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Activation of PI3K/Akt mediates the protective effect of diallyl trisulfide on doxorubicin induced cardiac apoptosis

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Current Research in Toxicology 2023年 5卷 100136页

作者： Wen, Su-Ying Ng, Shang-Chuan Ho, Wen-Kun Huang, Han-Zhe Huang, Chih-Yang Kuo, Wei-Wen Department of Dermatology Taipei City Hospital Renai Branch Taipei Taiwan Department of Cosmetic Applications and Management Mackay Junior College of Medicine Nursing and Management Taipei Taiwan Department of Health Care Management National Taipei University of Nursing and Health Sciences Taipei Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Department of Biotechnology Asia University Taichung Taiwan

diallyl trisulfide (dATS), an organosulfide compound derived from garlic, is renowned for its potent antioxidant properties, particularly in countering the generation of reactive oxygen species (ROS). It has also gained recognition as a potential agent for preventing heart-related conditions. doxorubicin (dox), a commonly used chemotherapeutic drug, is known to induce severe cardiac complications by promoting ROS production. Therefore, it was imperative to investigate whether dATS possesses cardioprotective capabilities against dox-induced cardiac apoptosis and elucidate the underlying mechanisms. In this study, we observed that the intracellular ROS levels and cardiac apoptosis were heightened in H9c2 cells exposed to dox (1 μM). However, treatment with 10 μM dATS effectively mitigated the dox-induced ROS generation and apoptotic signaling, concurrently activating the PI3K/Akt pathway. Notably, the anti-apoptotic effects of dATS were attenuated when PI3K siRNA and the LY294002 PI3K inhibitor were employed. Furthermore, the TUNEL assay results demonstrated a significant reduction in dox-induced apoptosis with dATS treatment. In summary, our findings indicate that dATS can activate the PI3K/Akt pathway, reducing ROS production in cardiac cells exposed to dox, and subsequently rescue cardiac cells from apoptosis. © 2023 The Authors

关键词： Cardiac apoptosis dially trisulfide doxorubicin Reactive oxygen species

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Bioeconomic potential of lignocellulosic by-products: Steam explosion-based fractionation into solid and liquid phases for fiber and methane production

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Bioresource technology 2025年 433卷 132723页

作者： Fabian Orth Benedikt Hülsemann Jayen Aris Kriswantoro Ting-Wu Ko Chen-Yeon Chu State Institute of Agricultural Engineering and Bioenergy University of Hohenheim Garbenstraße 9 70599 Stuttgart Germany. Electronic address: fabian.orth@uni-hohenheim.de. State Institute of Agricultural Engineering and Bioenergy University of Hohenheim Garbenstraße 9 70599 Stuttgart Germany. State Institute of Agricultural Engineering and Bioenergy University of Hohenheim Garbenstraße 9 70599 Stuttgart Germany Ph.D. Program of Mechanical and Aeronautical Engineering Feng Chia University Wenhua 100 407 Taichung Taiwan School of Life Sciences and Technology Institut Teknologi Bandung Ganesa 10 40132 Bandung Indonesia. Institute of Green Products Feng Chia University Wenhua 100 407 Taichung Taiwan Master's Program of Green Energy Science and Technology Feng Chia University Wenhua 100 407 Taichung Taiwan.

This study examines lignocellulosic by-products from agriculture and food industry for methane production. Banana peels, cacao bean shells, rice straw, tomato plant residues, and wheat straw underwent steam explosion treatment (SE) at 160 °C and 10 min followed by solid-liquid separation. Specific methane yield increased between 8.6 % to 19.6 % for rice and wheat straw and cacao bean shells after SE treatment, while decreasing for banana peels (14.1 %). The liquid phase demonstrated high specific methane yield potential, with SMY between 227 and 336 L kg. Meanwhile, the fiber-rich solid phase offers potential for both energy applications and material utilization. The process supports both bioeconomic strategies and greenhouse gas reduction efforts through sustainable valorization of agricultural waste streams in circular economy models. However, further research is needed to optimize SE conditions and investigate other applications for the solid such as peat substitution.

关键词： Biogas Feedstock Separation Specific Methane Yield Treatment

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Correction to: Biological synthesis and characterization of iron oxide (FeO) nanoparticles using Pleurotus citrinopileatus extract and its biomedical applications

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Biomass Conversion and Biorefinery 2023年第11期14卷 12587-12587页

作者： Manimaran, Kumar Yanto, dede Heri Yuli Govindasamy, Mani Karunanithi, Bogeshwaran Alasmary, Fatmah Ali Habab, Reem Abdulrahman Research Center for Applied Microbiology National Research and Innovation Agency (BRIN) Cibinong Republic of Indonesia Department of Product Development Institute of Biotechnology Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India Faculty International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Korea University Seongbuk-gu Republic of Korea Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam India Department of Petroleum Engineering Dhaanish Ahmed College of Engineering Chennai India Department of Chemistry College of Science King Saud University Riyadh Saudi Arabia

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Immobilization of poly(hexamethylene biguanide) to cellulose acetate- and cellulose-based nanofiber membranes for antibacterial and cytotoxic studies

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Biochemical engineering Journal 2024年 205卷

作者： dinh Thi My Huong Chi-Yun Wang Pin-Yi Chen Chien Wei Ooi Xue Er Crystal Thew Bing-Lan Liu Chen-Yaw Chiu Shen-Long Tsai Kuei-Hsiang Chen Yu-Kaung Chang Department Chemical Technology and Environment University of Technology and Education the University of Da Nang Da Nang City Viet Nam Department Chemical Engineering/ Graduate School of Biochemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan Department Chemical Engineering National Taiwan University of Science and Technology Taipei City 10607 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Bone and Joint Research Centre Chang Gung Memorial Hospital Taoyuan City 333423 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Chemical Engineering Department School of Engineering Monash University Malaysia Jalan Lagoon Selatan Bandar Sunway Selangor 47500 Malaysia Advanced Engineering Platform School of Engineering Monash University Malaysia Jalan Lagoon Selatan 47500 Bandar Sunway Selangor Malaysia Department of Applied Chemistry Chaoyang University of Technology Taichung 413310 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist Taoyuan City 320315 Taiwan

To develop the environmental antibacterial membrane, the physical attachments of poly (hexamethylene biguanide) hydrochloride (phMB) on the cellulose acetate (CA) and regenerated cellulose (RC) electrospun nanofiber membranes were employed. The immobilization of phMB increased the antibacterial efficacy ( AE , %) of nanofiber membranes from 65.67% to approximately 86.13% for CA-phMB and from 35.09% to approximately 100% for RC-phMB. The results of the chemical and physical characteristics indicate that the degree of deacetylation of CA nanofiber, the surface charge of the nanofiber, and the density of phMB immobilized onto the nanofiber primarily affect the antibacterial efficacy. The use of mathematical models, such as the Temkin equilibrium model for phMB immobilization and the Monod-type model for the relationship between antibacterial activity and immobilization density of phMB provides a deeper understanding of the interactions and kinetics involved. The rapid achievement of ∼100% AE after only 10 min of contact with Escherichia coli ( E. coli ) is a notable finding, indicating the quick and efficient antibacterial action of RC-phMB nanofiber membranes. Furthermore, maintaining approximately 100% AE after 20 days of storage underscores the long-term stability of phMB immobilized on RC nanofiber membranes. The findings suggest that RC-phMB holds great promise as an antibacterial material for biomedical applications, food packaging industries, and filtration or treatment of water.

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Innovative Endoscopic Approach for Staple Line Leaks Following Sleeve Gastrectomy: Promising Outcomes with Considerable Concerns

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Obesity surgery 2024年第3期34卷 1029-1030页

作者： Ting-Wei Chang Ya-Wei Huang Chih-Kun Huang Po-Chih Chang Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan. Weight Management Center Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan. Department of Nursing Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan. Body Science and Metabolic Disorders International Medical Center China Medical University Hospital Taichung City Taiwan. Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan. dr.changpochih@***. Weight Management Center Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan. dr.changpochih@***. School of Medicine College of Medicine National Sun Yat-sen University Taiwan Republic of China. dr.changpochih@***. Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan. dr.changpochih@***. Ph.D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan. dr.changpochih@***.

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Anethole mitigates H2O2-induced inflammation in HIG-82 synoviocytes by suppressing the aquaporin 1 expression and activating the protein kinase A pathway

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Environmental Toxicology 2024年第2期39卷 965-978页

作者： Huang, Tai-Lung Chang, Yu-Chun Tsai, Bruce Chi-Kang Chen, Tung-Sheng Kao, Shih-Wen Tsai, Yung-Yun Lin, Shinn-Zong Yao, Chun-Hsu Lin, Kuan-Ho Kuo, Wei-Wen Huang, Chih-Yang Department of Biological Science and Technology College of Life Sciences China Medical University Taichung Taiwan Department of Orthopedics Chung-Kang Branch Cheng Ching General Hospital Taichung Taiwan Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan School of Life Science National Taiwan Normal University Taipei Taiwan Department of Orthopaedic Surgery Chung-Shan Medical University Hospital Taichung Taiwan Department of Physical Therapy Asia University Taichung Taiwan Department of Neurosurgery Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Bioinnovation Center Buddhist Tzu Chi Medical Foundation Hualien Taiwan Department of Biomedical Imaging and Radiological Science China Medical University Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan Biomaterials Translational Research Center China Medical University Hospital Taichung Taiwan Department of Bioinformatics and Medical Engineering Asia University Taichung Taiwan Division of Cardiovascular Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan Department of Emergency Medicine China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Ph.D. Program for Biotechnology Industry China Medical University Taichung Taiwan Department of Medical Research China Medical University Hospital China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting approximately 1% of the global population, with a higher prevalence in women than in men. Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of RA. Anethole, a prominent compound derived from fennel (Foeniculum vulgare), possesses a spectrum of therapeutic properties, including anti-arthritic, anti-inflammatory, antioxidant, and tumor-suppressive effects. However, its specific impact on RA remains underexplored. This study sought to uncover the potential therapeutic value of anethole in treating RA by employing an H2O2-induced inflammation model with HIG-82 synovial cells. Our results demonstrated that exposure to H2O2 induced the inflammation and apoptosis in these cells. Remarkably, anethole treatment effectively countered these inflammatory and apoptotic processes triggered by H2O2. Moreover, we identified the aquaporin 1 (AQP1) and protein kinase A (PKA) pathway as critical regulators of inflammation and apoptosis. H2O2 stimulation led to an increase in the AQP1 expression and a decrease in p-PKA-C, contributing to cartilage degradation. Conversely, anethole not only downregulated the AQP1 expression but also activated the PKA pathway, effectively suppressing cell inflammation and apoptosis. Furthermore, anethole also inhibited the enzymes responsible for cartilage degradation. In summary, our findings highlight the potential of anethole as a therapeutic agent for mitigating H2O2-induced inflammation and apoptosis in synovial cells, offering promising prospects for future RA treatments. © 2023 Wiley Periodicals LLC.

关键词： Cell death

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Cover Feature: Sodium Ion-Conducting Electrolytes Based on Chloroaluminate Ionic Liquids and δ-NaCl (ChemSusChem 20/2024)

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ChemSusChem 2024年第20期17卷

作者： Sumit Kumar Rajesh Raghupathy Prof. Keti Vezzù dr. Mounesha N. Garaga dr. Xiaoping Zhu Prof. Steve Greenbaum Prof. Vito di Noto Prof. Michele Vittadello Department of Chemistry and Environmental Science Medgar Evers College of the City University of New York (CUNY) 1638 Bedford Avenue Brooklyn NY 11225 USA Bioorganic Research Laboratory Department of Chemistry University of Delhi University Enclave Delhi 110007 India Nano and Bioelectrochemistry Research Laboratory and Carbon Dioxide Research and Green Technology Centre Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Tiruvalam Road Vellore 632014 India Section of Chemistry for the Technology (ChemTech) Department of Industrial Engineering University of Padova Via Marzolo 9 I-35131 Padova PD Italy Department of Physics Hunter College of CUNY 695 Park Avenue New York NY 10021 USA Ph.D. Program in Physics The Graduate Center of CUNY 365 5th Avenue New York New York 10016 USA Centro Studi di Economia e Tecnica dell'Energia Giorgio Levi Cases Via Marzolo 9 I-35131 Padova PD Italy Ph.D. Program in Chemistry The Graduate Center of CUNY 365 5th Avenue New York New York 10016 USA

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A Global Genome-wide Scan with Optimal Cutoff Mining for Emerging Biomarkers in Head and Neck Squamous Cell Carcinoma

Research Square

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Research Square 2020年

作者： Chi, Li-Hsing Wu, Alexander T.H. Hsiao, Michael Li, Yu-Chuan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Academia Sinica Taipei Taiwan Division of Oral and Maxillofacial Surgery Department of Dentistry Taipei Medical University Hospital Taipei Taiwan Genomics Research Center Academia Sinica Taipei Taiwan Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Background: The survival analysis of the Cancer Genome Atlas (TCGA) dataset is a well-known method to discover the gene expression-based prognostic biomarkers of head and neck squamous cell carcinoma (HNSCC). In order to utilize a continuous gene expression for survival analysis, it is necessary to determine a cutoff point by the dichotomization of the patients. There is some optimization software for cutoff determination. However, those predetermined cutoffs by software usually set at the median, 1/4 quantile, or 3/4 quantile of RNA sequencing (RNA-Seq) value to find a significant P-value of the Kaplan-Meier curve. There are few clinicopathological features available on their pre-processed data sets. Methods: We developed a comprehensive workflow by R script, running on the Rstudio platform. It includes data retrieving and pre-processing, feature selection, cutoff mining engine, Kaplan-Meier survival analysis, Cox proportional hazard modeling, and biomarker discovery. Results: Using this workflow on the TCGA HNSCC cohort, we scanned human protein-coding genes (20,500) programmatically. After adjustment with other confounders, we found that the clinical tumor stage and the surgical margin involvement are independent risk factors in patient survival. According to the resulting tables with Bonferroni adjusted P-value under optimal cutoff as well as hazard ratio (>= 1.5), there were ten candidate biomarkers, named as dKK1, CAMK2N1, STC2, PGK1, SURF4, USP10, NdFIP1, FOXA2, STIP1, and dKC1, which are significantly associated with the poor prognosis of overall survival (OS). At the same time, the other ten genes were over-expressed in the better survival patients (with hazard ratio © 2020, CC BY.

关键词： Tumors

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Retraction notice to ‘Applications of engineered biochar in remediation of heavy metal(loid)s pollution from wastewater: Current perspectives toward sustainable development goals’ [Sci. Total Environ., 926 (2024) 171859] (science of the Total Environment (2024) 926, (S0048969724020023), (10.1016/***.2024.171859))

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science of the Total Environment 2025年 976卷 179291页

作者： Tran, Thien-Khanh Huynh, Loan Nguyen, Hoang-Lam Nguyen, Minh-Ky Lin, Chitsan Hoang, Tuan-dung Hung, Nguyen Tri Q. Nguyen, X. Hoan Chang, S. Woong Nguyen, d. duc Advanced Applied Sciences Research Group Dong Nai Technology University Bien Hoa City76100 Viet Nam Faculty of Technology Dong Nai Technology University Bien Hoa City76100 Viet Nam Department of Civil Engineering McGill University Montreal Canada Faculty of Environment and Natural Resources Nong Lam University Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City700000 Viet Nam Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung81157 Taiwan School of Chemistry and Life Science Hanoi University of Science and Technology No. 1 Dai Co Viet Hai Ba Trung Hanoi100000 Viet Nam Vietnam National University Hanoi - School of Interdisciplinary Sciences and Arts 144 Xuan Thuy Street Cau Giay District Hanoi100000 Viet Nam Ho Chi Minh City University of Industry and Trade Ho Chi Minh City Viet Nam Department of Civil & Energy System Engineering Kyonggi University Suwon16227 Korea Republic of Institute of Applied Technology and Sustainable Development Nguyen Tat Thanh University Ho Chi Minh City700000 Viet Nam

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://***/about/policies/article-withdrawal). This article has been retracted at the request of the Authors. The corresponding author approached the journal to make it aware that significant portions of the text of the STOTEN article had already been included in the following publication involving several members of the same authorship group: Minh-Ky Nguyen, Chitsan Lin, Nguyen Tri Quang Hung, Hoang-Lam Nguyen, Hong-Giang Hoang, Huu-Tuan Tran, Mohammed Hadi, Chapter 8 - Biochar and engineering applications in remediation of heavy metal pollutants from wastewater toward sustainable development, Editor(s): Xuan-Thanh Bui, Ashok Pandey, Thanh-Tin Nguyen, Shu-Yuan Pan, Low Cost Water and Wastewater Treatment Systems: Conventional and Recent Advances, Elsevier, 2025, Pages 195-233, ISBN 9780443236624, https://***/10.1016/B978-0-443-23662-4.00016-0. The authors realise that redundant publications overweigh the relative importance of published findings, and therefore requested the retraction of the STOTEN article. The authors also apologies for any inconvenience caused. © 2025 Elsevier B.V.

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Electrochemical sensor based on ZnO@MWCNT/ glassy carbon electrode for the detection of warfarin (blood anticoagulant)

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Surfaces and Interfaces 2025年 67卷

作者： Manjunath, Kumbar Mudakappa Yemmi, Rajeshwari Swamy, B.E. Kumara Eldesoky, Gaber E. Govindasamy, Mani Division of Plant Breeding and Genetics Central Coffee Research Institute Karnataka Chikkamagaluru 577117 India Department of Industrial Chemistry Kuvempu University Karnataka Shivamogga India Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemistry Korea University Seoul Seongbuk-gu South Korea

This study employed ZnO nanoparticles, multi-walled carbon nanotubes (MWCNTs), and a modified glassy carbon electrode (GCE) as a quick and sensitive method for detecting warfarin at biological ph levels. The ultrasonication technique was utilized in the synthesis of the ZnO@MWCNTs nanocomposite. The ZnO@MWCNTs were characterized using Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), X-ray diffraction (XRd), spectroscopy, analytical techniques, and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry (CV) as well as differential pulse voltammetry (dPV) techniques are employed in the presence of PBS buffer as an electrolyte. We observed unique oxidative peak currents an indication of the electrochemical mechanism of warfarin at low potentials for ZnO @MWCNTs/GCE. Moreover, we successfully attained effective electrochemical detection of warfarin utilizing the proposed sensor, which exhibited an excellent low limit of detection (LOd) of 0.0188 μM across a linear range of 0.02–2867.37 μM. The proposed sensor exhibits excellent storage stability, repeatability, and reproducibility, and has been effectively utilized for the quantification of warfarin in real samples, including blood serum and urine as obtained good recovery and RSd value. © 2025 Elsevier B.V.

关键词： differential pulse voltammetry Glassy carbon electrode Multiwalled carbon nanotubes Warfarin ZnO nanoparticles

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