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FluoroFusion: NHC-Catalyzed Nucleophilic Aromatic Substitution Reaction Unveils Functional Perfluorinated diarylmethanones

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Organic letters 2024年第11期26卷 2338-2342页

作者： Cheng-Lin Chan Shao-Chi Lee Pei-Shan Lin Radyn Vanessa phaz P Tapales Jia-Syuan Li Chun-An Lai Jyh-Tsung Lee Chien-Hung Li Hsuan-Hung Liao Department of Chemistry National Sun Yat-sen University Kaohsiung 804201 Taiwan (R.O.C.). Department of International Ph.D. Program for Science National Sun Yat-sen University Kaohsiung 804201 Taiwan (R.O.C.). Department of Chemistry National Chung Hsing University Taichung 402202 Taiwan (R.O.C.). KAUST Catalysis Center (KCC) King Abdullah University of Science and Technology (KAUST) Thuwal 23955 Saudi Arabia. Department of Applied and Medicinal Chemistry Kaohsiung Medical University Kaohsiung 807378 Taiwan (R.O.C.).

A mild, facile, and metal-free approach via the -heterocyclic carbene-catalyzed SAr reaction between aryl aldehydes with perfluoroarenes to obtain the coveted functional perfluorinated diarylmethanones is disclosed. This method accommodates a diverse substrate range and exhibits notable tolerance toward various functional groups. Our success in modifying biologically relevant molecules, crafting a fully fluorinated bioisosteric analogue of drug candidate , and highlighting the potential of these ketones as valuable electrolyte additives for lithium-ion batteries (LIBs) underscores the versatility of our methodology.

关键词： Additives Aldehydes Aromatic compounds Chemical reactions Electrolytes

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Thermal history-driven void formation in silicon crystals: A discrete model approach

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Case Studies in Thermal engineering 2025年 73卷

作者： Amir Reza Ansari dezfoli Department of Intelligent Automation Engineering National Chin-Yi University of Technology Taichung Taiwan ROC Ph.D. Program at Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan ROC

As the growth rate rises to achieve more substantial production rates in silicon crystal growth through the Czochralski (CZ) process, vacancy agglomeration leading to void defect formation becomes particularly notable due to the elevated ratio of growth rate to thermal gradient (V/G). To explore this phenomenon, a computational platform was developed that integrates a fully transient three-dimensional finite-element (FE) model and a cellular automaton (CA) model to simulate void nucleation and growth. This study offers a new discrete model for simulating void formation during the CZ process. It delivers a thorough analysis of the thermal dynamics within the furnace, the morphology of the solid-liquid interface, and the spatial distribution of point defects, including vacancies and interstitials. The model accounts for transient phenomena such as the synchronized movement of the crystal and crucible, the thermal capacity of furnace components, the thermal inertia of the solidification interface, and the evolving suspect formations governed by time-dependent conditions. The CA model, combined with the FE framework, evaluates void formation based on point defect concentration, temperature distribution, and nucleation density criteria. Experimental validation was carried out using wafers extracted from silicon ingots at different growth stages (50 mm, 250 mm, and 600 mm). Wafer cleaning and etching procedures were employed to increase defect visibility, and defect detection was carried out using a laser-based particle counting system. The results confirmed the presence and spatial distribution of voids, which accord with the simulation predictions.

关键词： Czochralski process Void formation Vacancy agglomeration Finite-element modeling Cellular automaton simulation Point defect dynamics

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#136 : Osteopontin Facilitates Embryo Growth, Implantation, and Cellular Metabolism via Interacting withαvβ3 and RGS2 Pathway: Evidence from Mouse Embryos and a 3d In-Vitro Implantation Model

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Fertility & Reproduction 2023年第4期5卷 706-706页

作者： Nguyen Tuong Ho Pei-Yu Liao Chii Tzeng Shu-Huei Kao International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan School of Medical Laboratory Science and Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan Taipei Fertility Center Taipei Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background and Aims: We conducted a study on mice to investigate how osteopontin, a mediator of cell-cell and cell-extracellular matrix (ECM) communication and invasion, influences embryonic development, metabolism, and implantation potential, with confirmation by a 3d in-vitro implantation model. Method: Embryos were collected from female mice and cultured under different conditions: HTF only, HTF supplemented with OPN at different doses, and OPN-supplemented HTF with anti- α v β 3 Ab or RGS2 inhibitors. Embryo morphology, development, and implantation rates were evaluated. Microarrays were used to evaluate gene expression profiling. Choriocarcinoma JAR and epithelial RL95-2 cell lines were adopted for the in-vitro implantation model. Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were used to measure cellular metabolism levels. Results: The supplementation of OPN best enhanced the rate of embryo hatching-out and implantation onto the matrigel at 100 nM, but a higher degeneration rate was seen at a higher concentration ( ≥ 200 nM). In OPN-treated embryos, microarray analysis showed 51 significantly down-regulated genes and 60 up-regulated genes, including RGS2. Inhibition of α v β 3 integrin decreased embryo implantation rates and down-regulated RGS2. Validation of the 3d implantation model using JAR spheroids and RL95-2 monolayer showed a similar effect. OPN also increased OCR and ECAR of the JAR cells, and migration assays revealed increased migration ability in OPN-overexpressed JAR cells, which was then inhibited by α v β 3 and RGS2 inhibitors. Conclusion: Osteopontin, at a reasonable concentration, could enhance embryo development and implantation by interacting with α v β 3 integrin, subsequently facilitating the RGS2 pathway. OPN has the potential to be a supplement during in vitro embryo culture in ART intervention.

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PVA-based bioinks for 3d bioprinting: A comprehensive review of their applications in tissue engineering

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Bioprinting 2025年 49卷

作者： Narges Johari Zary Adabavazeh Francesco Baino Materials Engineering Group Golpayegan College of Engineering Isfahan University of Technology Golpayegan Iran Ph.D. Program Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan ROC Institute of Materials Physics and Engineering Department of Applied Science and Technology Politecnico di Torino Torino Italy

3d bioprinting is an innovative approach that overcomes the limitations of traditional methods for creating cell-laden biomaterials and constructs. It allows for the fabrication of complex and biologically active tissue structures. This review aims to provide a comprehensive evaluation of polyvinyl alcohol (PVA)-based bioinks within a 3d bioprinting framework. PVA-based bioinks exhibit remarkable properties, such as biocompatibility, biodegradability, and the ability to enhance cell growth and differentiation. These properties make them appropriate for many tissue engineering applications. The study evaluates the physicochemical and biological properties of PVA bioinks, including how they combine with other materials such as gelatin, chitin, chitosan, alginate, agarose, cellulose, κ-carrageenan, methacrylate, nanoparticles, mineral additives, carbon nanotubes, graphene oxide, and extracellular matrix components. Furthermore, this review evaluates the benefits of market availability and enhanced printing resolution, in addition to the challenges posed by complexity, dependency on support baths, and the risk of contamination. The objective of this review is to draw attention to the capabilities of PVA-based bioinks and provide guidelines for future research to improve the effectiveness of these materials in tissue engineering and regenerative medicine.

关键词： Bioprinting Bioink Polyvinyl alcohol PVA-based bioinks

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Oxygen-producing composite dressing activated by photothermal and piezoelectric effects for accelerated healing of infected wounds

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Chemical engineering Journal 2023年 476卷

作者： Lai, Yen-Han Roy Barman, Snigdha Ganguly, Anindita Pal, Arnab Yu, Jui-Han Chou, Syun-Hong Huang, E-Wen Lin, Zong-Hong Chen, San-Yuan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Science China Medical University Hospital Taichung40400 Taiwan School of Dentistry College of Dental Medicine Kaohsiung Medical University Kaohsiung80708 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan

The process of wound healing is often obstructed by the prevalence of bacterial infection at the wound site. Hence, innovative strategies to alleviate infection is extremely necessary to realize effective wound recovery in a timely manner. Here, we report a self-activated composite dressing consisting of piezoelectric and photothermal functional layers for combating wound infection and provide the desired treatment. The synergistic dressing is functionalized with piezoelectric Poly-L-lactic acid (PLLA) which under the effect of ultrasound irradiation controllably generates reactive oxygen species (ROS) for antibacterial activity, thus facilitating the dressing to inhibit the growth of bacteria at the wound bed. Further, the dressing is modified with calcium peroxide (CaO2) which can effectively convert the generated ROS into molecular oxygen (O2) in presence of catalase enzyme for treating chronic hypoxia in the infected wounds. The sustained generation of O2 by the wound dressing augmented the cell proliferation, migration and tissue regeneration aiding in wound healing. By combining the inherent photothermal activity of reduced graphene oxide (rGO), the synergistic dressing under NIR irradiation enhanced the wound recovery by upregulating the heat shock protein 90 (Hsp90) secretion owing to the heat generation on the wounds. The results obtained demonstrate that the self-triggered multifunctional wound dressing is a promising candidate for clinical treatment of infected wounds with a user-friendly interface. © 2023 Elsevier B.V.

关键词： Ultrasonics

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Separation of Electric Guitar Sound based on stacked Recurrent Neural Network

Separation of Electric Guitar Sound based on stacked Recurre...

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International Conference on Technologies and Applications of Artificial Intelligence (TAAI)

作者： Wen-Hsing Lai Siou-Lin Wang National Kaohsiung University of Science and Technology Kaohsiung Taiwan Ph.D. Program in Engineering Science and Technology National Kaohsiung University of Science and Technology Kaohsiung Taiwan

ISBN: (数字)9781665403801

ISBN: (纸本)9781665447379

Most audio source separation-related studies have been speech/singing separation, and those on musical instruments separation have been relatively scant. In this research, a stacked recurrent neural network was used to train a model to extract electric guitar sound from mixtures of electric guitar and other musical instruments. Objective assessment scores indicate that the proposed method can extract the electric guitar sounds from the musical mixtures successfully.

关键词： Training Performance evaluation Recurrent neural networks Instruments Music data models Music information retrieval

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Research on data Security and Privacy of Smart Grids

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International Journal of Network Security 2024年第5期26卷 901-910页

作者： Hwang, Min-Shiang Chang, Yung-Ling Lin, Ko-Yu Lin, Iuon-Chang Yang, Cheng-Ying Department of Computer Science & Information Engineering Asia University 500 Lioufeng Rd. Wufeng Taichung Taichung41354 Taiwan Fintech and Blockchain Research Center Asia University 500 Lioufeng Rd. Wufeng Taichung Taichung41354 Taiwan The Ph.D. Program in Artificial Intelligence Asia University Taiwan Department of Management Information Systems National Chung Hsing University 500 Lioufeng Rd. Wufeng Taichung Taichung41354 Taiwan Department of Computer Science University of Taipei Taipei Taiwan

developing a smart grid is a trend nowadays and an indispensable basic necessity of life. In recent years, the electricity demand has risen rapidly due to economic development and quality of life improvement. The power grid in significant cities is unstable due to old equipment, and power outages occur frequently. The smart grid can adjust the grid’s distribution strategy through the consumer’s real-time electricity demand so that the consumer’s electricity consumption data is always transmitted to the grid. Failure to protect the privacy and security of such information will expose consumers’ habits and even make the grid unnecessarily wasteful. The smart grid’s abnormality detection efficiency determines the overall grid’s stability. Failure to detect anomalies or power theft in the grid promptly will not only lead to the selection of the wrong distribution strategy for the smart grid but also reduce the transmission efficiency of the grid. This research ensures the privacy and security of transmitted data to enhance the efficiency of abnormality detection in the smart grid. The research issues are divided into privacy of transmitted data, data security authentication, and anomaly detection efficiency. © (2024), (International Journal of Network Security). All rights reserved.

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Evaluating the Robustness of Complementary Channel Ferroelectric FETs Against Total Ionizing dose Towards Radiation-Tolerant Embedded Nonvolatile Memory

TechRxiv

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TechRxiv 2023年

作者： Jiang, Zhouhang Guo, Zixiang Luo, Xuyi Sayed, Munazza Faris, Zubair Mulaosmanovic, Halid duenkel, Stefan Soss, Steven Beyer, Sven Gong, Xiao Kurinec, Santosh Narayanan, Vijaykrishnan Amrouch, Hussam Zhang, Enxia Fleetwood, daniel M. Schrimpf, Ronald d. Ni, Kai The Microsystems Engineering Ph.D. Program The Mechanical Engineering Rochester Institute of Technology RochesterNY14623 United States The Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN37235 United States University of Stuttgart Stuttgart70174 Germany Germany The Munich Institute of Robotics and Machine Intelligence Arcisstrasse 21 Munich80333 Germany The GlobalFoundries Fab1 LLC Dresden Germany The Department of Electrical Computer Engineering National University of Singapore 119077 Singapore The Department of Computer Science and Engineering Penn State University University ParkPA16802 United States The Department of Electrical and Microelectric Engineering Rochester Institute of Technology RochesterNY14623 United States

In this work, a thorough assessment of the robustness of complementary channel HfO2 ferroelectric FET (FeFET) against total ionizing dose (TId) radiation is conducted, with the goal of determining its suitability for use as high-performance and energy-efficient embedded nonvolatile memory (eNVM) for space applications. We demonstrate that: i) ferroelectric HfO2 thin film is robust against X-ray and proton irradiation;ii) FeFET exhibits a polarization state dependent radiation sensitivity where the high-VTH (HVT) state sees noticeable negative VTH shift and low-VTH (LVT) is immune to irradiation, irrespective of the channel type;iii) the state dependence is ascribed to the depolarization field in the HVT, which points toward the channel and facilitates the transport and trapping of radiation-generated holes close to the channel. In the future, radiation hardening techniques need to be considered. © 2023, CC BY.

关键词： Radiation effects

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Novel visible-light-induced P-doped g-C3N4/α-Bi2O3 nanocomposite photocatalysts for enhanced degradation of refractory endocrine disruptors—benzophenones

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Applied Surface science 2023年 607卷

作者： Berekute, Abiyu Kerebo Yu, Kuo-Pin Chuang, Yi-Hsueh Lin, Kun-Yi International Ph.D. Program in Environmental Science and Technology National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental and Occupational Health Sciences National Yang Ming Chiao Tung University Taipei11221 Taiwan Institute of Environmental Engineering National Yang Ming Chiao Tung University Hsinchu City30010 Taiwan Department of Environmental Engineering and Innovation and Development Center of Sustainable Agriculture & Research Center of Sustainable Energy and Nanotechnology National Chung Hsing University 250 Kuo-Kuang Road Taichung Taiwan

The Z-scheme heterojunction design can not only minimize photogenerated electron-hole pair recombination but also ensure strong redox abilities for driving photocatalytic reactions. Hence, novel P-g-C3N4/α-Bi2O3 binary nanocomposites were successfully fabricated by a combined hydrothermal-calcination method. The as-synthesized samples were systematically characterized by X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy/energy-dispersive X-ray spectroscopy, transmission electron microscopy, ultraviolet–visible spectroscopy, photoluminescence (PL) spectroscopy, N2 isotherm measurement, electrochemical impedance spectroscopy (EIS), thermogravimetric analysis, and electron paramagnetic resonance. The photocatalytic efficiency of the as-prepared samples was assessed via decontamination of refractory and endocrine-disrupting benzophenones (BPs) under visible light irradiation. The 25 wt% P-g-C3N4/α-Bi2O3 nanocomposite exhibited higher photocatalytic activity for 4-hydroxybenzophenone (4H-BP) and benzophenone-1 degradation than P-g-C3N4 and α-Bi2O3. The apparent enhancement of the photocatalytic activity might be mainly attributed to the enhanced light-harvesting ability and the heterojunction formation, which significantly facilitates photogenerated charge carrier separation and transfer, as confirmed by the PL and EIS findings. Notably, 25 wt% P-g-C3N4/α-Bi2O3 exhibited robust reusability and stability with high efficiency in 4H-BP removal after four repeated photocatalytic cycles. © 2022 Elsevier B.V.

关键词： Heterojunctions

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Occurrence and fate of pharmaceutical pollutants in wastewater: Insights on ecotoxicity, health risk, and state–of–the-art removal

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Chemosphere 2024年 354卷 141678页

作者： Nguyen, Minh-Ky Lin, Chitsan Bui, Xuan-Thanh Rakib, Md. Refat Jahan Nguyen, Hoang-Lam Truong, Quoc-Minh Hoang, Hong-Giang Tran, Huu-Tuan Malafaia, Guilherme Idris, Abubakr M. Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ho Chi Minh City700000 Viet Nam Department of Environmental Science and Management North South University Dhaka Bashundhara1229 Bangladesh Department of Civil Engineering McGill University Montreal Canada Faculty of Management Science Thu Dau Mot University Binh Duong 75000 Viet Nam Faculty of Medicine Dong Nai Technology University Dong Nai Bien Hoa76100 Viet Nam Laboratory of Ecology and Environmental Management Science and Technology Advanced Institute Van Lang University Ho Chi Minh City700000 Viet Nam Faculty of Applied Technology School of Engineering and Technology Van Lang University Ho Chi Minh City700000 Viet Nam Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia MG Uberlândia Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás GO Goiânia Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute GO Urutaí Brazil Department of Chemistry College of Science King Khalid University Abha62529 Saudi Arabia King Khalid University Abha62529 Saudi Arabia

pharmaceutical active compound (phAC) residues are considered an emerging micropollutant that enters the aquatic environment and causes harmful ecotoxicity. The significant sources of phACs in the environment include the pharmaceutical industry, hospital streams, and agricultural wastes (animal husbandry). Recent investigations demonstrated that wastewater treatment plants (WWTPs) are an important source of phACs discharging ecosystems. Several commonly reported that phACs are detected in a range level from ng L−1 to μg L−1 concentration in WWTP effluents. These compounds can have acute and chronic adverse impacts on natural wildlife, including flora and fauna. The approaches for phAC removals in WWTPs include bioremediation, adsorption (e.g., biochar, chitosan, and graphene), and advanced oxidation processes (AOPs). Overall, adsorption and AOPs can effectively remove phACs from wastewater aided by oxidizing radicals. Heterogeneous photocatalysis has also proved to be a sustainable solution. Bioremediation approaches such as membrane bioreactors (MBRs), constructed wetlands (CWs), and microalgal-based systems were applied to minimize pharmaceutical pollution. Noteworthy, applying MBRs has illustrated high removal efficiencies of up to 99%, promising prospective future. However, WWTPs should be combined with advanced solutions, e.g., AOPs/photodegradation, microalgae–bacteria consortia, etc., to treat and minimize their accumulation. More effective and novel technologies (e.g., new generation bioremediation) for phAC degradation must be investigated and specially designed for a low-cost and full-scale. Investigating green and eco-friendly phACs with advantages, e.g., low persistence, no bioaccumulation, less or non-toxicity, and environmentally friendly, is also necessary. © 2024 Elsevier Ltd

关键词： Microalgae

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