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Nature Cancer 2024年第3期5卷 400-419页

作者： Huang, Yu-Kai Cheng, Wei-Chung Kuo, Ting-Ting Yang, Juan-Cheng Wu, Yang-Chang Wu, Heng-Hsiung Lo, Chia-Chien Hsieh, Chih-Ying Wong, Sze-Ching Lu, Chih-Hao Wu, Wan-Ling Liu, Shih-Jen Li, Yi-Chuan Lin, Ching-Chan Shen, Chia-Ning Hung, Mien-Chie Lin, Jaw-Town Yeh, Chun-Chieh Sher, Yuh-Pyng Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Cancer Biology and Precision Therapeutics Center China Medical University Taichung Taiwan Ph.D. Program for Cancer Biology and Drug Discovery China Medical University and Academia Sinica Taichung Taiwan School of Chinese Medicine College of Chinese Medicine China Medical University Taichung Taiwan Graduate Institute of Integrated Medicine College of Chinese Medicine China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology College of Medical and Health Science Asia University Taichung Taiwan Center for Molecular Medicine China Medical University Hospital Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Taipei Taiwan National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan Division of Hematology and Oncology China Medical University Hospital Taichung Taiwan Genomics Research Center Academia Sinica Taipei Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine E-Da Hospital Kaohsiung Taiwan Department of Medicine School of Medicine China Medical University Taichung Taiwan Department of Surgery Organ Transplantation Center China Medical University Hospital Taichung Taiwan Institute of Biochemistry and Molecular Biology China Medical University Taichung Taiwan

Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PdAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and metalloproteinase domain (AdAM)9 as a modulator of PdAC progression via stabilization of wild-type and mutant KRAS proteins. Mechanistically, AdAM9 loss increases the interaction of KRAS with plasminogen activator inhibitor 1 (PAI-1), which functions as a selective autophagy receptor in conjunction with light chain 3 (LC3), triggering lysosomal degradation of KRAS. Suppression of AdAM9 by a small-molecule inhibitor restricts disease progression in spontaneous models, and combination with gemcitabine elicits dramatic regression of patient-derived tumors. Our findings provide a promising strategy to target the KRAS signaling cascade and demonstrate a potential modality to enhance sensitivity to chemotherapy in PdAC. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.

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Electrochemical detection of antimalarial drug (Amodiaquine) using dy-MOF@MWCNTs composites to prevent erythrocytic stages of plasmodium species in human bodies

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Microchemical Journal 2024年 202卷

作者： Peter, X. Thatheyus Kuo, Chih-Yu Malar, P. Govindasamy, Mani Rajaji, Umamaheswari Yusuf, Kareem Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur 603203 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia

Herein, we report on fabrication of dysprosium-based metal–organic framework (dy-MOF)@multiwalled carbon nanotubes (MWCNT) composites modified with glassy carbon electrode (dy-MOF@MWCNT/GC) as a working electrode for Antimalarial drug detection. dy-MOF@MWCNT composites was prepared by sonochemical process along with ultrasonication. The composite structure, phase purity, morphology and composition of the composites were confirmed by X-ray diffraction, Scanning electron microscope, and X-ray photoelectron spectroscopy. Further, dy@MWCNT composites were deposited on a glassy carbon electrode by drop casting method, and used as an electrode material to efficiently detect Amodiaquine (Add) by electrochemical techniques such as CV and dPV. The as-prepared dy@MWCNT composite material showed the oxidation peak current of Add to be ∼ 60 % higher than other unmodified GC electrodes and showed a low charge transfer resistance (R_ct) of 24 Ω. The dy@MWCNT provided a broad linear range of 0.4 to 20 µM with a limit of detection of 0.377 μM and sensitivity of 1.817 μA.μM⁻¹ for the detection of Add. According to the ph study, the amount of electrons and protons involved in the electrochemical processes of Add was calculated and a plausible mechanism for Add electro-oxidation was proposed. Thus, the prepared sensor exhibited practical usefulness by determining the Add drug in human urine samples. Hence, the results shows that the dy@MWCNT- modified sensor has good electrocatalytic activity for the redox of Add. © 2024 Elsevier B.V.

关键词： Amodiaquine Antimalarial drug Carbon nanomaterials Electrochemical sensor Metal organic framework

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Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s disease

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Journal of Alzheimer's disease 2023年第3期96卷 877-912页

作者： Mani, Shalini dubey, Rajni Lai, I-Chun Babu, M. Arockia Tyagi, Sakshi Swargiary, Geeta Mody, deepansh Singh, Manisha Agarwal, Shriya Iqbal, danish Kumar, Sanjay Hamed, Munerah Sachdeva, Punya Almutary, Abdulmajeed G. Albadrani, Hind Muteb Ojha, Shreesh Singh, Sandeep Kumar Jha, Niraj Kumar Centre for Emerging Diseases Department of Biotechnology Jaypee Institute of Information Technology UP Noida India Division of Cardiology Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Division of Radiation Oncology Department of Oncology Taipei Veterans General Hospital Taipei Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Academia Sinica Taipei Taiwan Institute of Pharmaceutical Research GLA University Mathura India Department of Molecular Sciences Macquarie University Sydney Australia Department of Health Information Management College of Applied Medical Sciences Buraydah Private Colleges Buraydah Saudi Arabia Department of Life Sciences School of Basic Sciences and Research (SBSR) Sharda University Uttar Pradesh Greater Noida India Department of Pathology Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia GloNeuro Vishwakarma Road Noida India Department of Biomedical Sciences College of Health Sciences Abu Dhabi University Abu Dhabi United Arab Emirates Department of Clinical Laboratory Sciences College of Applied Medical Sciences Imam Abdulrahman Bin Faisal University Eastern Province Dammam Saudi Arabia Department of Pharmacology and Therapeutics College of Medicine and Health Sciences United Arab Emirates University Abu Dhabi United Arab Emirates Indian Scientific Education and Technology Foundation Lucknow India Department of Biotechnology School of Engineering & Technology (SET) Sharda University Uttar Pradesh Greater Noida India School of Bioengineering and Biosciences Lovely Professional University Punjab Phagwara India Department of Biotechnology School of Applied & Life Sciences (SALS) Uttaranchal University Uttarakhand Dehradun India Department of Biotechnology Engineering and Food Technology Chandigarh University Mohali India

Alzheimer’s disease (Ad) is characterized by the progressive degeneration of neuronal cells. With the increase in aged population, there is a prevalence of irreversible neurodegenerative changes, causing a significant mental, social, and economic burden globally. The factors contributing to Ad are multidimensional, highly complex, and not completely understood. However, it is widely known that aging, neuroinflammation, and excessive production of reactive oxygen species (ROS), along with other free radicals, substantially contribute to oxidative stress and cell death, which are inextricably linked. While oxidative stress is undeniably important in Ad, limiting free radicals and ROS levels is an intriguing and potential strategy for deferring the process of neurodegeneration and alleviating associated symptoms. Therapeutic compounds from natural sources have recently become increasingly accepted and have been effectively studied for Ad treatment. These phytocompounds are widely available and a multitude of holistic therapeutic efficiencies for treating Ad owing to their antioxidant, anti-inflammatory, and biological activities. Some of these compounds also function by stimulating cholinergic neurotransmission, facilitating the suppression of beta-site amyloid precursor protein-cleaving enzyme 1, α-synuclein, and monoamine oxidase proteins, and deterring the occurrence of Ad. Additionally, various phenolic, flavonoid, and terpenoid phytocompounds have been extensively described as potential palliative agents for Ad progression. Preclinical studies have shown their involvement in modulating the cellular redox balance and minimizing ROS formation, displaying them as antioxidant agents with neuroprotective abilities. This review emphasizes the mechanistic role of natural products in the treatment of Ad and discusses the various pathological hypotheses proposed for Ad. © 2023 – IOS Press. All rights reserved.

关键词： Alzheimer’s disease antioxidants neuroprotection oxidative stress therapeutics vitamins

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Fabrication of Solvent-Free PCL/β-TCP Composite Fiber for 3d Printing: physiochemical and Biological Investigation

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Polymers 2023年第6期15卷 1391-1391页

作者： Ngo, Sin Ting Lee, Wei-Fang Wu, Yi-Fan Salamanca, Eisner Aung, Lwin Moe Chao, Yan-Qiao Tsao, Ting-Chia Hseuh, Hao-Wen Lee, Yi-Huan Wang, Ching-Chiung Chang, Wei-Jen Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei110 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei110 Taiwan School of Dentistry College of Oral Medicine Taipei Medical University Taipei110 Taiwan Department of Molecular Science and Engineering National Taipei University of Technology Taipei106 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei110 Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei110 Taiwan Dental Department Taipei Medical University Shuang Ho Hospital New Taipei235 Taiwan

Manufacturing three-dimensional (3d) objects with polymers/bioceramic composite materials has been investigated in recent years. In this study, we manufactured and evaluated solvent-free polycaprolactone (PCL) and beta-tricalcium phosphate (β-TCP) composite fiber as a scaffold material for 3d printing. To investigate the optimal ratio of feedstock material for 3d printing, the physical and biological characteristics of four different ratios of β-TCP compounds mixed with PCL were investigated. PCL/β-TCP ratios of 0 wt.%, 10 wt.%, 20 wt.%, and 30 wt.% were fabricated, with PCL melted at 65 °C and blended with β-TCP with no solvent added during the fabrication process. Electron microscopy revealed an even distribution of β-TCP in the PCL fibers, while Fourier transform infrared spectroscopy demonstrated that the biomaterial compounds remained intact after the heating and manufacturing process. In addition, adding 20% β-TCP into the PCL/β-TCP mixture significantly increased hardness and Young’s Modulus by 10% and 26.5%, respectively, suggesting that PCL-20 has better resistance to deformation under load. Cell viability, alkaline phosphatase (ALPase) activity, osteogenic gene expression, and mineralization were also observed to increase according to the amount of β-TCP added. Cell viability and ALPase activity were 20% higher with PCL-30, while upregulation for osteoblast-related gene expression was better with PCL-20. In conclusion, PCL-20 and PCL-30 fibers fabricated without solvent exhibited excellent mechanical properties, high biocompatibility, and high osteogenic ability, making them promising materials for 3d printing customized bone scaffolds promptly, sustainably, and cost-effectively. © 2023 by the authors.

关键词： Bone

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Polymethoxyflavone from Citrus depressa as an inhibitor against various variants of SARS-CoV-2 spike protein

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Journal of Ethnopharmacology 2024年 320卷 117412页

作者： Liu, Ta-Wei Hsu, Su-Jung Hsieh, Yves S.Y. Liu, Hui-Kang Lee, Ching-Kuo School of Pharmacy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Graduate Institute of Pharmacognosy College of Pharmacy Taipei Medical University Taipei 11042 Taiwan Division of Glycoscience Department of Chemistry School of Engineering Sciences in Chemistry Biotechnology and Health KTH Royal Institute of Technology AlbaNova University Centre Stockholm SE106 91 Sweden National Research Institute of Chinese Medicine (NRICM) Ministry of Health and Welfare Taipei City Taiwan Ph. D. Program in the Clinical Drug Development of Herbal Medicine Taipei Medical University Taipei Taiwan

Ethnopharmacological relevance: In traditional Taiwanese medicine, Citrus depressa Hayata serves as the raw material of Chen-Pi which has been widely used to treat respiratory ailments. Scientific investigations have validated the attributes of C. depressa, elucidating its valuable properties, including antioxidative, anti-inflammatory, anticancer, neuroprotion, hepatoprotection, and hypolipidemic effects. Aim of the study: This study aims to isolate a universal inhibitor of the SARS-CoV-2 spike protein from C. depressa and confirm the mechanism by which these inhibitors disrupt the binding of the spike protein to hACE2. Materials and methods: The whole fruit of C. depressa was subjected to ethanol extraction, following by partitioning to obtain water, butanol, and ethyl acetate fractions. To identify the inhibitory components in citrus fruits, we performed both the SPR assay and the SARS-CoV-2 pseudo-virus assays. Subsequently, we employed a bioassay-guided approach to efficiently isolate and characterize the bioactive constituents that hindered the interaction between the SARS-CoV-2 spike protein and hACE2, using a combination of MPLC and Semi-preparative HPLC for compound isolation. ELISA based spike protein binding assay evaluate the inhibitory activities of the extract and potential constituents against multiple spike protein variants. To further shed light on the inhibitory mechanism, candidate inhibitors were validated through the SPR assay and molecular docking. Results: The crude extract and ethyl acetate layer derived from C. depressa showed significant inhibitory activity on SARS-CoV-2 Omicron BA.4/5, with IC₅₀ of 77.4 μg/mL and 100 μg/mL, respectively. Ten potential compounds from C. depressa have been identified with inhibitory activity against various SARS-CoV-2 spike proteins. 2′-hydroxy-4,4′,5′,6′-tetramethoxychalcone (Cd3) and 5-hydroxy-3′,4′,6,7,8-pentamethoxyflavone (Cd8) also showed good inhibitory activity to the spike protein, with K

关键词： ACE-2 Citrus depress Polymethoxyflavone SARS-CoV-2 Spike protein

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Novel visible-light-active P-g-CN-based α-Bi2O3/WO3 ternary photocatalysts with a dual Z-scheme heterostructure for the efficient decomposition of refractory ultraviolet filters and environmental hormones: Benzophenones

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Environmental research 2023年 234卷

作者： Berekute, Abiyu Kerebo Yu, Kuo-Pin Chuang, Yi-Hsueh Brad Lin, Kun-Yi Andrew International Ph.D. Program in Environmental Science and Technology National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental and Occupational Health Sciences National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental Engineering National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Department of Environmental Engineering and Innovation and Development Center of Sustainable Agriculture & Research Center of Sustainable Energy and Nano Technology National Chung Hsing University 250 Kuo-Kuang Road Taichung Taiwan Department of Chemistry College of Natural and Computational Sciences Arba Minch University Arbaminch Ethiopia

The ubiquitous and refractory benzophenone (BP)-type ultraviolet filters, which are also endocrine disruptors, were commonly detected in the aquatic matrix and could not be efficiently removed by conventional wastewater treatment processes, thus causing extensive concern. Herein, a novel ternary nanocomposite, P-g-CN/α-Bi2O3/WO3 (P-gBW), was successfully fabricated by mixing cocalcinated components and applied to the decomposition of BP-type ultraviolet filters. The dual-Z-scheme heterostructure of P-gBW enhances visible-light absorption, efficiently facilitates separation and mobility, and prolongs the lifetime of photoinduced charge carriers via double charge transfer mechanisms. The optimum 95 wt% P-gBW exhibited excellent photocatalytic activity, degrading 96% 4-hydroxy benzophenone (4HBP) within 150 min and 93% 2,2′,4,4′-tetrahydroxybenzophenone (BP-2) within 100 min under visible-light illumination, respectively. The pseudo-first-order rate constant of 4HBP (1.15 h−1) was 6.8-, 3.1-, 3.3- and 2.2-fold higher than those of WO3, P-g-CN, α-Bi2O3, and P-g-CN/α-Bi2O3, respectively, while that of BP-2 (1.71 h−1) was 5.2-, 2.2-, 3.2- and 1.5-fold higher, respectively. The improved photocatalytic degradation was attributed to efficient photoinduced charge carrier separation and migration and prevented the recombination of electron holes, as verified by photoluminescence, transient photocurrent response, and electrochemical impedance spectroscopy. Trapping experiments, electron paramagnetic resonance, and band energy position indicated an efficient dual-Z-scheme heterostructure. © 2023 Elsevier Inc.

关键词： Tungsten compounds

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Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemia

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Haematologica 2023年第5期108卷 1284-1299页

作者： Binay K Sahoo Yuh-Charn Lin Cheng-Fen Tu Chien-Chin Lin Wei-Ju Liao Fu-An Li Ling-Hui Li Kurt Yun Mou Steve R Roffler Shu-Ping Wang Chi-Tai Yeh Chi-Yuan Yao Hsin-An Hou Wen-Chien Chou Hwei-Fang Tien Ruey-Bing Yang Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei. Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Physiology School of Medicine College of Medicine Taipei Medical University Taipei. Institute of Biomedical Sciences Academia Sinica Taipei. Department of Laboratory Medicine Division of Hematology and Department of Internal Medicine National Taiwan University Taipei. Department of Medical Research and Education Taipei Medical University Shuang Ho Hospital New Taipei City. Division of Hematology and Department of Internal Medicine Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Biomedical Translation Research Center Academia Sinica Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei. rbyang@ibms.sinica.edu.tw.

A hallmark of mixed lineage leukemia gene-rearranged (MLL-r) acute myeloid leukemia that offers an opportunity for targeted therapy is addiction to protein tyrosine kinase signaling. One such signal is the receptor tyrosine kinase Fms-like receptor tyrosine kinase 3 (FLT3) upregulated by cooperation of the transcription factors homeobox A9 (HOXA9) and Meis homeobox 1 (MEIS1). Signal peptide-CUB-EGF-like repeat-containing protein (SCUBE) family proteins have previously been shown to act as a co-receptor for augmenting signaling activity of a receptor tyrosine kinase (e.g., vascular endothelial growth factor receptor). However, whether SCUBE1 is involved in the pathological activation of FLT3 during MLL-r leukemogenesis remains unknown. Here we first show that SCUBE1 is a direct target of HOXA9/MEIS1 that is highly expressed on the MLL-r cell surface and predicts poor prognosis in de novo acute myeloid leukemia. We further demonstrate, by using a conditional knockout mouse model, that Scube1 is required for both the initiation and maintenance of MLL-AF9-induced leukemogenesis in vivo. Further proteomic, molecular and biochemical analyses revealed that the membrane-tethered SCUBE1 binds to the FLT3 ligand and the extracellular ligand-binding domains of FLT3, thus facilitating activation of the signal axis FLT3-LYN (a non-receptor tyrosine kinase) to initiate leukemic growth and survival signals. Importantly, targeting surface SCUBE1 by an anti-SCUBE1 monomethyl auristatin E antibody-drug conjugate led to significantly decreased cell viability specifically in MLL-r leukemia. Our study indicates a novel function of SCUBE1 in leukemia and unravels the molecular mechanism of SCUBE1 in MLL-r acute myeloid leukemia. Thus, SCUBE1 is a potential therapeutic target for treating leukemia caused by MLL rearrangements.

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development of anti-aflatoxin B1 nanobodies from a novel mutagenesis-derived synthetic library for traditional Chinese medicine and foods safety testing

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Journal of biological engineering 2023年第1期17卷 30页

作者： Yu-Ching Lee Gar-Hwa Lai Tsai-Yu Lin Tien-Sheng Tseng Tsung-Hsun Tsai Wang-Chuan Chen Cheng-Chung Lee Keng-Chang Tsai TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Orthopedics Kaohsiung Veterans General Hospital Kaohsiung Taiwan. Institute of Molecular Biology National Chung Hsing University Taichung Taiwan. Department of Psychiatry Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan. The School of Chinese Medicine for Post Baccalaureate I-Shou University Kaohsiung Taiwan. Department of Chinese Medicine E-Da Hospital Kaohsiung Taiwan. The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan. tkc@nricm.edu.tw. National Research Institute of Chinese Medicine Ministry of Health and Welfare No. 155-1 Sec. 2 Linong St. Beitou District Taipei 11221 Taiwan. tkc@nricm.edu.tw.

BACKGROUNd:The main commercially available methods for detecting small molecules of mycotoxins in traditional Chinese medicine (TCM) and functional foods are enzyme-linked immunosorbent assay and mass spectrometry. Regarding the development of diagnostic antibody reagents, effective methods for the rapid preparation of specific monoclonal antibodies are inadequate. METHOdS:In this study, a novel synthetic phage-displayed nanobody Golden Glove (SynaGG) library with a glove-like cavity configuration was established using phage display technology in synthetic biology. We applied this unique SynaGG library on the small molecule aflatoxin B1 (AFB1), which has strong hepatotoxicity, to isolate specific nanobodies with high affinity for AFB1. RESULT:These nanobodies exhibit no cross-reactivity with the hapten methotrexate, which is recognized by the original antibody template. By binding to AFB1, two nanobodies can neutralize AFB1-induced hepatocyte growth inhibition. Using molecular docking, we found that the unique non-hypervariable complementarity-determining region 4 (CdR4) loop region of the nanobody was involved in the interaction with AFB1. Specifically, the CdR4's positively charged amino acid arginine directed the binding interaction between the nanobody and AFB1. We then rationally optimized the interaction between AFB1 and the nanobody by mutating serine at position 2 into valine. The binding affinity of the nanobody to AFB1 was effectively improved, and this result supported the use of molecular structure simulation for antibody optimization. CONCLUSION:In summary, this study revealed that the novel SynaGG library, which was constructed through computer-aided design, can be used to isolate nanobodies that specifically bind to small molecules. The results of this study could facilitate the development of nanobody materials to detect small molecules for the rapid screening of TCM materials and foods in the future.

关键词： Aflatoxin B1 Glove-like cavity Nanobody Nonhypervariable complementarity-determining region 4 loop phage display technology

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Reduced miR-223 increases blood neutrophil extracellular trap and promotes skin inflammation in atopic dermatitis

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Allergy 2023年第12期78卷 3252-3254页

作者： Tsai-Ling Liao Chi-Chien Lin Yi-Hsing Chen Kuo-Tung Tang Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan. Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan. Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Institute of Biomedical Science the iEGG and Animal Biotechnology Center National Chung-Hsing University Taichung Taiwan. Department of Medical Research China Medical University Hospital Taichung Taiwan. Department of Pharmacology College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Division of Allergy Immunology and Rheumatology Taichung Veterans General Hospital Taichung Taiwan. Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan.

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Application of vetiver grass (Vetiveria Zizanioides L.) for organic matter removal from contaminated surface water

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Bioresource Technology Reports 2023年 22卷

作者： Nguyen, Minh Ky Hung, Nguyen Tri Quang Nguyen, Cong Manh Lin, Chitsan Nguyen, Tuan Anh Nguyen, Hoang-Lam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc Dist. Ho Chi Minh City700000 Viet Nam Research Institute for Biotechnology and Environment Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc Dist. Ho Chi Minh City700000 Viet Nam Department of Civil Engineering McGill University Montreal Canada

This study presents the vertical flow constructed wetlands (VFCWs) as a green solution for organic matter removal in contaminated surface water – a case study in Vietnam. The experiments were conducted with hydraulic loading rates (HLRs) of 500 mL/m2/min (T1), 1000 mL/m2/min (T2), and 1500 mL/m2/min (T3) using Vetiver grass (V) and Control (C). The findings indicated that Vetiver grass (Vetiveria Zizanioides L.) based-VFCWs model achieves a removal efficiency of 90 % for biochemical oxygen demand (BOd5) and >80 % for chemical oxygen demand (COd). This could explain the significant contribution of aquatic plants to the VFCWs based on vertical flow characteristics. Analysis of variance showed that HLRs significantly influence the treatment efficiency of BOd5 and COd (P © 2023 Elsevier Ltd

关键词： Irrigation

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