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Jing-Si Herbal Tea Suppresses H2O2-Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes

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Environmental Toxicology 2024年第12期39卷 5347-5356页

作者： Kao, Shih-Wen Chang, Yu-Chun Lin, Feng-Huei Huang, Tai-Lung Chen, Tung-Sheng Lin, Shinn-Zong Lin, Kuan-Ho Kuo, Wei-Wen Ho, Tsung-Jung Huang, Chih-Yang Graduate Institute of Aging Medicine China Medical University Taichung Taiwan Department of Orthopedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University Taipei Taiwan Division of Biomedical Engineering and Nanomedicine Research National Health Research Institute Miaoli Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu chi University Hualien Taiwan Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan

Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans;however, its undesired activation results in tissue damage and cell death. The onset of chronic inflammation and oxidative stress are the key characteristics of autoimmune inflammatory diseases such as rheumatoid arthritis (RA), for which an effective treatment is yet to be developed. Therefore, in this study, we investigated the protective effects and molecular mechanisms of a novel herbal preparation, Jing-Si herbal tea (JS), against H2O2-induced inflammation and cellular damage in HIG-82 synoviocytes. We found that JS did not show any significant alterations in cell viability at 2O2-induced pathological oxidative stress (ROS) in HIG-82 cells. Interestingly, JS treatment not only reduced the ROS levels but also significantly repressed the protein expressions of collagen degrading proteases in a dose-dependent manner. Treatment with JS showed enhanced cell viability against H2O2-induced toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and Bcl-2 were increased, whereas MMP-13, AdAMTS-2, Cytochrome C, and cleaved Caspase 3 were decreased by JS under inflammatory agents H2O2, MIA, LPS, and TNF-α treatment, respectively, in HIG-82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2-treated HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases. © 2024 Wiley Periodicals LLC.

关键词： Cell death

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Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery

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Nucleic Acids Research 2023年第19期51卷 10768-10781页

作者： Liu, Ze Wang, Justin Shi, Yi Yee, Brian A Terrey, Markus Zhang, Qian Lee, Jenq-Chang Lin, Kuo-I Wang, Andrew H-J Ackerman, Susan L Yeo, Gene W Cui, Haissi Yang, Xiang-Lei Department of Molecular Medicine Scripps Research Institute La Jolla 92037 CA United States Department of Biochemistry School of Medicine Nankai University Tianjin China Department of Cellular and Molecular Medicine University of California San Diego La Jolla 92093 CA United States Howard Hughes Medical Institute Department of Cellular and Molecular Medicine School of Medicine University of California San Diego La Jolla 92093 CA United States Department of Surgery National Cheng Kung University Medical College and Hospital Taiwan Genomics Research Center Academia Sinica Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei 110 Taiwan Department of Neurobiology University of California San Diego La Jolla 92093 CA United States

Translational readthrough of UGA stop codons by selenocysteine-specific tRNA (tRNASec) enables the synthesis of selenoproteins. Seryl-tRNA synthetase (SerRS) charges tRNASec with serine, which is modified into selenocysteine and delivered to the ribosome by a designated elongation factor (eEFSec in eukaryotes). Here we found that components of the human selenocysteine incorporation machinery (SerRS, tRNASec, and eEFSec) also increased translational readthrough of non-selenocysteine genes, including VEGFA, to create C-terminally extended isoforms. SerRS recognizes target mRNAs through a stem-loop structure that resembles the variable loop of its cognate tRNAs. This function of SerRS depends on both its enzymatic activity and a vertebrate-specific domain. Through eCLIP-seq, we identified additional SerRS-interacting mRNAs as potential readthrough genes. Moreover, SerRS overexpression was sufficient to reverse premature termination caused by a pathogenic nonsense mutation. Our findings expand the repertoire of selenoprotein biosynthesis machinery and suggest an avenue for therapeutic targeting of nonsense mutations using endogenous factors. © 2023 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research.

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Oxidation behaviour of Al2O3-forming Cr-based alloys at elevated temperatures

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Corrosion science 2024年 235卷

作者： Liu, Che-Jen Huang, Kai-Yu Lin, Wei-Chih Chen, Tso-Wei Lo, Kai-Chi Hsu, Wei-Lin Gorsse, Stéphane Yeh, An-Chou Ph.D. Program in Prospective Functional Materials Industry National Tsing Hua University 101 Sec. 2 Kuang-Fu Road Hsinchu30013 Taiwan High Entropy Materials Center National Tsing Hua University 101 Section 2 Kuang-Fu Road Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University 101 Sec. 2 Kuang-Fu Road Hsinchu30013 Taiwan Univ. Bordeaux CNRS Bordeaux INP ICMCB UMR 5026 PessacF-33600 France

This work presents oxidation behaviours of Al-bearing Cr-based alloys GA1 (51Cr-22Al-13Mo-9Ta-5Si in at%) and GA2 (40Cr-33Al-13Mo-9Ta-5Si in at%) at 1100–1400 ˚C for up to 24 h. The formation of oxides on the surfaces was influenced by constituent phases;BCC phase was rich in Al and formed only α-Al2O3, complex oxides (Cr2O3, AlTaO4, CrTaO4, and Ta2O5) occurred on top of C14 Laves phase. Sufficient Al content is crucial to the formation of protective α-Al2O3, as GA2 was able to resist severe oxidation at 1400 ˚C with an oxidation weight gain of only 3.3 mg/cm2 after 24 h. © 2024 Elsevier Ltd

关键词： Aluminum oxide

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Electrochemical biosensor based on an atomic layered composite of graphene oxide/graphene as an electrode material towards selective and sensitive detection of miRNA-21

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Microchemical Journal 2024年 199卷

作者： Huang, Min-Shin Govindasamy, Mani Chinnapaiyan, Sathishkumar Lin, Yi-Ting Lu, Shao-Yang Samukawa, Seiji Huang, Chi-Hsien Department of Materials Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai-602105 Tamil Nadu India Institute of Fluid Science Tohoku University Sendai 980-8577 Japan College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300093 Taiwan Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan City 33305 Taiwan College of Engineering Chang Gung University Taoyuan City 33302 Taiwan

development of an efficient technique towards the detection of miRNAs is highly significant for the timely diagnosis and prognosis of cancers. In this study, we utilized the chemical vapor deposition (CVd) technique to grow bilayer graphene (BLG) on copper foil and subsequently transferred the BLG to fluorine doped tin oxide (FTO) substrate via a facile wet transfer technique. The upper layer of the BLG was modified to graphene oxide (GO) with a low damage plasma treatment (LdPT) process to serve as a biomolecule receiving layer and the lower graphene layer (G) serves as an electron transport layer. The developed GO/G/FTO platform offers superior sensing ability towards the miRNA-21. The results demonstrated that the proposed GO/G/FTO substrate detect the miRNA-21 with a wide linear range (10 fM ∼ 1 nM), low limit of detection (3.18 fM), high sensitivity (0.6 mApM⁻¹cm⁻²), selectivity and stability via the differential pulse voltammetry method. Additionally, the sensors can efficiently discriminate the target miRNA-21 from its complementary base mismatched counterparts. The proposed approach serves as an excellent tool for the early diagnosis of diseases. © 2024 Elsevier B.V.

关键词： Atomic layer oxidation Biosensor Cancer biomarkers Electrochemical Graphene oxide Plasma treatment

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design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CdK8) inhibitors

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Biomedicine and pharmacotherapy 2023年第1期159卷 114258-114258页

作者： Hsu, Jui-Yi Hsu, Kai-Cheng Sun, Ching Chou, Ching-Hsuan Lin, Tony Eight Sung, Tzu-Ying Tseng, Hui-Ju Yen, Shih-Chung Yang, Chia-Ron Huang, Wei-Jan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan TMU Research Center for Drug Discovery Taipei Medical University Taipei Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei Taiwan Cancer Center Wan Fang Hospital Taipei Medical University Taipei Taiwan School of Pharmacy College of Medicine National Taiwan University Taipei Taiwan Biomedical Translation Research Center Academia Sinica Taipei Taiwan Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California Los Angeles CA United States Warshel Institute for Computational Biology The Chinese University of Hong Kong (Shenzhen) Guangdong Shenzhen China School of Pharmacy Taipei Medical University Taipei Taiwan

Cyclin-dependent protein kinase 8 (CdK8) plays important roles in regulating fibrotic growth factors and inflammatory signaling pathways. Long-term chronic inflammation of the lungs can lead to idiopathic pulmonary fibrosis (IPF). Abnormal alveolar epithelial regeneration leads to the release of various fibrotic growth factors and the activation of inflammatory cells. CdK8 regulates profibrotic cytokines broadly implicated in the pathogenesis of fibrosis. Therefore, inhibition of CdK8 is considered a promising strategy for treating IPF. Here, CdK8 inhibitors were designed and optimized using a fragment-based drug design strategy. Testing results revealed that 71% of the synthesized compounds inhibited CdK8 activity better than the original compound E966–0530. Of these compounds, compound 4k exhibited the strongest CdK8 enzyme-inhibiting activity (IC₅₀ =129 nM). Notably, it displayed a 13-fold increase in potency when compared to E966–0530. Experiments on toxicity and inhibition of epithelial-mesenchymal transition (EMT) protein expressions showed that compound 4k can inhibit EMT protein expressions, but with no significant cytotoxicity for alveolar epithelial cells. Compound 4k showed a potent inhibitory effect in cell migration assays. Furthermore, compound 4k significantly inhibited the phosphorylation of p-Smad3 and RNA Pol II, which are critical mediators in the fibrotic response signaling pathway. Compound 4k remarkably reduced TGF-β1-induced oxidative stress. The above results reveal optimized CdK8 inhibitors with potential use for IPF therapeutic treatment. © 2023 The Authors

关键词： Cyclin-dependent protein kinase 8 (CdK8) Idiopathic pulmonary fibrosis (IPF) Indolin-2-one Kinase inhibitor Lead optimization

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deep Unsupervised Learning for Biomedical Image Translation from Harmonic Generation Microscopy Image to H&E-stained Image

Deep Unsupervised Learning for Biomedical Image Translation ...

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Conference on Lasers and Electro-Optics (CLEO)

作者： Wei-Ju Chen En-Yu Liao Tsung-Ming Tai Yi-Hua Liao Chi-Kuang Sun Cheng-Kuang Lee Simon See Hung-Wen Chen International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics National Taiwan University Taipei Taiwan NVIDIA AI Technology Center NVIDIA Taipei Taiwan Department of Dermatology National Taiwan University Hospital and College of Medicine National Taiwan University Taipei Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu Taiwan

This work proposes an unsupervised deep learning-based image translation from Harmonic generation microscopy (HGM) to widely used H&E-stained images. The proposed methodology is promising and hopefully will facili... 详细信息

ISBN: (纸本)9781957171258

关键词： Harmonic generation Image analysis Image stacking Second harmonic generation Third harmonic generation Three dimensional imaging

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Impact of Scheduled Acceleration on Weekends on Labor Productivity-Case Studies of Construction in Taiwan

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Journal of the Chinese Institute of Civil and Hydraulic engineering 2020年第1期32卷 23-33页

作者： Lin, Chien-Liang Lai, Yu-Che Construction Engineering National Kaohsiung University of Science and Technology Kaohsiung81164 Taiwan Ph. D Program in Engineering Science and Technology National Kaohsiung University of Science and Technology Kaohsiung82445 Taiwan

Most previous research has revealed that labour efficiency deteriorates with the increase of days worked, especially for schedule acceleration carried out 6 or 7 days per week. It means that labor productivity on weekdays is better than on weekends. However, the phenomenon may not be universally applicable to everywhere. To clarify the impact of schedule acceleration on weekends on labor productivity, this study investigates the efficiency of acceleration from three construction projects in Taiwan. data Envelopment Analysis (dEA) was utilized to examine work hours as the input and the physical quantity of completed work as the output. Further interview for construction workers was performed. The results revealed that (1) acceleration on weekends will not cause the deduction of labor productivity in construction industry in Taiwan;(2) inefficiency was not found on Saturdays because labors are used to work overtime and get higher pay in construction industry in Taiwan;(3) except for getting higher pay, better efficiency was measured on Sundays because the effect of less congestion. The main contribution of this paper is to reveal that the labor productivity on weekends could be better than on weekdays, and further investigate the reasons of the result. Not only this finding reverses previous perspective from construction industry and academic, but also it implies that labor productivity will be influenced by many factors. Furthermore, it reveals the importance of continuing planning and management. In the process of revising Labor Standard Act, the results can provide insights for legislator and industry practitioners in appropriately allocating human resources. © 2020, Chinese Institute of Civil and Hydraulic engineering. All right reserved.

关键词： Construction industry

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Towards Robust Natural-Looking Mammography Lesion Synthesis on Ipsilateral dual-Views Breast Cancer Analysis

arXiv

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arXiv 2023年

作者： Nguyen, Thanh-Huy Kha, Quang Hien Truong, Thai Ngoc Toan Lam, Ba Thinh Ngo, Ba Hung dinh, Quang Vinh Le, Nguyen Quoc Khanh Department of Biomedical Engineering National Cheng Kung University Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taiwan Viet Nam Ho Chi Minh City International University Viet Nam Graduate School of Data Science Chonnam National University Korea Republic of Vietnamese-German University Viet Nam Research Center for Artificial Intelligence in Medicine Taipei Medical University Taiwan Professional Master Program in Artificial Intelligence in Medicine Taiwan

In recent years, many mammographic image analysis methods have been introduced for improving cancer classification tasks. Two major issues of mammogram classification tasks are leveraging multi-view mammographic information and class-imbalance handling. In the first problem, many multi-view methods have been released for concatenating features of two or more views for the training and inference stage. Having said that, most multi-view existing methods are not explainable in the meaning of feature fusion, and treat many views equally for diagnosing. Our work aims to propose a simple but novel method for enhancing examined view (main view) by leveraging low-level feature information from the auxiliary view (ipsilateral view) before learning the high-level feature that contains the cancerous features. For the second issue, we also propose a simple but novel malignant mammogram synthesis framework for upsampling minor class samples. Our easy-to-implement and no-training framework has eliminated the current limitation of the CutMix algorithm which are unreliable synthesized images with random pasted patches, hard-contour problems, and domain shift problems. Our results on Vindr-Mammo and CMMd datasets show the effectiveness of our two new frameworks for both multi-view training and synthesizing mammographic images, outperforming the previous conventional methods in our experimental settings. © 2023, CC BY-NC-SA.

关键词： Mammography

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Color Refractive Error Exam for Speech disorder

Color Refractive Error Exam for Speech Disorder

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IEEE International Symposium on Intelligent Signal Processing and Communication Systems (ISPACS)

作者： Feng-Ming Yeh Liang-Ying Huang Chun-Yu Chiang Rong-Seng Chang Chuen-Lin Tien Ya-Hui Hsieh der-Chin Chen Department of Optometry Yuanpei University of Medical Technology Hsinchu Taiwan Department of Optics and Photonics National Central University Taoyuan Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung Taiwan Department of Electrical Engineering Feng Chia University Taichung Taiwan Department of Healthcare Information and Management Ming Chuan University Taoyuan Taiwan

In this study, a micro-led display, an eye chart player software, and image capture and processing module were used to construct a color refractive error exam for subject with speech disorder. This method can be used to test subjects with refractive errors, eye's color vision and other pathological problems. The micro-led display uses an eye chart player program to display the capital letters E and the other fonts, and the gaps of the E letters can be tumbled in any direction. When subjects with speech disorder were examined for vision, the E chart was displayed sequentially from big letters to small letters, and the image capture and processing module was synchronized with the eye chart player program. The subjects only need to point out the direction of the gap with gestures, and the image capture and processing module can simultaneously capture the gestures of the subjects to judge visual test status. In this study, twenty subjects were tested and all obtained the correct VA value and wore excellent eye glasses. The characteristic of this innovative method is that the subjects with a speech disorder can use simple hand gestures to complete the visual exam through the image capture and processing module during the inspection.

关键词： Visualization Pathology Image color analysis Glass Image capture Signal processing Inspection

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Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

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International Journal of Nanomedicine 2023年 18卷 1413-1431页

作者： Chu, Ya-Chun Fang, Hsu-Wei Wu, Yu-Yi Tang, Yu-Jun Hsieh, Erh-Hsuan She, Yizhou Chang, Che-Yi Lin, I-Chan Chen, Yin-Ju Liu, Guei-Sheung Tseng, Ching-Li Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei City Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Center for Precision Medicine and Translational Cancer Research Taipei Medical University Hospital Taipei City Taiwan Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital East Melbourne VIC Australia Ophthalmology Department of Surgery University of Melbourne East Melbourne VIC Australia Menzies Institute for Medical Research University of Tasmania Hobart TAS Australia Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan

Background: Corneal neovascularization (NV) is a process of abnormal vessel growth into the transparent cornea from the limbus and can disturb the light passing through the cornea, resulting in vision loss or even blindness. The use of nanomedicine as an effective therapeutic formulation in ophthalmology has led to higher drug bioavailability and a slow drug release rate. In this research, we designed and explored the feasibility of a new nanomedicine, gp91 ds-tat (gp91) peptide-encapsulated gelatin nanoparticles (GNP-gp91), for inhibiting corneal angiogenesis. Methods: GNP-gp91 were prepared by a two-step desolvation method. The characterization and cytocompatibility of GNP-gp91 were analyzed. The inhibition effect of GNP-gp91 on HUVEC cell migration and tube formation was observed by an inverted microscope. The drug retention test in mouse cornea was observed by in vivo imaging system, fluorescence microscope, and dAPI/TAMRA staining. Finally, the therapeutic efficacy and evaluation of neovascularization-related factors were conducted through the in vivo corneal NV mice model via topical delivery. Results: The prepared GNP-gp91 had a nano-scale diameter (550.6 nm) with positive charge (21.7 mV) slow-release behavior (25%, 240hr). In vitro test revealed that GNP-gp91 enhanced the inhibition of cell migration and tube formation capacity via higher internalization of HUVEC. Topical administration (eyedrops) of the GNP-gp91 significantly prolongs the retention time (46%, 20 min) in the mouse cornea. In chemically burned corneal neovascularization models, corneal vessel area with a significant reduction in GNP-gp91 group (7.89%) was revealed when compared with PBS (33.99%) and gp91 (19.67%) treated groups via every two days dosing. Moreover, GNP-gp91 significantly reduced the concentration of Nox2, VEGF and MMP9 in NV’s cornea. Conclusion: The nanomedicine, GNP-gp91, was successfully synthesized for ophthalmological application. These data suggest that GNP-gp91 contain

关键词： control release corneal neovascularization eye drops gelatin gp91 peptide nanoparticles ocular retention

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