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diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy

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Environmental Toxicology 2023年第8期38卷 2022-2030页

作者： Chen, Sheng-Yuan Chiu, Chien-Chih Hung, Chun-Tzu Pan, Wen-Hsiung Chen, Yen-Chun Bow, Yung-ding Li, Wan-Ju Hsu, Sheng-Kai Lin, I-Ling Wen, Zhi-Hong Wu, Chang-Yi Department of Medicine Division of Cardiology Zuoying Branch of Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan Department of Biotechnology Kaohsiung Medical University Kaohsiung Taiwan Department of Biological Sciences National Sun Yat-Sen University Kaohsiung Taiwan Center for Cancer Research Kaohsiung Medical University Kaohsiung Taiwan National Laboratory Animal Center National Applied Research Laboratories Taipei Taiwan Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung Taiwan Ph.D. Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical University Kaohsiung Taiwan Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan Department of Marine Biotechnology and Research National Sun Yat-sen University Kaohsiung Taiwan

Breast cancer is a leading cause of cancer-related death worldwide, and chemoresistance often leads to poor patient outcomes. In this study, we investigated the anticancer activity of synthetic diphenyl disulfide (dPdS) in breast cancer cell lines. dPdS inhibited cellular proliferation and viability in a dose-dependent manner and reduced colony formation, an index of clonogenicity. Annexin-V and 7-AAd double staining showed that dPdS could induce the apoptosis of breast cancer cells. Western blotting of the expression of Bax p21 and its cleaved form p18 suggested the activation of p18 Bax-induced apoptosis. Furthermore, the increased expression of the autophagy marker LC3B-II indicated autophagic lysosome accumulation induced by dPdS. Our findings suggest that dPdS has potential as a candidate for treating breast cancer, and further modifications and optimizations are warranted. © 2023 Wiley Periodicals LLC.

关键词： Cell death

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Structure-guided identification and characterization of potent inhibitors targeting phoP and MtrA to combat mycobacteria

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Computational and Structural biotechnology Journal 2024年 23卷 1477-1488页

作者： Su, Han-Li Lai, Shu-Jung Tsai, Keng-Chang Fung, Kit-Man Lung, Tse-Lin Hsu, Hsing-Mien Wu, Yi-Chen Liu, Ching-Hui Lai, Hui-Xiang Lin, Jiun-Han Tseng, Tien-Sheng Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian Hospital Chiayi City600 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Research Center for Cancer Biology China Medical University Taichung Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Academia Sinica Taipei11529 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung Taiwan Department of Industrial Technology Ministry of Economic Affairs Taipei Taiwan Food Industry Research and Development Institute Hsinchu City Taiwan

Mycobacteria are causative agents of tuberculosis (TB), which is a global health concern. drug-resistant TB strains are rapidly emerging, thereby necessitating the urgent development of new drugs. Two-component signal transduction systems (TCSs) are signaling pathways involved in the regulation of various bacterial behaviors and responses to environmental stimuli. Applying specific inhibitors of TCSs can disrupt bacterial signaling, growth, and virulence, and can help combat drug-resistant TB. We conducted a comprehensive pharmacophore-based inhibitor screening and biochemical and biophysical examinations to identify, characterize, and validate potential inhibitors targeting the response regulators phoP and MtrA of mycobacteria. The constructed pharmacophore model phar-PR-n4 identified effective inhibitors of formation of the phoP–dNA complex: ST132 (IC50 = 29 ± 1.6 µM) and ST166 (IC50 = 18 ± 1.3 µM). ST166 (Kd = 18.4 ± 4.3 μM) and ST132 (Kd = 14.5 ± 0.1 μM) strongly targeted phoP in a slow-on, slow-off manner. The inhibitory potency and binding affinity of ST166 and ST132 for MtrAC were comparable to those of phoP. Structural analyses and molecular dynamics simulations revealed that ST166 and ST132 mainly interact with the α8-helix and C-terminal β-hairpin of phoP, with functionally essential residue hotspots for structure-based inhibitor optimization. Moreover, ST166 has in vitro antibacterial activity against Macrobacterium marinum. Thus, ST166, with its characteristic 1,2,5,6-tetrathiocane and terminal sulphonic groups, has excellent potential as a candidate for the development of novel antimicrobial agents to combat pathogenic mycobacteria. © 2024 The Authors

关键词： Antimicrobial agents

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photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II photoacoustic/photothermal Nanotheranostics

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ACS Applied Materials and Interfaces 2024年第31期16卷 40611-40627页

作者： Chuang, Yao-Chen Hsia, Yu Chu, Chia-Hui Maharajan, Sivasubramanian Hsu, Fang-Chi Lee, Hsin-Lun Chiou, Jeng Fong Ch’ang, Hui-Ju Liao, Lun-de Lo, Leu-Wei Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Zhunan35053 Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei110301 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei110301 Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei110301 Taiwan National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan35053 Taiwan

Here we demonstrate that cancer metastasis could be modulated by the judicious tuning of physical parameters such as photothermal temperature in nanoparticle-mediated photothermal therapy (PTT). This is supported by theranostic nanosystem design and characterization, in vitro and in vivo analyses, and transcriptome-based gene profiling. In this work, the highly efficient near-infrared II (NIR-II) photoacoustic image (PA)-guided PTT are selectively activated using our developed matrix metalloproteinase (MMP)-triggered in situ assembly of gold nanodandelions (GNds@gelatin). Unlike other "always-on" NIR PTT agents lacking specific bioactivation and suffering from the intrinsic nonspecific pseudosignals and treatment-related side effects such as metastasis, our GNds@gelatin possesses important advantages while deployed in cancer PTT that include the following: (1) The theranostic effects could be "turned on" only after specific MMP-2/-9 activity and with acidity in the tumor microenvironment. (2) The quantitative PA diagnosis allows for precise PTT planning for better cancer treatment. (3) GNds@gelatin could noninvasively quantify MMP activity and efficiently harness NIR-I (808 nm) and NIR-II (1064 nm) energies for tumor ablation. (4) The multibranched nanostructures reabsorb scattered laser photons, thus enhancing the surface plasmons for the pronounced photothermal conversion of aggregated GNds@gelatin in situ. (5) It is noteworthy that in situ tumor eradication at higher PTT temperature (>55 °C) mediated by GNds@gelatin could induce subsequent metastasis, which could be otherwise abolished at lower PTT temperatures (50 °C > T > 43 °C). (6) Furthermore, the gene profiling using transcriptome-based microarray including GO and KEGG analyses revealed that 315 differentially expressed genes were identified in higher PTT temperature treated tumors compared with lower PTT temperature ones. These were enriched into some well-known cancer-related pathways, such as cell migrat

关键词： Plasmonics

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TiO2 Hole Transport Layer Incorporated in a Thermally Evaporated Sb2Se3 photoelectrode Exhibiting Low Onset Potential for photoelectrochemical Applications

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Energy and Fuels 2024年第17期38卷 16936-16948页

作者： Xavier, Thatheyus Peter Piraviperumal, Malar Kuo, Chih-Yu Govindasamy, Mani Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur603203 India Department of Chemical Engineering & Biotechnology National Taipei University of Technology Taipei City10608 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India Taipei10608 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

developing cost-effective photoelectrodes with a low band gap in the NIR-visible regions remains a challenge to achieve effective hydrogen production. We report the details of superstrate-configured photocathodes, consisting of antimony selenide (Sb2Se3) light absorbing layers with titanium dioxide (TiO2) as a hole transport layer, exhibiting the capability for hydrogen evolution with broad range light absorption enabled by the low band gap value of ∼1.2 eV of Sb2Se3. Strong anisotropy is a significant characteristic property of Sb2Se3, allowing superior electrical transportation along the [hkl] crystallographic orientation, which is obtained via close space evaporation of presynthesized bulk material at a growth temperature of 250 °C, over the solution-processed TiO2 film on a fluorine-doped tin oxide (FTO) substrate. The superstrate-configured FTO/TiO2/Sb2Se3 photocathode exhibited a photocurrent density of 100 μA cm-2 at −0.3 V vs RHE in 0.5 M H2SO4 under 1 sun illumination. To further improve photocurrent density, Pt as a cocatalyst was deposited over Sb2Se3 that led to enhanced photocurrent to 3 mA cm-2 at −0.3 V vs RHE in 0.5 M H2SO4 under 1 sun illumination. despite the relatively lower photocurrent observed, which resulted due to a large conduction band offset (ΔECB = 0.99 eV) of the TiO2/Sb2Se3 interface in a superstrate configuration, a significantly lower onset potential of −0.1 V vs RHE was observed. The results are encouraging due to the low band gap of Sb2Se3, photocorrosion stability, and straightforward fabrication, which is expected to assist for significant outcomes. © 2024 American Chemical Society.

关键词： Titanium dioxide

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Synergistic sodium alginate- and biochar-immobilized cells for enhancing fermentative hydrogen production from food waste

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Environmental Science and Pollution research 2024年第56期31卷 64524-64533页

作者： Ngamnurak, phonsini Plangklang, Pensri Pomdaeng, Prakaidao Ko, Ting-Wu Reungsang, Alissara Chu, Chen-Yeon Graduate School Khon Kaen University Khon Kaen40002 Thailand Department of Biology Technology Faculty of Technology Khon Kaen University Khon Kaen40002 Thailand Research Group for Development of Microbial Hydrogen Production Process From Biomass Khon Kaen University Khon Kaen40002 Thailand Institute of Green Products Feng Chia University Taichung Taiwan Ph.D. Program of Mechanical and Aeronautical Engineering Feng Chia University Taichung Taiwan Master’s Program of Green Energy Science and Technology Feng Chia University Taichung Taiwan Academy of Science Royal Society of Thailand Bangkok10300 Thailand

An immobilized hydrogen-producing consortium investigated biohydrogen production from food waste using a combination of sodium alginate and cassava rhizome biochar. We investigated the effect of varying the biochar concentration from 0 to 3% and the size of immobilized cells from 1 to 7 mm. Immobilized cells were prepared using 50% (v/v) enriched hydrogen-producing consortium, 2% (w/v) sodium alginate, and 0 to 3% (w/v) cassava rhizome biochar. The optimal conditions for achieving the highest hydrogen production in the batch fermentation reactor were identified as a biochar concentration of 2% (w/v) and an immobilized cell size of 2 mm. The highest hydrogen yield, maximum hydrogen production rate, and lag time recorded were 0.69 mmol H2/g-COd, 0.02 mmol H2/g-COd.h, and 41.51 h, respectively. This research highlights the potential of cassava biochar technology for efficient biohydrogen production from food waste, contributing to renewable energy generation and sustainable waste management. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Anaerobic digestion

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Application of 3-d nonlinear wave-load and structural-response simulations in naval ship design

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NAVAL ENGINEERS JOURNAL 1997年第3期109卷 253-266页

作者： Engle, A Lin, W Salvesen, N Shin, Y Allen H. Engle:is a naval architect in the Hydrodynamic Division of the Naval Sea Systems /Command (NavSea). He received his B.S. degree in engineering scinece from the State University of New York at Buffalo in 1977 and his M.S. degree in ocean engineering from the Unviersity of Hawaii in 1979. Corrently Mr. Engle is the program director of the Navy's Hydrodynamic Loads Technology Development Program. Mr. Engle is Chairman of SNAME Panel on Hull Loadings (HS-1) and contributing member to the International Ship and Offshore Structures Congress's Committee on Dynamics. Moei-Min Lin:is a senior research scientist at the Ship technology Division of Sciences Applications International Corporation (SAIC). He received his B.S. degree in naval architecture and marine engineering from the National Cheng-Kung University Taiwan in 1977 and his Ph.D. degree in ocean engineering from MIT in 1985. He is an expert in computational ship hydrodynamics. He has been the P.I. for development of the Large Amplitude Motions Program (LAMP) system. Nils Salvesen:is the manager of the Ship Technology Division of the Science Application International Corporation (SAIC).He received his B.S. and Ph.D. degree from the Development Naval Architecture and Marine Engineering of the University of Michigan in 1960 and 1966 respectively. He has more then thirty years of experience in the development of ship motion simulation and wave load prediction methods. More than twenty-five years ago he developed the original strip-theory code on which the Navy's ship motions program (SMP) is based. Yung-Sup Shin:is the principal engineer responsible for the hydrodynamic projects in the Research and Development Department of the American Bureau of Shipping New York. He received a Ph.D. degree in hydrodynamic from the Department of Naval Architecture and Marine Engineering of the University of Michigan. In the past eighteen years at ABS he has been involved in the theortical development and analysis of various marine hydrodynamic problems. In recent year

despite the limits inherent within linearized frequency-domain ship motion and wave load computer codes, strip theory has been found to provide the design community with a fairly robust, practical design tool with reasonable accuracy for most conventional displacement monohulls. However, the advent of new design concepts including multi-hulls and application of new materials as well as the push to incorporate reliability methods within surface ship structural design criteria has highlighted the need for more rigorous methods of developing a lifetime load spectrum. In this paper, a multilevel computation system for predicting ship motions and wave loads, up through and including extreme sea conditions, is presented. This system includes a traditional strip theory approach and newly developed linear and nonlinear three-dimensional time-domain methods. The new nonlinear methods are currently in the process of being validated by the U.S. Navy. The status of the current development is presented. Sample numerical results from the new nonlinear methods are compared with both linear frequency domain predictions and model tests.

关键词： Naval vessels

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Structure-Guided discovery of Pd-1/Pd-L1 Interaction Inhibitors: Peptide design, Screening, and Optimization via Computation-Aided phage display Engineering

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Journal of Chemical Information and Modeling 2024年第5期64卷 1615-1627页

作者： Tseng, Tien-Sheng Lee, Chao-Chang Chen, Po-Juei Lin, Chiu-Yuen Chen, Wang-Chuan Lee, Yu-Ching Lin, Jiun-Han Chen, Kaun-Wen Tsai, Keng-Chang Institute of Molecular Biology National Chung Hsing University Taichung40202 Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei11221 Taiwan The School of Chinese Medicine for Post Baccalaureate I-Shou University Kaohsiung824005 Taiwan Department of Chinese Medicine E-Da Hospital Kaohsiung824005 Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei11031 Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Department of Industrial Technology Ministry of Economic Affairs Taipei100210 Taiwan Food Industry Research and Development Institute Hsinchu30062 Taiwan Molecular Science and Digital Innovation Center Genetics Generation Advancement Corporation Taipei11949 Taiwan

Cancer immunotherapy harnesses the immune system to combat tumors and has emerged as a major cancer treatment modality. The Pd-1/Pd-L1 immune checkpoint modulates interactions between tumor cells and T cells and has been extensively targeted in cancer immunotherapy. However, the monoclonal antibodies known to target this immune checkpoint have considerable side effects, and novel Pd-1/Pd-L1 inhibitors are therefore required. Herein, a peptide inhibitor to disrupt Pd-1/Pd-L1 interactions was designed through structure-driven phage display engineering coupled to computational modification and optimization. BetaPb, a novel peptide library constructed by using the known structure of Pd-1/Pd-L, was used to develop inhibitors against the immune checkpoint, and specific peptides with high affinity toward Pd-1 were screened through enzyme-linked immunosorbent assays, homogeneous time-resolved fluorescence, and biolayer interferometry. A potential inhibitor, B8, was preliminarily screened through biopanning. The binding affinity of B8 toward Pd-1 was confirmed through computation-aided optimization. Assessment of B8 variants (B8.1, B8.2, B8.3, B8.4, and B8.5) demonstrated their attenuation of Pd-1/Pd-L1 interactions. B8.4 exhibited the strongest attenuation efficiency at a half-maximal effective concentration of 0.1 μM and the strongest binding affinity to Pd-1 (equilibrium dissociation constant = 0.1 μM). B8.4 outperformed the known Pd-1/Pd-L1 interaction inhibitor PL120131 in disrupting Pd-1/Pd-L1 interactions, revealing that B8.4 has remarkable potential for modification to yield an antitumor agent. This study provides valuable information for the future development of peptide-based drugs, therapeutics, and immunotherapies for cancer. © 2024 American Chemical Society.

关键词： Peptides

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dSG2 attenuates gemcitabine efficacy through PTX3 in lung adenocarcinoma

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Biochimica et Biophysica Acta - Molecular Basis of disease 2025年第6期1871卷 167881页

作者： Wang, Chin-Chou Lin, Jo-Ying Wang, Chih-Yang Shen, Wan-Jou Liao, Pin-Chen Ho, Yu-Fang Lin, Che-Wei Wang, Shao-An Ko, Ching-Chung dey, Sanskriti Ta, Hoang dang Khoa Xuan, do Thi Minh Kumar, Sachin William, Bianca Tobias Wang, Ju-Ming Wang, Wei-Jan Divisions of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan Department of Respiratory Therapy Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan Department of Internal Medicine Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Taiwan Department of Biological Science and Technology China Medical University Taichung 40676 Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei 11031 Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei 11031 Taiwan Graduate Institute of Biomedical Sciences College of Medicine China Medical University Taichung 40402 Taiwan Department of Medical Imaging Chi-Mei Medical Center Tainan Taiwan Department of Health and Nutrition Chia Nan University of Pharmacy and Science Tainan Taiwan School of Medicine College of Medicine National Sun Yat-Sen University Kaohsiung Taiwan Faculty of Pharmacy Van Lang University 69/68 Dang Thuy Tram Street Ward 13 Binh Thanh District Ho Chi Minh City 70000 Viet Nam Faculty of Biotechnology and Applied Sciences Shoolini University of Biotechnology and Management Sciences Himachal Pradesh India Department of Biomedicine School of Life Sciences Indonesia International Institute for Life Sciences Jl Pulomas Barat Kav 88 Jakarta Timur 13210 Indonesia Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Me

Lung adenocarcinoma (LUAd) is the most prevalent subtype of lung cancer, often diagnosed at an advanced stage with poor prognosis and limited treatment options. The desmoglein (dSG) family plays a crucial role in maintaining cell adhesion and tissue integrity. Upregulation of dSG proteins has been implicated in tumorigenesis, invasion, and metastasis across various cancers. However, the role of dSG in lung cancer, particularly as a biomarker influencing the efficacy of anti-cancer drugs, remains unclear. In this study, dSG2 was significantly overexpressed in LUAd tumor tissues and correlated with poor prognosis, as revealed by TCGA database analysis. Additionally, analyses of single-cell sequencing, KEGG, and GSEA multi-omics databases demonstrated that dSG2 modulates multiple oncogenic pathways, particularly the apoptosis pathway, with a strong positive correlation between dSG2 and PTX3 expression. In vitro experiments showed that dSG2 knockdown enhanced gemcitabine-induced apoptosis by downregulating the NFκB/STAT3/PTX3 signaling axis. Furthermore, adding recombinant PTX3 protein in dSG2 knockdown cells restored STAT3 activation, reducing gemcitabine efficacy, indicating that dSG2 contributes to gemcitabine resistance through PTX3-mediated mechanisms. This study identifies dSG2 as a critical mediator of gemcitabine resistance in LUAd through its regulation of the PTX3/NFκB/STAT3 pathway. The findings suggest that targeting dSG2 could enhance the therapeutic efficacy of gemcitabine in LUAd patients, offering a novel therapeutic strategy and biomarker for overcoming chemoresistance in this aggressive cancer subtype. © 2025 Elsevier B.V.

关键词： dSG2 Gemcitabine resistance Lung adenocarcinoma NFκB PTX3

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Transformative lactera-polypyrrole@carrageenan microparticles leveraging NIR for skin regeneration and stress relief

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International Journal of Biological Macromolecules 2025年 316卷 144436页

作者： Sih-Chi Chuang Shih-An Yu Pei-Chia Hung Andrew E.-Y. Chuang Jia-Wei Liang Lekshmi Rethi Chih-Kuang Chen Hsu-Wei Fang Hieu Trung Nguyen Hsien-Tsung Lu Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 10608 Taiwan Hsuan Chen Technology CO. LTD. New Taipei City 22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Taoyuan Taiwan. School of Medicine Chang Gung University Taoyuan Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam Department of Orthopedics Taipei Medical University Hospital Taipei City 11031 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan

Effective wound healing remains a significant challenge in regenerative medicine, particularly in minimizing inflammation and promoting scarless recovery. This study introduces a bioengineered LAC-PPy@Car MF composite, designed to leverage near-infrared (NIR)-induced photothermal therapy alongside biotherapeutics to facilitate tissue regeneration. The composite integrates the photothermal properties of polypyrrole (PPy) with the anti-inflammatory and regenerative potential of Lactera (LAC) and Carrageenan (Car). Upon NIR activation, the composite generates localized mild-hyperthermia, reducing oxidative stress, enhancing Aryl Hydrocarbon Receptor (AhR) activity, and upregulating heat shock proteins (HSP). These effects synergistically create a bioactive environment conducive to cellular proliferation and tissue repair. Biochemical evaluations demonstrate that LAC-PPy@Car MF effectively reduces oxidative stress, stimulates fibroblast migration, and promotes the proliferation of skin cells. Immunofluorescence staining reveals significant activation of AhR and HSP in treated tissues, correlating with cellular proliferation and improved skin architecture. The NIR-triggered photothermal effect contributes to the therapeutic potential of the composite, ensuring precise and minimally invasive treatment for burn injuries. These findings position phototherapeutic LAC-PPy@Car MF as a promising candidate for advanced wound healing applications. Its dual functionality, combining photothermal therapy with bioactive healing properties, offers a transformative approach to regenerative medicine, paving the way for improved clinical outcomes in wound care.

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GENERATION OF HYdROGEN GAS A RESULT OF dRILLING WITHIN THE SATURATEd ZONE

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GROUNd WATER MONITORING ANd REMEdIATION 1994年第4期14卷 140-147页

作者： BJORNSTAd, BN MCKINLEY, JP STEVENS, TO RAWSON, SA FREdERICKSON, JK LONG, PE Bruce N. Bjornstad is a senior research scientist in the Geology and Geophysics Group of the Pacific Northwest Laboratory (P.O. Box 999 Richland WA 99352). Since earning an M.S. degree in geology from Eastern Washington University in 1980 he has been involved in characterization and modeling studies related to the sedimentology and geohydrology of the Hanford Site. More recently he has become involved in the geochemical and microbiological characterization of the deep subsurface. James P. McKinley is a research scientist in the Interfacial Geochemistry Group at the Pacific Northwest Laboratory. He received a Ph.D. in geology from the University of New Mexico in 1990. His work includes studies of aqueous geochemistry and chemical interactions at the solid-solution interface. Todd O. Stevens is a staff scientist in the Environmental Microbiology Group at Pacific Northwest Laboratory. He received a Ph.D. in bacteriology from the University of Idaho in 1989. His work has focused on bioremediation of contaminated soils and sediments and on microbial ecology of anaerobic habitats. More recently he has participated in microbial ecology studies of the deep terrestrial subsurface. Shirley A. Rawson is manager of the Transport Geochemistry Group at Pacific Northwest Laboratory. She earned a Ph.D. in geological sciences in 1984 from University of Oregon. For the last three years she has been co-investigator of a DOE- sponsored research project on the hydrogeological and geochemical processes influencing the occurrence of subsurface microorganisms. Her research interests include the effects of diagenetic reactions (microbial and abiotic) on sediment permeability and the impacts on solute transport. James K. Fredrickson is a staff scientist in the Environmental Microbiology Group at Pacific Northwest Laboratory. He received a Ph.D. in microbiology and soil science from Washington State University. He has been involved in the DOE's Subsurface Science Program for more than eight years and is currently serving as a scientifi

Hydrogen gas was discovered within the steel casing above standing water in a percussion-drilled borehole on the Hanford Site in south-central Washington state. In situ measurements of the borehole fluids indicated anoxic, low-Eh (<-400 mV) conditions. Ground water sampled from adjacent wells in the same formation indicated that the ground water was oxygenated. H2 was generated during percussion drilling, due to the decomposition of borehole waters as a result of aqueous reactions with drilled sediment and steel from the drilling tools or casing. The generation of H2 within percussion-drilled boreholes that extend below the water table may be more common than previously realized. The ambient concentration of H2 produced during drilling was limited by microbial activity within the casing-resident fluids. H2 was generated abiotically in the laboratory, whereby sterilized borehole slurry samples produced 100 times more H2 than unsterilized samples. It appears that H2 is metabolized by microorganisms and concentrations might be significantly greater if not for microbial metabolism.

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