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Review of Nitrous Oxide intoxication

Journal of Internal Medicine of Taiwan 2021年第3期32卷 180-184页

作者： Tseng, Min-Feng Feng, Chia-Hsien Lin, Yi-Ching Liao, Chen-Yi Wu, Chia-Chao Ph.D. Program in Toxicology College of Pharmacy Kaofisiung Medical University Kaohsiung Taiwan Department of Fragrance and Cosmetic Science College of Pharmacy Kaofisiung Medical University Kaohsiung Taiwan Department of Internal Medicine Zuoying Branch of Kaofisiung Armed Forces General Hospital Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan Department of Laboratory Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Department of Pediatrics Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan Department of Laboratory Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Armed Forces General Hospital Kaohsiung Taiwan

Inhalants for recreational use in the United States rise in the 1950s and is widespread among adolescents now. The main use of inhalants Is for entertainment. After Inhalation, nitrous oxide can be rapidly absorbed into the blood through the alveolar capillaries and act neurologic effect. Nitrous oxide related neurologic dysfunction was related to serum vitamin B12 levels decline. Acute and chronic nitrous oxide intoxication will lead to central nervous system(CNS), pulmonary and cardiovascular damages including confusion, pneumonitis, dyspnea and arrhythmia. The treatment of nitrous-oxide Induced neuropathy can be alleviated by ceasing nitrous oxide use, vitamin B12 supplements. © 2021 Society of Internal Medicine of Taiwan. All rights reserved.

关键词： Nitrous oxide Inhalants Vitamin B12

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The discrete fourier transform for golden angle Linogram sampling

arXiv

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arXiv 2019年

作者： Helou, Elias S. Zibetti, Marcelo V.W. Axel, Leon Block, Kai Tobias Regatte, Ravinder R. Herman, Gabor T. Institute of Mathematical Sciences and Computation University of São Paulo São CarlosSP Brazil Center for Biomedical Imaging Department of Radiology New York University School of Medicine New YorkNY United States Ph.D. Program in Computer Science City University of New York New YorkNY United States

Estimation of the discrete-Time Fourier Transform (dTFT) at points of a finite domain arises in many imaging applications. A new approach to this task, the Golden Angle Linogram Fourier domain (GALFd), is presented, together with a computationally fast and accurate tool, named Golden Angle Linogram Evaluation (GALE), for approximating the dTFT at points of a GALFd. A GALFd resembles a Linogram Fourier domain (LFd), which is efficient and accurate. A limitation of linograms is that embedding an LFd into a larger one requires many extra points, at least doubling the domain’s cardinality. The GALFd, on the other hand, allows for incremental inclusion of relatively few data points. Approximation error bounds and floating point operations counts are presented to show that GALE computes accurately and efficiently the dTFT at the points of a GALFd. The ability to extend the data collection in small increments is beneficial in applications such as Magnetic Resonance Imaging. Experiments for simulated and for real-world data are presented to substantiate the theoretical claims. The mathematical analysis, algorithms, and software developed in the paper are equally suitable to other angular distributions of rays and therefore we bring the benefits of linograms to arbitrary radial *** Codes 65T50, 94A08, 97N40 Copyright © 2019, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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ClustMap: A topology-aware MPI process placement algorithm for multi-core clusters 1

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2nd International Conference on Intelligent Computing and Communication, ICICC 2017

作者： Manwade, K.B. Kulkarni, d.B. Department of Computer Science and Engineering Ph.D. Research Center Walchand College of Engineering SangliMaharashtra India Shivaji University KolhapurMaharashtra India Department of Information Technology Walchand College of Engineering SangliMaharashtra India

ISBN: (数字)9789811072451

ISBN: (纸本)9789811072444

Many high-performance computing applications are using MPI (Message Passing Interface) for communication. The performance of MPI library affects the performance of MPI applications. Various techniques like communication latency reduction, increasing bandwidth, and increasing scalability are available for improving the performance of message passing. In multi-core cluster environment, the communication latency can be further reduced by topology-aware process placement. This technique involves three steps: finding communication pattern of MPI application (application topology), finding architecture details of underlying multi-core cluster (system topology), and mapping processes to cores. In this paper, we have proposed novel "ClustMap" algorithm for the third step. By using this algorithm, both system and application topologies are mapped. The experimental results show that the proposed algorithm outperforms over existing process placement techniques. © 2018, Springer Nature Singapore Pte Ltd.

关键词： Message passing

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Enhanced exopolysaccharide production of Cordyceps militaris via mycelial cell immobilization on plastic composite support in repeated-batch fermentation

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International Journal of Biological Macromolecules 2023年第1期250卷 126267页

作者： Lin, Shin-Ping Sung, Ting-Hsuan Angkawijaya, Artik Elisa Go, Alchris Woo Hsieh, Chang-Wei Hsu, Hsien-Yi Santoso, Shella Permatasari Cheng, Kuan-Chen School of Food Safety Taipei Medical University #250 Wuxing Street Xinyi Dist. Taipei11042 Taiwan Research Center of Biomedical Device Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Nutrition and Health Sciences Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Center for Sustainable Resource Science RIKEN Yokohama230-0045 Japan Department of Chemical Engineering National Taiwan University of Science and Technology #43 Sec. 4 Keelung Rd Taipei10607 Taiwan Department of Food Science and Biotechnology National Chung Hsing University South Dist. Taichung City40227 Taiwan Department of Medical Research China Medical University Hospital North Dist. Taichung City404333 Taiwan Taiwan Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Energy and Environment Department of Materials Science and Engineering City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Jl. Kalijudan 37 East Java Surabaya60114 Indonesia Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung40

Repeated-batch fermentation with fungal mycelia immobilized in plastic composite support (PCS) eliminates the lag phase during fermentation and improves metabolite productivity. The strategy is implemented herein, and a novel modified PCS is developed to enhance exopolysaccharide (EPS) production from the medicinal fungus Cordyceps militaris. A modified PCS (SYE + PCS) was made by compositing polypropylene (PP) with a nutrient mixture containing soybean hull, peptone, yeast extract, and minerals (SYE+). The use of SYE + PCS has consistent cell productivity throughout the multiple fermentation cycles, which resulted in a more higher cell productivity after second batch compared to unmodified PCS. The cell grown on SYE + PCS also generates a higher yield of EPS (3.36, 6.93, and 5.72 g/L in the first, second, and third fermentation cycles, respectively) up to three-fold higher than the cell immobilized on unmodified PCS. It is also worth noting that the EPS from mycelium grown on SYE + PCS contains up to 2.3-fold higher cordycepin than those on unmodified PCS. The presence of nutrients in SYE + PCS also affects the hydrophobicity and surface roughness of the PC, improving mycelial cell adhesion. This study also provides a preliminary antioxidant activity assessment of EPS from immobilized C. militaris grown with SYE + PCS. © 2023

关键词： Mycelium

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Correction to: Biological synthesis and characterization of iron oxide (FeO) nanoparticles using Pleurotus citrinopileatus extract and its biomedical applications

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Biomass Conversion and Biorefinery 2023年第11期14卷 12587-12587页

作者： Manimaran, Kumar Yanto, dede Heri Yuli Govindasamy, Mani Karunanithi, Bogeshwaran Alasmary, Fatmah Ali Habab, Reem Abdulrahman Research Center for Applied Microbiology National Research and Innovation Agency (BRIN) Cibinong Republic of Indonesia Department of Product Development Institute of Biotechnology Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India Faculty International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Korea University Seongbuk-gu Republic of Korea Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam India Department of Petroleum Engineering Dhaanish Ahmed College of Engineering Chennai India Department of Chemistry College of Science King Saud University Riyadh Saudi Arabia

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Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury

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Molecular neurobiology 2023年第4期60卷 2200-2208页

作者： Shao-Ming Wang Jung-Yu C Hsu Chiung-Yuan Ko Hsiang-En Wu Yu-Wei Hsiao Ju-Ming Wang Graduate Institute of Biomedical Sciences China Medical University Taichung 404333 Taiwan. wangs@mail.cmu.edu.tw. Neuroscience and Brain Disease Center China Medical University Taichung Taiwan. wangs@mail.cmu.edu.tw. Department of Neurology China Medical University Hospital Taichung Taiwan. wangs@mail.cmu.edu.tw. Department of Cell Biology and Anatomy College of Medicine National Cheng Kung University Tainan Taiwan. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. TMU Research Center of Neuroscience Taipei Medical University Taipei Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Taiwan. Cellular Pathobiology Section Integrative Neuroscience Research Branch Intramural Research Program National Institute on Drug Abuse NIH/DHHS Suite 3512 333 Cassell Drive Baltimore MD 21224 USA. Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan. Department of Biotechnology and Bioindustry Sciences College of Bioscience and Biotechnology National Cheng Kung University Tainan Taiwan. yumingw@mail.ncku.edu.tw. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan. yumingw@mail.ncku.edu.tw. International Research Center for Wound Repair and Regeneration National Cheng Kung University Tainan Taiwan. yumingw@mail.ncku.edu.tw. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. yumingw@mail.ncku.edu.tw. Institute of Bioinformatics and Biosignal Transduction College of Bioscience and Biotechnology National Cheng Kung University Tainan 701 Taiwan. yumingw@mail.ncku.edu.tw.

Astroglial-fibrotic scars resulted from spinal cord injury affect motor and sensory function, leading to paralysis. In particular, the fibrotic scar is a main barrier that disrupts neuronal regeneration after spinal cord injury. However, the association between astrocytes and fibrotic scar formation is not yet understood. We have previously demonstrated that the transcriptional factor Cebpd contributes to astrogliosis, which promotes glial scar formation after spinal cord injury. Herein, we show that fibrotic scar formation was decreased in the epicenter region in Cebpd mice after contusive spinal cord injury and astrocytic Cebpd promoted fibroblast migration through secretion of Ptx3. Furthermore, the expression of Mmp3 was increased under recombinant protein Ptx3 treatment in fibroblasts by observing microarray data, resulting in fibroblast migration. In addition, regulation of Mmp3 occurs through the NFκB signaling pathway by using an irreversible inhibitor of IκBα phosphorylation in pretreated fibroblasts. Of note, we used the synthetic peptide RI37, which blocks fibroblast migration and decreases fibroblast Mmp3 expression in IL-1β-treated astrocyte conditioned media. Collectively, our data suggest that fibroblast migration can be affected by astrocytic Cebpd through the Ptx3/NFκB/Mmp3 axis pathway and that the RI37 peptide may act as a therapeutic medicine to inhibit fibrotic scar formation after spinal cord injury.

关键词： Astrocyte Cebpd Fibrotic scar Ptx3 Spinal cord injury

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Local single-dose radiation improves adoptive cell therapy with tumor infiltrating lymphocytes

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International Journal of Radiation Oncology*Biology*physics 2025年

作者： N. Obertopp R.A. Bekker G.d. Grass T. Zelenka A. Thomas M. Potez J. Ali J. Blauvelt A.M. Hall M.S. Hall C.H. Chung H. Enderling S. Pilon-Thomas Department of Immunology H. Lee Moffitt Cancer Center & Research Institute Tampa Florida USA Cancer Biology Ph.D. Program University of South Florida Tampa Florida USA Department of Integrated Mathematical Oncology H. Lee Moffitt Cancer Center & Research Institute Tampa Florida USA Department of Radiation Oncology H. Lee Moffitt Cancer Center & Research Institute Tampa Florida USA Department of Head and Neck-Endocrine Oncology H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston Texas 77030 USA Institute for Data Science in Oncology The University of Texas MD Anderson Cancer Center Houston Texas 77030 USA

Introduction The potential for radiation therapy (RT) to enhance adoptive cell therapy (ACT) with tumor-reactive T cells has not been fully explored. This study evaluated combining RT with ACT, applying RT at two critical time points: (1) before tumor resection to improve TIL ex vivo expansion of tumor infiltrating lymphocytes (TIL) and (2) on the day of ACT using antigen-specific T cells to enhance T-cell infiltration after transfer. Methods Using a murine HPV+ head and neck squamous cell carcinoma model, we administered single-dose RT (8 Gy x 1) five days before tumor resection. RNA sequencing was performed to measure chemokine expression post-RT. Tumor fragments were cultured in IL-2 for TIL expansion, and TIL reactivity was assessed through cytokine production assays. Tumor-bearing mice were treated with ACT with TIL expanded from untreated or RT-treated tumors. In additional experiments, we assessed whether RT given in combination with ACT could improve infiltration of T cells and anti-tumor activity. Results RT preconditioning significantly enhanced ex vivo TIL expansion (96% vs. 74%, p<0.05) and increased TNFα production (p=0.03), indicating improved reactivity. RT also significantly increased the expansion of TNFα+GzmB+ Cd8+ TILs (p=0.02), suggesting enhanced polyfunctionality within a cytotoxic subset. RNA sequencing revealed upregulation of key chemokines (e.g., CCL21, CXCL10 ) and their receptors ( CCR7, CXCR4 ), supporting enhanced TIL recruitment. ACT with TIL from RT-preconditioned tumors demonstrated superior tumor control, with 50% of mice achieving complete tumor regression (CR) compared to 12.5% in controls. RT on the day of ACT increased T-cell infiltration into tumor and improved tumor rejection compared to mice receiving either ACT or RT alone. Conclusions RT at two distinct time points—before tumor resection to enhance TIL expansion and on the day of ACT to boost T-cell infiltration—significantly improves TIL the efficacy of ACT. These findings

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Building a Model for Predicting Target Gene Expression in Rice T-dNA Insertional Mutants by Machine Learning Approaches

Research Square

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Research Square 2020年

作者： Liao, Chi-Chou Chen, Liang-Jwu Lo, Shuen-Fang Chen, Chi-Wei Chen, Jia-Jyun Chu, Yen-Wei Institute of Molecular Biology National Chung Hsing University Taichung Taiwan Agricultural Biotechnology Center National Chung Hsing University Taichung Taiwan Institute of Molecular Biology Academia Sinica Taipei Taiwan Department of Computer Science and Engineering National Chung Hsing University Taichung Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan Biotechnology Center National Chung Hsing University Taichung Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung402 Taiwan

Background: T-dNA activation-tagging technology is widely used to enhance flanking gene expression near the site of insertion for functional genomics research in rice. However, whether the expression of a gene of interest is enhanced must be validated experimentally. Results: In this study, we built a model to predict gene expression in T-dNA mutants by machine learning approaches, thereby improving the efficiency of screening for activated genes. We gathered experimental consisting of gene expression data in T-dNA mutants and captured the PROMOTER and MIddLE sequences for encoding. In first-layer models, SVM models were constructed with nine features consisting of information about biological function and local and global sequences. Feature-encoding based on the PROMOTER sequence was weighted by logistic regression. The second-layer models integrated 16 first-layer models with feature selection and the algorithm, which were selected from nine feature selection methods and 65 classified methods, respectively. The accuracy of the final two-layer machine learning model, referred to as was 99.3% based on fivefold cross-validation, and 85.6% based on independent-testing. Conclusion: We discovered that the information within the local sequence had a greater contribution than the global sequence with respect to classification had a good predictive ability for target genes within 20 from the 35S enhancer. Based on the analysis of significant sequences, the G-box regulatory sequence may also play an important role in the mechanism of activation of the 35S enhancer. © 2020, CC BY.

关键词： Gene expression

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Enhancing miso production with optimized puffed-rice koji and its biological function evaluation

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Food Bioscience 2024年 60卷

作者： Lin, Shin-Ping Chou, Yu-Chieh Chen, Chiao-En Lai, Yen-Tso Hsieh, Chen-Che Tsai, Tsung-Yu Lin, Yun-Hsin Santoso, Shella Permatasari Lin, Hui-Wen Cheng, Kuan-Chen School of Food Safety Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Research Center of Biomedical Device Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University 250 Wu-Hsing Street Taipei 11031 Taiwan Institute of Food Science and Technology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei 10617 Taiwan Department of Food and Nutrition Providence University 200 Sec. 7 Taiwan Boulevard Shalu Dist. Taichung 43301 Taiwan Institute of Biotechnology National Taiwan University 1 Roosevelt Rd. Sec. 4 Taipei 10617 Taiwan Department of Food Science Fu Jen Catholic University 510 Zhongzheng Rd. Xinzhuang Dist. New Taipei City 242062 Taiwan Department of Chemical Engineering Widya Mandala Surabaya Catholic University 37 Jl. Kalijudan 37 East Java Surabaya 60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability 37 Jl. Kalijudan East Java Surabaya 60114 Indonesia Department of Optometry Asia University 500 Lioufeng Rd. Wufeng Taichung 41354 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung 40402 Taiwan

In order to enhance enzyme activities of koji and further improve the health benefits and nutritional value of miso, puffed rice was used to prepare koji with optimization of fermentation utilizing response surface methodology (RSM), and the optimized puffed rice koji was used to produce miso and low-salt miso. Results showed that β-glucosidase activity increased by 1.98-fold after RSM optimization. The optimized puffed rice koji also showed the highest β-amylase and protease activities (237.1 and 968.8 units/g, respectively) compared to rice koji (108.7 and 637.4 units/g, respectively). Moreover, miso made from puffed-rice koji presented a much higher polyphenol content, antioxidant activity, and aglycone conversion. These findings clarified the relationship between changes in enzyme activities in koji and the important components of miso, and also advance solid-state fermentation research and development of functional miso. © 2024

关键词： Aspergillus oryzae Koji Miso Puffed rice Solid-state fermentation β-glucosidase

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Breed as One of Significant Factors that determine the Level of Yield and Its Quality

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IOP Conference Series: Earth and Environmental science 2022年第4期988卷

作者： E V Matvienko A L Zolkin d K Suchkov L A Pankratova PhD in Biological Science Junior Researcher of the Laboratory of Breeding and Seed Farming of Cereal and Sorghum Crops Volga NIISS - branch of the Samara Scientific Center of the Russian Academy of Sciences Ph.D. in Engineering Science Senior Lecturer of Computer and Information Sciences Department of the Povolzhskiy State University of Telecommunications and Informatics Junior Researcher Federal Research Center for Agroecology Integrated Land Reclamation and Protective Afforestation of the Russian Academy of Sciences (Laboratory for Predicting the Bio-productivity of Agroforestscapes) PhD in Geography Senior Lecturer of the Physical Geography and Landscape Planning Department Institute of Earth Sciences St.Petersburg State University

Breed is studied in the article as of significant factors that determine the level of yield and its quality. World experience shows that the consistent increase in the yield of cultivated crops is based on the improvement of the cultivation technology and the achievements of breeding. The production of agricultural products is based on the variety of breeds. According to A.A. Zhuchenko, breed determines the basic requirements for cultivation technologies: productivity, energy efficiency, environmentally friendly quality and environmental protection. It is believed that 25% of the yield is determined by the genetic characteristics of the cultivated breed. The role of the genotype in increasing and stabilizing the yield is constantly increasing, and the contribution of the breed during zoning is estimated at 30 ... 50%.

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