangchieh Chen Changyi Liu Yunyi Huang Chengchung Yen Jingru Weng Yehlin Lu Wenchi Hou Tony Eight Lin Ihorng Pan Kuokuei Huang Weijan Huang Kaicheng Hsu Program in Biotechnology Research and Development College of PharmacyTaipei Medical University Graduate Institute of Pharmacognosy College of PharmacyTaipei Medical University School of Pharmacy College of PharmacyTaipei Medical University Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical University Department of Marine Technology and Resources College of Marine SciencesSun Yat-sen University Herbal Medicinal Product Div. Industrial Technology Research Institute Ph.D.Program for the Clinical Drug Discovery from Botanical Herbs College of PharmacyTaipei Medical University School of Pharmacy “Defense Medical Center”

Alzheimer's disease(Ad) is a progressive neurodegenerative disorder with multiple ***-amyloid(AB) self-aggregation and overexpression of class IIa histone deacetylases(HdACs) are strongly implicated with Ad *** this study,a series of novel diarylheptanoid derivatives were designed,synthesized and evaluated for use as dual Aβ self-aggregation and class IIa HdAC *** these compounds,4 j,5 c and Se displayed effective inhibitions for AB self-aggregation,HdACS activity and HdAC7 activity with IC50 values of < 10 μ*** compounds contain three common features:(1) a catechol or pyrogallol moiety,(2) a carbonyl linker and(3) an aromatic ring that can function as an HdAC cap and create hydrophobic interactions with Aβ***,compounds 4 j,5 c and 5 e showed no significant cytotoxicity to human neuroblastoma SH-SY5 Y cells and also exhibited neuroprotective effect against H2O2-induced ***,these promising in vitro data highlighted compounds 4 j,5 c and 5 e as lead compounds that are worthy for further investigation.

关键词： Alzheimer's disease Aβ aggregation Histone deacetylase Isoform-selective inhibitors dual inhibitors

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198 The effect of magnolol on the TNF-α/IL-23/Th-17 axis of the imiquimod induced psoriasis-like dermatitis mice

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Journal of Investigative dermatology 2020年第7期140卷 S23-S23页

作者： J. Guo Y. Cheng Y. Ro Z. Wu S. Jee Medical Research Institute Cathay General Hospital New Taipei City Taiwan Fu Jen Catholic University Ph.D. Program in Pharmaceutical Biotechnology New Taipei City Taiwan Department of Dermatology Cathay General Hospital Taipei Taiwan

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Structural insights into the role of N-terminal integrity in phoSL for core-fucosylated N-glycan recognition

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International Journal of Biological Macromolecules 2024年 255卷 128309页

作者： Lou, Yuan-Chao Tu, Cheng-Fen Chou, Chun-Chi Yeh, Hsin-Hong Chien, Chia-Yu Sadotra, Sushant Chen, Chinpan Yang, Ruey-Bing Hsu, Chun-Hua Institute of Biomedical Sciences Academia Sinica Taipei115 Taiwan Department of Agricultural Chemistry National Taiwan University Taipei106 Taiwan Chemical Biology and Molecular Biophysics Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Institute of Bioinformatics and Structural Biology National Tsing Hua University Hsinchu300 Taiwan Biomedical Translation Research Center Academia Sinica Taipei115 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei110 Taiwan Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica Taipei106 Taiwan Institute of Biochemical Sciences National Taiwan University Taipei106 Taiwan Center for Computational and Systems Biology National Taiwan University Taipei106 Taiwan

phoSL (pholiota squarrosa Lectin) has an exceptional binding affinity for biomolecules with core-fucosylated N-glycans. This modification involves the addition of fucose to the inner N-acetylglucosamine within the N-glycan structure and is known to influence many physiological processes. Nevertheless, the molecular interactions underlying high-affinity binding of native phoSL to core-fucosylated N-glycans remain largely unknown. In this study, we devised a strategy to produce phoSL with the essential structural characteristics of the native protein (n-phoSL). To do so, a fusion protein was expressed in E. coli and purified. Then, enzymatic cleavage and incubation with glutathione were utilized to recapitulate the native primary structure and disulfide bonding pattern. Subsequently, we identified the residues crucial for n-phoSL binding to core-fucosylated chitobiose (N2F) via NMR spectroscopy. Additionally, crystal structures were solved for both apo n-phoSL and its N2F complex. These analyses suggested a pivotal role of the N-terminal amine in maintaining the integrity of the binding pocket and actively contributing to core-fucose recognition. In support of this idea, the inclusion of additional residues at the N-terminus considerably reduced binding affinity and phoSL cytotoxicity toward breast cancer cells. Taken together, these findings can facilitate the utilization of phoSL in basic research, diagnostics and therapeutic strategies. © 2023 Elsevier B.V.

关键词： Proteins

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VIRTUAL PROTOTYPING USING KNOWLEdGE - BASEd MOdELING ANd SIMULATION TECHNIQUES

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NAVAL ENGINEERS JOURNAL 1993年第3期105卷 201-212页

作者： SHEA, JG The Author:holds bachelor and master of engineering degrees in mechanical engineering a M.Eng. in engineering management and is currently fulfilling requirements for the M.S. and Ph.D. degrees in computer science at the University of Louisville. He is employed as program manager Phalanx Advanced Engineering Development at the Naval Ordnance Station Crane Div. NavSurfWarCen Louisville Ky. During his tenure with Phalanx Mr. Shea has contributed to system reliability improvement system performance upgrading and the development of the Phalanx HOL (RISC) Computer. Mr. Shea is a member of ASNE the Institute of Electrical and Electronics Engineers American Institute of Aeronautics and Astronautics Society for Computer Simulation International Test & Evaluation Association and the Military Operations Research Society.

Knowledge-based modeling and simulation bridges the gap between ''conventional'' artificial intelligence implementations (such as expert systems) and more traditional computer-aided design techniques. We are currently developing software, whose primary function is to capture a user-input design specification and produce a ''virtual'' rapid prototvpe in the form of executable rule-based code. This code can then be exercised either as an interactive part of a hardware-in-the-loop testbed simulator or as a component of an object-oriented ''behavioral'' simulation environment. While the phalanx Testbed is the immediate beneficiary of this work, the techniques described have a wide range of application in the modeling of conceptual design and performance characteristics. This paper describes the system architecture and software tools that we are applying to generate virtual rapid prototypes for use in the phalanx Testbed. Particular attention is paid to defining the intelligent knowledge-capture mechanisms and model generation methodologies that we are using to translate design knowledge and performance requirements into rule-based simulations. The object-oriented programming approach to the merging of ''new'' data with previouslv-captured and stored data is discussed, and the issues of verifying and validating prototypes generated using such partiallv ''reengineered'' models are examined. An application currently in use as an investigative prototype for testbed development, a simple position controller servomechanism used to control the azimuth angle of a target-tracking sensor, is used to illustrate the process.

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