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arXiv 2024年

作者： Yang, Haibo Qiu, Peiwen Khanduri, Prashant Fang, Minghong Liu, Jia Department of Computing and Information Sciences Ph.D. Rochester Institute of Technology RochesterNY United States Department of Electrical and Computer Engineering The Ohio State University ColumbusOH United States Department of Computer Science Wayne State University DetroitMI United States Department of Electrical and Computer Engineering Duke University DurhamNC United States

Existing works in federated learning (FL) often assume an ideal system with either full client or uniformly distributed client participation. However, in practice, it has been observed that some clients may never participate in FL training (aka incomplete client participation) due to a myriad of system heterogeneity factors. A popular approach to mitigate impacts of incomplete client participation is the server-assisted federated learning (SA-FL) framework, where the server is equipped with an auxiliary dataset. However, despite SA-FL has been empirically shown to be effective in addressing the incomplete client participation problem, there remains a lack of theoretical understanding for SA-FL. Meanwhile, the ramifications of incomplete client participation in conventional FL are also poorly understood. These theoretical gaps motivate us to rigorously investigate SA-FL. Toward this end, we first show that conventional FL is not PAC-learnable under incomplete client participation in the worst case. Then, we show that the PAC-learnability of FL with incomplete client participation can indeed be revived by SA-FL, which theoretically justifies the use of SA-FL for the first time. Lastly, to provide practical guidance for SA-FL training under incomplete client participation, we propose the SAFARI (server-assisted federated averaging) algorithm that enjoys the same linear convergence speedup guarantees as classic FL with ideal client participation assumptions, offering the first SA-FL algorithm with convergence guarantee. Extensive experiments on different datasets show SAFARI significantly improves the performance under incomplete client participation. © 2024, CC BY-NC-Nd.

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Inclusive design of Advanced Wearable Health Monitoring Systems: Validating a Contact Pressure Prediction Model with a Sports Bra

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SSRN 2024年

作者： Youn, Seonyoung Mathur, Kavita Mills, Amanda C. Fiber and Polymer Science Ph.D. candidate North Carolina State University RaleighNC27606 United States Department of Textile and Apparel Technology and Management North Carolina State University RaleighNC27606 United States Department of Textile Engineering Chemistry and Science North Carolina State University RaleighNC27606 United States

The integration of wearable biosignal monitoring systems into daily healthcare has marked a significant advancement in medical care. Yet, the design of these devices often neglects the anatomical specificity of individual bodies, compromising both functionality and comfort. This oversight is particularly pronounced in research on the effective placement of 3-lead electrodes, selecting suitable materials, and customizing fit for women's diverse body shapes. To address this gap, this research introduces a novel design methodology for the development of advanced wearable health-monitoring garments, focusing on smart sports bras as a case study. This approach emphasizes contact pressure (CP) optimization for electrode placement, material selection, and sizing to enhance biosignal acquisition and comfort for the wearer. The study identifies optimal horizontal 3-lead electrode placements and configurations, the most effective across three female participants with diverse body mass indices (BMIs). Furthermore, the research employs a simulation-based contact pressure model (CP model) to precisely engineer desired pressure levels through strategic material selection and sizing adjustments. Guided by the CP model, screen-printed silver/silver chloride electrodes are incorporated into single jersey knit fabric, adjusted by a 20% pattern size reduction for a tailored electrocardiogram (ECG) chest band in the optimized configuration. This achieves a signal-to-noise ratio of 40.9, closely comparable to the 41.9 ratio obtained with traditional wet electrodes, while also exhibiting a higher QRS amplitude above 0.84mV, benchmarked against 12-lead electrodes for reliability. The study further identifies an optimal contact pressure range of 0.56-1.24 kPa for ECG chest bands and a subjective pressure tolerance range of 0.93 to 1.8 kPa in the chest area across female subjects. Finally, the smart sports bra integration demonstrates clear QRS complexes and high biopotential amplitude, whi

关键词： Electrocardiograms

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Structural optimization and biological evaluation of indolin-2-one derivatives as novel CdK8 inhibitors for idiopathic pulmonary fibrosis

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Biomedicine and pharmacotherapy 2025年 184卷 117891-117891页

作者： Hsu, Jui-Yi Hsu, Kai-Cheng Chou, Ching-Hsuan He, Tzu-Ying Lin, Tony Eight Sung, Tzu-Ying Yen, Shih-Chung Hsieh, Jui-Hua Yang, Chia-Ron Huang, Wei-Jan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan Cancer Center Wan Fang Hospital Taipei Medical University Taipei Taiwan School of Pharmacy College of Medicine National Taiwan University Taipei Taiwan Warshel Institute for Computational Biology School of Medicine The Chinese University of Hong Kong (Shenzhen) Shenzhen China Division of Translational Toxicology National Institute of Environmental Health Sciences National Institutes of Health Durham NC United States School of Pharmacy Taipei Medical University Taipei Taiwan

Cyclin-dependent kinase 8 (CdK8) plays a crucial role in the transforming growth factor beta (TGF-β) signaling pathway, which is critical to the pathology of idiopathic pulmonary fibrosis (IPF). CdK8 promotes the epithelial-mesenchymal transition (EMT) and excessive extracellular matrix (ECM) deposition, making it a promising target for IPF treatment. This study focused on optimizing F059–1017, a previously identified CdK8 inhibitor, to enhance its potency. Through integrated structure-based modifications, a series of compounds was synthesized, and their inhibitory effects on CdK8 were tested. Results indicated that substituting with cyclopentanone significantly improved the inhibitory activity, and compound 4j demonstrated the best potency (IC₅₀ = 16 nM). Notably, compared to F059–1017, its potency increased 35-fold, and kinase profiling revealed that the compound was selective for CdK8. Compound 4j inhibited the TGF-β1-induced EMT, cell migration, and morphological changes in A549 cells at a concentration of 0.1 μM and inhibited ECM and EMT protein expressions. In addition, the compound blocked TGF-β1-induced transcriptional changes and inhibited Smad3 and RNA polymerase II phosphorylation. These results highlight the potential of the optimized CdK8 inhibitor as a prospective drug for IPF treatment. © 2025 The Authors

关键词： Cyclin-dependent protein kinase 8 Epithelial-mesenchymal transition Indolin-2-one, Idiopathic pulmonary fibrosis Structural optimization Transforming growth factor beta

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Automated Eight-Arm Maze Trajectory Tracking System for Feature Extraction of TBI Animals

Automated Eight-Arm Maze Trajectory Tracking System for Feat...

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ACIS International Conference on Software engineering, Artificial Intelligence, Networking, and Parallel/distributed Computing (SNPd)

作者： Shu-Cing Wu Chi-Yuan Lin Liang-Jyun Hong Chi-Chun Chen Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taiwan National Chin-Yi University of Technology Taichung Taiwan

ISBN: (纸本)9781665447324

Traumatic Brain Injury (TBI) is most commonly accident injury in modern society. The deterioration of cognition and memory is a common phenomenon caused by TBI. Most of the basic experiments used rats for pathological research. Moreover, an eight-arm maze was often used to test the spatial learning behavior of brain diseases, such as Alzheimer’s disease and TBI. However, most of maze experimental data were collected in manual records. This process would take a lot of manpower and time. Therefore, the research built an automatic tracking trajectory system of the eight-arm maze to collect experiment data. Furthermore, the path trajectory of the rat can be recorded in time. Finally, these path trajectory data were used to analysis behavior feature of TBI animals. The results showed that TBI rats have a 40%~80% chance of having a trajectory to the right.

关键词： Pathology Trajectory tracking Manuals Rats Feature extraction Cognition Trajectory

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Removal of nitrogen and phosphorus pollutants from swine wastewater

Removal of nitrogen and phosphorus pollutants from swine was...

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2021 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2021

作者： Nguyen, Minh-Ky Lin, Chitsan Nhut, Huynh Tan Trung Hiep, Nguyen Hung, Nguyen T.Q. Huu Tuan, Tran National Kaohsiung University of Science and Technology College of Maritime Ph.D. Program In Maritime Science and Technology Kaohsiung Taiwan National Kaohsiung University of Science and Technology Department of Marine Environmental Engineering Kaohsiung Taiwan Nong Lam University of Ho Chi Minh City Faculty of Environment and Natural Resources Ho Chi Minh Viet Nam National Kaohsiung University of Science and Technology College of Maritime Kaohsiung Taiwan

ISBN: (纸本)9781665419512

This study investigated the simultaneous removal of nitrogen and phosphorus from swine wastewater by a magnesium ammonium phosphate crystallization. The precipitation of struvite was determined from swine wastewater, obtaining the optimal ph, Mg/N/P molar ratio, and reaction time were 9.0, 1.6/1/1.5 and 30 min, respectively. Ammonium and phosphate removal efficiencies were 98.1 ± 0.5% and 98.9 ± 0.4% under optimal conditions, and the highest crystallization mass obtained was 14.6 ± 0.6 g/L. Results illustrated that struvite precipitation is an efficient method for removing ammonium and phosphate in swine wastewater. © 2021 IEEE.

关键词： phosphorus

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Exfoliated MXene nanosheet by double layer forces for preparing magnetic adsorbents of toxic metal ions and recycling with hyperthermic effect

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Separation and Purification technology 2024年 349卷

作者： Chen, Chih-Wei Chang, Chi-Jung Liaw, Shien-Kuei Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Division of Neurosurgery Department of Surgery Chi Mei Medical Center Tainan710 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Seatwen Taichung40724 Taiwan Department of Electronic and Computer Engineering National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine and Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

The conventional etching method for exfoliating MXene using hydrofluoric acid solution is time-consuming and inefficient in productivity. A double layer force is generated through polarization among the heterogeneous layers of MXene due to their different dielectric properties. The exfoliated MXene by the polarization method in an acidic solution was employed to synthesize magnetic MXene (MXFe) with Fe3O4 nanoparticles. MXFe was coated on polyacrylonitrile microspheres (PANs) as precursors (PAN@MXFe) by Pickering emulsion polymerization. The core@shell polyvinyltetrazole@MXFe (PVT@MXFe) was obtained as the adsorbent after subsequent cyano-tetrazole conversion of PAN@MFs for the removal of toxic metal ions. The maximum adsorption capacities of Hg(II) on the MXFe and PVT@MXFe coating 2 wt% of MXFe were 579 and 324 mg/g, respectively, indicating the high use efficiency of MXFe. At 8.5 kHz of high frequency, hyperthermia occurs on the PVT@MXFe, facilitating the desorption of the toxic metal ions from the adsorbents. Compared with reuse using an acidic solution, the PVT@MXFe can be reused repeatedly 10 times without obvious damage under the AMF. Our proposed polarization exfoliation method not only provides a novel methodology to exfoliate MXene but also develops an ideal adsorbent for universal adsorption, simple separation, stable regeneration, and low secondary pollution. © 2024 Elsevier B.V.

关键词： Synthesis (chemical)

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Optical sensor for dissolved ammonia by embedding eosin Y in cellulose acetate and silicone rubber via the phase inversion method

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Microchemical Journal 2025年 213卷

作者： Putro, dimas Trio Sari, desy Purnama Chu, Cheng-Shane International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan

This study presents the phase inversion method for fabricating a new optical sensing membrane designed for dissolved ammonia detection. Eosin Y was embedded into composite materials of cellulose acetate (CA) and silicone rubber to enhance optical performance and modify the membrane structure. Sensing performance was evaluated using luminescence quenching, which involved measuring changes in both intensity and wavelength. The fabricated membrane exhibited a microporous structure with pore diameters ranging from 1 to 10 µm, a quenching response (I₀/I₄₀₀) of 15.15, a response time (↓t₉₀) of 53 s, and effective detection at a concentration of 400 mM, a room temperature (20–25 °C), and ph 6.02, with sensing response slightly decreasing at elevated temperatures (up to 50 °C) and at ph 3.17 and 9.29. The nonlinear quenching response plot was converted into a linear form using the decibel (dB) formula, significantly improving linearity (R² = 0.9862). The membrane also exhibited excellent selectivity and the ability to detect in both gas and dissolved phases. Additionally, the sensing mechanism was investigated, revealing a combination of static and dynamic quenching, which led to an intensity decrease and a bathochromic shift of 16.56 nm. These findings highlight the potential of the developed optical sensor for rapid and highly selective ammonia monitoring in various environments. © 2025 Elsevier B.V.

关键词： Bathochromic shift dissolved ammonia detection Eosin Y Optical sensing membrane phase inversion method

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development of the Al2o3-B2o3-Sio2 Glass For Thermal Barrier Coating

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SSRN 2023年

作者： Qiu, Jun-Yan Montecillo, Rhys Chen, Pin-Yi Tu, Chi-Shun Chen, Cheng-Sao Feng, Kuei-Chih International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Department of Mechanical Engineering Hwa Hsia University of Technology New Taipei City23530 Taiwan

The glass coating is an important technique in the aerospace industry as a thermal insulation role to protect the inner layer to form a thermal protection system (TPS) at elevated temperature. The results show an increase of the glass transition temperature (from 650 °C to 750 °C) in B2O3-SiO2 systems with increasing SiO2 content and the devitrification of the α-cristobalite phase. The Al2O3 additive in B2O3-SiO2 glass can increase the glass transition temperature from 750 °C to 1000 °C, and also inhibit the α-cristobalite phase. The transformation from the unstable α-cristobalite phase to the amorphous phase occurs at specimen with 10 wt% Al2O3 addition. Microstructure characterization shows the flat morphology without cracks on the surface. This study demonstrates that the Al2O3- B2O3-SiO2 glass has a thermally stable behavior which can be used as an effective thermal barrier coating at elevated temperature. © 2023, The Authors. All rights reserved.

关键词： Silica

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Fabrication of tantalum silicate films with low TCR and low resistivity by magnetron sputtering

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Vacuum 2024年 226卷

作者： Chen, Cheng-Lung Huang, Cheng Chen, Sheng-Chi Liu, Yen-Chen Chuang, Min-Chen Wen, Chao-Kuang Huang, Wei-Sheng Yang, Wen-Sheng Chen, Yang-Yuan Graduate School of Materials Science National Yunlin University of Science and Technology Yunlin64002 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology 243 New Taipei City Taiwan College of Engineering and Center for Green Technology Chang Gung University 333 Taoyuan Taiwan International Ph.D. Program in Plasma and Thin Film Technology Ming Chi University of Technology 243 New Taipei City Taiwan TPH Research & Develop Dept. Chien Hwa Coating Technology Inc. Hsinchu300 Taiwan National Engineering Research Center for Rare Earth Materials Grirem Advanced Materials Co. Ltd. General Research Institute for Nonferrous Metals Beijing100088 China Institute of Physics Academia Sinica 115 Taipei Taiwan

Tantalum silicate (Ta–Si–O) thin film materials have gained significant interest in hybrid renewable energy systems and thin-film resistors due to their exceptional thermal stability and adjustable electrical properties. In this study, we investigated the effects of target compositions and sputtering power densities on the material structures, chemical compositions, microstructures, and electrical properties of Ta–Si–O films. Two target compositions, Ta65(SiO2)35 and Ta80(SiO2)20, were utilized in the deposition process. Notably, we observed substantial variations in the temperature coefficient of resistance (TCR) value and resistivity of Ta–Si–O thin films with different Ta concentrations. Most importantly, when the Ta content of the film is controlled at 62 ± 0.6 % by using this target, the resistivity of the Ta0.62Si0.20O0.18 film can be as small as 2.31 ± 0.05 × 10−4 Ω-cm and has an extremely small TCR of 22 ± 0.4 ppm/°C, which shows an excellent opportunity for the development of precision thin film resistors. A TCR value close to zero can be finely tuned by controlling the Ta concentration in the Ta–Si–O film. These intriguing electrical behaviors were found to be highly correlated with the predominant formation of metallic Ta5Si3 as the main structural phase in the films. This work presents a simple and effective approach to produce Ta–Si–O thin films with near-zero TCR, making them highly suitable for applications under high-temperature conditions. Our findings contribute to the development of tailored thin film materials with desirable electrical properties for advanced electronic and energy devices. © 2024 Elsevier Ltd

关键词： Thin films

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Performance Enhancement of Electrochemiluminescence with the Immunosensor Controlled Using Magnetized Masks for the determination of Epithelial Cancer Biomarker EpCAM

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Analytical Chemistry 2023年第2期95卷 986-993页

作者： Huang, Chun-Yao Lin, Feng-Yen Chang, Chi-Jung Lu, Chien-Hsing Chen, Jem-Kun Taipei Heart Institute Taipei Medical University 250 Wu-Hsing Street Taipei110 Taiwan Division of Cardiology and Cardiovascular Research Center Taipei Medical University Hospital 252 Wu-Hsing Street Taipei110 Taiwan Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei110 Taiwan Department of Biomedical Sciences and Engineering National Central University 300 Zhongda Road Taoyuan City320317 Taiwan Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Taichung40724 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital 1650 Taiwan Boulevard Sect. 4 Taichung40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

The performance of an electrochemiluminescence (ECL) immunosensor was improved with a particle gradient. SiO2-coated magnetic beads were adopted as nanocarriers for gradient manipulation and immobilized with the primary antibody. Cadmium telluride quantum dots were coated with a layer of protein G for conjugation and orientation of the secondary antibody as signal labels. ECL immunosensor gradients on the electrode were formed by magnetolithography (ML) with magnetized nickel masks of column and stripe arrays. The immunosensor generally aggregated as an island on the substrate, leading to a decrease of efficiency in the characteristic signals. Stripe arrays of magnetized nickel were designed to generate cylindrical magnetic flux on the substrate to improve the particle manipulation with the gradient. Various gradients of the sandwich-structured immunosensor substantially affected the electrochemical performance. Compared to the gradient-free immunosensor, the gradient of the immunosensor generated by ML using a 3 μm stripe array mask enhanced the ECL intensity ∼2.2 times. The results of quantification of epithelial cell adhesion molecules (EpCAM) with the gradient immunosensor showed a broad linear range (15-420 pg mL-1), a low limit of detection (5.5 pg mL-1), and high reliability for EpCAM-spiked serum samples, indicating that the immunosensor gradient substantially enhances the performance of the ECL assay. © 2022 American Chemical Society.

关键词： Immunosensors

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