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Current Progress of COPd Early detection: Key Points and Novel Strategies

International Journal of COPd 2023年 18卷 1511-1524页

作者： Lin, Ching-Hsiung Cheng, Shih-Lung Chen, Chiung-Zuei Chen, Chia-Hung Lin, Sheng-Hao Wang, Hao-Chien Division of Chest Medicine Changhua Christian Hospital Changhua 500 Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 402 Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Department of Recreation and Holistic Wellness MingDao University Changhua Taiwan Department of Internal Medicine Far Eastern Memorial Hospital Taipei 220 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan 320 Taiwan Division of Pulmonary Medicine Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine China Medical University Hospital Taichung 404 Taiwan Department of Internal Medicine National Taiwan University Hospital Taipei 100 Taiwan

Chronic obstructive pulmonary disease (COPd) is a major cause of morbidity and mortality worldwide, with approxi-mately 70% to 80% of adults with COPd being undiagnosed. Patients with undiagnosed COPd are at increased risk of poor outcomes and a worsened quality of life, making early detection a crucial strategy to mitigate the impact of COPd and reduce the burden on healthcare systems. In the past decade, increased interest has been focused on the development of effective strategies and instrument for COPd early detection. However, identifying undiagnosed cases of COPd is still challenging. Both screening and case-finding approaches have been adopted to identify undiagnosed COPd, with case-finding being recommended by the 2023 Global Initiative for Chronic Obstructive Lung disease (GOLd) guideline and the updated United States Preventive Services Task Force (USPTF) recommendation. Nonetheless, the approaches, criteria, and instruments used for early detection of COPd are varied. However, advances in the taxonomy and risk factors of COPd are continuously being investigated. It is important to continuously assess the current state of knowledge on COPd early detection, given the challenges associated with identifying undiagnosed COPd. This review aims to highlight recent advances in early detection of COPd. To discuss the current challenge and opportunity in COPd early detection, providing an overview of existing literature on COPd case-finding strategies, including the approaches, criteria for subjects, and instruments. The review also summarizes the current progress in COPd case-findings and proposes a COPd case-finding flowchart as an efficient method for identifying at risk COPd patients. © 2023 Lin et al.

关键词： at-risk case-finding COPd early detection undiagnosed

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Oxygen-producing composite dressing activated by photothermal and piezoelectric effects for accelerated healing of infected wounds

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Chemical Engineering Journal 2023年 476卷

作者： Lai, Yen-Han Roy Barman, Snigdha Ganguly, Anindita Pal, Arnab Yu, Jui-Han Chou, Syun-Hong Huang, E-Wen Lin, Zong-Hong Chen, San-Yuan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Science China Medical University Hospital Taichung40400 Taiwan School of Dentistry College of Dental Medicine Kaohsiung Medical University Kaohsiung80708 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan

The process of wound healing is often obstructed by the prevalence of bacterial infection at the wound site. Hence, innovative strategies to alleviate infection is extremely necessary to realize effective wound recovery in a timely manner. Here, we report a self-activated composite dressing consisting of piezoelectric and photothermal functional layers for combating wound infection and provide the desired treatment. The synergistic dressing is functionalized with piezoelectric Poly-L-lactic acid (PLLA) which under the effect of ultrasound irradiation controllably generates reactive oxygen species (ROS) for antibacterial activity, thus facilitating the dressing to inhibit the growth of bacteria at the wound bed. Further, the dressing is modified with calcium peroxide (CaO2) which can effectively convert the generated ROS into molecular oxygen (O2) in presence of catalase enzyme for treating chronic hypoxia in the infected wounds. The sustained generation of O2 by the wound dressing augmented the cell proliferation, migration and tissue regeneration aiding in wound healing. By combining the inherent photothermal activity of reduced graphene oxide (rGO), the synergistic dressing under NIR irradiation enhanced the wound recovery by upregulating the heat shock protein 90 (Hsp90) secretion owing to the heat generation on the wounds. The results obtained demonstrate that the self-triggered multifunctional wound dressing is a promising candidate for clinical treatment of infected wounds with a user-friendly interface. © 2023 Elsevier B.V.

关键词： Ultrasonics

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phase-engineered heterostructures of Mo2C by plasma-assisted selenization and sulfurization processes toward excellent hydrogen evolution reaction

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Nano Energy 2024年 122卷

作者： Kimbulapitiya, K.M.M.d.K. Rehman, Bushra Wani, Sumayah Shakil Chen, Chieh-Ting Cyu, Ruei-Hong Manikandan, Arumugam date, Manisha Kondiba Peng, Yu-Ren Kumara, R.J.G.L.R. Chuang, Feng-Chuan Chueh, Yu-Lun Department of Physics National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Materials Science and Engineering National Tsing-Hua University Hsinchu Taiwan College of Semiconductor Research National Tsing-Hua University Hsinchu30013 Taiwan Center for Nanotechnology Materials Science and Microsystem National Tsing-Hua University Hsinchu Taiwan Ph.D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan Physics Division National Center for Theoretical Sciences Hsinchu30013 Taiwan Center for Theoretical and Computational Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Physics National Tsing Hua University Hsinchu30013 Taiwan

due to the outstanding semiconducting and metallic properties, 2d materials such as Transition Metal dichalcogenides (TMds) and Transition Metal Carbides (TMCs) appear to be promising candidate for Nano-scale electronics devices. Among them, 2d - Mo2C (Molybdenum carbide) has attracted attention as a new member of the MXene group, owing to its potential applications for superconductors, electronics devices, and catalysts for Hydrogen evolution Reactions (HER). Structural modification toward the creation of novel heterostructures with phase engineering opens new pathways for different applications. Herein, we prepared a large area Mo2C film by chemical vapor deposition method. The upper region of Mo2C layers can be oxidized to create Mo2C/MoOx heterostructures. Furthermore, those oxide layers were further transformed into MoSe2 and MoS2 by plasma-assisted selenization and sulfurization processes at different temperatures with a fixed plasma power of 150 W. The heterostructures demonstrated outstanding electrocatalytic activity for HER due to an existed metallic phase and active sites present after plasma-assisted selenization and sulfurization processes at the low temperature. The performance of the HER decreases at high temperatures owing to their semiconducting phase. The pristine Mo2C showed a Tafel slope of 72 mV dec−1 and an overpotential of 276 mV at 10 mA/cm2, while the Mo2C/MoSe2 heterostructure synthesized at 350 °C350 °exhibited an improved Tafel slope of 66 mV dec−1 and overpotential of 257 mV at 10 mA/ cm2. Additionally, the Mo2C/MoS2 heterostructure prepared at 350 °C also demonstrated a 263 mV improvement in overpotential at 10 mA/cm2. All the heterostructures showed excellent stability over a period of 10 h except Mo2C/MoOx. This work opens new strategies to fabricate high-quality MXene and TMds heterostructures with metal-semiconductor interface. © 2024

关键词： Molybdenum compounds

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Tn antigen suppresses lipopolysaccharide-induced dermatitis via Clec10a

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Biochemical and Biophysical Research Communications 2025年 772卷 152024页

作者： Shigematsu, Katsunobu Matsuda, Kenshiro Nabekura, Tsukasa Kanemaru, Kazumasa Shibuya, Kazuko Tateno, Hiroaki Shibuya, Akira Department of Immunology Institute of Medicine University of Tsukuba Ibaraki Tsukuba 305-8577 Japan Ph.D. Program in Humanics University of Tsukuba Ibaraki Tsukuba 305-8577 Japan Life Science Center for Survival Dynamics Tsukuba Advanced Research Alliance University of Tsukuba Ibaraki Tsukuba 305-8577 Japan R&D Center for Innovative Drug Discovery University of Tsukuba Ibaraki Tsukuba 305-8577 Japan Cellular and Molecular Biotechnology Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 6 1-1-1 Higashi Ibaraki Tsukuba 305-8566 Japan

C-type lectin domain family 10 member A (Clec10a), also called macrophage galactose-type lectin 1 (MGL1) or Cd301a, is expressed on myeloid cells, including macrophages in the skin. Several pieces of evidence suggest that Clec10a physically binds to O-linked mucin-like molecules, but the functional ligand that mediates signaling in macrophages remains undetermined. We previously reported that house dust mite (HdM) treatment on the skin produced a greater amount of Toll-like receptor 4 (TLR4)-mediated inflammatory cytokines from macrophage in Clec10a-deficient mice than in wild-type (WT) mice, suggesting that a functional ligand for Clec10a contained in HdM inhibited TLR4-mediated skin macrophage activation. In this study, we investigated the glycan structure of a functional Clec10a ligand (Clec10a-L) contained in HdM. We showed that Clec10a bound to O-linked mucin-like molecules such as polyacrylamide (PAA)-conjugated Tn antigen (Tn antigen-PAA), Core1-PAA, LacNAc-PAA, Lewis A-PAA, and Lewis X-PAA. Among them, plate-coated Tn antigen-PAA, Lewis A-PAA, and Lewis X-PAA activated Clec10a expressed on the reporter cells. However, intradermal injection of only Tn antigen-PAA, but not Lewis A-PAA and Lewis X-PAA, ameliorated LPS-induced dermatitis in WT but not Clec10a-deficient mice. Moreover, Tn antigen-PAA suppressed LPS-induced production of inflammatory cytokines IL-6 and TNF-α by bone marrow-derived cultured macrophage in vitro. These results indicate that Tn antigen is a functional Clec10a-L in HdM that suppresses TLR4-induced macrophage activation in the skin. © 2025 The Authors

关键词： Atopic dermatitis House dust mite NC/Nga mouse Toll-like receptors

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A novel strategy towards the fabrication of highly stable and sensitive non-enzymatic glucose sensor based on Ni3N thin films using high power impulse magnetron sputtering

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Applied Surface science 2024年 669卷

作者： Pardhi, Nishchal Cheng, Wei-Chun Chen, Sheng-Chi Akshay Joshi, Shikha Govindasamy, Mani Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City243303 Taiwan College of Engineering and Center for Green Technology Chang Gung University Taoyuan333 Taiwan Department of Materials Engineering Indian Institute of Science Bangalore560012 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Glucose level surveillance in mankind is considered the greatest need of recent times to achieve healthy lifestyle goals due to its health-related concern for humans. To fulfill the need, Nickel-based compounds emerge with excellent bio-mimic properties. However, due to the poor electrical properties of oxides and hydroxides of Ni, developing a supporting base that can enhance electron transportation is mandatory. The present work is dedicated to non-enzymatic glucose detection by electrochemical means on the Ni3N thin film on an Indium-doped Tin Oxide (ITO) substrate as a working electrode in an alkaline medium. The Ni3N films use HiPIMS as a deposition technique due to its high ionization rate of sputtered species and dense plasma which helps the Ni ions to react with nitrogen in the formation of a perfect Ni3N phase, and it is a green process that can contribute to sustainable manufacturing. Ni3N thin film deposited at a 60 % N2 flow ratio shows the largest crystallinity and catalytic properties, which helps this modified electrode to have significant potential for glucose detection. The Ni3N modified electrode acquires a lower linear range of 0.001–1.25 mM with sensitivity and Limit of detection (LOd) of 337.46 µAmM–1cm−2, and 0.78 µM, respectively, and a higher linear range of 1.25–7.3161 mM with a sensitivity of 158.58 µAmM–1cm−2. The amperometric measurements reveal the fast response of the electrode towards glucose detection at 2.46 secs. The key measures of the electrode according to the corresponding measurements are satisfactory selectivity, reproducibility, repeatability, and operational stability. The modified electrode shows a significant response for real samples such as commercially available honey, apple juice, and biological fluids. © 2024 Elsevier B.V.

关键词： Thin films

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Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left- and right-sided breast cancer

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Thoracic Cancer 2023年第26期14卷 2696-2706页

作者： Wang, Shan-Ying Tsai, Wei-Ta Lin, Kuan-Heng Yu, Chih-Wei Yang, Shu-Ya Shueng, Pei-Wei Wu, Yen-Wen Hsu, Chen-Xiong Wu, Tung-Hsin Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan Department of Nuclear Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Department of Radiation Oncology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan Division of Radiation Oncology Department of Radiology Far Eastern Memorial Hospital New Taipei City Taiwan Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan Department of Radiation Oncology China Medical University Hsinchu Hospital Zhubei City Taiwan Institute of Nuclear Engineering and Science National Tsing Hua University Hsinchu City Taiwan Department of Nuclear Medicine Cheng Hsin General Hospital Taipei Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Division of Cardiology Cardiovascular Medical Center Far Eastern Memorial Hospital New Taipei City Taiwan

Background: This study aimed to utilize an innovative method of integrating the 20 subvolume dose of left ventricle and the Tl-201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters in patients with left- and right-sided breast cancer after radiation therapy. Methods: Female patients with breast cancer underwent SPECT MPI before commencing radiotherapy and 12 months later were enrolled from January 2014 to december 2018. The images of CT simulation and SPECT MPI were integrated into the treatment planning system. The differences of doses and parameters of MPI in all cardiac subvolumes between left- and right-sided breast cancer patients were analyzed. Results: Patients with left-sided breast cancer (n = 61) received a higher radiation dose to the heart, left ventricular, and its territories and subvolumes, compared to patients with right-sided breast cancer (n = 19). The 20-segment analysis also showed statistically significant disparities in the average radiation doses received by the two groups. In different coronary artery territories, the end-diastolic perfusion and end-systolic perfusion showed a decrease in both sides, with no significant differences. However, the wall motion and wall thickening showed a significant decline in subregions within the left- and right-sided coronary artery territories. Conclusion: This study demonstrates an innovative integrated method combining the left ventricular 20 regional doses with SPECT MPI which shows that left-sided breast cancer patients receive a higher subvolume dose than right-sided breast cancer patients. Further research is needed to confirm the potential impact on heart function after radiotherapy on both sides. © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

关键词： myocardial perfusion imaging radiation therapy subvolume dose

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Potential PCR amplification bias in identifying complex ecological patterns: Higher species compositional homogeneity revealed in smaller-size coral reef zooplankton by metatranscriptomics

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Molecular Ecology Resources 2024年第3期24卷 e13911-e13911页

作者： Mattos, Felipe M. G. dreyer, Niklas Fong, Chia-Ling Wen, Yung-Hui Victoria Jain, dharmesh de Vivo, Mattia Huang, Yu-Sin Mwihaki, John Karichu Wang, Tzi-Yuan Ho, Ming-Jay Tsai, Isheng Jason Wang, John Chan, Benny K. K. Machida, Ryuji J. Biodiversity Research Center Academia Sinica Taipei Taiwan Department of Life Science National Taiwan Normal University Taipei Taiwan Biodiversity Program Taiwan International Graduate Program Academia Sinica and National Taiwan Normal University Taipei Taiwan Natural History Museum of Denmark Invertebrate Zoology University of Copenhagen Copenhagen Denmark Institute of Plant and Microbial Biology Academia Sinica Taipei Taiwan Ph.D. Program in Microbial Genomics National Chung Hsing University and Academia Sinica Taipei Taiwan Graduate Institute of Biotechnology National Chung Hsing University Taichung Taiwan Molecular and Biological Agricultural Sciences Taiwan International Graduate Program Academia Sinica and National Chung Hsing University Taipei Taiwan

PCR-based high-throughput sequencing has permitted comprehensive resolution analyses of zooplankton diversity dynamics. However, significant methodological issues still surround analyses of complex bulk community samples, not least as in prevailing PCR-based approaches. Marine drifting animals—zooplankton—play essential ecological roles in the pelagic ecosystem, transferring energy and elements to higher trophic levels, such as fishes, cetaceans and others. In the present study, we collected 48 size-fractionated zooplankton samples in the vicinity of a coral reef island with environmental gradients. To investigate the spatiotemporal dynamics of zooplankton diversity patterns and the effect of PCR amplification biases across these complex communities, we first took metatranscriptomics approach. Comprehensive computational analyses revealed a clear pattern of higher/lower homogeneity in smaller/larger zooplankton compositions across samples respectively. Our study thus suggests changes in the role of dispersal across the sizes. Next, we applied in silico PCR to the metatranscriptomics datasets, in order to estimate the extent of PCR amplification bias. Irrespective of stringency criteria, we observed clear separations of size fraction sample clusters in both metatranscriptomics and in silico datasets. In contrast, the pattern—smaller-fractioned communities had higher compositional homogeneity than larger ones—was observed in the metatranscriptomics data but not in the in silico datasets. To investigate this discrepancy further, we analysed the mismatches of widely used mitochondrial CO1 primers and identified priming site mismatches likely driving PCR-based biases. Our results suggest the use of metatranscriptomics or, although less ideal, redesigning the CO1 primers is necessary to circumvent these issues. © 2023 The Authors. Molecular Ecology Resources published by John Wiley & Sons Ltd.

关键词： coral reef diversity in silico PCR metatranscriptomics size fraction zooplankton

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The Mid-Infrared Region Absorption of Graphene-based photodetector with Au-grating Structure

The Mid-Infrared Region Absorption of Graphene-based Photode...

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IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMEd)

作者： Wei-Yu Long Kuan-Chou Lin Yu-Xuan Lu Chih-Ting Lin B.S. degree from the Department of Electrical Engineering from National Taiwan University. He is currently a Ph.D candidate in the Graduate School of Advanced Technology National Taiwan University B.S. degree in civil engineering from National Taiwan University and M.S. degree in Institute of Electronics Engineering National Taiwan University B.S. degree from the Department of Materials Science and Engineering from Central South University China B.S. degree in civil engineering from National Taiwan University the M.S. degree in Institute of Applied Mechanics from National Taiwan University and the Ph.D. degree in electrical engineering and computer science University of Michigan Ann Arbor MI USA

Graphene, a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice, has garnered immense attention for its exceptional electrical conductivity, transparency, and mechanical strength. These properties make graphene an ideal candidate for photodetectors, as it can efficiently convert incident photons into electrical signals. The integration of graphene into surface plasmonic devices has opened up new avenues for photodetection technology. In our research, we combine graphene and surface plasmonic devices to realize a high responsivity mid-infrared graphene photodetector with a grating metal/graphene/SiO 2 structure. The Bruker Vertex70 Fourier-transform infrared spectroscopy (FTIR) was used for the mid-infrared spectrum measurement. With different linewidth of Au grating structure, the peak of absorption redshifts as the grating linewidth increases and the intensity is also different. Further, by adding graphene, the total absorption increases. due to these advantages, the Au-grating graphene device can be used as infrared photodetectors.

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Optically Tunable Many-Body Exciton-phonon Quantum Interference

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Advanced science 2024年第40期11卷 e2404741页

作者： Chang, Si-Jie Huang, Po-Chun Su, Jia-Sian Hsieh, Yu-Wei Quiroz Reyes, Carlos Jose Fan, Ting-Hsuan Sun, Han-Sheng Nguyem, Ai-phuong Liu, Te-I Cheng, Ho-Wen Lin, Ching-Wei Hayashi, Michitoshi Yong, Chaw-Keong Department of Physics National Taiwan University Taipei10617 Taiwan Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei235603 Taiwan Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Graduate Program of Molecular Science and Technology National Taiwan University Taipei106319 Taiwan Center for Condensed Matter Sciences National Taiwan University Taipei10617 Taiwan Center of Atomic Initiative for New Materials National Taiwan University Taipei10617 Taiwan National Center for Theoretical Sciences Taipei10617 Taiwan

This study introduces a novel paradigm for achieving widely tunable many-body Fano quantum interference in low-dimensional semiconducting nanostructures, beyond the conventional requirement of closely matched energy levels between discrete and continuum states observed in atomic Fano systems. Leveraging Floquet engineering, the remarkable tunability of Fano lineshapes is demonstrated, even when the original discrete and continuum states are separated by over 1 eV. Specifically, by controlling the quantum pathways of discrete phonon Raman scattering using femtosecond laser pulses, the Raman intermediate states across the excitonic Floquet band are tuned. This manipulation yields continuous transitions of Fano lineshapes from antiresonance to dispersive and to symmetric Lorentzian profiles, accompanied by significant variations in Fano parameter q and Raman intensity spanning 2 orders of magnitude. A subtle shift in the excitonic Floquet resonance is further shown, achieved by controlling the intensity of the femtosecond laser, which profoundly modifies quantum interference strength from destructive to constructive interference. The study reveals the crucial roles of Floquet engineering in coherent light-matter interactions and opens up new avenues for coherent control of Fano quantum interference over a broad energy spectrum in low-dimensional semiconducting nanostructures. © 2024 The Author(s). Advanced science published by Wiley-VCH GmbH.

关键词： Femtosecond lasers

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COVId-19 Associated Bacteremia withChryseobacterium indologenesCo-HarboringblaINd-2,blaCIAandblaCcrA

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Infection and drug Resistance 2022年 15卷 167-170页

作者： Ting-Kuang Yeh Zong-Hao Li Yao-Ting Huang Po-Yu Liu 1 Division of Infectious Diseases Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan 2 Department of Computer Science and Information Engineering National Chung Cheng University Chiayi Taiwan 1 Division of Infectious Diseases Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan3 Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan4 Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan

We report a COVId-19 case with carbapenem resistantChryseobacterium indologenesbacteremia. Whole genome sequencing identified the presence ofblaINd-2,blaCIAandblaCcrA. To our knowledge, this is the first report ofChryseobacterium indologenescomplicating COVId-19 and the detection ofblaCcrAinC. indologenes. The presence ofblaCcrAinChryseobacteriumwas overlooked previously may related to substantial sequence divergence with the original allele inBacteroides fragilis. Antimicrobial resistance (AMR) is a challenge to global health in the age of COVId-19 pandemic. Further study and surveillance of underlying mechanisms is needed.

关键词： COVId-19 SARS-CoV-2 Chryseobacterium indologenes resistance

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