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CHEMISTRY & BIOLOGY 2010年第4期17卷 311-312页

作者： McCarthy, Alice Main Text “In June 2003 the scientific and medical communities at MIT Harvard University and its affiliated hospitals and the Whitehead Institute banded together as collaborating partners to form the Eli and Edythe L. Broad Institute based in Cambridge MA. The Broad Institute established with initial funding from a $100 million philanthropic donation from the Los Angeles-based Broad family was primarily viewed as a marriage between the Whitehead Institute's Center for Genome Research (WICGR) and the Harvard Institute of Chemistry and Cell Biology (ICCB). Eli Broad founder and chairman of AIG SunAmerica Inc. explained “the purpose of the Broad Institute is to create a new type of research institute to build on the accomplishments of the human genome project and to move to clinical applications to both prevent and cure diseases.” Every Thursday morning we meet with perhaps 20 faculty members and 100 other researchers to discuss what we're all doing and should be doing next. -David Altschuler This paragraph was written five years ago when the Broad Institute was in its very earliest days as a life science research community (McCarthy 2005). Since that time “the Broad” as it's known has kept true to Eli Broad's vision having attracted a talented group of researchers faculty trainees and professional staff. This 1600 person research community known internally as “Broadies” includes faculty staff and students from throughout the MIT and Harvard biomedical research communities and beyond with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. “What is special about the Broad is that we have people from Harvard MIT and the Harvard hospitals come together and work on problems of shared interest that could not be solved in their own individuals labs” explains David Altshuler M.D. Ph.D. Deputy Director and one of the Broad's six core faculty members. “These problems require expertise beyond any one principal investigator and in

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Approximate reliability-based optimization using a three-step approach based on subset simulation

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JOURNAL OF engineering MECHANICS 2007年第4期133卷 481-493页

作者： Ching, Jianye Hsieh, Yi-Hung Assistant Professor Dept. of Construction Engineering National Taiwan Univ. of Science and Technology Taiwan (corresponding author) Ph.D. Student Dept. of Construction Engineering National Taiwan Univ. of Science and Technology Taiwan

A novel three-step approach is proposed to solve reliability-based optimization (RBO) problems. The new approach is based on a novel approach previously developed by the authors for estimating failure probability functions. The major advantage of the new approach is that it is applicable to RBO problems with high-dimensional uncertainties and with arbitrary system complexities. The basic idea is to transform the reliability constraint in the target RBO problem into nonprobabilistic one by first estimating the failure probability function and the confidence intervals using minimal amount of computation, in fact, using just a single subset simulation (SubSim) run for each reliability constraint. Samples of the failure probability function are then drawn from the confidence intervals. In the second step, candidate solutions of the RBO problems are found based on the samples, and in the third step, the final design solution is screened out of the candidates to ensure that the failure probability of the final design meets the target, which also only costs a single SubSim run. Four numerical examples are investigated to verify the proposed novel approach. The results show that the approach is capable of finding approximate solutions that are usually close to the actual solution of the target RBO problem.

关键词： Optimization Simulation Stochastic processes Reliability

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Comparison of the hydrolysis of polyethylene terephthalate fibers by a hydrolase from Fusarium oxysporum LCH I and Fusarium solani f. sp. pisi

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Biotechnology Journal 2007年第3期2卷 361-364页

作者： Nimchua, Thidarat Punnapayak, Hunsa Zimmermann, Wolfgang Department of Microbiology and Bioprocess Technology Institute of Biochemistry University of Leipzig 04103 Leipzig Germany Biological Science Ph.D. Program Faculty of Science Chulalongkorn University Bangkok Thailand Plant Biomass Utilization Research Unit Department of Botany Chulalongkorn University Bangkok Thailand

The hydrolysis of polyethylene terephthalate (PET) fibers by two fungal hydrolases was investigated. The hydrolase from a newly isolated Fusarium oxysporum strain (LCH 1) was more efficient in releasing terephthalic acid from PET fibers compared to the enzyme from F. solani f. sp. pisi dSM 62420 when equal amounts of p-nitrophenyl butyrate-hydrolyzing activity were employed. PET fabrics treated under the same conditions with the enzyme from F. oxysporum LCH 1 also showed a considerably higher increase in hydrophilicity compared to fabrics treated with the enzyme from F. solani f. sp. pisi dSM 62420. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词： Cutinase Enzymatic hydrolysis Hydrolase Polyethylene terephthalate fibers

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Tfe Solberg Award

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Naval Engineers Journal 2009年第5期112卷

作者： dr. Roy L. Streit Since 1992 Dr. Streit has focused a significant amount of his energy to assignment problems in acoustic warfare data fusion systems. This work led him to the formulation of the PDD Principle a broadly useful theoretical method that enables the derivation of new classes of discrete-continuous estimation algorithms for solving assignment problems without requiring enumeration and pruning. In recognition of his outstanding work in this area Dr. Streit received the NAVSEA Scientist of the Year Award for 1997. Dr. Streit has also been pursuing avenues for analyzing the loss in broadband detection performance of an acoustic array in the presence of interferences. Because examining all possible separations between the signal and many interferers is infeasible he has proposed a Poisson process model for the number and location (s) of the interferers. In this same time period Dr. Streit has also been investigating issues in environmental modeling and localization by proposing a novel integral method for solving the bearings-only target motion analysis problem which enables a natural heuristic for compensating for mismatch between the model predictions and the real world. Most recently Dr. Streit has proposed the Numerical ACoustic Hull ARray (NACHAR) Project as a revolutionary and ambitious approach to hull array design. Its premise is that optimizing the detection capability of large hull arrays requires the full integration of hull sensor array and beamformer design processes. Because NACHAR crosses an unusual number of technical disciplines it involves researchers from several departments. The diversity of Dr. Streif s technical background makes him uniquely suited to lead the project Dr. Streifs truly impressive scientific achievements are complemented by a noteworthy list of professional activities that accentuate his value to Division Newport and the Navy. He represents the United States in The Technical Cooperation Program Maritime Activities Panel 9 (Sonar Technology) and participates in the Division New

for his significant engineering research and development in sonar array research and acoustic transient signals as set forth in the following

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Study on dryout point and heat transfer in subcooled flow boiling through vertical narrow annular channels

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Journal of Energy and Power engineering 2007年第1期1卷 15-21页

作者： dING Guo-zhong HUANG Su-yi SU Shun-yu LI Jia HU Xing-hua Corresponding author： HUANG Hu-lin Ph.D. professor research fields： solar energy application MHD flow and heat transfer. E-mail： hlhuang@***. School of Energy and Power Engineering Huazhong University of Science and Technology Wuhan 430074 China

The purpose of this study is to conduct the dryout point and heat transfer correlation for subcooled boiling flow in narrow annuli. First, the dryout point of subcooled flow boiling of water was measured in narrow annular channels under the working condition of pressure ranging from 0.1 to 0.3 MPa and low mass flow rate from 6 to 60 kgm^-2 s^-1. Experimental test channels were annular and heated bilaterally with the channel gap of lmm and 1.5mm, and heated length of *** location of the dryout was observed and measured by experiment with investigating the various system parameter effects on dryout point, and the results show that the location of dryout point is basically stable and repeating and the heat transfer coefficient increased with heat flux, mass flux and pressure, however, decreases with the gap size. Next, new correlations of CHF and critical vapor quality for narrow annular channels was proposed and calculation results shown a good agreement with the experimental data.

关键词： dryout point heat transfer subcooled flow boiling narrow annular channels

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A Case Study on the Innovation Process from Mission-Oriented Basic Research Stage to Applied Research Stage

A Case Study on the Innovation Process from Mission-Oriented...

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Portland International Conference on Management of engineering and technology (PICMET)

作者： Hideki Yoshida Joji Shinohara Tadashi Sasa Eiichi Maruyama Japan Science and Technology Agency (JST) Task Force for Evaluation of Basic Research Programs Tokyo JAPAN National Graduate Institute for Policy Studies (GRIPS) Ph.D. program in Science and Technology Policy Tokyo JAPAN RIKEN Cenier’ for Intellectual Property Strategies Saitama JAPAN

The role of the stage-gate II, interface between mission-oriented basic research and applied research, has been investigated by means of the case studies on typical JST ( Japan science and technology Agent) projects. The disincentive factors of the breakthrough at the stage-gate II, the patterns of the mission-oriented basic research processes based on this case study, and the success factors of the breakthrough at the stage-gate II are found. Moreover, the stage-gate II is found to be the important indicator of mission-oriented basic research for the innovation process.

关键词： Technological innovation Research and development Intellectual property Computer aided software engineering Councils Guidelines Robustness Government International collaboration Statistics

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IMPROVEd CONTINUATION METHOd CONTROLLER FOR PWM SYSTEMS: AN EXPERIMENTAL CASE STUdY

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Asian Journal of Control 2008年第1期1卷

作者： T. Iwata M. Yamakita K. Furuta Dept. of Mechanical and Environment Informatics Tokyo Institute of Technology. Takaaki Iwata received the BE degrees in Mechanical Engineering in 1990 from Waseda University Japan. From 1990 to 1996 he jointed NOK Co. Ltd. In 1996 he received his ME degrees in Mechanical and Environmental Informatics from Tokyo Institute of Technology. He is currently a PhD student of Tokyo Institute of Technology. He is a member of SICE RSJ JSME and IEEE. Dept. of Control and Systems Engineering Tokyo Institute of Technology. Masaki Yamakita received Be ME and PhD from Tokyo Institute of Technology in 1984 1986 and 1989 respectively. From 1989 he was a Research Associate in the Department of Control Engineering of Tokyo Institute of Technology and from 1993 he was a Lecturer at Tokyohashi University of Technology. He is currently an Associate Professor in the Department of Control and Systems Engineering of Tokyo Institute of Technology. His research interests include robotics learning control robust control and non-linear control. Katsuhisa Furuta was born in Tokyo Japan in 1940. He received his B.S. M.S. and Ph.D. degrees in Chemical Engineering from Tokyo Institute of Technology in 1962 1964 and 1967 respectively. Since 1967 he has been a teaching staff of Tokyo Institute of Technology where he is currently a Professor of Graduate School of Information Science and Engineering. He is a fellow of IEEE and SICE. He is now a member of Science Council of Japan the secretary of the engineering division a council member of IFAC and the President of SICE in 1999.

In this paper, an improved version of online continuation method controller for PWM systems is presented. The online continuation method controller solves the PWM-type deadbeat control problem numerically. By using this algorithm, iterations for solving the set of nonlinear equations always start from a good solution candidate and therefore it can be used online. The original continuation method is modified so that it is applicable to real systems. The validity of the proposed control method is demonstrated by a laboratory-scale flexible arm manipulator.

关键词： PWM continuation method homotopy deadbeat GPC

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An On-line Cavitation Monitoring System for Large Kaplan Turbines

An On-line Cavitation Monitoring System for Large Kaplan Tur...

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IEEE General Meeting Power& Energy Society

作者： Huixuan Shi Zhaohui Li Yaxiong Bi Ph.D. candidate HUST. full professor HUST associate dean Faculty of Hydropower Digitalization Engineering Hust senior engineer China Three Gorges Project Corporation professor Huazhong University of Science and Technology.

Cavitation erodes hydro turbines and reduces their performance. As cavitation varies with the operating condition and the service time of turbines, an on-line monitoring system for water turbines (TrbMAU) is developed. Both audible sound (20 Hz~20 kHz) and ultrasound (50 kHz~300 kHz) are continuously monitored. The signal characteristics such as standard deviation, noise level and frequency compositions are evaluated. The evaluation results are stored in database in association with the operating condition donated by water head and wicket gate opening (or power output). According to the frequency characteristics, the sound emitted by cavitation is distinguished from the others such as water flow sound and mechanical sound. The cavitation intensity on different water head and power has been traced out. The degree of cavitation erosion is estimated according to the cavitation intensity at a fixed operating condition such as rated power and designed water head. The TrbMAU has been put into service in Gezhouba Hydro Power Plant. The application results are presented.

关键词： Ultrasonic imaging Power generation Hydraulic turbines Frequency Blades Acoustic testing Condition monitoring Vibrations Acoustic emission Bismuth

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A Study On Iterative Learning Control With Adjustment Of Learning Interval For Monotone Convergence In The Sense Of Sup-Norm

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Asian Journal of Control 2008年第1期4卷

作者： Kwang-Hyun Park Zeungnam Bien Division of EE Department of EECS Korea Advanced Institute of Science and Technology 373–1 Kusong-dong Yusong-gu Taejon 305–701 Korea. Zeungname Bien:received the B.S. degree in electronics engineering from Seoul National University Seoul Korea in 1969 and the M.S. and Ph.D. degrees in electrical engineering from the University of Iowa Iowa City Iowa U.S.A. in 1972 and 1975 respectively. During 1976–1977 academic years he taught as assistant professor at the Department of Electrical Engineering University of Iowa. Then Dr. Bien joined Korea Advanced Institute of Science and Technology summer 1977 and is now Professor of Control Engineering at the Department of Electrical Engineering and Computer Science KAIST. Dr. Bien was the president of the Korea Fuzzy Logic and Intelligent Systems Society during 1990–1995 and also the general chair of IFSA World Congress 1993 and for FUZZ-IEEE99 respectively. He is currently co-Editor-in-Chief for International Journal of Fuzzy Systems (IJFS) Associate Editor for IEEE Transactions on Fuzzy Systems and a regional editor for the International Journal of Intelligent Automation and Soft Computing. He has been serving as Vice President for IFSA since 1997 and is now Chief Chairman of Institute of Electronics Engineers of Korea and Director of Humanfriendly Welfare Robot System Research Center. His current research interests include intelligent control methods with emphasis on fuzzy logic systems service robotics and rehabilitation engineering and large-scale industrial control systems. Kwang-Hyun Park:received the B.S. M.S. and Ph.D. degrees in electrical engineering and computer science from KAIST Korea in 1994 19997 and 2001 respectively. He is now a researcher at Human-friendly Welfare Robot System Research Center. His research interests include learning control machine learning human-friendly interfaces and service robotics.

It has been found that some huge overshoot in the sense of sup-norm may be observed when typical iterative learning control (ILC) algorithms are applied to LTI systems, even though monotone convergence in the sense of λ-norm is guaranteed. In this paper, a new ILC algorithm with adjustment of learning interval is proposed to resolve such an undesirable phenomenon, and it is shown that the output error can be monotonically converged to zero in the sense of sup-norm when the proposed ILC algorithm is applied. A numerical example is given to show the effectiveness of the proposed algorithm.

关键词： Iterative learning control monotone convergence learning interval sup-norm

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TRACKING CONTROL IN THE PRESENCE OF NONLINEAR dYNAMIC FRICTIONAL EFFECTS: ROBOT EXTENSION

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Asian Journal of Control 2008年第3期1卷

作者： M. Feemster d.M. dawson A. Behal W. dixon Matthew Feemster received the B.S degree in Electrical Engineering from Clemson University Clemson South Carolina in December 1994. Upon graduation he remained at Clemson University and received the M.S. degree in Electrical Engineering in 1997. During this time he also served as a research/teaching assistant. His research work focused on the design and implementation of various nonlinear control algorithms with emphasis on the induction motor and mechanical systems with friction present. He is currently working toward his Ph.D. degree in Electrical Engineering at Clemson University. Darren M. Dawson was born in 1962 in Macon Georgia. He received an Associate Degree in Mathematics from Macon Junior College in 1982 and a B.S. Degree in Electrical Engineering from the Georgia Institute of Technology in 1984. He then worked for Westinghouse as a control engineer from 1985 to 1987. In 1987 he returned to the Georgia Institute of Technology where he received the Ph.D. Degree in Electrical Engineering in March 1990. During this time he also served as a research/teaching assistant. In July 1990 he joined the Electrical and Computer Engineering Department and the Center for Advanced Manufacturing (CAM) at Clemson University where he currently holds the position of Professor. Under the CAM director's supervision he currently leads the Robotics and Manufacturing Automation Laboratory which is jointly operated by the Electrical and Mechanical Engineering departments. His main research interests are in the fields of nonlinear based robust adaptive and learning control with application to electro-mechanical systems including robot manipulators motor drives magnetic bearings flexible cables flexible beams and high-speed transport systems. Aman Behal was born in India in 1973. He received his Masters Degree in Electrical Engineering from Indian Institute of Technology Bombay in 1996. He is currently working towards a Ph.D in Controls and Robotics at Clemson University. His research focuses on the control of no

In this paper, we extend the observer/control strategies previously published in [25] to an n -link, serially connected, direct drive, rigid link, revolute robot operating in the presence of nonlinear friction effects modeled by the Lu-Gre model. In addition, we also present a new adaptive control technique for compensating for the nonlinear parameterizable Stribeck effects. Specifically, an adaptive observer/controller scheme is developed which contains a feedforward approximation of the Stribeck effects. This feedforward approximation is used in a composite controller/observer strategy which forces the average square integral of the position tracking error to an arbitrarily small value. Experimental results are included to illustrate the performance of the proposed controllers.

关键词： Friction compensation nonlinear control

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