检索结果-内蒙古大学图书馆

Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left- and right-sided breast cancer

引用

Thoracic Cancer 2023年第26期14卷 2696-2706页

作者： Wang, Shan-Ying Tsai, Wei-Ta Lin, Kuan-Heng Yu, Chih-Wei Yang, Shu-Ya Shueng, Pei-Wei Wu, Yen-Wen Hsu, Chen-Xiong Wu, Tung-Hsin Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan Department of Nuclear Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Department of Radiation Oncology Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan Division of Radiation Oncology Department of Radiology Far Eastern Memorial Hospital New Taipei City Taiwan Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan Department of Radiation Oncology China Medical University Hsinchu Hospital Zhubei City Taiwan Institute of Nuclear Engineering and Science National Tsing Hua University Hsinchu City Taiwan Department of Nuclear Medicine Cheng Hsin General Hospital Taipei Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Division of Cardiology Cardiovascular Medical Center Far Eastern Memorial Hospital New Taipei City Taiwan

Background: This study aimed to utilize an innovative method of integrating the 20 subvolume dose of left ventricle and the Tl-201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters in patients with left- and right-sided breast cancer after radiation therapy. Methods: Female patients with breast cancer underwent SPECT MPI before commencing radiotherapy and 12 months later were enrolled from January 2014 to december 2018. The images of CT simulation and SPECT MPI were integrated into the treatment planning system. The differences of doses and parameters of MPI in all cardiac subvolumes between left- and right-sided breast cancer patients were analyzed. Results: Patients with left-sided breast cancer (n = 61) received a higher radiation dose to the heart, left ventricular, and its territories and subvolumes, compared to patients with right-sided breast cancer (n = 19). The 20-segment analysis also showed statistically significant disparities in the average radiation doses received by the two groups. In different coronary artery territories, the end-diastolic perfusion and end-systolic perfusion showed a decrease in both sides, with no significant differences. However, the wall motion and wall thickening showed a significant decline in subregions within the left- and right-sided coronary artery territories. Conclusion: This study demonstrates an innovative integrated method combining the left ventricular 20 regional doses with SPECT MPI which shows that left-sided breast cancer patients receive a higher subvolume dose than right-sided breast cancer patients. Further research is needed to confirm the potential impact on heart function after radiotherapy on both sides. © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

关键词： myocardial perfusion imaging radiation therapy subvolume dose

来源：评论

学校读者我要写书评

暂无评论

Embedding diselenide Cross-Linked Polymer Nanoparticles In-Situ Using Ring-Opening Metathesis Polymerization (Romp) of Norbornene derived Block Copolymers for Ros-Responsive doxorubicin (dox) drug delivery

SSRN

引用

SSRN 2025年

作者： Rao, Neralla Vijayakameswara Mathew, Jacob Le, Trong-Nghia Lee, Cheng-Kang Huang, Ru Department of Chemical Engineering National Taiwan University of Science and Technology Taipei Taiwan School of Pharmacy College of Pharmacy Taipei Medical University Taipei Taiwan Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taipei Taiwan National Taiwan University of Science and Technology Taiwan

Norborene-derived block polymers with selenol-containing components and norbornene-polyethylene (PNEG) components are proposed for the development of diselenide-crosslinked polymer nanoparticles (dC PNPs), in situ, which are responsive to the abnormal ROS levels in the tumoral region, as anticancer drug carriers. These nanoparticles can be designed to release anticancer drugs selectively in the tumor microenvironment, minimizing systemic toxicity and enhancing therapeutic efficacy. The diselenide bonds in the polymer degrade in response to high levels of reactive oxygen species (ROS), which are characteristic of cancerous tissues, thereby releasing the drug at the target site. In micelles, doxorubicin (dOX) is effectively encapsulated in the hydrophobic core and the shell is strengthened by diselenide crosslinks (dOX- dC PNPs). A dLS particle stability study demonstrated that structural integrity was maintained for three days under physiological conditions. However, the hydrophobic diselenide bond successfully fragmented into hydrophilic selenic acid derivatives under ROS conditions, leading to the release of the payload from the drug-containing matrix. Validation of the drug release showed that 52% of the payload was released at a H2O2 concentration of 10 µM, ensuring the reactive matrix reaction;s optimal accuracy. A toxicity study on a normal cell line (L929) confirmed the polymer's biocompatibility, while the encapsulated model exhibited significant toxicity to a cancer cell line (Hela). In contrast to free dOX, dOX-loaded polymer nanoparticles (PNPs) displayed a lower toxicity threshold, attributed to their capacity for gradual drug release over time. Furthermore, a comparison of cellular uptake reveals that while free dOX provides immediate drug availability, dOX loaded PNPs offer a more controlled and sustained release mechanism. In cancer therapy, this characteristic enhances therapeutic efficacy while minimizing side effects associated with high concentrati

关键词： Tissue culture

来源：评论

学校读者我要写书评

暂无评论

Rapid label-free detection of Pseudomonas aeruginosa using a fluidic grating chip with a reflective laser system

引用

Biosensors and Bioelectronics: X 2022年 10卷

作者： Chen, Jie-Jun Cheng, Chih-Chia Chang, Chi-Jung Lu, Chien-Hsing Chen, Jem-Kun Department of Materials and Science Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei106 Taiwan Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei10607 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Seatwen Taichung40724 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung Taiwan Institute of Biomedical Sciences Ph.D. Progrom in Translational Medicine and Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung Taiwan

Stripe arrays of poly(methacrylic acid) (PMAA) brushes were grafted using a photoresist template to fabricate one-dimensional photonic crystal (OPCs). The as-prepared samples were first bound with protein G to immobilize and orient tails of the antibody of Pa (abY). A fluidic diffraction chip based on the abY-tailed PMMA OPC was fabricated to examine the ability of Pa detection from whole blood specimen. Pa was attached to the abY-tailed PMMA OPC after flowing through the fluidic chip, which changed the diffraction intensity. A laser beam was employed to analyze the reflective signals of OPCs at an incident angle of 45°. The abY-tailed PMAA OPC possessed an optical feature with a characteristic diffraction effect such that the projection of the laser beam on the plane of the OPC chip was parallel to the strips in SII configurations, whereas they were perpendicular in ST configurations. The degree of the diffraction intensity exhibited a linear response to Pa at concentrations from 102 to 107 CFU mL−1, and the limit of detection was 100 CFU mL−1, indicating the excellent sensitivity in Pa-spiked whole blood samples. The proposed platform provides a rapid, label-free method for Pa detection to improve the administration of antibiotics in a timely manner. © 2022 The Authors

关键词： Laser beams

来源：评论

学校读者我要写书评

暂无评论

Crystal structure-controlled synthesis of NiMoO4/NiO hierarchical microspheres for high-performance supercapacitors and photocatalysts

引用

Journal of Energy Storage 2024年 97卷

作者： Lee, Kuen-Chan Huang, Jen-Hsien Wu, Yen-Ju Wang, Kuan-Syun Cho, Er-Chieh Hsu, Shih-Chieh Liu, Ting-Yu Department of Science Education National Taipei University of Education No. 134 Sec. 2 Heping E. Road Da-an District Taipei City106 Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Green Material Technology Green Technology Research Institute CPC Corporation No.2 Zuonan Rd. Nanzi District Kaohsiung City81126 Taiwan 1-2-1 Sengen Tsukuba Ibaraki305-0047 Japan Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan School of Pharmacy College of Pharmacy Taipei Medical University 250 Wuxing Street Taipei City110 Taiwan Department of Chemical and Materials Engineering Tamkang University No. 151 Yingzhuan Road Tamsui District New Taipei City25137 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan City32003 Taiwan College of Engineering & Center for Sustainability and Energy Technologies Chang Gung University Taoyuan33302 Taiwan

Global environmental challenges and energy crises have driven researchers to develop multifunctional and highly efficient nanomaterials. This study presents dual-functional NiMoO4 (NMO)/NiO hierarchical microspheres that can serve as supercapacitors and photocatalysts prepared using a microwave-assisted hydrothermal method. The α- and β-phase contents of NMO can be regulated by controlling the post-annealing temperature and ph value of the precursor solution. The as-prepared NMO/NiO nanocomposites exhibited dual Faradaic redox reactions attributed to NMO and NiO, leading to remarkable supercapacitor performance. In addition, the constructed heterojunction between NMO and NiO also improved charge separation, leading to excellent photocatalytic capability. Based on the results, NMO with a higher β-phase content showed better supercapacitive and photocatalytic performance owing to its higher conductivity. The optimal NMO/NiO composite displayed a specific capacitance of 943 F g−1 at 1 A/g and excellent cycling stability, with 83.1 % retention at 5 A/g after 4000 cycles. Additionally, it demonstrated an outstanding photocatalytic capability for the degradation of methylene blue (MB), achieving a rate constant of (0.0113 min−1). © 2024 Elsevier Ltd

关键词： Supercapacitor

来源：评论

学校读者我要写书评

暂无评论

Small molecule tractable PARP inhibitors: Scaffold construction approaches, mechanistic insights and structure activity relationship

引用

Bioorganic Chemistry 2023年 141卷 106893页

作者： Thakur, Amandeep Rana, Mandeep Ritika Mathew, Jacob Nepali, Sanya Pan, Chun-Hsu Liou, Jing Ping Nepali, Kunal School of Pharmacy College of Pharmacy Taipei Medical University Taipei 110031 Taiwan College of Medicine Taipei Medical University Taipei 110031 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei 106335 Taiwan Manipal School of Life Sciences Manipal Academy of Higher Education Manipal 576104 India Ph.D. Program in Drug Discovery and Development Industry College of Pharmacy Taipei Medical University Taiwan

diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold hopping, isosteric replacement, high-throughput screening, induction and separation of chirality, structure modifications of phytoconstituents and use of structural templates have been exhaustively leveraged in the last decade to load the chemical toolbox of PARP inhibitors. Resultantly, numerous promising scaffolds have been pinpointed that in turn have led to the resuscitation of the credence to PARP inhibitors as cancer therapeutics. This review briefly presents the physiological functions of PARPs, the pharmacokinetics, and pharmacodynamics, and the interaction profiles of FdA-approved PARP inhibitors. Comprehensively covered is the section on the drug design strategies employed by drug discovery enthusiasts for furnishing PARP inhibitors. The impact of structural variations in the template of designed scaffolds on enzymatic and cellular activity (structure–activity relationship studies) has been discussed. The insights gained through the biological evaluation such as profiling of physicochemical properties and in vitro AdME properties, PK assessments, and high-dose pharmacology are covered. © 2023 Elsevier Inc.

关键词： BRCA mutations Cancer dNA damage Molecular hybridization PARP inhibitors Scaffold hopping Tumor

来源：评论

学校读者我要写书评

暂无评论

Investigation of ecological risk of microplastics in peatland areas: A case study in Vietnam

引用

Environmental Research 2023年 220卷 115190页

作者： Nguyen, Minh Ky Lin, Chitsan Quang Hung, Nguyen Tri Hoang, Hong-Giang Vo, dai-Viet N. Tran, Huu-Tuan Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Faculty of Environment and Natural Resources Nong Lam University of Ho Chi Minh City Hamlet 6 Linh Trung Ward Thu Duc Dist. Ho Chi Minh City700000 Viet Nam Faculty of Medicine Dong Nai Technology University Bien Hoa Dong Nai 76100 Viet Nam Nguyen Tat Thanh University Ho Chi Minh City700000 Viet Nam Laboratory of Ecology and Environmental Management Science and Technology Advanced Institute Van Lang University Ho Chi Minh City700000 Viet Nam Faculty of Applied Technology School of Engineering and Technology Van Lang University Ho Chi Minh City700000 Viet Nam

This study aims to investigate the distribution and ecological risk assessment of microplastics (MPs) in peatland areas located in Long An province, Vietnam's Mekong delta. In general, polyvinyl chloride (60.7%), polyethylene (25.8%), and polypropylene (11.9%) were the most abundant polymers determined in the thirty sediment samples. The hazard index (HI) remarked a level of III for MPs contamination in Tan Thanh and Thanh Hoa districts. The pollution load index (PLI) and potential ecological risk index (RI) indicated that the contamination risk of MPs polymer types in the studied sites is relatively high. According to PLI values, MPs levels of peatlands in Tan Thanh and Thanh Hoa are high and moderate, respectively, while the peatland sediments in duc Hue district are less contaminated. Furthermore, ecological risk indexes in the peatland areas were relatively high, with PLIoverall (level III);HIoverall (level V), and RIoverall (extreme danger). Hence, this study proposed a SWOT framework for challenges of MPs pollution in order to manage peatlands appropriately and minimize ecological risks. As a result, several practical strategies and appropriate approaches have been recommended to reduce microplastics towards a circular economy. These findings provide the initial quantitative assessment insights into hazard levels and ecological impacts of MPs in Vietnam's Mekong delta peatlands. © 2022 Elsevier Inc.

关键词： Risk assessment

来源：评论

学校读者我要写书评

暂无评论

Ultrasound-guided drug delivery system utilizing piezocatalytic MoS2 nanomaterials for anti-inflammatory therapy

引用

Nano Energy 2024年 127卷

作者： Lin, Ssu-Chi Joshi, Ravindra Ganguly, Anindita Barman, Snigdha Roy Pal, Arnab Kaswan, Kuldeep Liu, Kuei-Lin Nain, Amit Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Engineering Indian Institute of Science Karnataka Bangalore560012 India Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan

Traditional drug delivery systems lack the potential of controlled drug release, thereby decreasing drug utilization and release efficiency. Herein, a next generation of stimuli-responsive drug delivery platform is designed based on piezocatalytic molybdenum disulfide nanoflowers (MoS2 NFs) which can be triggered by ultrasound (US) stimulation for effective acute inflammation therapy. Under US irradiation, MoS2 NFs undergoes piezocatalysis to generate reactive oxygen species (ROS) owing to piezoelectric polarization, thus releasing loaded anti-inflammatory drug Indomethacin (INd) to the targeted inflammation site. The cumulative release of INd elevated significantly with the increase in the duration for US exposure due to the amplified ROS generation, which displayed a highly controllable nature of the as-designed drug delivery platform. For convenient applications, the INd loaded MoS2 NFs (INd@MoS2 NFs) was functionalized onto commercial dressings and their tunable in-vivo drug release performance was demonstrated in paw edema model. INd@MoS2 NFs upon US irradiation, controllably released INd into the site-specific inflamed paw which significantly inhibited 56 % of paw swelling in 6 h by suppressing the infiltration of neutrophils and expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α). The highly controllable drug delivery system holds great potential in facilitating personalized, user-friendly theranostic applications with improved patient outcomes. © 2024 Elsevier Ltd

关键词： Ultrasonics

来源：评论

学校读者我要写书评

暂无评论

The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem

引用

iscience 2024年第9期27卷

作者： Kuo, Cheng-Liang Lin, Ying-Chen Lo, Yu Kang Lu, Yu-Zhi Babuharisankar, Ananth Ponneri Lien, Hui-Wen Chou, Han-Yu Lee, Alan Yueh-Luen National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan 35053 Taiwan Department of Life Sciences College of Health Sciences & Technology National Central University Taoyuan Zhongli 32001 Taiwan Ph.D. Program in Tissue Engineering and Regenerative Medicine College of Medicine National Chung Hsing University Taichung 40402 Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung 40402 Taiwan Department of Biotechnology College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan

Mitochondria play important roles in cell fate, calcium signaling, mitophagy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a signaling organelle in the cell and communicate with other organelles to constitute the mitochondrial information processing system (MIPS) that transduce input-to-output biological information. The success in immunotherapy, a concept of systemic therapy, has been proved to be dependent on paracrine interactions within the tumor microenvironment (TME) and distant organs including microbiota and immune components. We will adopt a broader view from the concept of TME to tumor micro- and macroenvironment (TM²E) or tumor-organ ecosystem (TOE). In this review, we will discuss the role of mitochondrial signaling by mitochondrial ROS, calcium flux, metabolites, mtdNA, vesicle transportation, and mitochondria-derived peptide in the TME and TOE, in particular immune regulation and effective cancer immunotherapy. © 2024 The Author(s)

关键词： Cancer Immune response Microenvironment

来源：评论

学校读者我要写书评

暂无评论

Faster GröBner Bases Via domain-Specific Ordering in Parameter Identifiability of Ode Models

SSRN

引用

SSRN 2023年

作者： Bessonov, Mariya Ilmer, Ilia Konstantinova, Tatiana Ovchinnikov, Alexey Pogudin, Gleb Soto, Pedro Brookhaven National Laboratory United States Department of Mathematics CUNY NYC College of Technology New YorkNY United States Ph.D. Program in Computer Science CUNY Graduate Center New YorkNY United States Department of Mathematics CUNY Queens College New YorkNY United States LIX CNRS École Polytechnique Institute Polytechnique de Paris Paris France Mathematical Institute University of Oxford Oxford United Kingdom

We consider a specific class of polynomial systems that arise in parameter identifiability problems of models of ordinary differential equations (OdE) and discover a method for speeding up the Gr¨obner basis computation by using specific variable ordering and weights coming from the structure of the OdE model. We provide empirical results that show improvement across different symbolic computing frameworks. © 2023, The Authors. All rights reserved.

关键词： Ordinary differential equations

来源：评论

学校读者我要写书评

暂无评论

defect engineering Centrosymmetric 2d Material Flexocatalysts

引用

Small 2024年第31期20卷 2401116-2401116页

作者： Chen, Yu-Ching Chen, Po-Han Liao, Yin-Song Chou, Jyh-Pin Wu, Jyh Ming Department of Materials Science and Engineering National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan Ph.D. Program in Prospective Functional Materials Industry National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan Tsing Hua Interdisciplinary Program National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan Department of Physics National Changhua University of Education No. 1 Jin-De Road Changhua500 Taiwan High Entropy Materials Center National Tsing Hua University 101 Section 2 Kuang Fu Road Hsinchu300 Taiwan

In this study, the flexoelectric characteristics of 2d TiO2 nanosheets are examined. The theoretical calculations and experimental results reveal an excellent strain-induced flexoelectric potential (flexopotential) by an effective defect engineering strategy, which suppresses the recombination of electron–hole pairs, thus substantially improving the catalytic activity of the TiO2 nanosheets in the degradation of Rhodamine B dye and the hydrogen evolution reaction in a dark environment. The results indicate that strain-induced bandgap reduction enhances the catalytic activity of the TiO2 nanosheets. In addition, the TiO2 nanosheets degraded Rhodamine B, with kobs being ≈1.5 × 10−2 min−1 in dark, while TiO2 nanoparticles show only an adsorption effect. 2d TiO2 nanosheets achieve a hydrogen production rate of 137.9 µmol g−1 h−1 under a dark environment, 197% higher than those of TiO2 nanoparticles (70.1 µmol g−1 h−1). The flexopotential of the TiO2 nanosheets is enhanced by increasing the bending moment, with excellent flexopotential along the y-axis. density functional theory is used to identify the stress-induced bandgap reduction and oxygen vacancy formation, which results in the self-dissociation of H2O on the surface of the TiO in the dark. The present findings provide novel insights into the role of TiO2 flexocatalysis in electrochemical reactions. © 2024 Wiley-VCH GmbH.

关键词： Titanium dioxide

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：