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Strategic Procurement and Competitive Advantage

International Journal of Purchasing and Materials Management 1993年第3期29卷 12-20页

作者： Rajagopal, Shan Bernard, Kenneth N. 1 Shan Rajagopal is a Lecturer in the Department of Marketing at the University of Strathclyde. He received his Ph.D. degree in the development of competitive purchasing strategy from the University of Strathdyde. Dr. Rajagopal's research interests include strategic purchasing global sourcing and relationship management. Prior to joining the academic community he worked for ten years in industry on a world wide basis.2 Kenneth Bernard is a Lecturer in the Department of Marketing at the University of Strathdyde specializing in business-to-business marketing procurement relationship management and technology transfer. Prior to joining the academic community he worked for more than twenty years in marketing management on a world wide basis. He currently is Course Director of the University's MSc in International Marketing Open Learning program.

Since the mid‐1970s there has been a growing, if sporadic, interest in strategic approaches to the procurement process, with an emphasis on the scope for proactivity. However, there has been little consideration of the contribution that may be made to the overall competitive efforts of the organization. This article begins to address this missing link by going back to the fundamental objectives of the purchasing activity and by outlining a framework for the development of a competitive purchasing strategy. The main thrust of such a program centers on the integration of purchasing and procurement operations to satisfy the needs of direct and indirect customers, necessitating constructive management of both inter‐company and intra‐company relationships. The conclusion reached is that purchasing and marketing are not merely interdependent, but that making the “right” procurement decisions is a necessary ingredient in competitive success. Copyright © 1993, Wiley Blackwell. All rights reserved

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SCUBE2 regulates adherens junction dynamics and vascular barrier function during inflammation

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Cardiovascular research 2024年第13期120卷 1636-1649页

作者： Lin, Yuh-Charn Chang, Ya-Jen Gau, Shiang-Shin Lo, Chun-Min Yang, Ruey-Bing Department of Physiology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan Institute of Biomedical Sciences Academia Sinica 128 Academia Rd. Sec. 2 Taipei 115201 Taiwan Graduate School of Biostudies Kyoto University Kyoto 6068501 Japan Institute for Integrated Cell-Material Sciences (WPI-iCeMS) Kyoto University Kyoto 6068501 Japan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei 112304 Taiwan Biomedical Translation Research Center Academia Sinica 99 Ln. 130 Academia Rd. Sec. 1 Taipei 115201 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University 250 Wuxing St. Taipei 110301 Taiwan

Aims: SCUBE2 (signal peptide-CUB-epidermal growth factor-like domain-containing protein 2) is a secreted or membrane-bound protein originally identified from endothelial cells (ECs). Our previous work showed that SCUBE2 forms a complex with E-cadherin and stabilizes epithelial adherens junctions (AJs) to promote epithelial phenotypes. However, it remains unclear whether SCUBE2 also interacts with vascular endothelial (VE)-cadherin and modulates EC barrier function. In this study, we investigated whether and how SCUBE2 in ECs regulates vascular barrier maintenance. Methods and results: We showed that SCUBE2 colocalized and interacted with VE-cadherin and VE-protein tyrosine phosphatase (VE-PTP) within EC AJs. Furthermore, SCUBE2 knockdown disrupted EC AJs and increased EC permeability. Expression of EC SCUBE2 was suppressed at both mRNA and protein levels via the nuclear factor-κB signalling pathway in response to pro-inflammatory cytokines or permeability-inducing agents. In line with these findings, EC-specific deletion of Scube2 (EC-KO) in mice impaired baseline barrier function and worsened vascular leakiness of peripheral capillaries after local injection of histamine or vascular endothelial growth factor. EC-KO mice were also sensitive to pulmonary vascular hyperpermeability and leucocyte infiltration in response to acute endotoxin- or influenza virus-induced systemic inflammation. Meanwhile, EC-specific SCUBE2-overexpressing mice were protected from these effects. Molecular studies suggested that SCUBE2 acts as a scaffold molecule enabling VE-PTP to dephosphorylate VE-cadherin, which prevents VE-cadherin internalization and stabilizes EC AJs. As such, loss of SCUBE2 resulted in hyperphosphorylation of VE-cadherin at tyrosine 685, which led to its endocytosis, thus destabilizing EC AJs and reducing barrier function. All of these effects were exacerbated by inflammatory insults. Conclusion: We found that SCUBE2 contributes to vascular integrity by recruiting VE-

关键词： Adherens junctions SCUBE2 Vascular permeability VE-cadherin VE-PTP

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Empirical testing: The prototyper's evaluation mechanism

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NAVAL ENGINEERS JOURNAL 1997年第1期109卷 41-46页

作者： Hafner, AN Arnold N. Hafner Ph.D.:is founder and president of Information Systems Research (ISR). He has twenty-five years of experience in systems development and is published in the field of systems development management. He served as corporate research scientist at Systems Exploration Inc. from 1988 to 1991 program director at Computer Science Corporation from 1983 to 1988 director of operations at Republic Management Systems Corporation from 1981 to 1983 and program manager at Computer Science Corporation from 1972 to 1981. A 1962 graduate of the US. Naval Academy he holds a doctoral degree in human behavior and engineering degrees in electronics and communications. He has taught courses on information systems and systems management at most of the colleges in the San Diego area. Dr. Hafner has presented fourteen refereed research papers while publishing sixteen articles and a book A Manager's Guide to Software System Development.

Evaluating complex systems is the subject of this paper, the third in a series investigating prototyping. It provides an interesting and helpful overview of how to evaluate systems prototypes and outlines the iterative stream of developer-user interactions that is replacing older approaches to testing and evaluating new military systems, which promise to reduce the time required to develop and field future military capabilities. Changes to the acquisition process, such as those the paper sketches, will facilitate the nation's rapid transit through its current revolution in military affairs.

关键词： Systems analysis

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phage display-derived alpaca nanobodies as potential therapeutics for Naja atra snake envenomation

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Applied and Environmental Microbiology 2024年第8期90卷 e0012124页

作者： Wang, Wei-Chu Chang, Jungshan Lee, Chi-Hsin Chiang, Yu-Wei Leu, Sy-Jye Mao, Yan-Chiao Chiang, Jen-Ron Yang, Chun-Kai Wu, Chao-Jung Yang, Yi-Yuan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Core Laboratory of Antibody Generation and Research Taipei Medical University Taipei Taiwan Department of Medical Research Taipei Veterans General Hospital Taipei Taiwan Department of Biology and Anatomy National Defense Medical Center Taipei Taiwan Foundation for Poison Control Taipei Taiwan Department of Microbiology and Immunology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medicine National Defense Medical Centre Taipei Taiwan Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan Division of Clinical Toxicology Department of Emergency Medicine Taichung Veterans General Hospital Taichung Taiwan Bioproduction Plants National Institute of Infectious Diseases and Vaccinology National Health Research Institutes Miaoli Taiwan Interdisciplinary Research on Ecology and Sustainability National Dong Hwa University Hualien Taiwan

Naja atra, the Chinese cobra, is a major cause of snake envenomation in Asia, causing hundreds of thousands of clinical incidents annually. The current treatment, horse serum-derived antivenom, has unpredictable side effects and presents manufacturing challenges. This study focused on developing new-generation snake venom antidotes by using microbial phage display technology to derive nanobodies from an alpaca immunized with attenuated N. atra venom. Following confirmation of the immune response in the alpaca, we amplified VHH genes from isolated peripheral blood mononuclear cells and constructed a phage display VHH library of 1.0 × 107 transformants. After four rounds of biopanning, the enriched phages exhibited increased binding activity to N. atra venom. Four nanobody clones with high binding affinities were selected: aNAH1, aNAH6, aNAH7, and aNAH9. Specificity testing against venom from various snake species, including two Southeast Asian cobra species, revealed nanobodies specific to the genus Naja. An in vivo mouse venom neutralization assay demonstrated that all nanobodies prolonged mouse survival and aNAH6 protected 66.6% of the mice from the lethal dosage. These findings highlight the potential of phage display-derived nanobodies as valuable antidotes for N. atra venom, laying the groundwork for future applications in snakebite treatment. Copyright © 2024 American Society for Microbiology. All Rights Reserved.

关键词： Mammals

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LOCAL INdUSTRIAL development GROUPS: PERSPECTIVES ANd PROFILES

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Review of Policy research 1987年第3期6卷 569-583页

作者： Ottensmeyer, Edward J. Humphrey, Craig R. Erickson, Rodney A. EDWARD OTTENSMEYER (Ph. D. Indiana University) is Assistant Professor of Management at Clark University Worcester Massachusetts. His recent research has focused on strategic issue management systems on strategy development in not-for-profit organizations and on the management of technological innovation. CRAIG HUMPHREY (Ph. D. Brown University) is Associate Professor of Sociology at the Pennsylvania State University University Park Pennsylvania. H i s research has dealt with community development and change. RODNEY ERICKSON (Ph.D. University of Washington) is Professor of Geography and of Business Administration at the Pennsylvania State University University Park Pennsylvania. He also serves as the director of the Pennsylvania Economic Analysis Program at Penn State. His research has focused on theories of regional economic change industrial location and economic development policies.

Local industrial development groups (LIdGs) are often among the most visible organizations involved in community economic development. LIdGs annually spend billions of dollars directly or indirectly in various promotional and community improvement efforts. Yet relatively little is known about their organizational forms, their operating strategies, or their real impact on the economic development of communities. The study reported here was undertaken by researchers from three academic backgrounds in order to capture a rich, comprehensive view of this organizational type. In this paper, we discuss the research perspectives which informed our overall approach to the study, and subsequently, we present and discuss a preliminary profile of LIdGs, based on our recent national survey. Copyright © 1987, Wiley Blackwell. All rights reserved

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Total synthesis and metabolic stability of hispidulin and its d-Labelled derivative

Total synthesis and metabolic stability of hispidulin and it...

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第11届世界华人药物化学研讨会（ISCMC 2018）

作者： Liangchi Chen Kaicheng Hsu Lihchu Chiou Huiju Tseng Weijan Huang Graduate Institute of Pharmacognosy College of PharmacyTaipei Medical University School of Pharmacy College of PharmacyTaipei Medical University Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and TechnologyTaipei Medical University Graduate Institute of Brain and Mind Sciences College of MedicineTaiwan University Graduate Institute of Pharmacology College of MedicineTaiwan University Ph.D.Program in Biotechnology Research and Development College of PharmacyTaipei Medical University Ph.D.Program for the Clinical Drug Discovery from Botanical Herbs College of PharmacyTaipei Medical University School of Pharmacy “Defense Medical Center”

Hispidulin is a naturally occurring flavone known to have various central nervous system(CNS) *** synthetic approaches to synthesizing hispidulin have proven unsatisfactory due to their low feasibility and poor overall *** solve these problems,this study developed a novel scheme for synthesizing hispidulin,which had an improved overall yield as well as more concise reaction steps compared to previous methods ***,using the same synthetic strategy,d-labelled hispidulin was synthesized to investigate its metabolic stability against human liver *** work may produce *** entities for enriching the library of hispidulin-derived compounds.

关键词： hispidulin total synthesis flavone microsome stability deuterium-labelled compound

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Retraction notice to ‘Applications of engineered biochar in remediation of heavy metal(loid)s pollution from wastewater: Current perspectives toward sustainable development goals’ [Sci. Total Environ., 926 (2024) 171859] (Science of the Total Environment (2024) 926, (S0048969724020023), (10.1016/***.2024.171859))

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Science of the Total Environment 2025年 976卷 179291页

作者： Tran, Thien-Khanh Huynh, Loan Nguyen, Hoang-Lam Nguyen, Minh-Ky Lin, Chitsan Hoang, Tuan-dung Hung, Nguyen Tri Q. Nguyen, X. Hoan Chang, S. Woong Nguyen, d. duc Advanced Applied Sciences Research Group Dong Nai Technology University Bien Hoa City76100 Viet Nam Faculty of Technology Dong Nai Technology University Bien Hoa City76100 Viet Nam Department of Civil Engineering McGill University Montreal Canada Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan School of Chemistry and Life Science Hanoi University of Science and Technology No. 1 Dai Co Viet Hai Ba Trung Hanoi100000 Viet Nam Vietnam National University Hanoi - School of Interdisciplinary Sciences and Arts 144 Xuan Thuy Street Cau Giay District Hanoi100000 Viet Nam Ho Chi Minh City University of Industry and Trade Ho Chi Minh City Viet Nam Department of Civil & Energy System Engineering Kyonggi University Suwon16227 Korea Republic of Institute of Applied Technology and Sustainable Development Nguyen Tat Thanh University Ho Chi Minh City700000 Viet Nam

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://***/about/policies/article-withdrawal). This article has been retracted at the request of the Authors. The corresponding author approached the journal to make it aware that significant portions of the text of the STOTEN article had already been included in the following publication involving several members of the same authorship group: Minh-Ky Nguyen, Chitsan Lin, Nguyen Tri Quang Hung, Hoang-Lam Nguyen, Hong-Giang Hoang, Huu-Tuan Tran, Mohammed Hadi, Chapter 8 - Biochar and engineering applications in remediation of heavy metal pollutants from wastewater toward sustainable development, Editor(s): Xuan-Thanh Bui, Ashok Pandey, Thanh-Tin Nguyen, Shu-Yuan Pan, Low Cost Water and Wastewater Treatment Systems: Conventional and Recent Advances, Elsevier, 2025, Pages 195-233, ISBN 9780443236624, https://***/10.1016/B978-0-443-23662-4.00016-0. The authors realise that redundant publications overweigh the relative importance of published findings, and therefore requested the retraction of the STOTEN article. The authors also apologies for any inconvenience caused. © 2025 Elsevier B.V.

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OXYGEN-TRANSFER THROUGH FLEXIBLE TUBING ANd ITS EFFECTS ON GROUNd-WATER SAMPLING RESULTS

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GROUNd WATER MONITORING ANd REMEdIATION 1988年第3期8卷 83-89页

作者： HOLM, TR GEORGE, GK BARCELONA, MJ Thomas R. Holm is an associate chemist in the Aquatic Chemistry Section of the Illinois State Water Survey (2204 Griffith Dr. Champaign IL 61820-7495) a division of the Illinois Department of Energy and Natural Resources. His research interests include ground water geochemistry trace-metal speciation and arsenic chemistry. Prior to joining the Water Survey he was a research assistant prof essor at the University of Minnesota (Twin Cities) where he studied the geochemistry of aquifer thermal energy storage. Before that he was a postdoctoral research associate in the Water Chemistry Program of the University of Wisconsin (Madison) where he investigated arsenic speciation and cycling in fresh water sediments. He received his B.S. in chemistry from Portland State University and his M.S. and Ph.D. in environmental engineering science from the California Institute of Technology. Gregory K. George is' an assistant chemist in the Aquatic Chemistry Section of the Illinois State Water Survey (2204 Griffith Dr. Champaign IL 61820-7495). His research work has focused on evaluation and improvement of analytical methods for naturally occurring aquatic organic matter and on the development and validation of analytical and sampling methods for ground water oxidants. He was previously a research technician with the University of Illinois Institute for Environmental Studies where he determined dissolved 226Ra for a ground water treatment project. He received a B.S. in chemistry from the University of Illinois (Urbana-Champaign). Michael J. Barcelona is the head of the Aquatic Chemistry Section of the Illinois State Water Survey (2204 Griffith Dr. Champaign IL 61820-7495). His research interests include ground water geochemistry contaminant detection monitoring and verification techniques with an emphasis on ground water resource protection and management. He has been involved in various aspects of ground water research and policy matters extensively in the past eight years. He has a B.A. in chemistry from St. Mary's

A model for the diffusion of gases through polymeric tubing was derived which predicts that the amount of gas transferred is proportional to the tubing length and inversely proportional to the pumping rate. The model was experimentally tested and confirmed for oxygen transfer through fluorinated ethylene-propylene copolymer (FEP) tubing using tubing lengths and flow rates typical of ground water sampling. diffusion can introduce measurable concentrations of oxygen into initially anoxic water. diffusive loss of carbon dioxide from water that is oversaturated with respect to atmospheric CO 2 does not measurably affect ph under similar usage conditions.

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GENETIC-ENGINEERING ANd ENVIRONMENTAL-POLLUTION - POTENTIAL ANd UNCERTAINTIES

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BIO-TECHNOLOGY 1983年第8期1卷 670-673页

作者： ZABORSKY, OR Oskar R. Zaborsky Ph.D. is a program director in the Division of Chemical and Process Engineering of the National Science Foundation 1800 G Street Washington DC 20550. The views conclusions and recommendations expressed herein are those of the author and do not necessarily reflect the views and policies of the National Science Foundation.REFERENCES Conference on "Genetic Control of Environmental Pollutants" July 31-August 3 1983 University of Washington School of Public Health & Community Medicine and Department of Environmental Health Seattle WA. The proceedings are to be published by Plenum Press.Recent reports covering the handling of hazardous industrial wastes including biological processes are (a) "Management of Hazardous Industrial Wastes: Research and Development Needs" National Research Council National Academy Press Washington D.C. 1983 (b) "Technologies and Management Strategies for Hazardous Waste Control " Congress of the United States Office of Technology Assessment Washington D.C. 1983.An expanded report on the technology market analysis regulatory and legislative factors dealing with biotechnology applications to hazardous wastes has been produced by Dr. Thomas O.Peyton AmTech Consultants Vienna VA for the OTA study.Baross J.A. and Deming J.W.1983. Growth of 'black smoker' bacteria at temperatures of at least 250C. Nature303: 423-426.|Article|ISI|ChemPort|

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Biological Evaluation of Sulfonate and Sulfate Analogues of Lithocholic Acid: A Bioisosterism-Guided Approach Towards the discovery of Potential Sialyltransferase Inhibitors for Antimetastatic Study

SSRN

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SSRN 2023年

作者： Perez, Ser John Lynon P. Chen, Chia-Ling Chang, Tzu-Ting Li, Wen-Shan Institute of Chemistry Academia Sinica Taipei115 Taiwan Department of Applied Chemistry National Yang Ming Chiao Tung University Hsinchu300 Taiwan Sustainable Chemical Science and Technology Taiwan International Graduate Program Academia Sinica Taipei115 Taiwan Biomedical Translation Research Center Academia Sinica Taipei115 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung807 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taiwan Doctoral Degree Program in Marine Biotechnology National Sun Yat-Sen University Kaohsiung804 Taiwan Department of Chemistry College of Science Tamkang University New Taipei City251 Taiwan

The naturally occurring bile acid lithocholic acid (LCA) has been a crucial core structure for many non-sugar-containing sialyltranferase (ST) inhibitors documented in literature. With the aim of elucidating the impact of the terminal carboxyl acid substituent of LCA on its ST inhibition, in this present study, we report the (bio)isosteric replacement-based design and synthesis of sulfonate and sulfate analogues of LCA. Among these compounds, the sulfate analogue SPP-002 was found to selectively inhibit N-glycan sialylation by at least an order of magnitude, indicating a substantial improvement in both potency and selectivity when compared to the unmodified parent bile acid. Molecular docking analysis supported the stronger binding of the synthetic analogue in the enzyme active site. Treatment with SPP-002 also hampered the migration, adhesion, and invasion of MdA-MB-231 cells in vitro by suppressing the expression of signaling proteins involved in the cancer metastasis-associated FAK/paxillin pathway. In totality, these findings offer not only a novel structural scaffold but also valuable insights for the future development of more potent and selective ST inhibitors with potential therapeutic effects against tumor cancer metastasis. © 2023, The Authors. All rights reserved.

关键词： Sulfur compounds

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