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Growth kinetics of Saccharomyces cerevisiae and tape yeast on the cassava pulp fermentation

Journal of physics: Conference Series 2020年第1期1500卷

作者： Beni Hidayat Udin Hasanudin M. Muslihudin Syamsu Akmal Siti Nurdjanah Neti Yuliana Agricultural Technology Department Politeknik Negeri Lampung 10 SoekarnoHatta Street Bandar Lampung 35144 Indonesia Ph.D. student of Agriculture Science Study Program University of Lampung 1 Soemantri Brojonegoro Street Bandar Lampung 35145 Indonesia Agricultural Product Technology Department Faculty of Agriculture University of Lampung 1 Soemantri Brojonegoro Street Bandar Lampung 35145 Indonesia

Saccharomyces cerevisiae is the most commonly used yeast in the fermentation process on high starch/carbohydrate substrates, for example, cassava pulp, a by-product from the tapioca industry. In addition to the pure culture of S. cerevisiae, the fermentation process of cassava pulp can be done using tape yeast (a consortium of yeast, fungal and bacteria). The objective of this research was to study the growth kinetics of S. cerevisiae and tape yeast on cassava pulp fermentation. The growth kinetics of Saccharomyces cerevisiae and tape yeast was observed through cells number, rate of starch degradation, rate of dietary fiber degradation, rate of cyanide degradation, and rate of protein formation. The research showed that the S. cerevisiae pure culture could grow better during cassava pulp fermentation compared to tape yeast, which is reflected by the logarithmic growth rate (up to 72 h versus 48 h). The difference in the growth rate between S. cerevisiae pure culture and tape yeast will cause a difference in starch degradation rate (73.02 mg/h versus 65.09 mg/h), dietary fiber degradation rate (87.33 mg/h versus 21.09 mg/h), cyanide degradation rate (92.57.10−2 ppm/h versus 97.49.10−2 ppm/h), protein formation rate (48.92 mg/h versus 50.08 mg/h).

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The design of Automatic Bird data Capture Systems

The Design of Automatic Bird Data Capture Systems

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IEEE International Conference on Consumer Electronics-Taiwan (ICCE-TW)

作者： Chia-Yuan Lin Yi-Chun Lin Che-Jui Chang Chi-Feng Chen Ming-Fong Tsai Department of Information Engineering and Computer Science Feng Chia University Taiwan Information and Communications Research Laboratories Industrial Technology Research Institute Taiwan Industrial Ph.D. Program of Internet of Things Feng Chia University Taiwan Departrnent of Electronic Engineering National United University Taiwan

This paper implements an automatic bird data capture system which uploads data captured from social network websites to the server and stores them in the database. When using the Facebook API to capture data of interest, the system needs to filter the captured data to avoid false data storage. This paper takes building an automatic system that includes reinforcing the training database of the bird community as a top priority.

关键词： Birds databases Facebook Machine learning Servers System implementation

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Corrigendum to "1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma" [Eur. J. Med. Chem. 140 (2017) 84-91]

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European journal of medicinal chemistry 2020年 202卷 112633页

作者： Yi-Min Liu Wei-Chun HuangFu Han-Li Huang Wei-Cheng Wu Yi-Lin Chen Yun Yen Hsiang-Ling Huang Chih-Ying Nien Mei-Jung Lai Shiow-Lin Pan Jing-Ping Liou School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan. The Ph.D. Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Center for Translational Medicine Taipei Medical University Taiwan. The Ph.D. Program for Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Pharmacology College of Medicine Taipei Medical University Taipei Taiwan. Electronic address: slpan@tmu.edu.tw. School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan School of Pharmacy National Defense Medical Center Taipei Taiwan. Electronic address: jpl@tmu.edu.tw.

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BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters

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Allergy 2023年第7期78卷 2036-2040页

作者： Yuan-Ting Hsu Chao-Chien Wu Chin-Chou Wang Wen-Yu Chung Chau-Chyun Sheu Yi-Hsin Yang Ming-Yen Cheng Ruay-Sheng Lai Sum-Yee Leung Chi-Cheng Lin Yu-Feng Wei Ching-Hsiung Lin Sheng-Hao Lin Jeng-Yuan Hsu Wei-Chang Huang Chia-Cheng Tseng Yung-Fa Lai Meng-Hsuan Cheng Huang-Chi Chen Chih-Jen Yang Chian-Heng Su Chien-Jen Wang Shih-Chang Hsu Chih-Hsing Hung Chon-Lin Lee Ming-Shyan Huang Shau-Ku Huang National Institute of Environmental Health Sciences National Health Research Institutes Miaoli Taiwan. Department of Internal Medicine Division of Pulmonary and Critical Care Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan. Department of Public Health Kaohsiung Medical University Kaohsiung Taiwan. Department of Computer Science and Information Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan. Department of Internal Medicine Division of Pulmonary and Critical Care Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan. Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. Department of Mathematics Hong Kong Baptist University Hong Kong China. Division of Chest Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan. Department of Internal Medicine Chest Division Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital Pingtung Taiwan. Department of Internal Medicine E-Da Cancer Hospital I-Shou University Kaohsiung Taiwan. Department of Internal Medicine Division of Chest Medicine Changhua Christian Hospital Changhua Taiwan. Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan. Department of Recreation and Holistic Wellness MingDao University Changhua Taiwan. Department of Medical Research Division of Clinical Research Taichung Veterans General Hospital Taichung Taiwan. Department of Internal Medicine Division of Chest Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Medical Technology Jen-Teh Junior College of Medicine Nursing and Management Miaoli Taiwan. School of Medicine Chung Shan Medical University Taichung Taiwan. Ph.D. Program in Translational Medicine National Chung Hsing Universi

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STRING-AVERAGING ALGORITHMS FOR CONVEX FEASIBILITY WITH INFINITELY MANY SETS

arXiv

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arXiv 2018年

作者： Kong, T. Yung Pajoohesh, Homeira Herman, Gabor T. Computer Science Department Queens College City University of New York FlushingNY11367 United States Mathematics Department Medgar Evers College City University of New York BrooklynNY11225 United States Computer Science Ph.D. Program The Graduate Center City University of New York New YorkNY10016 United States

Algorithms for convex feasibility find or approximate a point in the intersection of given closed convex sets. Typically there are only finitely many convex sets, but the case of infinitely many convex sets also has some applications. In this context, a string is a finite sequence of points each of which is obtained from the previous point by considering one of the convex sets. In a string-averaging algorithm, an iterative step from a first point to a second point computes a number of strings, all starting with the first point, and then calculates a (weighted) average of those strings’ end-points: This average is that iterative step’s second point, which is used as the first point for the next iterative step. For string-averaging algorithms based on strings in which each point either is the projection of the previous point on one of the convex sets or is equal to the previous point, we present theorems that provide answers to the following question: "How can the iterative steps be specified so that the string-averaging algorithm generates a convergent sequence whose limit lies in the intersection of the sets of a given convex feasibility problem?" This paper focuses on the case where the given collection of convex sets is infinite, whereas prior work on the same question that we are aware of has assumed the collection of convex sets is finite (or has been applicable only to a small subset of the algorithms we consider). The string-averaging algorithms that are shown to generate a convergent sequence whose limit lies in the intersection are also shown to be perturbation resilient, so they can be superiorized to generate sequences that also converge to a point of the intersection but in a manner that is superior with respect to some application-dependent criterion.46N10 46N40 47H09 47H10 47J25 47N10 65F10 65J99 65K10 90C25 90C30 Copyright © 2018, The Authors. All rights reserved.

关键词： Iterative methods

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Correction: Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAd+/ SIRT1 axis

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Journal of biomedical science 2024年第1期31卷 61页

作者： B Linju Yen Li-Tzu Wang Hsiu-Huang Wang Chin-Pao Hung Pei-Ju Hsu Chia-Chi Chang Chien-Yu Liao Huey-Kang Sytwu Men-Luh Yen Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. blyen@nhri.edu.tw. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University No. 250 Wuxing Street Taipei 11042 Taiwan. Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University No.250 Wuxing Street Taipei 11042 Taiwan. Regenerative Medicine Research Group Institute of Cellular & System Medicine National Health Research Institutes (NHRI) No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Life Sciences National Defense Medical Center (NDMC) No.161 Section Minquan East Road Taipei 11490 Taiwan. National Institute of Infectious Diseases & Vaccinology NHRI No.35 Keyan Road Zhunan 35053 Taiwan. Graduate Institute of Microbiology & Immunology NDMC No.161 Section 6 Minquan East Road Taipei 11490 Taiwan. Department of Obstetrics & Gynecology National Taiwan University (NTU) Hospital & College of Medicine NTU No.1 Section 1 Jen‑Ai Road Taipei 10051 Taiwan. mlyen@ntu.edu.tw.

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Unsupervised extraction of phenotypes from cancer clinical notes for association studies

arXiv

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arXiv 2019年

作者： Stark, Stefan G. Hyland, Stephanie L. Pradier, Melanie F. Lehmann, Kjong-Van Wicki, Andreas Perez-Cruz, Fernando Vogt, Julia E. Rätsch, Gunnar Computational Biology Program Memorial Sloan Kettering Cancer Center New York United States Tri-Institutional Ph.D. Program in Computational Biology and Medicine Weill Cornell Medicine New York United States Department of Computer Science ETH Zürich Zürich Switzerland Medical Informatics Group University Hospital Zürich Zürich Switzerland Swiss Institute for Bioinformatics Zurich Switzerland Department of Biology ETH Zürich Zürich Switzerland Department of Signal Processing and Information Theory University Carlos III in Madrid Leganés Spain School of Engineering and Applied Sciences Harvard University CambridgeMA United States Department of Biomedicine University of Basel Basel Switzerland Tumorzentrum University Hospital Basel Basel Switzerland Swiss Data Science Center ETH Zürich and EPFL Lausanne Switzerland Department of Mathematics and Computer Science University of Basel Basel Switzerland

The recent adoption of Electronic Health Records (EHRs) by healthcare providers has introduced an important source of data that provides detailed and highly specific insights into patient phenotypes over large cohorts. These datasets, in combination with machine learning and statistical approaches, generate new opportunities for research and clinical care. However, many methods require the patient representations to be in structured formats, while the information in the EHR is often locked in unstructured text designed for human readability. In this work, we develop the methodology to automatically extract clinical features from clinical narratives from large EHR corpora without the need for prior knowledge. We consider medical terms and sentences appearing in clinical narratives as atomic information units. We propose an efficient clustering strategy suitable for the analysis of large text corpora and utilize the clusters to represent information about the patient compactly. Additionally, we define the sentences on ontologic and natural language vocabularies to automatically detect pertinent combinations of concepts present in the corpus, even when an ontology is not available. To demonstrate the utility of our approach, we perform an association study of clinical features with somatic mutation profiles from 4,007 cancer patients and their tumors. We apply the proposed algorithm to a dataset consisting of .65 thousand documents with a total of .3.2 million sentences. After correcting for cancer type and other confounding factors, we identify a total of 340 significant statistical associations between the presence of somatic mutations and clinical features. We annotated these associations according to their novelty and we report several known associations. We also propose 37 plausible, testable hypothesis for associations where the underlying biological mechanism does not appear to be known. These results illustrate that the automated discovery of clinical features

关键词： diseases

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Adherence to an anti-inflammatory diet is associated with lower Alzheimer's disease mortality: A modifiable risk factor in a national cohort

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The journal of prevention of Alzheimer's disease 2025年 100221页

作者： Ching-Chi Hsu Shiow-Ing Wang Sebastian Yu Eric S Lin James Cheng-Chung Wei Board of Directors Wizcare Medical Corporation Aggregate Taichung 404022 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu 300044 Taiwan. Electronic address: chi7hsu@***. Center for Health Data Science Department of Medical Research Chung Shan Medical University Hospital Taichung 402306 Taiwan Department of Health Policy and Management College of Health Care and Management Chung Shan Medical University Taichung 402306 Taiwan. Electronic address: shiowing0107@***. Department of Dermatology College of Medicine Kaohsiung Medical University Kaohsiung 807378 Taiwan Department of Dermatology Kaohsiung Medical University Gangshan Hospital Kaohsiung 820111 Taiwan Department of Dermatology Kaohsiung Medical University Hospital Kaohsiung 807377 Taiwan Master of Public Health Program College of Public Health National Taiwan University Taipei 100025 Taiwan Neuroscience Research Center Kaohsiung Medical University Kaohsiung 807378 Taiwan. Electronic address: epor324@***. Department of Economics National Tsing Hua University Hsinchu 300044 Taiwan EMBA/MBA/MFB/MPM/HBA Programs National Tsing Hua University Hsinchu 300044 Taiwan. Electronic address: slin@mx.nthu.edu.tw. Institute of Medicine Chung Shan Medical University Taichung 402306 Taiwan Department of Allergy Immunology & Rheumatology Chung Shan Medical University Hospital Taichung 402306 Taiwan Graduate Institute of Integrated Medicine China Medical University Taichung 406040 Taiwan. Electronic address: jccwei@***.

BACKGROUNd:Chronic neuroinflammation contributes to Alzheimer's disease (Ad) pathogenesis, and diet is a modifiable factor influencing inflammation. The impact of an anti-inflammatory diet on Ad-specific mortality remains unclear. OBJECTIVES:To examine the association between adherence to an anti-inflammatory diet (measured as the percentage of dietary energy from anti-inflammatory foods) and Ad-specific mortality, as well as all-cause mortality, in a large national cohort, and to determine whether associations differ by sex or race/ethnicity. METHOdS:We analyzed 18,795 U.S. adults (≥18 years) from the 2007-2014 National Health and Nutrition Examination Survey. Anti-inflammatory diet adherence was defined as the percentage of total energy intake from anti-inflammatory foods, categorized as 0 %, <5 %, 5-9.99 %, or ≥10 %. Outcomes were Ad-specific mortality and all-cause mortality ascertained via the National death Index. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for mortality across intake categories, adjusting for demographic, lifestyle, and health factors. Analyses were stratified by sex, race/ethnicity, and age (≥45 years for Ad mortality). RESULTS:Participants with 0 % anti-inflammatory intake had a higher all-cause mortality risk (HR 3.82, 95 % CI 1.18-12.33) compared to those with ≥10 % intake. In the overall analysis, 0 % anti-inflammatory intake showed a trend of reduced Ad-specific mortality although its did not reach statistical significance after full adjustment (HR 3.04, 95 % CI 0.74-12.46 vs. ≥10 % intake; p>0.05). Notably, the inverse association between anti-inflammatory diet and Ad mortality emerged in subgroup analyses. Male participants and non-Hispanic White participants with 0 % intake had the highest Ad mortality hazards (HR 12.83 and 3.77, respectively, vs. ≥10 % intake), indicating significant risk reductions with anti-inflammatory diet in these groups. In contrast, no signific

关键词： Brain-gut axis Gut dysbiosis Ketogenic diet Neurodegeneration Neuroinflammation

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derivative-free superiorization: Principle and algorithm

arXiv

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arXiv 2019年

作者： Censor, Yair Garduño, Edgar Helou, Elias S. Herman, Gabor T. Department of Mathematics University of Haifa Mt. Carmel Haifa3498838 Israel Departamento de Ciencias de la Computación Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas Universidad Nacional Autónoma de México Cd. Universitaria Mexico CityC.P. 04510 Mexico Department of Applied Mathematics and Statistics University of São Paulo São Carlos São Paulo13566-590 Brazil Computer Science Ph.D. Program Graduate Center City University of New York New YorkNY10016 United States

The superiorization methodology is intended to work with input data of constrained minimization problems, that is, a target function and a set of constraints. However, it is based on an antipodal way of thinking to what leads to constrained minimization methods. Instead of adapting unconstrained minimization algorithms to handling constraints, it adapts feasibility-seeking algorithms to reduce (not necessarily minimize) target function values. This is done by inserting target-function-reducing perturbations into a feasibility-seeking algorithm while retaining its feasibility-seeking ability and without paying a high computational price. A superiorized algorithm that employs component-wise target function reduction steps is presented. This enables derivative-free superiorization (dFS), meaning that superiorization can be applied to target functions that have no calculable partial derivatives or subgradients. The numerical behavior of our derivative-free superiorization algorithm is illustrated on a data set generated by simulating a problem of image reconstruction from projections. The plots of proximity-target curves of our experiments demonstrate the advantage of the proposed derivative-free superiorization algorithm. Copyright © 2019, The Authors. All rights reserved.

关键词： Constrained optimization

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Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells

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Archivum immunologiae et therapiae experimentalis 2023年第1期71卷 21页

作者： Chien-Chih Chiu Kai-Chun Cheng Yi-Hsiung Lin Chen-Xi He Yung-ding Bow Chia-Yang Li Chang-Yi Wu Hui-Min david Wang Shwu-Jiuan Sheu Department of Biotechnology Kaohsiung Medical University Kaohsiung 807 Taiwan. Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Biological Sciences National Sun Yat-Sen University Kaohsiung 804 Taiwan. Center for Cancer Research Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Department of Ophthalmology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Department of Ophthalmology Kaohsiung Municipal Siaogang Hospital Kaohsiung 807 Taiwan. Department of Ophthalmology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. Division of Cardiology Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Center for Lipid Biosciences Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. Lipid Science and Aging Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan. Ph.D. Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung 807 Taiwan. Department of Ophthalmology Kaohsiung Medical University Hospital Kaohsiung 807 Taiwan. sjiuansheu@***. Department of Ophthalmology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 807 Taiwan. sjiuansheu@***.

Chronic hyperglycemia involves persistent high-glucose exposure and correlates with retinal degeneration. It causes various diseases, including diabetic retinopathy (dR), a major cause of adult vision loss. Most in vitro studies have investigated the damaging short-term effects of high glucose exposure on retinal pigment epithelial (RPE) cells. dR is also a severe complication of diabetes. In this study, we established a model with prolonged high-glucose exposure (15 and 75 mM exogenous glucose for two months) to mimic RPE tissue pathophysiology in patients with hyperglycemia. Prolonged high-glucose exposure attenuated glucose uptake and clonogenicity in ARPE-19 cells. It also significantly increased reactive oxygen species levels and decreased antioxidant protein (superoxide dismutase 2) levels in RPE cells, possibly causing oxidative stress and dNA damage and impairing proliferation. Western blotting showed that autophagic stress, endoplasmic reticulum stress, and genotoxic stress were induced by prolonged high-glucose exposure in RPE cells. despite a moderate apoptotic cell population detected using the Annexin V-staining assay, the increases in the senescence-associated proteins p53 and p21 and SA-β-gal-positive cells suggest that prolonged high-glucose exposure dominantly sensitized RPE cells to premature senescence. Comprehensive next-generation sequencing suggested that upregulation of oxidative stress and dNA damage-associated pathways contributed to stress-induced premature senescence of ARPE-19 cells. Our findings elucidate the pathophysiology of hyperglycemia-associated retinal diseases and should benefit the future development of preventive drugs. Prolonged high-glucose exposure downregulates glucose uptake and oxidative stress by increasing reactive oxygen species (ROS) production through regulation of superoxide dismutase 2 (SOd2) expression. Autophagic stress, ER stress, and dNA damage stress (genotoxic stress) are also induced by prolonged high-gluco

关键词： Autophagy diabetic retinopathy Hyperglycemia Oxidative stress Premature senescence

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