检索结果-内蒙古大学图书馆

arXiv 2022年

作者： Zhang, Shuo Liu, Yang Xie, Lei Ph.D. Program in Computer Science Graduate Center City University of New York United States Department of Computer Science Hunter College City University of New York United States Helen & Robert Appel Alzheimer’s Disease Research Institute Feil Family Brain & Mind Research Institute Weill Cornell Medicine Cornell University United States

Biological functions of RNAs are determined by their three-dimensional (3d) structures. Thus, given the limited number of experimentally determined RNA structures, the prediction of RNA structures will facilitate elucidating RNA functions and RNA-targeted drug discovery, but remains a challenging task. In this work, we propose a Graph Neural Network (GNN)-based scoring function trained only with the atomic types and coordinates on limited solved RNA 3d structures for distinguishing accurate structural models. The proposed physics-aware Multiplex Graph Neural Network (PaxNet) separately models the local and non-local interactions inspired by molecular mechanics. Furthermore, PaxNet contains an attention-based fusion module that learns the individual contribution of each interaction type for the final prediction. We rigorously evaluate the performance of PaxNet on two benchmarks and compare it with several state-of-the-art baselines. The results show that PaxNet significantly outperforms all the baselines overall, and demonstrate the potential of PaxNet for improving the 3d structure modeling of RNA and other macromolecules. Our code is available at https://***/zetayue/physics-aware-Multiplex-GNN. Copyright © 2022, The Authors. All rights reserved.

关键词： RNA

来源：评论

学校读者我要写书评

暂无评论

Immediate Effects of Vergence Exercises Using Automatic dual Rotational Risley Prisms on Accommodative Lag and Facility

引用

Ophthalmology and Therapy 2023年第6期12卷 3361-3372页

作者： Huang, Shuan-Yu Su, Hui-Rong Hu, Yun-Shao Lee, Chi-Hung Tsai, Ming-Shan Yeh, Shang-Min Chen, Ya-Yu Tsai, Tzu-Hsun Department of Optometry Central Taiwan University of Science and Technology Taichung 402 Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung 407 Taiwan Department of Optometry Chung Shan Medical University Taichung 402 Taiwan Department of Electrical Engineering Feng Chia University Taichung 407 Taiwan Department of Electrophysics National Chiayi University Chiayi 600 Taiwan Department of Optometry Da-Yeh University Changhua 515 Taiwan Department of Ophthalmology National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Taiwan Department of Ophthalmology National Taiwan University Hospital Taipei City 100225 Taiwan

Introduction: This study evaluated novel automatic dual rotational Risley prisms (AdRRPs) as a vergence exercise tool for patients with myopia to improve accommodative lag and accommodative facility. Methods: Participants with myopia aged 20–24 years were recruited. After vergence exercises with prisms (treatment group) or plano lenses (control group) using AdRRPs for 10 min, measurements were taken using an open-field autorefractor (Grand Seiko WAM-5500) at viewing distances of 0.4 m and 6.0 m. We measured accommodative facility using a ± 2.00 d accommodative flipper. Results: A total of 56 participants (treatment group, 39;control group, 17) performed vergence exercises using AdRRPs. Participants in the treatment group showed improvements in accommodative lag at a 0.4 m viewing distance, with measurements of 0.57 d (right eye;Od) and 0.53 d (left eye;OS) and 0.21 d (Od) and 0.27 d (OS) before and after the exercises, respectively (p < 0.001). Over-refractions using an open-field autorefractor with spherical equivalent contact lenses at a 6.0 m viewing distance were − 0.01 ± 0.30 d (Od) and 0.03 ± 0.34 d (OS) and 0.15 ± 0.32 d (Od) and 0.19 ± 0.28 d (OS) before and after the exercises, respectively (difference + 0.16 d;p < 0.001). Accommodative facility values before and after exercises were 14.88 ± 3.36 and 15.59 ± 3.60 cpm, respectively (p < 0.01). No significant differences in accommodative lag, relaxation, and accommodative facility before and after exercise were observed in the control group. Conclusions: Using AdRRPs in vergence exercises can improve accommodative lag, accommodative facility, and accommodative relaxation in adults with myopia. Further research to evaluate persistent and long-term effects is needed. © 2023, The Author(s).

关键词： Accommodative facility Accommodative lag Automatic dual rotational Risley prisms (AdRRPs) Vergence exercise

来源：评论

学校读者我要写书评

暂无评论

Efficient and Accurate physics-aware Multiplex Graph Neural Networks for 3d Small Molecules and Macromolecule Complexes

arXiv

引用

arXiv 2022年

作者： Zhang, Shuo Liu, Yang Xie, Lei Ph.D. Program in Computer Science The Graduate Center The City University of New York United States Department of Computer Science Hunter College The City University of New York United States Helen & Robert Appel Alzheimer’s Disease Research Institute Feil Family Brain & Mind Research Institute Weill Cornell Medicine Cornell University United States

Recent advances in applying Graph Neural Networks (GNNs) to molecular science have showcased the power of learning three-dimensional (3d) structure representations with GNNs. However, most existing GNNs suffer from the limitations of insufficient modeling of diverse interactions, computational expensive operations, and ignorance of vectorial values. Here, we tackle these limitations by proposing a novel GNN model, physics-aware Multiplex Graph Neural Network (PaxNet), to efficiently and accurately learn the representations of 3d molecules for both small organic compounds and macromolecule complexes. PaxNet separates the modeling of local and non-local interactions inspired by molecular mechanics, and reduces the expensive angle-related computations. Besides scalar properties, PaxNet can also predict vectorial properties by learning an associated vector for each atom. To evaluate the performance of PaxNet, we compare it with state-of-the-art baselines in two tasks. On small molecule dataset for predicting quantum chemical properties, PaxNet reduces the prediction error by 15% and uses 73% less memory than the best baseline. On macromolecule dataset for predicting protein-ligand binding affinities, PaxNet outperforms the best baseline while reducing the memory consumption by 33% and the inference time by 85%. Thus, PaxNet provides a universal, robust and accurate method for large-scale machine learning of molecules. Our code is available at https://***/zetayue/physics-aware-Multiplex-GNN. Copyright © 2022, The Authors. All rights reserved.

关键词： Macromolecules

来源：评论

学校读者我要写书评

暂无评论

Nanoarchitectonics of europium vanadate nanoparticles decorated carbon nanofibers for electrochemical detection of fungicide in fruits

引用

Journal of the Taiwan Institute of Chemical Engineers 2024年 161卷

作者： Huang, Song-Jeng Gokulkumar, Kumar Govindasamy, Mani Albaqami, Munirah d. Wabaidur, Saikh Mohammad Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei City106335 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia

Background: Fungicides, like carbendazim, have effects on male fertility. There have been sufficient studies conducted on certain chemical compounds to indicate a selective action at the epididymis level. To prevent contamination of food products with fungicides, most of the governments have established rules for the use of fungicides. However, even though this type of fungicide is primarily used in agriculture. More probably, it's contaminated with fruits and vegetables. In particular, carbendazim is one of the major fungicides in the agricultural usage Methods: This research work developed a europium vanadate (EuVO4) nanoparticle decorated carbon nanofiber (CNF) composites by hydrothermal-sonochemical approach. Based on this composite, Carbendazim sensing is developed through electrochemical oxidation based on EuVO4/f-CNF modified Glassy Carbon Electrode (GCE). By combining EuVO4 and f-CNF with the GCE, carbendazim detection can be highly effective. GCEs are rigid, making them ideal for depositing EuVO4/f-CNF, while their expansive surface area makes it possible to immobilize a greater amount of EuVO4/f-CNF, which could increase the Carbendazim sensing ability of the resulting modified GCEs with EuVO4/f-CNF. Main Findings: : The carbendazim sensing was actualized by the electrocatalytic oxidation of carbendazim on the composite modified electrode, and it is demonstrating a linear range of 0.125 to 23.875 – 33.81 to 131.375 µM with a remarkably limit of detection of 0.00612 µM. The EuVO4/f-CNF /GCE also showcased an excellent degree of stability, retaining 96.5 % of its initial activity even after 30 days. This research highlights the potential of EuVO4/f-CNF modified GCEs as robust, and efficient platform for the carbendazim detection under electrochemical approach. © 2024 Taiwan Institute of Chemical Engineers

关键词： Carbon nanofibers

来源：评论

学校读者我要写书评

暂无评论

The fermented product of high-yield surfactin strain Bacillus subtilis LYS1 improves the growth performance and intestinal villi morphology in broilers

引用

Poultry science 2023年第11期102卷 102839页

作者： Lee, Yueh-Sheng Ku, Kuo-Lung Chen, Po-Yuan Chen, Kuo-Lung Ph.D. Program of Agriculture Science National Chiayi University Chiayi city Taiwan Department of Applied Chemistry National Chiayi University Chiayi city Taiwan Research Institute Taiwan Sugar Corporation Tainan City Taiwan Department of Animal Science National Chiayi University Chiayi city Taiwan

This study aimed to select Bacillus spp. for surfactin production by solid-state fermentation and to investigate the physiochemical characterizations of the fermented product (FP) and its effect on growth performance, carcass trait, intestinal morphology, and clinical blood biochemistry of broilers. Accordingly, the correlations between the functional components of FP and the growth performance of broilers are elucidated. Four hundred eighty 1-day-old Ross 308 broiler chicks were randomly assigned to dietary supplementation of 2.5% fish meal, 2.5% unfermented product, or 2.5% FP produced by Bacillus subtilis LYS1 (LYS1), Bacillus amyloliquefaciens da16, B. subtilis Lo6 (Lo6), B. subtilis NSN7, B. subtilis subsp. natto N21, or B. subtilis N12. Each treatment had 6 replicates. The experimental period was 5 wk. Results showed that the Lo6 showed the highest protease activity among all fermented groups. The LYS1 showed the highest surfactin yields (10.69 mg/g) among all fermented groups (P < 0.05). The weight gain (WG), feed conversion ratio (FCR), and production efficiency factor (PEF) of LYS1 group were significantly better than unfermented group at 0 to 3 and 0 to 5-wk-old (P < 0.05). The Bacillus-like counts and surfactin content of FP were moderately correlated to WG (0.7 > r > 0.3), FCR (-0.3 > r > -0.7), and PEF (0.7 > r > 0.3) at 0 to 3 and 0 to 5-wk-old (P < 0.05). The protease activity of FP was moderately correlated to WG (0.7 > r > 0.3), FCR (-0.3 > r > -0.7), and PEF (0.7 > r > 0.3) at 0 to 3-wk-old (P < 0.05). The villus height to crypt depth ratio in duodenum and jejunum of fish meal group and LYS1 group were higher than unfermented group (P < 0.05). In conclusion, LYS1 shows the highest surfactin yields. diets supplemented with 2.5% LYS1 FP can improve the growth performance and the development of intestinal villi in broilers. Moreover, this study proves that the surfactin content, Bacillus-like counts, and protease activity of FP show a correlation to t

关键词： Bacillus subtilis LYS1 broiler growth performance intestinal villus surfactin

来源：评论

学校读者我要写书评

暂无评论

Ser38-His93-Asn91 triad confers resistance of JFH1 HCV NS5A-Y93H variant to NS5A inhibitors

引用

FEBS Journal 2024年第6期291卷 1264-1274页

作者： Lee, Wei-Ping Tsai, Keng-Chang Liao, Shi-Xian Huang, Yi-Hsiang Hou, Ming-Chih Lan, Keng-Hsin Department of Medical Research Taipei Veterans General Hospital Taiwan Institute of Biochemistry and Molecular Biology School of Life Sciences National Yang Ming Chiao Tung University Taipei Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei Taiwan The Ph.D. Program for Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taiwan Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Pharmacology College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan

HCV NS5A is a dimeric phosphoprotein involved in HCV replication. NS5A inhibitors are among direct-acting antivirals (dAA) for HCV therapy. The Y93H mutant of NS5A is resistant to NS5A inhibitors, but the precise mechanism remains unclear. In this report, we proposed a Ser38-His93-Asn91 triad to dissect the mechanism. Using pymol 1.3 software, the homology structure of JFH1 NS5A was determined based on the dimer structure of genotype 1b extracted from the database Protein dataBank (***/pdbsum) with codes 1ZH1 and 3FQM/3FQQ. FLAG-NS5A-WT failed to form dimer in the absence of nonstructural proteins from subgenomic replicon (NS3-5A);however, FLAG-NS5A-Y93H was able to form dimer without the aid of NS3-5A. The Ser38-His93-Asn91 triad in the dimer of the Y93H variant predicts a structural crash of the cleft receiving the NS5A inhibitor daclatasvir. The dimerization assay revealed that the existence of JFH1-NS5A-1ZH1 and -3FQM homology dimers depended on each other for existence and that both NS5A-WT 1ZH1 and 3FQM dimers cooperated to facilitate RNA replication. However, NS5A-Y93H 1ZH1 alone could form dimer and conduct RNA replication in the absence of the 3FQM structure. In conclusion, this study provides novel insight into the functional significance of the Ser38-His93-Asn91 triad in resistance of the Y93H variant to NS5A inhibitors. © 2023 Federation of European Biochemical Societies.

关键词： dimerization drug resistance Hepatitis C virus inhibitor NS5A Y93H mutant

来源：评论

学校读者我要写书评

暂无评论

Analyzing the Impact of deep Learning Approaches on Real-Time data Analysis in Machine Learning

Analyzing the Impact of Deep Learning Approaches on Real-Tim...

引用

International Conference on Power Energy, Environment and Intelligent Control (PEEIC)

作者： deepti Mounika Nalluri Chinna babu Mupparaju Aruna Sri Rongali Sohong dhar P. Ajitha Sloan School of Management Sloan Fellow Candidate 2023 MIT Masters in Computer Information Systems Murray State University USA Masters in Computer Science university of central Missouri warrensburg USA Graduate Doctoral Information Technology/Graduate (Information Technology Emphasis/Information Technology Ph.D.) University of The Cumberlands US Azure Microsoft library & information science Jadavpur University India School of Computing Sathyabama Institute of science and technology Chennai

deep learning is a powerful subset of synthetic intelligence, and it has the potential to significantly enhance the skills of machine getting to know. it's miles primarily based on the idea of artificial neural networks, which might be laptop fashions that are capable of gaining knowledge of from records and making decisions, just like the manner a human mind works. deep mastering isn't the same as traditional system mastering algorithms in that it can technique complex inputs with multiple layers of abstraction, main to greater accurate evaluation. deep studying algorithms are capable of unexpectedly examine raw facts and generate styles, making them perfect for actual-time statistics analysis. deep studying is capable of as it should be predicting behaviors and trends, which may be used to optimize procedures and enhance operational efficiencies. deep studying models can also be used for automated fault detection and predictive renovation, permitting businesses to count on and prevent capacity troubles. Additionally, deep mastering models frequently offer quicker consequences than other device studying or conventional techniques, as well as permitting an extra diploma of control over the resolution of the data being analyzed. This has widespread implications for real-time programs, such as medical diagnostics, independent automobiles, and manufacturing monitoring.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Expression of Concern for: Analyzing the Impact of deep Learning Approaches on Real-Time data Analysis in Machine Learning

Expression of Concern for: Analyzing the Impact of Deep Lear...

引用

International Conference on Power Energy, Environment and Intelligent Control (PEEIC)

ISBN: (数字)9798350357769

ISBN: (纸本)9798350357776

关键词：

来源：评论

学校读者我要写书评

暂无评论

Cross-Linking of White Proteins in Soft-Shell Turtle Eggs Using Transglutaminase, Reductant, and Thermal Pretreatment

引用

Processes 2023年第7期11卷 1941页

作者： Chen, Chun-Chi Kao, Ming-Ching Kuo, Meng-I Chen, Chao-Jung Jao, Cheng-Hsun Lee, Yongcheol Hsieh, Jung-Feng Department of Animal Science National Chiayi University Chiayi City 600 Taiwan Department of Food Science Fu Jen Catholic University New Taipei City242 Taiwan Ph.D. Program in Nutrition & Food Science Fu Jen Catholic University New Taipei City242 Taiwan Seoul Metropolitan Government Research Institute of Public Health and Environment Gwacheon13818 Korea Republic of Department of Food Science and Technology Oregon State University CorvallisOR97331 United States

The effects of transglutaminase (TGase), reductant, and thermal treatment on the cross-linking of white proteins in soft-shell turtle eggs were investigated. Egg white proteins were denatured by reductant (0.83% 2-mercaptoethanol, 2-ME) pretreatment and thermal pretreatment (95 °C and 5 min), and the denatured proteins were then catalyzed by TGase (1.0 unit/mL). SdS–PAGE showed that without any pretreatments, three major egg white proteins (210 kda, 115 kda, and 76 kda proteins) were inferior substrates for TGase. Only portions of the 210 kda protein (7.9%), 115 kda protein (11.4%), and 76 kda protein (42.9%) were polymerized by TGase into high-molecular-weight (MW) protein polymers (>180 kda) after incubation for 3 h at 40 °C. However, the combined use of TGase with 0.83% 2-ME and thermal pretreatment led to a significant increase (p © 2023 by the authors.

关键词： Proteins

来源：评论

学校读者我要写书评

暂无评论

Advances in liposomal nanotechnology: from concept to clinics

RSC Pharmaceutics

引用

RSC pharmaceutics 2024年第5期1卷 928-948页

作者： Reem M. Senjab Nour AlSawaftah Waad H. Abuwatfa Ghaleb A. Husseini Biomedical Engineering Program College of Engineering American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates ghusseini@aus.edu Materials Science and Engineering Ph.D. Program College of Arts and Sciences American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates Department of Chemical and Biological Engineering College of Engineering American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates Biosciences and Bioengineering PhD Program College of Engineering American University of Sharjah Sharjah P.O. Box 26666 United Arab Emirates

Liposomes, spherical phospholipid vesicles with a unique morphology mimicking that of body cells, have emerged as versatile nanoparticles for drug delivery. Their biocompatibility, low cytotoxicity, targeted delivery, and hydrophobic and hydrophilic characteristics make them stand out over traditional drug delivery systems. Liposomes can be tailored in size, composition, lamellarity, and surface charge, offering a unique level of customization for various applications. Extensive research in liposome technology has led to the development of a wide range of liposomal formulations with enhanced functionalities, such as PEGylated liposomes, ligand-targeted liposomes, and stimuli-responsive liposomes. Beyond their crucial role in cancer treatment, liposomes play a significant role in influenza, COVId-19, cancer, and hepatitis A vaccines. They are also utilized in pain management, fungal treatment, brain targeting, and topical and ocular drug delivery. This review offers insight into the types of liposomes, their composition, preparation methods, characterization methods, and clinical applications. Additionally, it discusses challenges and highlights potential future directions in liposome-based drug delivery.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：