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Macromol. Theory Simul. 3/2016

Macromolecular Theory and Simulations 2016年第3期25卷

作者： Ramaswamy I. Venkatanarayanan Sitaraman Krishnan Arvind Sreeram philip A. Yuya Nimitt G. Patel Adama Tandia John B. McLaughlin Department of Chemical and Biomolecular Engineering Clarkson University Potsdam NY 13699 USA Department of Mechanical and Aeronautical Engineering Clarkson University Potsdam NY 13699 USA Materials Science and Engineering Ph.D. Program Clarkson University Potsdam NY 13699 USA Corning Incorporated 1 Science Center Drive Corning NY 14831 USA

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The Null Field and the Interior Field Methods For Mixed Types of Boundary Conditions of Laplace's Equations in Elliptic domains with Elliptic Holes

The Null Field and the Interior Field Methods For Mixed Type...

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Joint International Conference on Trefftz Method Ⅶ and Method of Fundamental Solutions Ⅲ(Trefftz/MFS 2015)

作者： Liping Zhang Ming-Gong Lee Zi-Cai Li College of Science Zhejiang University of Technology Department of Leisure and Recreation Management Ph.D.Program in Engineering ScienceChung Hua University Department of Applied Mathematics Department of Computer Science and EngineeringNational Sun Yat-sen University

The particular solutions(PS) and fundamental solutions(FS) in polar coordinates can be found in many textbooks, but with much less coverage in elliptic coordinates [1]. Since the elliptic domains with elliptic holes may be found in some engineering problems, the PS and the FS expansions in elliptic coordinates are essential for numerical computations. For dirichlet problems of Laplace's equation in elliptic domains, the null field method(NFM), the interior field method(IFM) and the collocation Trefftz method(CTM) are reported in [2]. There seems to exist very few reports for mixed problems, where the dirichlet and Neumann conditions are assigned on the exterior and the interior boundaries, simultaneously. This paper is devoted to such mixed problems by the NFM and the IFM, and the explicit algebraic equations are derived for elliptic domains. Besides, other effective particular solutions(PS) are sought, and the collocation Trefftz method(CTM) [3] is employed. The CTM may be used for Robin problems in elliptic domains. The effective algorithms for the mixed problems of Laplace's equation on elliptic domains are the main goal of this paper.

关键词： Null field method Interior field method collocation Trefftz method circular domains elliptic domains Elliptic Holes fundamental solutions Particular Solutions dirichlet condition Neumann condition Robin Problems

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Virtual organization manufacturing resource planning: Flexible multi-objective mathematical programming

Virtual organization manufacturing resource planning: Flexib...

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2014 International Conference on E-Commerce, E-Business and E-Service, EEE 2014

作者： Hsu, Yao Huang, Jih-Jeng Chen, Jhao-Syuan Department of Business and Entrepreneurial Management Kainan University Taoyuan Taiwan Department of Computer Science and Information Management Soochow University Taipei Taiwan Ph.D. Program in Business Feng Chia University Taichung Taiwan

ISBN: (纸本)9781138026469

Optimizing production resource planning significantly affects the profits and competitive advantages of factories by increasing the size and complexity of organizations. Mathematical programming models are mainly used to optimize the allocation of traditional production planning. However, using traditional mathematical programming models to optimize certain types of organizations is difficult because of rigid parameters and new organizational types, such as virtual organizations. Studies have proposed the de Novo programming model and the changeable parameter model, which allow parameter modification. This study proposes a multi-objective flexible mathematical planning model, and combines the de Novo programming model and changeable parameter model to assist virtual organizations with the optimization planning of production resources for factories. The empirical results show that the proposed models produce better resource-planning results than do previous models. This study also provides decision makers with a more flexible operational model. © 2014 Taylor & Francis Group.

关键词： Mathematical programming

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Cover Image, Volume 7, Issue 6

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WIREs Cognitive science 2016年第6期7卷

作者： L. A. Petitto C. Langdon A. Stone d. Andriola G. Kartheiser C. Cochran NSF Science of Learning Center Visual Language and Visual Learning VL2 Gallaudet University Washington DC USA Brain and Language Laboratory for fNIRS Neuroimaging BL2 Gallaudet University Washington DC USA Ph.D. in Educational Neuroscience (PEN) Program Gallaudet University Washington DC USA Department of Psychology Gallaudet University Washington DC USA Department of Linguistics Gallaudet University Washington DC USA

The cover image, created by Laura-Ann Petitto, is based on the article Visual Sign phonology: Insights into Human Reading and Language from a Natural Soundless phonology , dOI: 10.1002/wcs.1404 . design Credit: Laura-...

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Implementation and evaluation of animation controls sufficient for conveying ASL facial expressions 14

Implementation and evaluation of animation controls sufficie...

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16th International ACM SIGACCESS Conference on computers and Accessibility, ASSETS 2014

作者： Kacorri, Hernisa Huenerfauth, Matt Graduate Center CUNY Computer Science Ph.D. Program 365 Fifth Ave. New YorkNY10016 United States Golisano College of Computing and Information Sciences 20 Lomb Memorial Drive RochesterNY14623 United States

ISBN: (纸本)9781450327206

Technology to automatically synthesize linguistically accurate and natural-looking animations of American Sign Language (ASL) from an easy-to-update script would make it easier to add ASL content to websites and media, thereby increasing information accessibility for many people who are deaf. We are investigating the synthesis of ASL facial expressions, which are grammatically required and essential to the meaning of sentences. To support this research, we have enhanced a virtual human character with face controls following the MPEG-4 Facial Action Parameter standard. In a user-study, we determined that these controls were sufficient for conveying understandable animations of facial expressions.

关键词： Animation

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Karl S. Rosengren, Sarah K. Brem, E. Margaret Evans, and Gale M. Sinatra (eds): Evolution Challenges: Integrating Research and Practice in Teaching and Learning about Evolution

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science & Education 2014年第4期24卷 481-485页

作者： Ross H. Nehm Department of Ecology and Evolution Ph.D. Program in Science Education Stony Brook University Stony Brook USA

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Frontispiece: Quantum Crystallography: Current developments and Future Perspectives

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Chemistry – A European Journal 2018年第43期24卷

作者： Alessandro Genoni Lukas Bučinský Nicolas Claiser Julia Contreras-García Birger dittrich Paulina M. dominiak Enrique Espinosa Carlo Gatti Paolo Giannozzi Jean-Michel Gillet dylan Jayatilaka Piero Macchi Anders Ø. Madsen Lou Massa Chérif F. Matta Kenneth M. Merz Jr. philip N. H. Nakashima Holger Ott Ulf Ryde Karlheinz Schwarz Marek Sierka Simon Grabowsky Université de Lorraine CNRS Laboratoire LPCT 1 Boulevard Arago F-57078 Metz France Institute of Physical Chemistry and Chemical Physics Slovak University of Technology FCHPT SUT Radlinského 9 SK-812 37 Bratislava Slovakia Université de Lorraine CNRS Laboratoire CRM2 Boulevard des Aiguillettes BP 70239 F-54506 Vandoeuvre-lès-Nancy France Sorbonne Universités UPMC Université Paris 06 CNRS Laboratoire de Chimie Théorique (LCT) 4 Place Jussieu F-75252 Paris Cedex 05 France Anorganische und Strukturchemie II Heinrich-Heine-Universität Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany Biological and Chemical Research Centre Department of Chemistry University of Warsaw ul. Żwirki i Wigury 101 02-089 Warszawa Poland CNR-ISTM Istituto di Scienze e Tecnologie Molecolari via Golgi 19 Milano I-20133 Italy Istituto Lombardo Accademia di Scienze e Lettere via Brera 28 20121 Milano Italy Department of Mathematics Computer Science and Physics University of Udine Via delle Scienze 208 I-33100 Udine Italy Structure Properties and Modeling of Solids Laboratory CentraleSupelec Paris-Saclay University 3 rue Joliot-Curie 91191 Gif-sur-Yvette France School of Molecular Sciences University of Western Australia 35 Stirling Highway Perth WA 6009 Australia Department of Chemistry and Biochemistry University of Bern Freiestrasse 3 CH-3012 Bern Switzerland Department of Pharmacy University of Copenhagen Universitetsparken 2 2100 Copenhagen Denmark Hunter College & the Ph.D. Program of the Graduate Center City University of New York New York USA Department of Chemistry and Physics Mount Saint Vincent University Halifax Nova Scotia B3M 2J6 Canada Department of Chemistry Dalhousie University Halifax Nova Scotia B3H 4J3 Canada Department of Chemistry Saint Mary's University Halifax Nova Scotia B3H 3C3 Canada Département de Chimie Université Laval Québec QC G1V 0A6 Canada Department of Chemistry and Department of Biochemistry and Molecular Biology Michigan Stat

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Effect of humic acids and sunlight on the cytotoxicity of engineered zinc oxide and titanium dioxide nanoparticles to a river bacterial assemblage

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Journal of Environmental sciences 2013年第9期25卷 1925-1935页

作者： Thabitha P.dasari Huey-Min Hwang Environmental Science Ph.D. Program Jackson State University Department of Biology Jackson State University

The effect of a terrestrial humic acid （HA） and Suwannee River HA on the cytotoxicity of engineered zinc oxide nanoparticles （ZnONPs） and titanium dioxide nanoparticles （TiO2NPs） to natural aquatic bacterial assemblages was measured with spread plate counting. The effect of HA （10 and 40 ppm） on the cytotoxicity of ZnONPs and TiO2NPs was tested factorially in the presence and absence of natural sunlight （light irradiation （LI））. The experiment was of full factorial, completely randomized design and the results were analyzed using the General Linear Model in SAS analytical software. The method of least squares means was used to separate the means or combinations of means. We determined the mechanism of toxicity via measurements of oxidative stress and metal ions. The toxicity of ZnONPs and TiO2NPs to natural aquatic bacterial assemblages appears to be concentration dependent. Moreover, the cytotoxicity of ZnONPs and TiO2NPs appeared to be affected by HA concentration, the presence of sunlight irradiation, and the dynamic multiple interactions among these factors. With respect to light versus darkness in the control group, the data indicate that bacterial viability was inhibited more in the light exposure than in the darkness exposure. The same was true in the HA treatment groups. With respect to terrestrial versus Suwanee River HA for a given nanoparticle, in light versus darkness, bacterial viability was more inhibited in the light treatment groups containing the terrestrial HA than in those containing Suwanee River HA. differences in the extent of reactive oxygen species formation, adsorption/binding of ZnONPs/TiO2NPs by HA, and the levels of free metal ions were speculated to account for the observed cytotoxicity. TEM images indicate the attachment and binding of the tested nanoparticles to natural bacterial assemblages. Besides the individual parameter, significant effects on bacterial viability count were also observed in the following combined treatments： HA-Zn

关键词： natural bacterial assemblages humic acid median lethal concentration （LC50 ） reactive oxygen species

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Genome-Wide Association Study in Thai Tsunami Survivors Identified Risk Alleles for Posttraumatic Stress disorder

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Open Journal of Genetics 2015年第2期5卷 43-57页

作者： Nuntika Thavichachart Taisei Mushiroda Thongchai Thavichachart Ongart Charoensook Anchalee Prasansuklab Prathan Rutchatajumroon Sookjaroen Tangwongchai Puangsoi Worakul Buranee Kanchanatawan Siriluck Suppapitiporn Atapol Sughondhabirom Chutima Roomruangwong Wasun Chantratita Atsushi Takahashi Michiaki Kubo Naoyuki Kamatani Yusuke Nakamura Department of Psychiatry Faculty of Medicine Chulalongkorn University Bangkok Thailand Laboratory for Pharmacogenetics RIKEN Center for Genomic Medicine Kanagawa Japan Thailand Center of Excellence for Life Sciences (Public Organization) Ministry of Science and Technology Bangkok Thailand Ph.D. Program in Clinical Biochemistry and Molecular Medicine Department of Clinical Chemistry Faculty of Allied Health Sciences Chulalongkorn University Bangkok Thailand Department of Pathology Faculty of Medicine Mahidol University Bangkok Thailand Laboratory for Statistical Analysis RIKEN Center for Genomic Medicine Kanagawa Japan Laboratory for Genotyping Development RIKEN Center for Genomic Medicine Kanagawa Japan Laboratory of Molecular Medicine Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan

Posttraumatic stress disorder (PTSd) is a psychiatric disorder found in individuals afflicted by a traumatic event. Multiple environmental and genetic factors can contribute to PTSd susceptibility. Since it is rare to find members of the same family afflicted by the same catastrophic event, it is not practical to determine PTSd susceptibility genes by a gene linkage analysis. A natural disaster, such as the 2004 Tsunami, provided us with a rare chance for a genetic analysis of PTSd. To identify SNPs associated with PTSd susceptibility, we conducted a genome-association study (GWAS) in Thai-Tsunami survivors. Initial phase of the study with 396 chronic PTSd patients and 457 controls, we identified top ninety SNPs (P -4), which were further assessed in the second phase with 395 chronic PTSd patients and 798 controls. Two SNPs (rs267950 and rs954406), were identified in the second phase, and subjected to fine mapping using a data set from both phases. SNP rs267943 showed the strongest association with PTSd susceptibility and was in complete linkage disequilibrium with SNP rs267950 with P = 6.15 × 10-8, OR = 1.46 and 95% CI = 1.19 - 1.79, reaching genome-wide significance. SNP rs267943 is located on chromosome 5 in the intron of the death-associated protein 1 (dAP1) gene and, when linked to a synthetic promoter, could regulate transcription. To our knowledge, this is the first GWAS for PTSd susceptibility in an Asian population which could provide an important insight into the genetic contribution of PTSd and may lead to new treatment strategies for PTSd.

关键词： death-Associated Protein 1 Gene (dAP1) Genetics Genome-Wide Association Study (GWAS) Posttraumatic Stress disorder (PTSd) Tsunami

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The upregulation of Myb and Peg3 may mediate EGCG inhibition effect on mouse lung adenocarcinoma

The upregulation of Myb and Peg3 may mediate EGCG inhibition...

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IEEE International Conference on Bioinformatics and Biomedicine

作者： Hong Zhou Joseph Manthey Ekaterina Lioutikova William Yang Kenji Yoshigoe Mary Qu Yang Hong Wang Department of Mathematical Sciences School of Health and Natural Sciences University of Saint Joseph Department of Computer Science George Washington Donaghey College of Engineering and Information Technology University of Arkansas at Little Rock and University of Arkansas for Medical Sciences Middle South Bioinformatics Center and Joint Bioinformatics Ph.D. Program George Washington Donaghey College of Engineering and Information Technology University of Arkansas at Little Rock and University of Arkansas for Medical Sciences Susan L. Cullman Laboratory for Cancer Research Department of Chemical Biology and Center for Cancer Prevention Research Ernest Mario School of Pharmacy Rutgers The State University of New Jersey

ISBN: (纸本)9781467368001

The antioxidant activity of green tea polyphenol epigallocatechin-3-gallate (EGCG) has been found to be critical in inhibiting carcinogenesis. In our previous study, we identified a set of protein coding genes and microRNAs whose expressions were significantly modulated in response to the EGCG treatment in tobacco carcinogen-induced lung adenocarcinoma in A/J mice. In this study, we further conducted some statistical analysis on our microarray data and employed The Cancer Genome Atlas (TCGA) lung adenocarcinoma datasets as additional control. We postulated that if a gene mediates EGCG's cancer inhibition, its expression level change caused by EGCG should be opposite to what occurred in the carcinogenesis. With this assumption, we identified Myb and Peg3 as the primary genes involved in the cancer inhibitory activities of EGCG.

关键词： EGCG Myb Peg3 Lung adenocarcinoma

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