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International Conference on Informatics and Computational sciences (ICICoS)

作者： Suhartono Jung-Lung Chiang Maria Mahardini Sakanti C. Bambang dwi Kuncoro Ph.D. Program Prospective Technology of Electrical Engineering and Computer Science National Chin-Yi University of Technology Taichung Taiwan R.O.C Graduate Institute of Precision Manufacturing National Chin-Yi University of Technology Taichung Taiwan R.O.C Department of Refrigeration Air Conditioning and Energy Engineering National Chin-Yi University of Technology Taichung Taiwan R.O.C

ISBN: (数字)9798350375886

ISBN: (纸本)9798350375893

This research aims to create a smart residential system that will improve parking management in residential areas using mini-server technology. Another aim is to provide a safe and effective smart parking solution for residential areas with limited capacity. This research method uses mini-server technology and control to create smart system ideas. Apart from that, this research also uses servo motor technology, proximity sensors, cameras, and IoT applications for smart parking management. The result is the creation of intelligent residential parking management, which uses a Raspberry Pi 5 Model B as a server and control to improve the parking management system in residential areas, and the use of number plate recognition technology to be applied to Smart City. This further research offers a new perspective on creating intelligent parking solutions using two input validation parameters simultaneously, namely facial and license plate recognition

关键词： Smart cities Automated parking Servers Security Internet of Things Usability Servomotors

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deep Unsupervised Learning for Biomedical Image Translation from Harmonic Generation Microscopy Image to H&E-stained Image

Deep Unsupervised Learning for Biomedical Image Translation ...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Chen, Wei-Ju Liao, En-Yu Tai, Tsung-Ming Liao, Yi-Hua Sun, Chi-Kuang Lee, Cheng-Kuang See, Simon Chen, Hung-Wen International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering Graduate Institute of Photonics and Optoelectronics National Taiwan University Taipei Taiwan NVIDIA AI Technology Center NVIDIA Taipei Taiwan Department of Dermatology National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan Institute of Photonics Technologies National Tsing Hua University Hsinchu Taiwan

This work proposes an unsupervised deep learning-based image translation from Harmonic generation microscopy (HGM) to widely used H&E-stained images. The proposed methodology is promising and hopefully will facili... 详细信息

ISBN: (纸本)9781957171258

关键词： deep learning

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Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3d-printed bioceramic and human adipose-derived stem cells laden biohydrogel

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Journal of Biological engineering 2023年第1期17卷 1-24页

作者： Lee, Chih-Yun Nedunchezian, Swathi Lin, Sung-Yen Su, Yu-Feng Wu, Che-Wei Wu, Shun-Cheng Chen, Chung-Hwan Wang, Chih-Kuang Ph.D. Program in Life Sciences College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan Orthopaedic Research Center College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Medicinal and Applied Chemistry College of Life Science Kaohsiung Medical University Kaohsiung 80708 Taiwan Departments of Orthopaedics School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Orthopaedics Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Orthopaedics Kaohsiung Municipal Ta-Tung Hospital Kaohsiung Medical University Kaohsiung 80145 Taiwan Faculty of Post-Baccalaureate Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80756 Taiwan Department of Surgery Division of Neurosurgery Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Nursing Asia University Taichung 41354 Taiwan Ph.D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan

Reconstruction of severe osteochondral defects in articular cartilage and subchondral trabecular bone remains a challenging problem. The well-integrated bilayer osteochondral graft design expects to be guided the chondrogenic and osteogenic differentiation for stem cells and provides a promising solution for osteochondral tissue repair in this study. The subchondral bone scaffold approach is based on the developed finer and denser 3d β-tricalcium phosphate (β-TCP) bioceramic scaffold process, which is made using a digital light processing (dLP) technology and the novel photocurable negative thermo-responsive (NTR) bioceramic slurry. Then, the concave-top disc sintered 3d-printed bioceramic incorporates the human adipose-derived stem cells (hAdSCs) laden photo-cured hybrid biohydrogel (HG + 0.5AFnSi) comprised of hyaluronic acid methacryloyl (HAMA), gelatin methacryloyl (GelMA), and 0.5% (w/v) acrylate-functionalized nano-silica (AFnSi) crosslinker. The 3d β-TCP bioceramic compartment is used to provide essential mechanical support for cartilage regeneration in the long term and slow biodegradation. However, the apparent density and compressive strength of the 3d β-TCP bioceramics can be obtained for ~ 94.8% theoretical density and 11.38 ± 1.72 MPa, respectively. In addition, the in vivo results demonstrated that the hAdSC + HG + 0.5AFnSi/3d β-TCP of the bilayer osteochondral graft showed a much better osteochondral defect repair outcome in a rabbit model. The other word, the subchondral bone scaffold of 3d β-TCP bioceramic could accelerate the bone formation and integration with the adjacent host cancellous tissue at 12 weeks after surgery. And then, a thicker cartilage layer with a smooth surface and uniformly aligned chondrocytes were observed by providing enough steady mechanical support of the 3d β-TCP bioceramic scaffold. © 2023, The Author(s).

关键词： Bioceramic scaffold digital light processing Gelatin methacryloyl Hyaluronic acid methacryloyl Osteochondral Tissue engineering

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discrete null field equation methods for solving Laplace's equation: Boundary layer computations

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Numerical Methods for Partial differential Equations 2024年第4期40卷

作者： Zhang, Li-Ping Li, Zi-Cai Lee, Ming-Gong Huang, Hung-Tsai School of Mathematical Sciences Qufu Normal University Shandong Qufu China Department of Applied Mathematics National Sun Yat-sen University Kaohsiung Taiwan Department of Tourism and Leisure/Ph.D. Program in Engineering Science Chung Hua University Hsinchu Taiwan Department of Data Science and Analytics I-Shou University Kaohsiung Taiwan

Consider dirichlet problems of Laplace's equation in a bounded simply-connected domain (Formula presented.), and use the null field equation (NFE) of Green's representation formulation, where the source nodes (Formula presented.) are located on a pseudo-boundary (Formula presented.) outside (Formula presented.) but not close to its boundary (Formula presented.). Simple algorithms are proposed in this article by using the central rule for the NFE, and the normal derivatives (Formula presented.) of the solutions on the boundary (Formula presented.) can be easily obtained. These algorithms are called the discrete null field equation method (dNFEM) because the collocation equations are, indeed, the direct discrete form of the NFE. The bounds of the condition number are like those by the method of fundamental solutions (MFS) yielding the exponential growth as the number of unknowns increases. One trouble of the dNFEM is the near singularity of integrations for the solutions in boundary layers in Green's representation formulation. The traditional BEM also suffers from the same trouble. To deal with the near singularity, quadrature by expansions and the sinh transformation are often used. To handle this trouble, however, we develop two kinds of new techniques: (I) the interpolation techniques by Taylor's formulas with piecewise (Formula presented.) -degree polynomials and the Fourier series, and (II) the mini-rules of integrals, such as the mini-Simpson's and the mini-Gaussian rules. Error analysis is made for technique I to achieve optimal convergence rates. Numerical experiments are carried out for disk domains to support the theoretical analysis made. The numerical performance of the dNFEM is excellent for disk domains to compete with the MFS. The errors with (Formula presented.) can be obtained by combination algorithms, which are satisfactory for most engineering problems. In summary, the new simple dNFEM is based on the NFE, which is different from the boundary elem

关键词： Fourier series

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Structure-Guided discovery of Pd-1/Pd-L1 Interaction Inhibitors: Peptide design, Screening, and Optimization via Computation-Aided phage display engineering

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Journal of Chemical Information and Modeling 2024年第5期64卷 1615-1627页

作者： Tseng, Tien-Sheng Lee, Chao-Chang Chen, Po-Juei Lin, Chiu-Yuen Chen, Wang-Chuan Lee, Yu-Ching Lin, Jiun-Han Chen, Kaun-Wen Tsai, Keng-Chang Institute of Molecular Biology National Chung Hsing University Taichung40202 Taiwan National Research Institute of Chinese Medicine Ministry of Health and Welfare Taipei11221 Taiwan The School of Chinese Medicine for Post Baccalaureate I-Shou University Kaohsiung824005 Taiwan Department of Chinese Medicine E-Da Hospital Kaohsiung824005 Taiwan TMU Research Center of Cancer Translational Medicine Taipei Medical University Taipei11031 Taiwan Ph.D. Program in Medical Biotechnology College of Medical Science and Technology Taipei Medical University Taipei11031 Taiwan Department of Industrial Technology Ministry of Economic Affairs Taipei100210 Taiwan Food Industry Research and Development Institute Hsinchu30062 Taiwan Molecular Science and Digital Innovation Center Genetics Generation Advancement Corporation Taipei11949 Taiwan

Cancer immunotherapy harnesses the immune system to combat tumors and has emerged as a major cancer treatment modality. The Pd-1/Pd-L1 immune checkpoint modulates interactions between tumor cells and T cells and has been extensively targeted in cancer immunotherapy. However, the monoclonal antibodies known to target this immune checkpoint have considerable side effects, and novel Pd-1/Pd-L1 inhibitors are therefore required. Herein, a peptide inhibitor to disrupt Pd-1/Pd-L1 interactions was designed through structure-driven phage display engineering coupled to computational modification and optimization. BetaPb, a novel peptide library constructed by using the known structure of Pd-1/Pd-L, was used to develop inhibitors against the immune checkpoint, and specific peptides with high affinity toward Pd-1 were screened through enzyme-linked immunosorbent assays, homogeneous time-resolved fluorescence, and biolayer interferometry. A potential inhibitor, B8, was preliminarily screened through biopanning. The binding affinity of B8 toward Pd-1 was confirmed through computation-aided optimization. Assessment of B8 variants (B8.1, B8.2, B8.3, B8.4, and B8.5) demonstrated their attenuation of Pd-1/Pd-L1 interactions. B8.4 exhibited the strongest attenuation efficiency at a half-maximal effective concentration of 0.1 μM and the strongest binding affinity to Pd-1 (equilibrium dissociation constant = 0.1 μM). B8.4 outperformed the known Pd-1/Pd-L1 interaction inhibitor PL120131 in disrupting Pd-1/Pd-L1 interactions, revealing that B8.4 has remarkable potential for modification to yield an antitumor agent. This study provides valuable information for the future development of peptide-based drugs, therapeutics, and immunotherapies for cancer. © 2024 American Chemical Society.

关键词： Peptides

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Improving iPSC differentiation Using a Nanodot Platform

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ACS Applied Materials and Interfaces 2024年第28期16卷 36030-36046页

作者： Chiew, Men Yee Wang, Erick Lan, Kuan-Chun Lin, Yan-Ren Hsueh, Yu-Huan Tu, Yuan-Kun Liu, Chu-Feng Chen, Po-Chun Lu, Huai-En Chen, Wen Liang Center for Regenerative Medicine and Cellular Therapy National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan College of Biological Science and Technology Industrial Ph. D. Program National Yang Ming Chiao Tung University Hsinchu300 Taiwan Kyoto University Kyoto606-8397 Japan Department of Emergency and Critical Care Medicine Changhua Christian Hospital Changhua500 Taiwan Department of Post Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung402 Taiwan School of Medicine Kaohsiung Medical University Kaohsiung807 Taiwan School of Medicine Chung Shan Medical University Taichung402 Taiwan College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Orthopedic Surgery E-Da Hospital I-Shou University Kaohsiung824 Taiwan Emergency Medicine Department Kaohsiung Chang Gung Memorial Hospital Kaohsiung833 Taiwan Ph. D. Degree Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Hsinchu300 Taiwan Bioresource Collection and Research Center Food Industry Research and Development Institute Hsinchu City300 Taiwan

differentiation of induced pluripotent stem cells (iPSCs) is an extremely complex process that has proven difficult to study. In this research, we utilized nanotopography to elucidate details regarding iPSC differentiation by developing a nanodot platform consisting of nanodot arrays of increasing diameter. Subjecting iPSCs cultured on the nanodot platform to a cardiomyocyte (CM) differentiation protocol revealed several significant gene expression profiles that were associated with poor differentiation. The observed expression trends were used to select existing small-molecule drugs capable of modulating differentiation efficiency. BRd K98 was repurposed to inhibit CM differentiation, while iPSCs treated with NSC-663284, carmofur, and KPT-330 all exhibited significant increases in not only CM marker expression but also spontaneous beating, suggesting improved CM differentiation. In addition, quantitative polymerase chain reaction was performed to determine the gene regulation responsible for modulating differentiation efficiency. Multiple genes involved in extracellular matrix remodeling were correlated with a CM differentiation efficiency, while genes involved in the cell cycle exhibited contrasting expression trends that warrant further studies. The results suggest that expression profiles determined via short time-series expression miner analysis of nanodot-cultured iPSC differentiation can not only reveal drugs capable of enhancing differentiation efficiency but also highlight crucial sets of genes related to processes such as extracellular matrix remodeling and the cell cycle that can be targeted for further investigation. Our findings confirm that the nanodot platform can be used to reveal complex mechanisms behind iPSC differentiation and could be an indispensable tool for optimizing iPSC technology for clinical applications. © 2024 The Authors. Published by American Chemical Society.

关键词： Efficiency

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Immediate Effects of Vergence Exercises Using Automatic dual Rotational Risley Prisms on Accommodative Lag and Facility

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Ophthalmology and Therapy 2023年第6期12卷 3361-3372页

作者： Huang, Shuan-Yu Su, Hui-Rong Hu, Yun-Shao Lee, Chi-Hung Tsai, Ming-Shan Yeh, Shang-Min Chen, Ya-Yu Tsai, Tzu-Hsun Department of Optometry Central Taiwan University of Science and Technology Taichung 402 Taiwan Ph.D. Program of Electrical and Communications Engineering Feng Chia University Taichung 407 Taiwan Department of Optometry Chung Shan Medical University Taichung 402 Taiwan Department of Electrical Engineering Feng Chia University Taichung 407 Taiwan Department of Electrophysics National Chiayi University Chiayi 600 Taiwan Department of Optometry Da-Yeh University Changhua 515 Taiwan Department of Ophthalmology National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Taiwan Department of Ophthalmology National Taiwan University Hospital Taipei City 100225 Taiwan

Introduction: This study evaluated novel automatic dual rotational Risley prisms (AdRRPs) as a vergence exercise tool for patients with myopia to improve accommodative lag and accommodative facility. Methods: Participants with myopia aged 20–24 years were recruited. After vergence exercises with prisms (treatment group) or plano lenses (control group) using AdRRPs for 10 min, measurements were taken using an open-field autorefractor (Grand Seiko WAM-5500) at viewing distances of 0.4 m and 6.0 m. We measured accommodative facility using a ± 2.00 d accommodative flipper. Results: A total of 56 participants (treatment group, 39;control group, 17) performed vergence exercises using AdRRPs. Participants in the treatment group showed improvements in accommodative lag at a 0.4 m viewing distance, with measurements of 0.57 d (right eye;Od) and 0.53 d (left eye;OS) and 0.21 d (Od) and 0.27 d (OS) before and after the exercises, respectively (p < 0.001). Over-refractions using an open-field autorefractor with spherical equivalent contact lenses at a 6.0 m viewing distance were − 0.01 ± 0.30 d (Od) and 0.03 ± 0.34 d (OS) and 0.15 ± 0.32 d (Od) and 0.19 ± 0.28 d (OS) before and after the exercises, respectively (difference + 0.16 d;p < 0.001). Accommodative facility values before and after exercises were 14.88 ± 3.36 and 15.59 ± 3.60 cpm, respectively (p < 0.01). No significant differences in accommodative lag, relaxation, and accommodative facility before and after exercise were observed in the control group. Conclusions: Using AdRRPs in vergence exercises can improve accommodative lag, accommodative facility, and accommodative relaxation in adults with myopia. Further research to evaluate persistent and long-term effects is needed. © 2023, The Author(s).

关键词： Accommodative facility Accommodative lag Automatic dual rotational Risley prisms (AdRRPs) Vergence exercise

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Enhanced removal of viral aerosols using nanosilver/TiO2-chitosan filters combined with a negative air ionizer

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Journal of Environmental Chemical engineering 2024年第3期12卷

作者： dlamini, Wonder Nathi Yao, Ting-Ching Lee, Hsin-Jui Berekute, Abiyu Kerebo Sallah-Ud-din, Rasham Siregar, Sepridawati Yu, Kuo-Pin Institute of Environmental and Occupational Health Sciences National Yang-Ming Chiao-Tung University Taipei Taiwan Department of International Ph.D. Program in Environmental Sciences and Technology University System of Taiwan Taipei Taiwan Department of Chemistry College of Natural and Computational Sciences Arba Minch University Arbaminch Ethiopia Faculty of Mineral Technology AKPRIND Institute of Science & Technology Yogyakarta Indonesia

The presence of airborne viruses in bioaerosols is a significant and ongoing public health concern. In this context, this study aimed to develop a new filter that integrates nanosilver into a TiO2-chitosan matrix (nano-Ag/TiO2-CS) to inactivate the non-enveloped bacteriophage MS2 as a viral aerosol surrogate. The materials were characterized using various techniques, such as X-ray diffraction (XRd), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), and X-ray photoelectron spectroscopy (XPS). The SEM images showed that the nano-Ag particles were spheres with a high surface area for virus interactions and that the fiber surfaces were covered by nano-Ag, which enhanced contact with viruses. The optimal 5 wt% nano-Ag/TiO2-CS filter combined with a negative air ionizer (NAI) showed the highest viral aerosol removal efficiency, which reached 97 %. The use of an NAI during filtration enhanced the inactivation of the viral aerosols. A long-term antiviral efficacy assessment showed that the nano-Ag/TiO2-CS filter demonstrated robust durability, which is vital for real-world applications. The nanofilter proposed in this work is simple, safe, and cost-effective for inactivating viral aerosols to improve indoor air quality. © 2024 Elsevier Ltd

关键词： Aerosols

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

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International Journal of Biological Macromolecules 2024年第PT 2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. dopamine (dP) was introduced to this hybrid (G-H-d) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-d material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing. © 2023

关键词： Adhesion

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technology Roadmap for Flexible Sensors

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ACS NANO 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex dagdeviren, Canan dauskardt, Reinhold H. di, Chong-an dickey, Michael d. duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, daniil Khademhosseini, Ali Kim, dae-Hyeong Kim, Il-doo Kireev, dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A*STAR) 2 Fusionopolis Way #08-03 Innovis Singapore 138634 Republic of Singapore；Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States；Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden；Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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