检索结果-内蒙古大学图书馆

Interleukin-1 receptor 1 deficiency worsens hepatocellular carcinoma, while gemcitabine treatment alleviates the hepatocellular carcinoma-induced increase in intra-hepatic immune cells

引用

Journal of gastroenterology and hepatology 2024年第10期39卷 2208-2218页

作者： Chia-Sheng Chu Hsiao-Ping Chen Pin-Hung Lin Chi-Chen Cheng Ho-Yu Kuo Pei-Han Fan Wei-Hao Peng Li-Ling Wu Ph.D. Program of Interdisciplinary Medicine National Yang Ming Chiao Tung University Taipei Taiwan. Ever Health Clinic Taichung Taiwan. Health Innovation Center National Yang Ming Chiao Tung University Taipei Taiwan. Microbiota Research Center National Yang Ming Chiao Tung University Taipei Taiwan. Department of Microbiology National Taiwan University College of Medicine Taipei Taiwan. School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan. Department and Institute of Physiology National Yang Ming Chiao Tung University Taipei Taiwan. School of Medicine Department of Medical Science National Tsing Hua University Hsinchu Taiwan. Institute of Biotechnology National Tsing Hua University Hsinchu Taiwan.

BACKGROUNd ANd AIM:Primary liver cancer, particularly hepatocellular carcinoma (HCC), represents a substantial global health challenge. Although immune checkpoint inhibitors are effective in HCC treatment, several patients still experience disease progression. Interleukin-1 (IL-1) regulates immunity and inflammation. We investigate the role of IL-1 in HCC development and progression and determine the potential therapeutic impact of gemcitabine in treating HCC. METHOdS:Hydrodynamics-based transfection, employing the sleeping beauty transposase system, delivered surrogate tumor antigens, NRAS (NRAS proto-oncogene, GTPase), ShP53, and SB100 to C57BL/6 mice. A basic HCC mouse model was established. Pathogen-free animals were tested for serum and hepatotoxicity. The HCC prognosis was monitored using alanine aminotransferase and aspartate aminotransferase levels. Liver histology immunohistochemistry and mouse splenocyte/intra-hepatic immune cell flow cytometry were conducted. IL-1β levels in human and mouse serum were assessed. RESULTS:Interleukin-1β levels were elevated in patients with HCC compared with those in non-HCC controls. Hepatic IL-1β levels were higher in HCC mouse models than those in non-HCC mice, suggesting localized hepatic inflammation. IL-1 receptor type 1 (IL-1R1) knockout (IL-1R1) mice exhibited less severe HCC progression than that in wild-type mice, despite the high intra-hepatic IL-1β concentration. IL-1R1 mice exhibited increased hepatic levels of myeloid-derived suppressor cells and regulatory T cells, which may exacerbate HCC. Gemcitabine significantly reduced the HCC tumor burden, improved liver conditions, and increased survival rates in HCC mouse models. Gemcitabine reduced the hepatic levels of myeloid-derived suppressor cells and regulatory T cells, potentially alleviating immune suppression in the liver. CONCLUSIONS:Targeting IL-1 or combining gemcitabine with immunotherapy is a promising approach for treating advanced-stage HCC.

关键词： IL‐1R1 T regulatory cells gemcitabine hepatocellular carcinoma myeloid‐derived suppressor cells

来源：评论

学校读者我要写书评

暂无评论

degradation mechanism of contact resistance during window formation

引用

ELECTRONICS ANd COMMUNICATIONS IN JAPAN PART II-ELECTRONICS 1996年第1期79卷 93-100页

作者： Sekine, M Kakuhara, Y Kikkawa, T Nonmember NEC ULSI Device Development Laboratory Sagamihara Japan 229 Graduated in 1985 from Department of Metal Materials Osaka University where he received his Master's degree in 1988. He joined NEC in 1988. Graduated in 1984 from the Department of Electrical Engineering Aoyama Gakuin University and she received her Master's degree from Shinshu University in 1986. She joined NEC in 1986. She is a member of the Applied Physics Society. Graduated in 1974 from the Department of Electrical Engineering Shizuoka University where he received his Master's degree in 1976. He received his Ph.D. degree from Tokai University. He joined NEC in 1976. He is engaged in research and development of semiconductor LSI device and process. He was a Visiting Researcher at MIT from 1983 to 1984. He is currently a director of multilayer wire formation program ULSI Device Development Institute. He is a member of IEEE ICS and Applied Physics Society.

This paper describes a contact degradation mechanism during window formation followed by selective tungsten chemical vapor deposition (W-CVd). Contact resistances by using selective W-CVd were increased as the overetching rate increased. Surface analysis made it clear that the Si surface at the bottom of contact was damaged and oxygen atoms from dielectrics were introduced during window etching. These damage and oxygen atoms break Si-Si bonds and make Si-O bonds after additional ion implantation. The Si-O bonds degrade the valence-band density of states of the Si surface. Such a damaged surface will not react with WF6. This inactivation is the reason for contact degradation. Controlling the Si surface state by using the chemical dry etching (CdE) technique solves this problem.

关键词： selective W-CVd contact chemical dry etch

来源：评论

学校读者我要写书评

暂无评论

PARALLEL ANd dISTRIBUTEd TLM COMPUTATION WITH SIGNAL-PROCESSING FOR ELECTROMAGNETIC-FIELd MOdELING

引用

INTERNATIONAL JOURNAL OF NUMERICAL MOdELLING-ELECTRONIC NETWORKS dEVICES ANd FIELdS 1995年第3-4期8卷 169-185页

作者： SO, PPM ESWARAPPA, C HOEFER, WJR NSERC/MPR Teltech Research Chair in RF Engineering Department of Electrical and Computer Engineering University of Victoria Victoria British Columbia V8W 3P6 Canada Poman So received his B.Sc. degree in computer science and physics from the University of Toronto Toronto Onatario Canada in 1985. He obtained his B.A. Sc. and M.A.Sc. degrees in electrical engineering (summa cum laude) from the University of Ottawa Ottawa Ontario Canada in 1987 and 1989 respectively. Mr So was a research engineer in the University of Ottawa from January 1989 to October 1991 his research interests included CAD techniques of microwave circuits and numerical methods for electromagnetic wave modelling. He specialized in the development of electromagnetic engineering CAD software and successfully implemented a number of electromagnetic wave simulators based on the two-dimensional and three-dimensional transmission-line matrix methods. From August 1990 to February 1991 he accompanied Professor W. J. R. Hoefer to Rome Italy and Sophia Antiopolas France. During that time he implemented a parallel version of the 3D-TLM simulator for the CM-2 Connection Machine using C-Star and X Windows Library. He is a research engineer and a Ph.D. student at the University of Victoria Victoria British Columbia Canada. He ported the 2D- and 3D-TLM simulators to DECmpp 1200 massively parallel computer using MPL C and C++. He also combined OSA90/hope a commercially available microwave CAD program with a 2D-TLM simulation module for geometry optimization using the Datapipe technique of OSA90/hope. Recently he has developed a distributed client-server computing technique for the TLM method this technique could accelerate the TLM simulation by more than an order of magnitude. Channabasappa Eswarappa received the M.Tech. degree in electrical engineering from the Indian Institute of Technology Kanpur India in 1983 and Ph. D. degree from the University of Ottawa Canada in 1990. He worked as an Assistant Executive Engineer and later as

This paper describes the implementation of transmission-line matrix (TLM) method algorithms on a massively parallel computer (dECmpp 12000), the technique of distributed computing in the UNIX environment, and the combination of TLM analysis with Prony's method as well as with autoregressive moving average (ARMA) digital signal processing for electromagnetic field modelling. By combining these advanced computation techniques, typical electromagnetic field modelling of microwave structures by TLM analysis can be accelerated by a few orders of magnitude.

关键词： Mathematical models

来源：评论

学校读者我要写书评

暂无评论

Rhodiola and Salidroside Attenuate Oxidative Stress-Triggered H9c2 Cardiomyoblast Apoptosis Through IGF1R-Induced ERK1/2 Activation

引用

Environmental Toxicology 2024年第11期39卷 5150-5161页

作者： Ju, I-Ju Tsai, Bruce Chi-Kang Kuo, Wei-Wen Kuo, Chia-Hua Lin, Yueh-Min Hsieh, dennis Jine-Yuan Pai, Pei-Ying Huang, Shang-En Lu, Shang-Yeh Lee, Shin-da Huang, Chih-Yang Division of General Medicine Department of Medical Education Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Department of Neurological Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan Laboratory of Exercise Biochemistry University of Taipei Taipei Taiwan Institute of Sports Sciences University of Taipei Taipei Taiwan Department of Kinesiology and Health Science College of William and Mary WilliamsburgVA United States School of Physical Education and Sports Science Soochow University Jiangsu Suzhou China Department of Pathology Changhua Christian Hospital Changhua Taiwan School of Medicine Chung Shan Medical University Taichung Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Division of Cardiovascular Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan School of Medicine College of Medicine China Medical University Taichung Taiwan Graduate Institute of Chinese Medicine China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan School of Rehabilitation Science Shanghai University of Traditional Chinese Medicine Shanghai China School of Rehabilitation Medicine Weifang Medical University Shandong Weifang China Department of Physical Therapy Graduate Institute of Rehabilitation Science China Medical University Taichung Taiwan Department of Medical Research China Medic

Oxidative stress is a pivotal factor in the pathogenesis of various cardiovascular diseases. Rhodiola, a traditional Chinese medicine, is recognized for its potent antioxidant properties. Salidroside, a phenylpropanoid glycoside derived from Rhodiola rosea, has shown remarkable antioxidant capabilities. This study aimed to elucidate the potential protective mechanisms of Rhodiola and salidroside against H2O2-induced cardiac apoptosis in H9c2 cardiomyoblast cells. H9c2 cells were exposed to H2O2 for 4 h, and subsequently treated with Rhodiola or salidroside for 24 h. Cell viability and apoptotic pathways were assessed. The involvement of insulin-like growth factor 1 receptor (IGF1R) and the activation of extracellular regulated protein kinases 1/2 (ERK1/2) were investigated. H2O2 (100 μM) exposure significantly induced cardiac apoptosis in H9c2 cells. However, treatment with Rhodiola (12.5, 25, and 50 μg/mL) and salidroside (0.1, 1, and 10 nM) effectively attenuated H2O2-induced cytotoxicity and apoptosis. This protective effect was associated with IGF1R-activated phosphorylation of ERK1/2, leading to the inhibition of Fas-dependent proteins, HIF-1α, Bax, and Bak expression in H9c2 cells. The images from hematoxylin and eosin staining and immunofluorescence assays also revealed the protective effects of Rhodiola and salidroside in H9c2 cells against oxidative damage. Our findings suggest that Rhodiola and salidroside possess antioxidative properties that mitigate H2O2-induced apoptosis in H9c2 cells. The protective mechanisms involve the activation of IGF1R and subsequent phosphorylation of ERK1/2. These results propose Rhodiola and salidroside as potential therapeutic agents for cardiomyocyte cytotoxicity and apoptosis induced by oxidative stress in heart diseases. Future studies may explore their clinical applications in cardiac health. © 2024 Wiley Periodicals LLC.

关键词： Cell death

来源：评论

学校读者我要写书评

暂无评论

Publisher Correction: Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition

引用

Scientific reports 2019年第1期9卷 18996页

作者： Panupong Mahalapbutr Nitchakan darai Wanwisa Panman Aunchan Opasmahakul Nawee Kungwan Supot Hannongbua Thanyada Rungrotmongkol Structural and Computational Biology Research Unit Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Program in Biotechnology Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Multidisciplinary Program of Petrochemistry and Polymer Science Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Computational Chemistry Center of Excellent Department of Chemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. Department of Chemistry Faculty of Science Chiang Mai University Chiang Mai 50200 Thailand. Center of Excellence in Materials Science and Technology Chiang Mai University Chiang Mai 50200 Thailand. Structural and Computational Biology Research Unit Department of Biochemistry Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. t.rungrotmongkol@***. Ph.D. Program in Bioinformatics and Computational Biology Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. t.rungrotmongkol@***. Molecular Sensory Science Center Faculty of Science Chulalongkorn University Bangkok 10330 Thailand. t.rungrotmongkol@***.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Nicotine Addiction: Implications for Public Health Policy

引用

Journal of Social Issues 2010年第1期53卷 13-33页

作者： Stephen J. Heishman Lynn T. Kozlowski Jack E. Henningfield Addiction Research Center National Institute on Drug Abuse National Institutes of Health Baltimore Maryland DR. STEPHEN J. HEISHMAN is a Research Psychologist in the Clinical Pharmacology Branch Intramural Research Program National Institute on Drug Abuse and Assistant Professor of Behavioral Biology Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine. Dr. Heishman received his Ph.D. in experimental psychology from the University of Louisville in 1985. He has served on the faculty of the Department of Psychology Saint Anselm College Manchester New Hampshire and received postdoctoral training in human behavioral pharmacology at Johns Hopkins University School of Medicine and the National Institute on Drug Abuse. Dr. Heishman has served as a consultant to the FAA and National Highway Traffic Safety Administration on issues relating to the effects of drug abuse on performance. He has published over thirty research articles in the fields of behavioral pharmacology and drug addiction and in 1994 he published an extensive review of the effects of nicotine on human performance. College of Health and Human Development Pennsylvania State University. DR. LYNN T. KOZLOWSKI got his Ph.D. in Psychology from Columbia University in 1975. He was an Assistant Professor of Psychology at Wesleyan University until 1979 when he moved to Toronto. For ten years he worked at the Addiction Research Foundation in Toronto where he was a Senior Scientist and Head of the behavioral research program on tobacco use. He was also a Professor of Preventive Medicine and Biostatistics and a Professor of Psychology at the University of Toronto. In 1990 he moved to Penn State to join the newly created Ph.D. program in Biobehavioral Health. He is now Head of the Department of Biobehavioral Health the newest department at Penn State. Dr. Kozlowski is on the Editorial Boards of theJournal of Substance Abuseand thePsychology of Addiction.He is Assistant Editor of Addiction. Dr. Kozlowski's res

Although the morbidity and mortality caused by cigarette smoking occur in adulthood, the initiation of tobacco use and the development of nicotine addiction typically occur during adolescence. The purpose of this paper is to examine the determinants of nicotine addiction, focusing on the development of addiction in youth, and to explore implications for public health policy. An understanding of the pharmacological and nonpharmacological factors that determine the course of nicotine addiction is critical in developing rational policies regarding tobacco products. The Food and drug Administration's rule to regulate cigarettes and smokeless tobacco products is discussed. The fact that smokers typically make the transition from casual use to nicotine addiction during adolescence argues for developing and implementing effective prevention efforts and smoking cessation treatment programs that are youth-oriented.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury

引用

Molecular neurobiology 2023年第4期60卷 2200-2208页

作者： Shao-Ming Wang Jung-Yu C Hsu Chiung-Yuan Ko Hsiang-En Wu Yu-Wei Hsiao Ju-Ming Wang Graduate Institute of Biomedical Sciences China Medical University Taichung 404333 Taiwan. wangs@mail.cmu.edu.tw. Neuroscience and Brain Disease Center China Medical University Taichung Taiwan. wangs@mail.cmu.edu.tw. Department of Neurology China Medical University Hospital Taichung Taiwan. wangs@mail.cmu.edu.tw. Department of Cell Biology and Anatomy College of Medicine National Cheng Kung University Tainan Taiwan. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. TMU Research Center of Neuroscience Taipei Medical University Taipei Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Taiwan. Cellular Pathobiology Section Integrative Neuroscience Research Branch Intramural Research Program National Institute on Drug Abuse NIH/DHHS Suite 3512 333 Cassell Drive Baltimore MD 21224 USA. Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan. Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan. yumingw@mail.ncku.edu.tw. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan. yumingw@mail.ncku.edu.tw. International Research Center for Wound Repair and Regeneration National Cheng Kung University Tainan Taiwan. yumingw@mail.ncku.edu.tw. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. yumingw@mail.ncku.edu.tw. Institute of Bioinformatics and Biosignal Transduction College of Bioscience and Biotechnology National Cheng Kung University Tainan 701 Taiwan. yumingw@mail.ncku.edu.tw.

Astroglial-fibrotic scars resulted from spinal cord injury affect motor and sensory function, leading to paralysis. In particular, the fibrotic scar is a main barrier that disrupts neuronal regeneration after spinal cord injury. However, the association between astrocytes and fibrotic scar formation is not yet understood. We have previously demonstrated that the transcriptional factor Cebpd contributes to astrogliosis, which promotes glial scar formation after spinal cord injury. Herein, we show that fibrotic scar formation was decreased in the epicenter region in Cebpd mice after contusive spinal cord injury and astrocytic Cebpd promoted fibroblast migration through secretion of Ptx3. Furthermore, the expression of Mmp3 was increased under recombinant protein Ptx3 treatment in fibroblasts by observing microarray data, resulting in fibroblast migration. In addition, regulation of Mmp3 occurs through the NFκB signaling pathway by using an irreversible inhibitor of IκBα phosphorylation in pretreated fibroblasts. Of note, we used the synthetic peptide RI37, which blocks fibroblast migration and decreases fibroblast Mmp3 expression in IL-1β-treated astrocyte conditioned media. Collectively, our data suggest that fibroblast migration can be affected by astrocytic Cebpd through the Ptx3/NFκB/Mmp3 axis pathway and that the RI37 peptide may act as a therapeutic medicine to inhibit fibrotic scar formation after spinal cord injury.

关键词： Astrocyte Cebpd Fibrotic scar Ptx3 Spinal cord injury

来源：评论

学校读者我要写书评

暂无评论

Overall mortality risk analysis for rectal cancer using deep learning-based fuzzy systems

引用

Computers in Biology and Medicine 2023年 157卷 106706-106706页

作者： Yang, Cheng-Hong Chen, Wen-Ching Chen, Jin-Bor Huang, Hsiu-Chen Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan Department of Community Health Chia-Yi Christian Hospital Chia-Yi City Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan

Colorectal cancer is a leading cause of cancer mortality worldwide, with an increasing incidence rate in developing countries. Integration of genetic information with cancer therapy guidance has shown promise in cancer treatment, indicating its potential as an essential tool in translation oncology. However, the high-throughput analysis and variability of genomic data poses a major challenge to conventional analytic approaches. In this study, we propose an advanced analytic approach, named "Fuzzy-based RNNCoxph," incorporated fuzzy logic, recurrent neural networks (RNNs), and Cox proportional hazards regression (Coxph) for detecting missense variants associated with high-risk of all-cause mortality in rectum adenocarcinoma. The test data set was downloaded from "Rectum adenocarcinoma, TCGA-REAd" the Genomic data Commons (GdC) portal. In this study, four model-based risk score models were derived using RNN, Coxph, RNNCoxph.d.ition, and RNNCoxphMultiplication. The RNNCoxph.d.ition and RNNCoxphMultiplication models were obtained as the sum and product of the RNN risk degree matrix and the Coxph risk degree matrix, respectively. Moreover, the fuzzy logic system was used to calculate the survival risk values of missense variants and classified their membership grade to improve the identification of high-risk gene variation locations associated with cancer mortality. The four models were integrated to develop an advanced risk estimation model. There were 20 028 variants associated with survival status, amongst 17 638 variants were associated with survival and 2390 variants associated with mortality. The proposed Fuzzy-based RNNCoxph model obtained a balanced accuracy of 93.7%, which was significantly higher than that of the other four test methods. In particular, the Coxph model is commonly used in medical researches and the XGBoost model is famous for its high accuracy in machine learning. The results suggest that the Fuzzy-based RNNCoxph model exhibits a higher efficacy

关键词： Fuzzy logic

来源：评论

学校读者我要写书评

暂无评论

CoAl2O4 nanoparticles modified carbon nanofibers as high-efficiency bifunctional electrocatalyst: An efficient electrochemical aqueous asymmetric supercapacitors and non-enzymatic electrochemical sensors

引用

Journal of Alloys and Compounds 2023年 931卷 1页

作者： Chinnapaiyan, Sathishkumar das, Himadri Tanaya Chen, Shen-Ming Govindasamy, Mani Alshgari, Razan A. Fan, Chi-Hsuan Huang, Chi-Hsien Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Centre for Advanced Materials and Applications Utkal University Vani vihar Odisha Bhubaneswar751004 India Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Korea University of Technology and Education Chungcheongnam-do Cheonan-si31253 Korea Republic of Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan33378 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The thriving energy demand of the gradually increasing population and modernized life style requires development in energy storage devices for usage in commercial electronic devices. In this particular work, we have explored electrochemical performances of bimetallic oxide CoAl2O4 and tuned its performance by decorating it on the carbon nanofibers. The CoAl2O4/CNFs are synthesized by deep eutectic solvents based hydrothermal method. The synthesized CoAl2O4 nanoparticle was found electrochemically active and the incorporation of CNFs end up boosting, its electrochemical performances as battery-type electrode. The obtained nanocomposites were characterized by various techniques. The electrochemically active CoAl2O4/CNFs exhibited 2.2-fold higher charge storage capacity than CoAl2O4. The CoAl2O4/CNFs exhibited specific capacity as high as 132 C/g at a constant applied current density of 1 A/g in 1 M KOH. The asymmetric device fabricated with CoAl2O4/CNFs electrodes exhibited excellent energy density of 20 Wh/kg at power density of 3000 W/kg. The CoAl2O4/CNFs electrode long-term stability has been minutely observed;the high Coulombic efficiency of 90% and high rate of capacity retention 95 %. In this work, an enzyme-free electrochemical sensor based on CoAl2O4/CNFs composite was developed for the detection of luteolin (LUT). Further modification of CoAl2O4/CNFs composite can improve the high surface area and catalytic capability of the composites. Under the optimal detection conditions, the prepared sensor has good linearity in the detection of LUT within range 30 nM − 73.5 μM with a limit of detection (LOd) of 0.0124 μM (12.4 nM). The stability and selectivity of the sensor is high, and can be used to detect LUT in various real samples. © 2022 Elsevier B.V.

关键词： Electrochemical sensors

来源：评论

学校读者我要写书评

暂无评论

From dissemination to Propagation: A New Paradigm for Education developers

引用

Change 2017年第4期49卷 35-42页

作者： Froyd, Jeffrey E. Henderson, Charles Cole, Renée S. Friedrichsen, debra Khatri, Raina Stanford, Courtney Jeffrey E. Froyd is a Research Professor at Texas A&M University. His research interests include sustained adoption of improvements in learning and teaching systematic reviews in engineering education evaluation of faculty campus climates and assessment of complex learning outcomes. Charles Henderson is a Professor at Western Michigan University with a joint appointment between the Department of Physics and the Mallinson Institute for Science Education. His research focuses on promoting productive changes in higher education at the individual department institution and national levels. Renée S. Cole is an Associate Professor of Chemistry at the University of Iowa. She teaches introductory and advanced courses in chemistry and runs a research program focused on the design and assessment of instructional materials and teaching strategies and faculty professional development. Debra Friedrichsen founded and operates a small consulting company. She received her Ph.D. from Oregon State University in Chemical Engineering with a dissertation focused on engineering education. Debra also has a MBA a MS and a patent for sensor development. Raina Khatri is a doctoral student in the Mallinson Institute for Science Education at Western Michigan University. Her research focus is understanding how education developers in STEM can promote sustained adoption of their innovations. Courtney Stanford is a postdoctoral researcher in the Department of Chemistry at Virginia Commonwealth University. Her current research focuses on the identification development and assessment of process skills (also known as professional skills) in active learning undergraduate STEM classrooms.

Scholarly studies and national reports document failure of current efforts to achieve broad, sustained adoption of research-based instructional practices, despite compelling bodies of evidence supporting efficacy of many of these practices. The authors of this paper argue that many change agents who are working to promote systemic adoption of these teaching practices use approaches that are characterized by what the authors call the "dissemination paradigm." A dissemination paradigm characterizes patterns of these current, failing efforts. Change agents, working within the dissemination paradigm, try to convince adopters that their innovations can help their students. Efforts within the dissemination paradigm have not led, and are unlikely to lead, to systemic adoption. The authors offer the "propagation paradigm" as an alternative with the potential to produce improved results. Change agents, working within the propagation paradigm, engage with adopters early and often to understand their instructional systems and interactively develop a strong product adaptable to specific contexts.

关键词： Models Change Agents Teaching Methods Information dissemination Educational Innovation Instructional Systems STEM Education Comparative Analysis

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：