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Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s disease

Journal of Alzheimer's disease 2023年第3期96卷 877-912页

作者： Mani, Shalini dubey, Rajni Lai, I-Chun Babu, M. Arockia Tyagi, Sakshi Swargiary, Geeta Mody, deepansh Singh, Manisha Agarwal, Shriya Iqbal, danish Kumar, Sanjay Hamed, Munerah Sachdeva, Punya Almutary, Abdulmajeed G. Albadrani, Hind Muteb Ojha, Shreesh Singh, Sandeep Kumar Jha, Niraj Kumar Centre for Emerging Diseases Department of Biotechnology Jaypee Institute of Information Technology UP Noida India Division of Cardiology Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Division of Radiation Oncology Department of Oncology Taipei Veterans General Hospital Taipei Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Academia Sinica Taipei Taiwan Institute of Pharmaceutical Research GLA University Mathura India Department of Molecular Sciences Macquarie University Sydney Australia Department of Health Information Management College of Applied Medical Sciences Buraydah Private Colleges Buraydah Saudi Arabia Department of Life Sciences School of Basic Sciences and Research (SBSR) Sharda University Uttar Pradesh Greater Noida India Department of Pathology Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia GloNeuro Vishwakarma Road Noida India Department of Biomedical Sciences College of Health Sciences Abu Dhabi University Abu Dhabi United Arab Emirates Department of Clinical Laboratory Sciences College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University Eastern Province Dammam Saudi Arabia Department of Pharmacology and Therapeutics College of Medicine and Health Sciences United Arab Emirates University Abu Dhabi United Arab Emirates Indian Scientific Education and Technology Foundation Lucknow India Department of Biotechnology School of Engineering & Technology (SET) Sharda University Uttar Pradesh Greater Noida India School of Bioengineering and Biosciences Lovely Professional University Punjab Phagwara India Department of Biotechnology School of Applied & Life Sciences (SALS) Uttaranchal University Uttarakhand Dehradun India Department of Biotechnology Engineering and Food Technology Chandigarh University Mohali India

Alzheimer’s disease (Ad) is characterized by the progressive degeneration of neuronal cells. With the increase in aged population, there is a prevalence of irreversible neurodegenerative changes, causing a significant mental, social, and economic burden globally. The factors contributing to Ad are multidimensional, highly complex, and not completely understood. However, it is widely known that aging, neuroinflammation, and excessive production of reactive oxygen species (ROS), along with other free radicals, substantially contribute to oxidative stress and cell death, which are inextricably linked. While oxidative stress is undeniably important in Ad, limiting free radicals and ROS levels is an intriguing and potential strategy for deferring the process of neurodegeneration and alleviating associated symptoms. Therapeutic compounds from natural sources have recently become increasingly accepted and have been effectively studied for Ad treatment. These phytocompounds are widely available and a multitude of holistic therapeutic efficiencies for treating Ad owing to their antioxidant, anti-inflammatory, and biological activities. Some of these compounds also function by stimulating cholinergic neurotransmission, facilitating the suppression of beta-site amyloid precursor protein-cleaving enzyme 1, α-synuclein, and monoamine oxidase proteins, and deterring the occurrence of Ad. Additionally, various phenolic, flavonoid, and terpenoid phytocompounds have been extensively described as potential palliative agents for Ad progression. Preclinical studies have shown their involvement in modulating the cellular redox balance and minimizing ROS formation, displaying them as antioxidant agents with neuroprotective abilities. This review emphasizes the mechanistic role of natural products in the treatment of Ad and discusses the various pathological hypotheses proposed for Ad. © 2023 – IOS Press. All rights reserved.

关键词： Alzheimer’s disease antioxidants neuroprotection oxidative stress therapeutics vitamins

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Inhibition of dengue viruses by N-methylcytisine thio derivatives through targeting viral envelope protein and NS2B-NS3 protease

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Bioorganic and Medicinal Chemistry Letters 2024年 99卷 129623页

作者： Lin, Chen-Sheng Lu, Chih-Hao Lin, Tsai-Hsiu Kiu, Yan-Tung Kan, Ju-Ying Chang, Yu-Jen Hung, Ping-Yi Tsypyshev, dmitry O. Tsypysheva, Inna P. Lin, Cheng-Wen Division of Gastroenterology Kuang Tien General Hospital No. 117 Shatian Rd Shalu District Taichung City 433 Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu City Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung 40402 Taiwan Department of Laboratory Medicine China Medical University Hospital Taichung 40402 Taiwan The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan Ufa Institute of Chemistry Ufa Federal Research Centre of the Russian Academy of Sciences 71 prosp. Oktyabrya Ufa 450054 Russian Federation Department of Medical Laboratory Science and Biotechnology Asia University Taichung41354 Taiwan

dengue virus (dENV) is a significant global health threat, causing millions of cases worldwide each year. developing antiviral drugs for dENV has been a challenging endeavor. Our previous study identified anti-dENV properties of two (-)-cytisine derivatives contained substitutions within the 2-pyridone core from a pool of 19 (-)-cytisine derivatives. This study aimed to expand on the previous research by investigating the antiviral potential of N-methylcytisine thio (mCy thio) derivatives against dENV, understanding the molecular mechanisms of antiviral activity for the active thio derivatives. The inhibitory assays on dENV-2-induced cytopathic effect and infectivity revealed that mCy thio derivatives 3 ((1R,5S)-3-methyl-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocine-8-thione) and 6 ((1S,5R)-3-methyl-2-thioxo-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one) were identified as the active compounds against both dENV-1 and dENV-2. derivative 6 displayed robust antiviral activity against dENV-2, with EC₅₀ values ranging from 0.002 to 0.005 μM in different cell lines. derivative 3 also exhibited significant antiviral activity against dENV-2. The study found that these compounds are effective at inhibiting dENV-2 at both the entry stage (including virus attachment) and post-entry stages of the viral life cycle. The study also investigated the inhibition of the dENV-2 NS2B-NS3 protease activity by these compounds. derivative 6 demonstrated notably stronger inhibition compared to mCy thio 3, revealing its dual antiviral action at both the entry and post-entry stages. Molecular docking simulations indicated that mCy thio derivatives 3 and 6 bind to the domain I and III of the dENV E protein, as well as the active of NS2B-NS3 protease, suggesting their molecular interactions with the virus. The study demonstrates the antiviral efficacy of N-methylcytisine thio derivatives against dENV. It provides valuable insights into the pot

关键词： Antiviral Attachment dengue virus E protein Entry N-methylcytisine thio derivative NS2B-NS3 protease Post-entry

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Complete genome sequence of Bacillus halotolerans F29-3, a fengycin-producing strain

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Microbiology Resource Announcements 2024年第4期13卷 e0124623页

作者： Shu, Hung-Yu Chen, Chien-Chi Ku, Hsin-Tzu Wang, Chun-Lin Wu, Keh-Ming Weng, Hui-Ying Liu, Shih-Tung Chen, Chyi-Liang Chiu, Cheng-Hsun Department of Bioscience Technology Chang Jung Christian University Tainan Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu Taiwan Bioinformatics Department Welgene Biotech Co. Ltd. Taipei Taiwan Biomedical Industry Ph.D. Program National Yang Ming Chiao Tung University Taipei Taiwan Department of Microbiology and Immunology College of Medicine Chang Gung University Taoyuan Taiwan Molecular Infectious Disease Research Center Chang Gung Memorial Hospital Taoyuan Taiwan Division of Pediatric Infectious Diseases Department of Pediatrics Chang Gung Memorial Hospital Taoyuan Taiwan

Bacillus halotolerans F29-3, a Gram-positive bacterium, is recognized for its synthesis of the antifungal substance fengycin. This announcement introduces the complete genome sequence and provides insights into the genetic products related to antibiotic secondary metabolites, including non-ribosomal peptide synthetase (NRPS), polyketide synthase (PKS), and NRPS/PKS combination. © 2024 Shu et al.

关键词： Bacillus halotolerans Bacillus subtilis fengycin non-ribosomal peptide synthetase polyketide synthase

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EMPASS - A MEANS FOR ASSESSING THE PERFORMANCE OF SHIPBOARd ELECTROMAGNETIC SYSTEMS

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NAVAL ENGINEERS JOURNAL 1980年第6期92卷 55-59页

作者： COPLEY, JA THE AUTHOR received his B.S. degree from West Virginia Institute of Technology and his M.S. and Ph.D. degrees from the Virginia Polytechnic Institute and State University. He has been employed by the U.S. Navy since 1963 and involved in naval weapon systems research development testing and evaluation. Currently he is employed at the Naval Surface Weapons Center. White Oak Silver Spring Md. His involvement in the EMPASS Program is concerned with the redesign and upgrading of the collection and analysis system to improve and expand its capabilities in order to keep pace with EM systems being introduced into the Fleet through the 1990 time period.

Currently the Fleet lacks a quantitative description of their electromagnetic (EM) capabilities and vulnerabilities. A ship's mission can be seriously degraded because of unsatisfactory performance of EM system due to various factors found in the operational environment. In addition, a ship can become vulnerable to a potential enemy by inadequate Emission Control (EMCON) of EM energy. The EMPASS measurement platform is capable of collecting and analyzing three-dimensional emission data in the operational environment. The word EMPASS is the acronym for ElectroMagnetic Performance of Aircraft and Ship Systems. EMPASS consists of a calibrated, specially equipped, measurement platform situated on an EP-3A aircraft with complementary ground based data reduction and analysis facilities. The products of the EMPASS program are the effectiveness evaluation of operational EM system, development of the criteria for the mat effective tactical use of EM systems, and the providing of the capability to conduct RdT&E in the operational EM environment. This paper presents a description of the EMPASS capabilities and the results of measurements of some representative EM system used in the Fleet.

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Fabrication of Solvent-Free PCL/β-TCP Composite Fiber for 3d Printing: physiochemical and Biological Investigation

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Polymers 2023年第6期15卷 1391-1391页

作者： Ngo, Sin Ting Lee, Wei-Fang Wu, Yi-Fan Salamanca, Eisner Aung, Lwin Moe Chao, Yan-Qiao Tsao, Ting-Chia Hseuh, Hao-Wen Lee, Yi-Huan Wang, Ching-Chiung Chang, Wei-Jen Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei110 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei110 Taiwan School of Dentistry College of Oral Medicine Taipei Medical University Taipei110 Taiwan Department of Molecular Science and Engineering National Taipei University of Technology Taipei106 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei110 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei110 Taiwan Dental Department Taipei Medical University Shuang Ho Hospital New Taipei235 Taiwan

Manufacturing three-dimensional (3d) objects with polymers/bioceramic composite materials has been investigated in recent years. In this study, we manufactured and evaluated solvent-free polycaprolactone (PCL) and beta-tricalcium phosphate (β-TCP) composite fiber as a scaffold material for 3d printing. To investigate the optimal ratio of feedstock material for 3d printing, the physical and biological characteristics of four different ratios of β-TCP compounds mixed with PCL were investigated. PCL/β-TCP ratios of 0 wt.%, 10 wt.%, 20 wt.%, and 30 wt.% were fabricated, with PCL melted at 65 °C and blended with β-TCP with no solvent added during the fabrication process. Electron microscopy revealed an even distribution of β-TCP in the PCL fibers, while Fourier transform infrared spectroscopy demonstrated that the biomaterial compounds remained intact after the heating and manufacturing process. In addition, adding 20% β-TCP into the PCL/β-TCP mixture significantly increased hardness and Young’s Modulus by 10% and 26.5%, respectively, suggesting that PCL-20 has better resistance to deformation under load. Cell viability, alkaline phosphatase (ALPase) activity, osteogenic gene expression, and mineralization were also observed to increase according to the amount of β-TCP added. Cell viability and ALPase activity were 20% higher with PCL-30, while upregulation for osteoblast-related gene expression was better with PCL-20. In conclusion, PCL-20 and PCL-30 fibers fabricated without solvent exhibited excellent mechanical properties, high biocompatibility, and high osteogenic ability, making them promising materials for 3d printing customized bone scaffolds promptly, sustainably, and cost-effectively. © 2023 by the authors.

关键词： Bone

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EVALUATING THE EFFECTIVENESS OF GROUNd-WATER EXTRACTION SYSTEMS

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GROUNd WATER MONITORING ANd REMEdIATION 1991年第1期11卷 119-124页

作者： HALEY, JL HANSON, B ENFIELd, C GLASS, J Jennifer Haley is a chemical engineer working in the Remedial Operations and Guidance Branch of the Hazardous Site Control Division/Office of Emergency and Remedial Response (U.S. EPA OS-220 401 M St. SW Washington D.C. 20460). One of her responsibilities during her three years at EPA has been completion of the EPA Guidance on Remedial Actions for Contaminated Ground Water at Superfund Sites. Prior to taking her current position at the EPA in May 1987 she worked for two years for the California Regional Water Quality Control Board overseeing ground water contamination investigations and cleanups in the South San Francisco Bay. She received a B.S. in chemical engineering from the University of California in Berkeley and an M.S. in environmental management from the University of San Francisco. Bill Hanson is an engineer with the U.S. Environmental Protection Agency (OS-220 401 M St. SW Washington D.C. 20460). He received both his B.S. in engineering and M.A. in environmental engineering from Duke University. Before joining the Environmental Protection Agency Hanson worked for several consulting engineering firms including CH2M Hill in Res ton Virginia. At EPA he first worked in the Effluent Guidelines Program where he was responsible for developing pretreatment and direct discharge regulations for the electroplating industry. Hanson has been with the Superfund program since its start. He is currently chief of the Remedial Operations and Guidance Branch. His branch is responsible for developing guidance for consistency of approach with respect to selection of remedy land ban treatment requirements and treatability protocols. Carl G. Enfield is a soil scientist at the Robert S. Ken Environmental Research Laboratory (U.S. EPA Office of Research and Development P.O. Box 1198 Ada OK 74820). He earned his B.S.C.E. in civil engineering and M.S. in agronomy at Purdue University and his Ph.D. in agricultural chemistry and soils at the University of Arizona. He currently serves as research director at EP

The most common process for remediating contaminated ground water is extraction and treatment. data from 19 on-going and completed ground water extraction systems were collected and analyzed (U.S. EPA 1989b) to evaluate the effectiveness of this process in achieving cleanup concentration goals for ground water. This analysis indicated several trends including (1) containment of ground water plumes was usually achieved;(2) contaminant concentrations dropped significantly initially followed by a leveling out;(3) after the period of initial rapid decline, the continued decreases in concentration were usually slower than anticipated;and (4) certain data important to optimizing system design and operation had often not been collected during the site characterization phase. Factors limiting the achievement of cleanup concentration goals fell into four basic categories: (1) hydrogeological factors, such as subsurface heterogeneity, low-permeability units, and presence of fractures;(2) contaminant-related factors, such as high sorption to soil and presence of non-aqueous phases (dissolution from a separate non-aqueous phases (dissolution from a separate non-aqueous phase or partitioning of contaminants from the residual non-aqueous phase);(3) continued migration from source areas and the size of the plume itself;and (4) system design factors, such as pumping rates, screened intervals, and extraction well locations. The findings of this study indicate that ground water extraction is an effective method for preventing additional migration of contaminant plumes and achieving risk reduction. However, the findings indicate that in many situations, it may not be practicable to rely solely on ground water extraction and treatment to achieve health-based cleanup concentrations throughout the contaminated zone and fulfill the primary goal of returning ground water to beneficial use. This study suggests several recommendations (U.S. EPA 1989a) for improving ground water response acti

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Novel visible-light-active P-g-CN-based α-Bi2O3/WO3 ternary photocatalysts with a dual Z-scheme heterostructure for the efficient decomposition of refractory ultraviolet filters and environmental hormones: Benzophenones

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Environmental research 2023年 234卷

作者： Berekute, Abiyu Kerebo Yu, Kuo-Pin Chuang, Yi-Hsueh Brad Lin, Kun-Yi Andrew International Ph.D. Program in Environmental Science and Technology National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental and Occupational Health Sciences National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental Engineering National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Department of Environmental Engineering and Innovation and Development Center of Sustainable Agriculture & Research Center of Sustainable Energy and Nano Technology National Chung Hsing University 250 Kuo-Kuang Road Taichung Taiwan Department of Chemistry College of Natural and Computational Sciences Arba Minch University Arbaminch Ethiopia

The ubiquitous and refractory benzophenone (BP)-type ultraviolet filters, which are also endocrine disruptors, were commonly detected in the aquatic matrix and could not be efficiently removed by conventional wastewater treatment processes, thus causing extensive concern. Herein, a novel ternary nanocomposite, P-g-CN/α-Bi2O3/WO3 (P-gBW), was successfully fabricated by mixing cocalcinated components and applied to the decomposition of BP-type ultraviolet filters. The dual-Z-scheme heterostructure of P-gBW enhances visible-light absorption, efficiently facilitates separation and mobility, and prolongs the lifetime of photoinduced charge carriers via double charge transfer mechanisms. The optimum 95 wt% P-gBW exhibited excellent photocatalytic activity, degrading 96% 4-hydroxy benzophenone (4HBP) within 150 min and 93% 2,2′,4,4′-tetrahydroxybenzophenone (BP-2) within 100 min under visible-light illumination, respectively. The pseudo-first-order rate constant of 4HBP (1.15 h−1) was 6.8-, 3.1-, 3.3- and 2.2-fold higher than those of WO3, P-g-CN, α-Bi2O3, and P-g-CN/α-Bi2O3, respectively, while that of BP-2 (1.71 h−1) was 5.2-, 2.2-, 3.2- and 1.5-fold higher, respectively. The improved photocatalytic degradation was attributed to efficient photoinduced charge carrier separation and migration and prevented the recombination of electron holes, as verified by photoluminescence, transient photocurrent response, and electrochemical impedance spectroscopy. Trapping experiments, electron paramagnetic resonance, and band energy position indicated an efficient dual-Z-scheme heterostructure. © 2023 Elsevier Inc.

关键词： Tungsten compounds

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Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia

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Haematologica 2023年第5期108卷 1284-1299页

作者： Binay K Sahoo Yuh-Charn Lin Cheng-Fen Tu Chien-Chin Lin Wei-Ju Liao Fu-An Li Ling-Hui Li Kurt Yun Mou Steve R Roffler Shu-Ping Wang Chi-Tai Yeh Chi-Yuan Yao Hsin-An Hou Wen-Chien Chou Hwei-Fang Tien Ruey-Bing Yang Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei. Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Physiology School of Medicine College of Medicine Taipei Medical University Taipei. Institute of Biomedical Sciences Academia Sinica Taipei. Department of Laboratory Medicine Division of Hematology and Department of Internal Medicine National Taiwan University Taipei. Department of Medical Research and Education Taipei Medical University Shuang Ho Hospital New Taipei City. Division of Hematology and Department of Internal Medicine Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Biomedical Translation Research Center Academia Sinica Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei. rbyang@ibms.sinica.edu.tw.

A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal is the receptor tyrosine kinase Fms-like receptor tyrosine kinase 3 (FLT3) upregulated by cooperation of the transcription factors homeobox A9 (HOXA9) and Meis homeobox 1 (MEIS1). Signal peptide-CUB-EGF-like repeat-containing protein (SCUBE) family proteins have previously been shown to act as a co-receptor for augmenting signaling activity of a receptor tyrosine kinase (e.g., vascular endothelial growth factor receptor). However, whether SCUBE1 is involved in the pathological activation of FLT3 during MLL-r leukemogenesis remains unknown. Here we first show that SCUBE1 is a direct target of HOXA9/MEIS1 that is highly expressed on the MLL-r cell surface and predicts poor prognosis in de novo acute myeloid leukemia. We further demonstrate, by using a conditional knockout mouse model, that Scube1 is required for both the initiation and maintenance of MLL-AF9-induced leukemogenesis in vivo. Further proteomic, molecular and biochemical analyses revealed that the membrane-tethered SCUBE1 binds to the FLT3 ligand and the extracellular ligand-binding domains of FLT3, thus facilitating activation of the signal axis FLT3-LYN (a non-receptor tyrosine kinase) to initiate leukemic growth and survival signals. Importantly, targeting surface SCUBE1 by an anti-SCUBE1 monomethyl auristatin E antibody-drug conjugate led to significantly decreased cell viability specifically in MLL-r leukemia. Our study indicates a novel function of SCUBE1 in leukemia and unravels the molecular mechanism of SCUBE1 in MLL-r acute myeloid leukemia. Thus, SCUBE1 is a potential therapeutic target for treating leukemia caused by MLL rearrangements.

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Superconducting magnetic gradiometers for underwater target detection

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NAVAL ENGINEERS JOURNAL 1998年第1期110卷 139-149页

作者： Clem, TR Ted R. Clem is a research physicist at the NSWC Coastal Systems Station (CSS). He has been managing the CSSs program to develop and demonstrate superconducting gradiometers since 1992. He joined the research staff at CSS in 1982. His research interests include the application of magnetic sensors for magnetic anomaly detection superconducting sensor development and demonstration and investgation of noise mechanisms associated with superconducting materials. He is also coordinator of low frequency applications in superconductivity for the Naval Consortium for Supercmductivity. The Chief of Naval Research awarded him for co-authoring the Best Nay Independent Research Paper in 1989. In addition he received the CSSas Award for Special Achievement in Science and Technology in 1985 for his endeavors to understand important noise sources in superconducting sensor technology and in 1989 for research with the high temperature superconducting materials. He is a member of the American Physical Society. Dx Clem graduated with a B.S. in physics from North Carolina State University and a Masters and a Ph.D. in bimthematics from North Carolina State University with dissertation research in theoretical statistical mechanics.

Passive magnetic sensors provide one means to conduct mobile area surveys and search operations for the detection of magnetic anomaly targets. Sensors incorporating Superconducting Quantum Interference devices (SQUIds) provide the greatest sensitivity for magnetic anomaly detection available with current technology. A superconducting magnetic-field gradiometer developed in the 1980's has been demonstrated in fusion with acoustic sensors to enhance shallow water sea mine detection and classification, especially for buried mine detection and the reduction of acoustic false alarm rates. This sensor incorporated niobium bulk and wire superconducting components cooled by liquid helium to a temperature of 4 degrees Kelvin (K). An advanced superconducting gradiometer prototype is being developed to increase sensitivity and detection range. This sensor features all thin film niobium superconducting components (replacing the bulk superconducting components used in the preceding generation) and a new liquid helium cooling concept. In the late 1980's, a new class of "high Tc" superconductors was discovered with critical temperatures above the boiling point of liquid nitrogen (77K). The use of liquid nitrogen refrigeration offers new opportunities for this sensor technology, providing significant reduction in the size of sensor packages and in the requirements for cryogenic support and logistics. As a result of this breakthrough, a high Tc sensor concept using liquid nitrogen refrigeration has been developed and a test article of that concept is being fabricated and evaluated. In this paper, these recent advances in sensor development will be reviewed and a current perspective on the role of magnetic sensors for underwater target detection, classification and localization will be addressed.

关键词： Magnetometers

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Boron carbide decorated tungsten disulfide nanosheet composite for determination of chloramphenicol in food and pharmaceutical samples

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Microchemical Journal 2024年 203卷

作者： Senthilkumar, dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Making the nanocomposites of metal oxides or metal sulfides with carbon source materials has a huge impact on the electrochemical determination of toxic chemicals. To determine the adverse side effects of the antibiotics, electrochemical sensors have been used as they can peek into the sensitivity of the drug sample. This work has done the sensitive amperometric evaluation of a chloramphenicol antibiotic by modifying the electrode of tungsten disulfide decorated boron carbide. Here, tungsten disulfide (WS₂) nanosheets and boron carbide (B₄C) materials were synthesized by conventional methods which give a good amount of yield. The composite was prepared by the green and cost-effective sonochemical approach with good morphology. The conductivity of the nanocomposite and the response to chloramphenicol were determined by cyclic voltammetry. The sensitivity, limit of detection (LOd), and the linear range were observed by the highly sensitive amperometric technique. From the amperometric analysis, the prepared nanocomposite shows nominal LOd as a 17.4 nM, a broad linear range (0.025–1134.6 µM), and good sensitivity of 1.52 µA µM⁻¹ cm⁻². Practicability of the modified sensor was studied in food and pharmaceutical samples with adequate recovery performances. Moreover, the modified electrode shows good stability, repeatability, reproducibility, and anti-interfering properties against the array of food and biological interferences. © 2024 Elsevier B.V.

关键词： Amperometric technique Antibiotic detection Boron carbide Food quality test Health analysis Tungsten disulfide

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