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arXiv 2022年

作者： Bessonov, Mariya Ilmer, Ilia Konstantinova, Tatiana Ovchinnikov, Alexey Pogudin, Gleb Soto, Pedro Department of Mathematics CUNY NYC College of Technology New YorkNY United States Ph.D. Program in Computer Science CUNY Graduate Center New YorkNY United States Department of Mathematics CUNY Queens College New YorkNY United States LIX CNRS École Polytechnique Institute Polytechnique de Paris Paris France

Symbolic computation for systems of differential equations is often computationally expensive. Many practical differential models have a form of polynomial or rational OdE system with specified outputs. A basic symbolic approach to analyze these models is to compute and then symbolically process the polynomial system obtained by sufficiently many Lie derivatives of the output functions with respect to the vector field given by the OdE system. In this paper, we present a method for speeding up Gröbner basis computation for such a class of polynomial systems by using specific monomial ordering, including weights for the variables, coming from the structure of the OdE model. We provide empirical results that show improvement across different symbolic computing frameworks and apply the method to speed up structural identifiability analysis of OdE models. © 2022, CC BY-NC-SA.

关键词： Polynomials

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Low-concentration imiquimod treatment promotes enhanced skin barrier functions through epidermal melanization reaction regulation

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Environmental Toxicology 2024年第9期39卷 4360-4371页

作者： Lin, Tzu-Kai Tsai, Chia-Lun Tsai, Bruce Chi-Kang Kuo, Chia-Hua Ho, Tsung-Jung Hsieh, dennis Jine-Yuan Kuo, Wei-Wen Huang, Chih-Yang Department of Dermatology Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan School of Medicine Tzu Chi University Hualien Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Sports Sciences University of Taipei Taipei Taiwan Laboratory of Exercise Biochemistry Institute of Sports Sciences University of Taipei Tianmu Campus Taipei Taiwan Department of Kinesiology and Health Science College of William and Mary WilliamsburgVA United States Department of Chinese Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Integration Center of Traditional Chinese and Modern Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan School of Post-Baccalaureate Chinese Medicine College of Medicine Tzu Chi University Hualien Taiwan School of Medical Laboratory and Biotechnology Chung Shan Medical University Taichung Taiwan Clinical Laboratory Chung Shan Medical University Hospital Taichung Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan School of Pharmacy China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

The primary function of the skin is to form a mechanical, permeability, antimicrobial, and ultraviolet radiation barrier, which is essential for maintaining physiological homeostasis. Our previous studies demonstrated that cutaneous pigmentation could promote skin barrier function in addition to providing anti-ultraviolet irradiation defense. The present study aimed to develop a new regimen that enhances skin barrier function by regulating skin pigmentation using low-concentration imiquimod. Results showed that topical application of low-concentration imiquimod effectively induced skin hyperpigmentation in the dorsal skin and external ear of mice without inducing inflammatory cell infiltration. An in vitro study also revealed that low-concentration imiquimod did not induce any cytotoxic effects on melanoma cells but triggered excessive melanin synthesis. In coculture systems, low-concentration imiquimod was noted to increase tyrosinase activity in a broader cellular context, revealing the potential role of neighboring cells in melanin production. The next-generation sequencing result indicated that PKCη and dnm3 might regulate melanin synthesis and release during imiquimod treatment. Overall, our study presents new insights into the regulation of melanin production by low-concentration imiquimod, both in a mice model and cultured cells. Furthermore, our study highlights the potential benefits of imiquimod in promoting melanin synthesis without causing skin disruptions or inducing inflammation, validating its potential to serve as a method for enhancing skin barrier functions by regulating the epidermal melanization reaction. © 2024 Wiley Periodicals LLC.

关键词： Irradiation

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Frequency-responsive sorption of metal ions onto magnetic polyvinyltetrazole microspheres through a solenoid-wrapped glass tube with magnetophoresis force

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Journal of Water Process engineering 2024年 63卷

作者： Chen, Chih-Wei Wang, Chih-Feng Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei 106 Taiwan Division of Neurosurgery Department of Surgery Chi Mei Medical Center Tainan 710 Taiwan Institute of Advanced Semiconductor Packaging and Testing National Sun Yat-sen University Kaohsiung 804 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung 40705 Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung 940227 Taiwan

Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetophoresis force (FMEP) is introduced to accelerate the adsorption of metal i... 详细信息

Concentration gradient predominantly determining both the diffusion rate and the removal rate of pollutants by adsorbents. An external magnetophoresis force (F_MEP) is introduced to accelerate the adsorption of metal ions on adsorbents under an alternating magnetic field (AMF). A solenoid-wrapped glass tube (SWGT) containing adsorbents is designed to generate F_MEP in a flowing system. Magnetic Fe₃O₄ nanoparticles (MFs) are coated on polyacrylonitrile microspheres (PANs) as precursors (PAN@MFs) by Pickering emulsion polymerization. The core@shell polyvinyltetrazole@MFs (PVT@MFs) are obtained as the adsorbents after subsequent cyano-tetrazole conversion of PAN@MFs for the adsorption of Pb(II), Cu(II), and Cr(III) ions. The theoretical adsorption rate constants of these metal ions onto the PVT@MFs in the presence of F_MEP are enhanced by approximately three times under an AMF at 1 kHz and 87.6 G. At a high frequency of 10 kHz, hyperthermia occurs on the PVT@MFs, facilitating the desorption of metal ions from the adsorbents. Compared with reuse using an acidic solution, the magnetic PVT@MFs can be reused up to 10 times by switching the frequency of the AMF between 1 and 10 kHz. Our proposed platform provides a novel methodology with a magnetic adsorbent for metal ions to rapidly improve either the adsorption or desorption processes. © 2024

关键词： Adsorption rate Hyperthermia Magnetic susceptibility Polyvinyltetrazole

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Applications of engineered biochar in remediation of heavy metal(loid)s pollution from wastewater: Current perspectives toward sustainable development goals

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science of the Total Environment 2024年 926卷 171859页

作者： Tran, Thien-Khanh Huynh, Loan Nguyen, Hoang-Lam Nguyen, Minh-Ky Lin, Chitsan Hoang, Tuan-dung Hung, Nguyen Tri Q. Nguyen, X. Hoan Chang, S. Woong Nguyen, d. duc Advanced Applied Sciences Research Group Dong Nai Technology University Bien Hoa City76100 Viet Nam Faculty of Technology Dong Nai Technology University Bien Hoa City76100 Viet Nam Department of Civil Engineering McGill University Montreal Canada Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan School of Chemistry and Life Science Hanoi University of Science and Technology No. 1 Dai Co Viet Hai Ba Trung Hanoi100000 Viet Nam Vietnam National University Hanoi - School of Interdisciplinary Sciences and Arts 144 Xuan Thuy Street Cau Giay District Hanoi100000 Viet Nam Ho Chi Minh City University of Industry and Trade Ho Chi Minh City Viet Nam Department of Civil & Energy System Engineering Kyonggi University Suwon16227 Korea Republic of Institute of Applied Technology and Sustainable Development Nguyen Tat Thanh University Ho Chi Minh City700000 Viet Nam

Environmental pollution of heavy metal(loid)s (HMs) caused adverse impacts, has become one of the emerging concerns and challenges worldwide. Metal(loid)s can pose significant threats to living organisms even when present in trace levels within environmental matrices. Extended exposure to these substances can lead to adverse health consequences in humans. Removing HM-contaminated water and moving toward sustainable development goals (SdGs) is critical. In this mission, biochar has recently gained attention in the environmental sector as a green and alternative material for wastewater removal. This work provides a comprehensive analysis of the remediation of typical HMs by biochars, associated with an understanding of remediation mechanisms, and gives practical solutions for ecologically sustainable. Applying engineered biochar in various fields, especially with nanoscale biochar-aided wastewater treatment approaches, can eliminate hazardous metal(loid) contaminants, highlighting an environmentally friendly and low-cost method. Surface modification of engineered biochar with nanomaterials is a potential strategy that positively influences its sorption capacity to remove contaminants. The research findings highlighted the biochars' ability to adsorb HM ions based on increased specific surface area (SSA), heightened porosity, and forming inner-sphere complexes with oxygen-rich groups. Utilizing biochar modification emerged as a viable approach for addressing lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and chromium (Cr) pollution in aqueous environments. Most biochars investigated demonstrated a removal efficiency >90 % (Cd, As, Hg) and can reach an impressive 99 % (Pb and Cr). Furthermore, biochar and advanced engineered applications are also considered alternative solutions based on the circular economy. © 2024 Elsevier B.V.

关键词： Nanostructured materials

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Ultrasensitive detection of ornidazole–antibiotic drug residues in water using NiMOFs functionalized MWCNT modified electrode

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Microchemical Journal 2024年 197卷

作者： Vignesh, Kondusamy Senthil Kumar, Annamalai Arumugam Napoleon, Ayyakannu Kuo, Chih-Yu Yusuf, Kareem Govindasamy, Mani Nano and Bioelectrochemistry Research Laboratory Carbon dioxide Research and Green Technology Centre and Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Nitroimidazole-based drugs are widely used as an antibiotic for the treatment of anaerobic bacterial and parasite illnesses. The widespread use of these drugs in animal feed and the consequent environmental pollution have become significant concerns in recent years. Simple, sensitive, and rapid detection of the antibody in various real samples is demanding research interest. Herein, we report a Nickel-metal organic framework functionalized Multiwalled Carbon nanotubes modified glassy carbon electrode (MWCNT@NiMOFs) as an ultrasensitive and rapid voltammetric sensor for the detection of ornidazole (ORdZ) in a neutral ph solution. The MWCNT@NiMOFs were prepared using a microwave-assisted solvothermal technique accompanied by an ultrasonication method. The designed MWCNT@NiMOFs offered a low charge transfer resistance (R_ct) of 141 Ω along with excellent electrocatalytic activity, and high current density at the lowered cathodic peak potential (-0.62 V vs Ag/AgCl) for ORdZ detection. The surface adsorption capacity (Γ_s) in terms of surface excess and heterogeneous charge transfer rate constant (k⁰) of the MWCNT@NiMOFs were calculated to be 3.29 × 10^-9 mol cm⁻² and 5.33 × 10^-3 cm s⁻¹, respectively. Under an optimal working condition, differential pulse voltammetry measurements of ORdZ have shown concentration linearity in a window, 100 nm to 10 µM range with excellent sensitivity, 5.69 × 10^-5A µM⁻¹ cm⁻², and detection limit, 26 nM (3.3/s). The designed MWCNT@NiMOFs offered appreciable reproducibility, and repeatability up to 30 days of storage time. The real-time quantitative evaluation of ORdZ in human urine and tap water specimens was done along with ∼ 100 % recovery values. Since the new approach is simple, selective, and separation-free, it can be extendable to a variety of real-time practical applications. © 2024 Elsevier B.V.

关键词： Electrocatalytic reduction Multi-walled carbon nanotubes Nickel Metal-organic frameworks Ornidazole drug Ultrasensitive detection

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Current Progress of COPd Early detection: Key Points and Novel Strategies

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International Journal of COPd 2023年 18卷 1511-1524页

作者： Lin, Ching-Hsiung Cheng, Shih-Lung Chen, Chiung-Zuei Chen, Chia-Hung Lin, Sheng-Hao Wang, Hao-Chien Division of Chest Medicine Changhua Christian Hospital Changhua 500 Taiwan Institute of Genomics and Bioinformatics National Chung Hsing University Taichung 402 Taiwan Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan Department of Recreation and Holistic Wellness MingDao University Changhua Taiwan Department of Internal Medicine Far Eastern Memorial Hospital Taipei 220 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan 320 Taiwan Division of Pulmonary Medicine Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan Division of Pulmonary and Critical Care Medicine Department of Internal Medicine China Medical University Hospital Taichung 404 Taiwan Department of Internal Medicine National Taiwan University Hospital Taipei 100 Taiwan

Chronic obstructive pulmonary disease (COPd) is a major cause of morbidity and mortality worldwide, with approxi-mately 70% to 80% of adults with COPd being undiagnosed. Patients with undiagnosed COPd are at increased risk of poor outcomes and a worsened quality of life, making early detection a crucial strategy to mitigate the impact of COPd and reduce the burden on healthcare systems. In the past decade, increased interest has been focused on the development of effective strategies and instrument for COPd early detection. However, identifying undiagnosed cases of COPd is still challenging. Both screening and case-finding approaches have been adopted to identify undiagnosed COPd, with case-finding being recommended by the 2023 Global Initiative for Chronic Obstructive Lung disease (GOLd) guideline and the updated United States Preventive Services Task Force (USPTF) recommendation. Nonetheless, the approaches, criteria, and instruments used for early detection of COPd are varied. However, advances in the taxonomy and risk factors of COPd are continuously being investigated. It is important to continuously assess the current state of knowledge on COPd early detection, given the challenges associated with identifying undiagnosed COPd. This review aims to highlight recent advances in early detection of COPd. To discuss the current challenge and opportunity in COPd early detection, providing an overview of existing literature on COPd case-finding strategies, including the approaches, criteria for subjects, and instruments. The review also summarizes the current progress in COPd case-findings and proposes a COPd case-finding flowchart as an efficient method for identifying at risk COPd patients. © 2023 Lin et al.

关键词： at-risk case-finding COPd early detection undiagnosed

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YAP-regulated type II alveolar epithelial cell differentiation mediated by human umbilical cord-derived mesenchymal stem cells in acute respiratory distress syndrome

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Biomedicine and pharmacotherapy 2023年第1期159卷 114302-114302页

作者： Chen, Xiao-Yue Chen, Kuan-Yuan Feng, Po-Hao Lee, Kang-Yun Fang, Yu-Ting Chen, You-Yin Lo, Yu-Chun Bhavsar, Pankaj K. Chung, Kian Fan Chuang, Hsiao-Chi Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan School of Respiratory Therapy College of Medicine Taipei Medical University Taipei Taiwan National Heart and Lung Institute Imperial College London London United Kingdom Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Division of Pulmonary Medicine Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan The Ph.D. Program for Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan

Acute respiratory distress syndrome (ARdS) contributes to higher mortality worldwide. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have immunomodulatory and regenerative potential. However, the effects of hUC-MSCs as an ARdS treatment remain unclear. We investigated the role of hUC-MSCs in the differentiation of type II alveolar epithelial cells (AECII) by regulating Yes-associated protein (YAP) in ARdS. Male C57BL/6JNarl mice were intratracheally (i.t.) administered lipopolysaccharide (LPS) to induce an ARdS model, followed by a single intravenous (i.v.) dose of hUC-MSCs. hUC-MSCs improved pulmonary function, decreased inflammation on day 3, and mitigated lung injury by reducing the lung injury score and increasing lung aeration (%) in mice on day 7 (p < 0.05). hUC-MSCs inactivated YAP on AECII and facilitated cell differentiation by decreasing Pro-surfactant protein C (Pro-SPC) and galectin 3 (LGALS3) while increasing podoplanin (T1α) in lungs of mice (p < 0.05). In AECII MLE-12 cells, both coculture with hUC-MSCs after LPS exposure and the YAP inhibitor, verteporfin, reduced Pro-SPC and LGALS3, whereas the YAP inhibitor increased T1α expression (p < 0.05). In conclusion, hUC-MSCs ameliorated lung injury of ARdS and regulated YAP to facilitate AECII differentiation. © 2023 The Authors

关键词： Alveoli Inflammation Pneumocytes Regeneration Stem cells

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phase-engineered heterostructures of Mo2C by plasma-assisted selenization and sulfurization processes toward excellent hydrogen evolution reaction

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Nano Energy 2024年 122卷

作者： Kimbulapitiya, K.M.M.d.K. Rehman, Bushra Wani, Sumayah Shakil Chen, Chieh-Ting Cyu, Ruei-Hong Manikandan, Arumugam date, Manisha Kondiba Peng, Yu-Ren Kumara, R.J.G.L.R. Chuang, Feng-Chuan Chueh, Yu-Lun Department of Physics National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Materials Science and Engineering National Tsing-Hua University Hsinchu Taiwan College of Semiconductor Research National Tsing-Hua University Hsinchu30013 Taiwan Center for Nanotechnology Materials Science and Microsystem National Tsing-Hua University Hsinchu Taiwan Ph.D. Program in Prospective Functional Materials Industry National Tsing Hua University Hsinchu30013 Taiwan Physics Division National Center for Theoretical Sciences Hsinchu30013 Taiwan Center for Theoretical and Computational Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Physics National Tsing Hua University Hsinchu30013 Taiwan

due to the outstanding semiconducting and metallic properties, 2d materials such as Transition Metal dichalcogenides (TMds) and Transition Metal Carbides (TMCs) appear to be promising candidate for Nano-scale electronics devices. Among them, 2d - Mo2C (Molybdenum carbide) has attracted attention as a new member of the MXene group, owing to its potential applications for superconductors, electronics devices, and catalysts for Hydrogen evolution Reactions (HER). Structural modification toward the creation of novel heterostructures with phase engineering opens new pathways for different applications. Herein, we prepared a large area Mo2C film by chemical vapor deposition method. The upper region of Mo2C layers can be oxidized to create Mo2C/MoOx heterostructures. Furthermore, those oxide layers were further transformed into MoSe2 and MoS2 by plasma-assisted selenization and sulfurization processes at different temperatures with a fixed plasma power of 150 W. The heterostructures demonstrated outstanding electrocatalytic activity for HER due to an existed metallic phase and active sites present after plasma-assisted selenization and sulfurization processes at the low temperature. The performance of the HER decreases at high temperatures owing to their semiconducting phase. The pristine Mo2C showed a Tafel slope of 72 mV dec−1 and an overpotential of 276 mV at 10 mA/cm2, while the Mo2C/MoSe2 heterostructure synthesized at 350 °C350 °exhibited an improved Tafel slope of 66 mV dec−1 and overpotential of 257 mV at 10 mA/ cm2. Additionally, the Mo2C/MoS2 heterostructure prepared at 350 °C also demonstrated a 263 mV improvement in overpotential at 10 mA/cm2. All the heterostructures showed excellent stability over a period of 10 h except Mo2C/MoOx. This work opens new strategies to fabricate high-quality MXene and TMds heterostructures with metal-semiconductor interface. © 2024

关键词： Molybdenum compounds

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Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic differentiation

SSRN

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SSRN 2023年

作者： Wu, Yu-Jie Wang, Chi-Yun Feng, Kuei-Chih Chien, R.R. Mana-Ay, Haidee Kung, Shyang-Yih Hou, Kuang-Hua Tu, Chi-Shun Chen, Pin-Yi Lai, Po-Liang International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan

The 3d-printed Ti-6Al-4V intervertebral fusion cage is fabricated to be biocompatible with improved stiffness, fatigue life, and osteogenic differentiation, which are greatly enhanced by heat treatment and surface modification. The flexible cage’s life, which exceeds the standard dynamic fatigue requirement of 5x106 cycles based on the ASTM F2077 and F2267 test methods, is achieved by heat treatment at 800 ℃ in argon atmosphere, shot peening, and adjusting the α to β phase ratio to increase mechanical toughness. Surface modification via sandblasting and chemical etching removes the surface oxide layer and forms submicron pores on the surface of the cage, which significantly boosts cell proliferation, differentiation, and osteoblast mineralization. This work exhibits a novel design of Ti-6Al-4V intervertebral fusion cage with biocompatible stiffness, enhanced fatigue life, and improved osteogenic differentiation achieved by reducing residual stress, modifying surface micro-pores, and optimizing microstructure. © 2023, The Authors. All rights reserved.

关键词： Aluminum alloys

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CompressedMediQ: Hybrid Quantum Machine Learning Pipeline for High-dimensional Neuroimaging data

CompressedMediQ: Hybrid Quantum Machine Learning Pipeline fo...

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2025 IEEE International Conference on Acoustics, Speech, and Signal Processing Workshops, ICASSPW 2025

作者： Chen, Kuan-Cheng Li, Yi-Tien Li, Tai-Yu Liu, Chen-Yu Lee, Po-Heng Henry Chen, Cheng-Yu Imperial College London Department of Electrical and Electronic Engineering London United Kingdom Imperial College London Centre for Quantum Engineering London United Kingdom Taipei Medical University Hospital Translational Imaging Research Center Taipei Taiwan Taipei Medical University Research Center for Neuroscience Taipei Taiwan Taipei Medical University Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Taiwan NARlabs National Center for High-Performance Computing Hsinchu Taiwan National Taiwan University Graduate Institute of Applied Physics Taipei Taiwan Taipei Medical University Hospital Department of Medical Imaging Taipei Taiwan National Defense Medical Center Department of Radiology Taipei Taiwan College of Medicine School of Medicine Department of Radiology Taipei Taiwan

ISBN: (纸本)9798331519315

This paper introduces CompressedMediQ, a novel hybrid quantum-classical machine learning pipeline specifically developed to address the computational challenges associated with high-dimensional multi-class neuroimaging data analysis. Standard neuroimaging datasets, such as large-scale MRI data from the Alzheimer's disease Neuroimaging Initiative and Neuroimaging in Frontotemporal dementia, present significant hurdles due to their vast size and complexity. CompressedMediQ integrates classical HPC nodes for advanced MRI pre-processing and Convolutional Neural Network (CNN)-PCA-based feature extraction and reduction, addressing the limited-qubit availability for quantum data encoding in the NISQ era. This is followed by Quantum Support Vector Machine (QSVM) classification. By utilizing quantum kernel methods, the pipeline optimizes feature mapping and classification, enhancing data separability and outperforming traditional neuroimaging analysis techniques. Experimental results highlight the pipeline's superior accuracy in dementia staging, validating the practical use of quantum machine learning in clinical diagnostics. despite the limitations of NISQ devices, this proof-of-concept demonstrates the transformative potential of quantum-enhanced learning, paving the way for scalable and precise diagnostic tools in healthcare and signal processing. © 2025 IEEE.

关键词： Network coding

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