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Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression

Scientific Reports 2023年第1期13卷 1-12页

作者： Sun, Shu-Pin phang, Chun-Ren Tzou, Shey-Cherng Chen, Chang-Mu Ko, Li-Wei International Ph.D. Program in Interdisciplinary Neuroscience (UST) College of Biological Science and Technology National Yang Ming Chiao Tung University 734 Engineering Bldg. 5 1001 Daxue Road Hsinchu 30010 Taiwan Department of Medical Research National Taiwan University Hospital Hsin-Chu Branch Hsinchu 300 Taiwan Institute of Molecular Medicine and Bioengineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Surgery College of Medicine and Hospital National Taiwan University No. 7 Zhongshan South Road Taipei 10002 Taiwan Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Institute of Electrical and Control Engineering Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Department of Biomedical Science and Environment Biology and the Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 807 Taiwan

This study aimed to integrate magnetic resonance imaging (MRI) and related somatosensory evoked potential (SSEP) features to assist in the diagnosis of spinal cord compression (SCC). MRI scans were graded from 0 to 3 according to the changes in the subarachnoid space and scan signals to confirm differences in SCC levels. The amplitude, latency, and time–frequency analysis (TFA) power of preoperative SSEP features were extracted and the changes were used as standard judgments to detect neurological function changes. Then the patient distribution was quantified according to the SSEP feature changes under the same and different MRI compression grades. Significant differences were found in the amplitude and TFA power between MRI grades. We estimated three degrees of amplitude anomalies and power loss under each MRI grade and found the presence or absence of power loss occurs after abnormal changes in amplitude only. For SCC, few integrated approach combines the advantages of both MRI and evoked potentials. However, integrating the amplitude and TFA power changes of SSEP features with MRI grading can help in the diagnosis and speculate progression of SCC. © 2023, The Author(s).

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Improving the Concentration of Students With Attention deficit Hyperactivity disorder and Autism Spectrum disorder: Electroencephalographic Analysis on the Effect of Learning Activity Interventions

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International Journal of Intelligent Technologies & Applied Statistics 2020年第1期13卷 49-63页

作者： Ming-Hseuh Tsai Sy-Ruen Huang Shao-Chin Chang Yu-Ling Lo Yun-Chieh Lu Research Center for Education Systems and Policy National Academy f or Educational Research New Taipei City Taiwan Chung Chou University of Science and Technology Changhua County Taiwan Ph.D. Program of Electrical and Communications Engineering Feng-Chia University Taichung City Taiwan Department of Early Childhood Education Asia University Taichung City Taiwan

This study examined whether the learning concentration of students with attention deficit hyperactivity disorder (AdHd) or autism spectrum disorder (ASd) can be improved through participation in one-on-one learning activities. A total of 13 students with AdHd or ASd were recruited to participate in various weekly one-on-one learning activities, in an effort to improve the concentration of students with special needs. Brainwave data were collected through electroencephalography and analyzed to explore students' concentration performance in different learning activities. To achieve the objective of this study, a multi-baseline design (ABAB), a type of single-subject design method, was employed. The experiment spanned 21 weeks, covering a fall and a spring semester: the first three weeks were defined as the 1st baseline phase, the 4th to 10th weeks as the 1st experimental phase, the 11th to 13th weeks as the 2nd baseline phase, and the 14th to 21th weeks as the 2nd experimental phase. The learning activities took place in the morning self-study period once a week, and the experiment was only suspended during two of the weeks because of school events. The purpose of the two baseline phases was to collect students' brainwave data. Students' brainwaves were measured for two minutes under two scenarios; first, while they were relaxed with eyes looking straight ahead; second, they were reading a passage. The purpose of the two experimental phases was to gradually enhance students' concentration by training them to perceive their own emotions through brainwave lamps. Initial results yielded different brainwave data for students with different types of disorders. After participating in the training on learning concentration, some students demonstrated improved concentration; however, after the 2nd experimental phase, students' concentration declined. The reason was that the activities in both experimental phases were identical, and thus, they no longer provoked students' inte

关键词： Attention def icit hyperactivity disorder (AdHd) Autism spectrum disorder (ASd) Brainwave test Concentration

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Long-term treatment with benzodiazepines and related Z-drugs exacerbates breast cancer: clinical evidence and molecular mechanisms

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Cellular & molecular biology letters 2025年第1期30卷 75页

作者： Wei-Chung Vivian Yang Yen-Yi Lin Jeak Ling ding Chin-Sheng Hung phung-Anh Nguyen Bo-Xiang Zhang Tsung-Han Hsieh Shu-Chun Chang The Ph.D. Program for Translational Medicine College for Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. International Ph.D. Program for Translational Science College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Reproductive Medicine Center Taipei Medical University Hospital Taipei 110 Taiwan. Department of Biological Sciences National University of Singapore Singapore 117543 Singapore. Division of Breast Surgery Department of Surgery Taipei Medical University Hospital Taipei 110 Taiwan. Division of General Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan. Clinical Data Center Office of Data Science Taipei Medical University Taipei 110 Taiwan. Clinical Big Data Research Center Taipei Medical University Hospital Taipei Medical University Taipei 110 Taiwan. Research Center of Health Care Industry Data Science College of Management Taipei Medical University Taipei 110 Taiwan. Graduate Institute of Data Science College of Management Taipei Medical University Taipei 110 Taiwan. Ji Yan Biomedical (JY BioMed) Co. Ltd Taipei 110 Taiwan. Precision Health Center Taipei Medical University Taipei 110 Taiwan. The Ph.D. Program for Translational Medicine College for Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. sc.chang@tmu.edu.tw. International Ph.D. Program for Translational Science College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. sc.chang@tmu.edu.tw. TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei 110 Taiwan. sc.chang@tmu.edu.tw. Yu Chun Biotech Co. Ltd Taipei 110 Taiwan. sc.chang@tmu.edu.tw.

BACKGROUNd:Benzodiazepines (diazepam) and related Z-drugs (Zolpidem), henceforth referred to as BZdRs, are widely used for clinical treatment of insomnia and anxiety disorders. BZdRs act on GABA type A receptors to inhibit neurotransmitters. We previously demonstrated that prolonged clinical use of BZdRs exacerbates the risk of breast cancer (BRCA). METHOdS:By biomedical, health informatics platform analyses and in vivo studies, we explored clinical association between BZdR usage and BRCA development and advancement. Furthermore, by retrospective studies on patient clinical data and in vitro empirical analyses of the impact of BZdR on BRCA cells, and together with ingenuity pathway analysis (IPA) analyses, we validated the signaling pathways and identified potential intermolecular crosstalk involved. RESULTS:Clinical data showed that BRCA patients on long term treatment with BZdRs suffered increased mortality rate (p = 0.034). Studies on patient samples indicated that among 16 GABA receptors examined, GABRA3 (a pro-tumorigenic player) was significantly upregulated by BZdRs, which advanced BRCA disease. To support our clinical findings, we examined in vivo, the impact of BZdRs on BRCA advancement using MdA-MB231 cells to mediate metastasis in mice model. Our results show that BZdRs indeed promoted cancer advancement to the lungs and localized in the tibia. Using BRCA cell lines, we revealed the molecular-cellular effects of prolonged treatment with BZdRs in vitro. We showed significant metastasis indicated by increased cancer cell migration and invasion, which correlated well with our clinical observations. We discovered that BZdR-mediated GABRA3 stimulation was associated with downregulation of anti-tumorigenic extracellular matrix (ECM) molecules (S100B, COL6A6 and VIT) and upregulation of pro-tumorigenic FBN3 in BRCA cells. Notably, GABRA3-shRNA and GABRA3-CRISPR/Cas9 disrupted the abovementioned dynamics dramatically and suppressed BRCA cell invasion induced by B

关键词： Benzodiazepines and Z-drugs Breast cancer CRISPR/Cas9 strategy Clinical database informatics Extracellular matrix GABA receptors Tumor microenvironment

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Sulfur-inspired layered g-C₃N₄-incorporated NiFe₂S₄ nanocomposite for electrochemical and real-time detection of vanillin in food samples

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Journal of the Taiwan Institute of Chemical Engineers 2025年 174卷

作者： Tamilselvan, Arun Gopika, Meenakumari Gopakumar Karuppanan, Aravinth Saraswathyamma, Beena Albassami, Norah A. Govindasamy, Mani Department of Physics SSN Research centre Sri Sivasubramaniya Nadar College of Engineering Tamilnadu Kalavakkam 603110 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of chemistry Amrita Vishwa Vidyapeetham Amritapuri Campus Clappana Kerala Kollam 690525 India Department of Chemistry Faculty of Science King Khalid University P.O.Box 9004 Abha 61413 Saudi Arabia Research Centre for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Background: Vanillin is a widely used flavoring agent and plays a crucial role in food safety, making its accurate detection essential. developing sensitive and cost-effective methods for vanillin detection is vital for ensuring food quality and consumer protection. Methods: This study introduces a novel sulfur-engineered g-C₃N₄/NiFe₂S₄ nanocomposite synthesized via a simple and scalable method. The composite was employed to modify a glassy carbon electrode (GCE), significantly improving its electrochemical properties. Structural and morphological characterizations confirmed the successful integration of g-C₃N₄ with NiFe₂S₄. differential pulse voltammetry (dPV) was conducted under optimized conditions (ph 7). Significant Findings: The modified GCE exhibited a substantially enhanced oxidation peak current for vanillin, indicating superior electrocatalytic activity. The sensor achieved a wide linear detection range (0.01 - 360 µmol L^-1), a low detection limit (0.00031 µmol L^-1), and excellent selectivity, stability, repeatability, and reproducibility. Uniquely, the synergy between g-C₃N₄ and NiFe₂S₄ provided enhanced charge transfer and surface activity. Application of the sensor to real food samples including ice cream, wafers, and coffee demonstrated accurate recovery and practical feasibility, underscoring its potential as a reliable tool for food safety monitoring in real-world scenarios. © 2025 Taiwan Institute of Chemical Engineers

关键词： Electrochemical detection Food analysis G-c3n4 Health care Nanocomposite Nife2s4

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different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model

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Experimental Neurology 2023年第1期362卷 114338页

作者： Lee, Chi-Wei Chu, Ming-Chia Wu, Han-Fang Chung, Yueh-Jung Hsieh, Tsung-Han Chang, Chieh-Yu Lin, Yen-Cheng Lu, Ting-Yi Chang, Ching-Hsiang Chi, Hsiang Chang, Hsun-Shuo Chen, Yih-Fung Li, Cheng-Ta Lin, Hui-Ching Department and Institute of Physiology School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Department of Optometry Hsin-Sheng College of Medical Care and Management Taoyuan Taiwan School of Pharmacy College of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan Department of Psychiatry Taipei Veterans General Hospital Taipei Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei Taiwan Institute of Brain Science National Yang Ming Chiao Tung University Taipei Taiwan Division of Psychiatry Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institute Taipei Taiwan

Treatment-resistant depression (TRd) is a condition wherein patients with depression fail to respond to antidepressant trials. A new form of repetitive transcranial magnetic stimulation (rTMS), called theta-burst stimulation (TBS), which includes intermittent theta-burst stimulation (iTBS) and continuous theta-burst stimulation (cTBS), is non-inferior to rTMS in TRd treatment. However, the mechanism of iTBS and cTBS underlying the treatment of TRd in the prefrontal cortex (PFC) remains unclear. Hence, we applied foot-shock stress as a traumatic event to develop a TRd rat model and investigated the different mechanisms of iTBS and cTBS. The iTBS and cTBS treatment were effective in depressive-like behavior and active coping behavior. The iTBS treatments improved impaired long-term potentiation and long-term depression (LTd), whereas the cTBS treatment only improved aberrant LTd. Moreover, the decrease in mature brain-derived neurotrophic factor (BdNF)-related protein levels were reversed by iTBS treatment. The decrease in proBdNF-related protein expression was improved by iTBS and cTBS treatment. Both iTBS and cTBS improved the decreased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and downregulation of mammalian target of the rapamycin (mTOR) signaling pathway. The iTBS produces both excitatory and inhibitory synaptic effects, and the cTBS only produces inhibitory synaptic effects in the PFC. © 2023

关键词： BdNF Continuous theta-burst stimulation Intermittent theta-burst stimulation Prefrontal cortex Synaptic plasticity Treatment-resistant depression

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Chemoresistance in acute myeloid leukemia: An alternative single-cell RNA sequencing approach

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Hematological oncology 2023年第3期41卷 499-509页

作者： Po-Liang Cheng Tzu-Hung Hsiao Chung-Hsing Chen Miao-Neng Hung Pei-Pei Jhan Li-Wen Lee Ting-Shuan Wu Jia-Rung Tsai Chieh-Lin Jerry Teng Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan. Research Center for Biomedical Science and Engineering National Tsing Hua University Hsinchu Taiwan. Department of Public Health Fu Jen Catholic University New Taipei City Taiwan. Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan. Division of Hematology/Medical Oncology Department of Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Life Science Tunghai University Taichung Taiwan. School of Medicine Chung Shan Medical University Taichung Taiwan. Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan.

Our previous study demonstrated that myc, mitochondrial oxidative phosphorylation, mTOR, and stemness are independently responsible for chemoresistance in acute myeloid leukemia (AML) cells. This study aimed to identify potential mechanisms of chemoresistance of the "7 + 3" induction in AML by using a single-cell RNA sequencing (scRNA-seq) approach. In the present study, 13 untreated patients with de novo AML were enrolled and stratified into two groups: complete remission (CR; n = 8) and non-CR (n = 5). Single-cell RNA sequencing was used to analyze genetic profiles of 28,950 AML cells from these patients; results were validated using a previously published bulk RNA-seq dataset. Our study results showed chemoresistant AML cells had premature accumulation during early hematopoiesis. Hematopoietic stem cell-like cells from the non-CR group expressed more leukemic stem cell markers (Cd9, Cd82, IL3RA, and IL1RAP) than those from the CR group. Chemoresistant progenitor cells had impaired myeloid differentiation owing to early arrest of hematopoiesis. Notably, AML cells analyzed by scRNA-seq and bulk RNA-seq harbored a comparable myeloid lineage cell fraction, which internally validated our results. Using the TCGA database, our analysis demonstrated that patients with AML with higher expression of chemoresistant genetic markers (IL3RA and IL1RAP) had a worse overall survival (p < 0.01 for IL3RA; p < 0.05 for IL1RAP). In conclusion, AML cells responsive and resistant to the "7 + 3" induction were derived from a diverse cancerous hematopoietic stem cell population, as indicated by the specific genetic biomarkers obtained using scRNA-seq approach. Furthermore, arrest of hematopoiesis was shown to occur earlier in chemoresistant AML cells, furthering the current understanding of chemoresistance in AML.

关键词： acute myeloid leukemia chemoresistance leukemia stem cells single-cell RNA-seq

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CCL5 Protects Cortical Neuron Function by Regulating M2 Microglia Activation After Mild Traumatic Brain Injury

SSRN

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SSRN 2022年

作者： Tsai, Yih-Jeng Ho, Man-Hau Yen, Chia-Hung Wang, Jia-Yi Burnouf, Thierry Chen, Chia-Yen Wang, Yun Chiang, Yung-Hsiao Hoffer, Barry J. Chou, Szu-Yi Department of Otolaryngology Head and Neck Surgery Shin Kong Wu HoSu Memorial Hospital Taipei Taiwan School of Medicine Fu Jen Catholic University New Taipei City Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University National Health Research Institute Taiwan Graduate Institute of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Biological Science and Technology National Pingtung University of Science and Technology Neipu Pingtung91201 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Neurosurgery Taipei Medical University Hospital Taipei11031 Taiwan Neuroscience Research Center Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan NeuroTMULille International Laboratory Taipei Medical University Taipei Taiwan International PhD Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Brain and Consciousness Research Centre TMU Shuang Ho Hospital New Taipei City Taiwan Center for Neuropsychiatric Research National Health Research Institutes Zhunan Miaoli County Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University 11031 Taiwan Department of Neurosurgery Case Western Reserve University School of Medicine ClevelandOH United States Scientist Emeritus National Institutes of Health United States International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Cytokines and chemokines play important roles in inflammation and repair following brain injury. M1 microglia are pro-inflammatory which produce cytokines and lead to neural injury;in contrast, M2 microglia are anti-inflammatory, release neurotrophic factors, and promote neural repair processes. Chemokine CCL5, increased after TBI, shows a neuroprotective function by reducing oxidative stress. CCL5 may contribute to the balance between oxidative stress and immune responses after brain injury. Herein, we investigated the role of CCL5 in microglial polarization after mild traumatic brain injury, focusing on the cerebral cortex.C57BL/6 and CCL5 knockout (CCL5-KO) mice were given a mild traumatic brain injury (TBI) using weight-drop. Neurological parameters such as motor and sensory functions were analyzed by mNSS score, accelerating rotarod, beam walking, and adhesive removal tests. Oxidative stress and neuron damage were measured by NAdph oxidase activity, hypoxyloprobe staining and FJC. Performance of motor and sensory functions in both WT and CCL5-KO mice were impaired after brain injury which recovered after 7 days-post-injury (dpi) in the WT group but only after 14 days in the CCL5-KO mouse group. RT-qPCR analysis revealed that pro-inflammation cytokines - IL-1β, TNF-α, and IL-6 were higher in CCL5-KO mice compared to WT mice at 4 and 14 dpi. In contrast, M2-like microglia markers - IL-10 and Agr-1 were increased in WT mouse cortical tissue at 4 dpi. Oxidative stress increased both M1 and M2- related cytokine expression in BV2 cells treated with H 2 O 2;CCL5 treatment increased M2- but suppressed M1- related cytokine gene activation. Intranasal delivery of CCL5 reduced neuronal oxidative stress, increased IL-10 expression and improved motor and sensory functions in CCL5-KO mice after brain *** summary, CCL5, which alters immune responses and protects neurons from TBI damage, has an important function in regulating M2-like microglial polarization during post-

关键词： Polarization

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Water-Vapor Responsive Metallo-Peptide Nanofibers

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Angewandte Chemie 2024年第47期136卷

作者： Avishek dey Elma Naranjo Ranajit Saha Sheng Zhang Maya Narayanan Nair Tai-de Li Xi Chen Rein V. Ulijn Nanoscience Initiative at Advanced Science Research Center of the Graduate Center of the City University of New York New York New York 10031 USA Department of Chemical Engineering The City College of New York 275 Convent Ave New York NY 10031 USA Department of Chemistry Cooch Behar Panchanan Barma University Cooch Behar West Bengal 736101 India Department of Physics City College of New York of City University of New York New York NY 10031 USA Ph.D. Program in Physics The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA Ph.D. Program in Chemistry The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA Department of Chemistry Hunter College City University of New York New York New York 10065 USA Ph.D. Program in Biochemistry The Graduate Center of the City University of New York 365 5th Ave New York NY 10016 USA

Short peptides are versatile molecules for the construction of supramolecular materials. Most reported peptide materials are hydrophobic, stiff, and show limited response to environmental conditions in the solid-state. Herein, we describe a design strategy for minimalistic supramolecular metallo-peptide nanofibers that, depending on their sequence, change stiffness, or reversibly assemble in the solid-state, in response to changes in relative humidity (RH). We tested a series of histidine (H) containing dipeptides with varying hydrophobicity, XH, where X is G, A, L, Y (glycine, alanine, leucine, and tyrosine). The one-dimensional fiber formation is supported by metal coordination and dynamic H-bonds. Solvent conditions were identified where GH/Zn and AH/Zn formed gels that upon air-drying gave rise to nanofibers. Upon exposure of the nanofiber networks to increasing RH, a reduction in stiffness was observed with GH/Zn fibers reversibly (dis-)assembled at 60–70 % RH driven by a rebalancing of hydrogen bonding interactions between peptides and water. When these metallo-peptide nanofibers were deposited on the surface of polyimide films and exposed to varying RH, peptide/water-vapor interactions in the solid-state mechanically transferred to the polymer film, leading to the rapid and reversible folding-unfolding of the films, thus demonstrating RH-responsive actuation.

关键词： Metallopeptide Actuation Humidity Responsive Assembly-disassembly Water Vapor Responsive

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Electronic structures of NANOMET-based nanocrystalline soft magnetic Alloys: Magnetic properties

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physica B: Condensed Matter 2025年 714卷

作者： Jihye Park Minyeong Choi Hyunkyung Lee Haein Choi-Yim Yang-Ki Hong Seong-Gon Kim C. Heath Turner Department of Applied Physics Sookmyung Women's University Seoul 04310 South Korea Hyundai Motor Company 150 HyundaiYeonguso-ro Namyang-eup Hwaseong-si Gyeonggi-do 18280 South Korea Department of Electrical and Computer Engineering and Materials Science Ph.D. Program The University of Alabama Tuscaloosa AL 35487 USA Department of Physics and Astronomy Mississippi State University Mississippi State MS 39762 USA Department of Chemical and Biological Engineering The University of Alabama Tuscaloosa AL 35487 USA

We developed new nanocrystalline Fe-Co-B-P-Cu soft magnetic alloys and studied their magnetic properties by calculating electronic structures using first-principles calculations based on density functional theory within the local spin density approximation and the Brillouin function. The supercell Fe-B-P-Cu was equilibrated at 3000 K for 12 ps using ab initio molecular dynamics (AIMd). Consequently, Fe, B, P, and Cu atoms are distributed randomly in an amorphous matrix formed by cooling it to 0 K. The ferromagnetic bcc α -(Fe 50 Co 50 ) crystallites were formed in the amorphous matrix by annealing the mixture at 300 K and cooling to 0 K. This resulted in the formation of nanocrystalline (Fe, Co)-B-P-Cu soft magnetic alloys. The ferromagnetic bcc α -Fe(Co) crystallites, embedded in an amorphous matrix, were confirmed experimentally for the first time. The experiment involved quickly cooling and heating a melted mixture of Fe, Co, B, Fe 3 P, and Cu to create both amorphous ribbons and crystallites. The Fe-Co-B-P-Cu alloy designed for the experiment has a saturation magnetization ( μ 0 M S ) of over 1.9 T (T) at 0 K and ranging from 1.87 to 1.92 T at 300 K. The magnetocrystalline anisotropy constant (K) decreased significantly to 142 J/m 3 from 5.2 × 104 J/m 3 with an increase in the number of embedded crystallites from one to five, indicating that the alloy became magnetically soft. At 300 K, the experimental μ 0 M S ranged from 1.79 to 1.89 T. Additionally, as the concentration of Co increased, the Curie temperature (T C ) also increased and reached about 800 °C at 3.5 at.%. The study revealed that the average grain size of the synthesized Fe-Co-B-P-Cu alloys was 29 nm. The experimental μ 0 M S was slightly lower than the calculated value for all designed Fe-Co-B-P-Cu alloys, indicating that the recrystallization process was not entirely controlled. The experimental results confirmed that the designed alloy system has achieved the target saturation magnetization of o

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Prediction of anterior cruciate ligament injury from MRI using deep learning

Prediction of anterior cruciate ligament injury from MRI usi...

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International Forum on Medical Imaging in Asia 2021, IFMIA 2021

作者： Truong, Nguyen Khanh Hung Nguyen, Thuan phuoc Kha, Quang Hien Le, Ngoc Hoang Le, Van Tuan Cao, Thi Luu, Ho Thanh Lam Le, Nguyen Quoc Khanh Kang, Jiunn-Horng International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Orthopedic and Trauma Cho Ray Hospital Ho Chi Minh city Viet Nam Mechatronics Engineering Ho Chi Minh City University of Technology Ho Chi Minh city Viet Nam Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Orthopedic and Rehabilitation Department University of Medicine and Pharmacy at Ho Chi Minh city Ho Chi Minh city Viet Nam Children's Hospital 2 Ho Chi Minh City Viet Nam Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei Taiwan Department of Physical Medicine and Rehabilitation School of Medicine College of Medicine Taipei Medical University Taipei Taiwan

ISBN: (数字)9781510644212

ISBN: (纸本)9781510644205

Knee injury emerges as one of the most common diseases, causing dislocation of knee joints, immobility, etc., in which the anterior cruciate ligament (ACL) injury is the most common one. The development of various artificial intelligence (AI) frameworks gained enormous attention in many areas, including injury prediction and health management via medical image analysis. The objective of the current study is to focus on a comprehensive high accurate prediction of ACL injury based on MRI medical images, and also demonstrate the ability of AI in practical and outline conceptual prediction and diagnosis frameworks for other types of knee injuries in the future. Our dataset comprised of knee MRI reports from Cho Ray Hospital, Vietnam which are composed of ACL and non-ACL injury patients. The MRI images were used as supporting data in the deep learning classification model with denseNet-121 algorithm. The successful establishment of an ACL injury diagnosis model from MRI will pave the way for us to develop more diagnostic models of other injuries in the body as well as the prediction of bone diseases. © 2021 SPIE.

关键词： Magnetic resonance imaging

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